Amino acid dipepetide frequency for Polyangium sp. SDU3-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.765AlaAla: 17.765 ± 0.12
1.849AlaCys: 1.849 ± 0.043
6.174AlaAsp: 6.174 ± 0.053
8.254AlaGlu: 8.254 ± 0.066
4.066AlaPhe: 4.066 ± 0.038
10.818AlaGly: 10.818 ± 0.069
2.541AlaHis: 2.541 ± 0.031
5.228AlaIle: 5.228 ± 0.041
3.856AlaLys: 3.856 ± 0.045
14.838AlaLeu: 14.838 ± 0.119
2.782AlaMet: 2.782 ± 0.032
2.205AlaAsn: 2.205 ± 0.033
8.318AlaPro: 8.318 ± 0.074
3.796AlaGln: 3.796 ± 0.04
11.868AlaArg: 11.868 ± 0.106
7.759AlaSer: 7.759 ± 0.054
6.017AlaThr: 6.017 ± 0.047
8.495AlaVal: 8.495 ± 0.052
1.783AlaTrp: 1.783 ± 0.025
2.36AlaTyr: 2.36 ± 0.026
0.0AlaXaa: 0.0 ± 0.0
Cys
1.523CysAla: 1.523 ± 0.032
0.173CysCys: 0.173 ± 0.011
0.912CysAsp: 0.912 ± 0.033
0.706CysGlu: 0.706 ± 0.018
0.307CysPhe: 0.307 ± 0.012
1.292CysGly: 1.292 ± 0.032
0.264CysHis: 0.264 ± 0.012
0.365CysIle: 0.365 ± 0.01
0.399CysLys: 0.399 ± 0.013
0.818CysLeu: 0.818 ± 0.019
0.212CysMet: 0.212 ± 0.009
0.399CysAsn: 0.399 ± 0.02
0.738CysPro: 0.738 ± 0.02
0.314CysGln: 0.314 ± 0.012
0.718CysArg: 0.718 ± 0.016
0.768CysSer: 0.768 ± 0.022
0.723CysThr: 0.723 ± 0.022
0.894CysVal: 0.894 ± 0.024
0.151CysTrp: 0.151 ± 0.01
0.231CysTyr: 0.231 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.806AspAla: 7.806 ± 0.056
0.685AspCys: 0.685 ± 0.027
3.542AspAsp: 3.542 ± 0.042
4.319AspGlu: 4.319 ± 0.041
1.772AspPhe: 1.772 ± 0.022
5.807AspGly: 5.807 ± 0.069
1.063AspHis: 1.063 ± 0.016
2.03AspIle: 2.03 ± 0.027
1.825AspLys: 1.825 ± 0.031
5.84AspLeu: 5.84 ± 0.047
0.889AspMet: 0.889 ± 0.017
1.088AspAsn: 1.088 ± 0.025
4.369AspPro: 4.369 ± 0.038
1.297AspGln: 1.297 ± 0.019
4.27AspArg: 4.27 ± 0.041
1.841AspSer: 1.841 ± 0.025
2.295AspThr: 2.295 ± 0.03
4.657AspVal: 4.657 ± 0.037
0.68AspTrp: 0.68 ± 0.015
1.059AspTyr: 1.059 ± 0.018
0.0AspXaa: 0.0 ± 0.0
Glu
9.01GluAla: 9.01 ± 0.066
0.541GluCys: 0.541 ± 0.015
3.344GluAsp: 3.344 ± 0.037
4.356GluGlu: 4.356 ± 0.042
1.24GluPhe: 1.24 ± 0.019
5.916GluGly: 5.916 ± 0.043
1.507GluHis: 1.507 ± 0.022
3.04GluIle: 3.04 ± 0.03
2.126GluLys: 2.126 ± 0.032
6.721GluLeu: 6.721 ± 0.054
1.296GluMet: 1.296 ± 0.02
1.213GluAsn: 1.213 ± 0.019
3.719GluPro: 3.719 ± 0.036
2.127GluGln: 2.127 ± 0.03
6.535GluArg: 6.535 ± 0.065
2.728GluSer: 2.728 ± 0.032
2.874GluThr: 2.874 ± 0.028
4.864GluVal: 4.864 ± 0.043
0.658GluTrp: 0.658 ± 0.016
0.969GluTyr: 0.969 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
3.799PheAla: 3.799 ± 0.035
0.383PheCys: 0.383 ± 0.011
2.302PheAsp: 2.302 ± 0.026
2.277PheGlu: 2.277 ± 0.029
1.228PhePhe: 1.228 ± 0.018
3.179PheGly: 3.179 ± 0.033
0.699PheHis: 0.699 ± 0.015
1.003PheIle: 1.003 ± 0.018
0.713PheLys: 0.713 ± 0.015
2.814PheLeu: 2.814 ± 0.029
0.566PheMet: 0.566 ± 0.012
0.65PheAsn: 0.65 ± 0.014
1.508PhePro: 1.508 ± 0.019
0.818PheGln: 0.818 ± 0.015
2.141PheArg: 2.141 ± 0.027
1.842PheSer: 1.842 ± 0.024
1.682PheThr: 1.682 ± 0.024
2.792PheVal: 2.792 ± 0.032
0.455PheTrp: 0.455 ± 0.011
0.773PheTyr: 0.773 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
11.733GlyAla: 11.733 ± 0.079
1.283GlyCys: 1.283 ± 0.026
5.18GlyAsp: 5.18 ± 0.044
5.882GlyGlu: 5.882 ± 0.043
2.882GlyPhe: 2.882 ± 0.032
9.687GlyGly: 9.687 ± 0.102
1.836GlyHis: 1.836 ± 0.029
3.615GlyIle: 3.615 ± 0.036
3.658GlyLys: 3.658 ± 0.036
7.736GlyLeu: 7.736 ± 0.054
2.106GlyMet: 2.106 ± 0.029
2.171GlyAsn: 2.171 ± 0.034
4.558GlyPro: 4.558 ± 0.04
2.637GlyGln: 2.637 ± 0.038
6.789GlyArg: 6.789 ± 0.061
5.253GlySer: 5.253 ± 0.046
5.104GlyThr: 5.104 ± 0.053
6.5GlyVal: 6.5 ± 0.052
1.21GlyTrp: 1.21 ± 0.021
1.971GlyTyr: 1.971 ± 0.026
0.0GlyXaa: 0.0 ± 0.0
His
2.688HisAla: 2.688 ± 0.032
0.248HisCys: 0.248 ± 0.009
1.219HisAsp: 1.219 ± 0.02
1.359HisGlu: 1.359 ± 0.025
0.747HisPhe: 0.747 ± 0.014
1.995HisGly: 1.995 ± 0.027
0.544HisHis: 0.544 ± 0.014
0.654HisIle: 0.654 ± 0.014
0.446HisLys: 0.446 ± 0.012
2.038HisLeu: 2.038 ± 0.027
0.338HisMet: 0.338 ± 0.01
0.345HisAsn: 0.345 ± 0.009
1.467HisPro: 1.467 ± 0.021
0.456HisGln: 0.456 ± 0.01
1.64HisArg: 1.64 ± 0.024
0.757HisSer: 0.757 ± 0.014
0.827HisThr: 0.827 ± 0.016
1.728HisVal: 1.728 ± 0.023
0.266HisTrp: 0.266 ± 0.008
0.518HisTyr: 0.518 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
5.657IleAla: 5.657 ± 0.044
0.415IleCys: 0.415 ± 0.01
3.066IleAsp: 3.066 ± 0.03
3.235IleGlu: 3.235 ± 0.035
1.148IlePhe: 1.148 ± 0.018
3.613IleGly: 3.613 ± 0.032
0.816IleHis: 0.816 ± 0.015
1.18IleIle: 1.18 ± 0.021
1.041IleLys: 1.041 ± 0.018
3.26IleLeu: 3.26 ± 0.031
0.496IleMet: 0.496 ± 0.014
0.737IleAsn: 0.737 ± 0.016
2.041IlePro: 2.041 ± 0.027
0.928IleGln: 0.928 ± 0.016
2.501IleArg: 2.501 ± 0.028
1.901IleSer: 1.901 ± 0.023
2.037IleThr: 2.037 ± 0.028
3.489IleVal: 3.489 ± 0.032
0.404IleTrp: 0.404 ± 0.011
0.796IleTyr: 0.796 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
3.536LysAla: 3.536 ± 0.039
0.309LysCys: 0.309 ± 0.016
1.824LysAsp: 1.824 ± 0.028
1.708LysGlu: 1.708 ± 0.026
0.654LysPhe: 0.654 ± 0.015
2.569LysGly: 2.569 ± 0.037
0.561LysHis: 0.561 ± 0.014
1.366LysIle: 1.366 ± 0.022
1.535LysLys: 1.535 ± 0.031
3.244LysLeu: 3.244 ± 0.04
0.629LysMet: 0.629 ± 0.013
0.858LysAsn: 0.858 ± 0.019
2.171LysPro: 2.171 ± 0.033
0.875LysGln: 0.875 ± 0.016
2.356LysArg: 2.356 ± 0.033
1.599LysSer: 1.599 ± 0.022
1.669LysThr: 1.669 ± 0.028
2.198LysVal: 2.198 ± 0.03
0.296LysTrp: 0.296 ± 0.009
0.581LysTyr: 0.581 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
13.903LeuAla: 13.903 ± 0.095
1.075LeuCys: 1.075 ± 0.018
6.225LeuAsp: 6.225 ± 0.047
6.55LeuGlu: 6.55 ± 0.068
3.192LeuPhe: 3.192 ± 0.036
9.621LeuGly: 9.621 ± 0.067
1.987LeuHis: 1.987 ± 0.024
2.79LeuIle: 2.79 ± 0.033
2.273LeuLys: 2.273 ± 0.026
9.797LeuLeu: 9.797 ± 0.088
1.402LeuMet: 1.402 ± 0.022
1.486LeuAsn: 1.486 ± 0.022
5.953LeuPro: 5.953 ± 0.052
2.1LeuGln: 2.1 ± 0.027
8.3LeuArg: 8.3 ± 0.061
5.985LeuSer: 5.985 ± 0.046
4.343LeuThr: 4.343 ± 0.037
8.559LeuVal: 8.559 ± 0.059
1.173LeuTrp: 1.173 ± 0.02
1.885LeuTyr: 1.885 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.344MetAla: 2.344 ± 0.03
0.175MetCys: 0.175 ± 0.007
0.868MetAsp: 0.868 ± 0.014
0.898MetGlu: 0.898 ± 0.015
0.511MetPhe: 0.511 ± 0.012
1.634MetGly: 1.634 ± 0.025
0.427MetHis: 0.427 ± 0.011
0.74MetIle: 0.74 ± 0.016
0.757MetLys: 0.757 ± 0.016
1.972MetLeu: 1.972 ± 0.027
0.417MetMet: 0.417 ± 0.016
0.563MetAsn: 0.563 ± 0.013
1.413MetPro: 1.413 ± 0.024
0.584MetGln: 0.584 ± 0.011
1.846MetArg: 1.846 ± 0.022
1.411MetSer: 1.411 ± 0.022
1.218MetThr: 1.218 ± 0.021
1.279MetVal: 1.279 ± 0.02
0.175MetTrp: 0.175 ± 0.007
0.266MetTyr: 0.266 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
2.626AsnAla: 2.626 ± 0.034
0.271AsnCys: 0.271 ± 0.015
1.273AsnAsp: 1.273 ± 0.024
1.254AsnGlu: 1.254 ± 0.02
0.626AsnPhe: 0.626 ± 0.015
2.17AsnGly: 2.17 ± 0.044
0.43AsnHis: 0.43 ± 0.01
0.818AsnIle: 0.818 ± 0.016
0.577AsnLys: 0.577 ± 0.014
1.938AsnLeu: 1.938 ± 0.027
0.363AsnMet: 0.363 ± 0.012
0.557AsnAsn: 0.557 ± 0.016
1.522AsnPro: 1.522 ± 0.022
0.561AsnGln: 0.561 ± 0.015
1.264AsnArg: 1.264 ± 0.02
0.732AsnSer: 0.732 ± 0.019
0.98AsnThr: 0.98 ± 0.02
1.733AsnVal: 1.733 ± 0.025
0.228AsnTrp: 0.228 ± 0.008
0.448AsnTyr: 0.448 ± 0.012
0.0AsnXaa: 0.0 ± 0.0
Pro
8.106ProAla: 8.106 ± 0.069
0.579ProCys: 0.579 ± 0.018
3.763ProAsp: 3.763 ± 0.036
4.737ProGlu: 4.737 ± 0.044
2.027ProPhe: 2.027 ± 0.025
5.539ProGly: 5.539 ± 0.047
1.097ProHis: 1.097 ± 0.02
2.252ProIle: 2.252 ± 0.026
1.828ProLys: 1.828 ± 0.029
5.389ProLeu: 5.389 ± 0.043
1.323ProMet: 1.323 ± 0.02
1.302ProAsn: 1.302 ± 0.023
5.555ProPro: 5.555 ± 0.085
1.55ProGln: 1.55 ± 0.025
4.409ProArg: 4.409 ± 0.05
4.139ProSer: 4.139 ± 0.04
3.028ProThr: 3.028 ± 0.034
4.285ProVal: 4.285 ± 0.04
0.8ProTrp: 0.8 ± 0.016
1.139ProTyr: 1.139 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
3.322GlnAla: 3.322 ± 0.035
0.349GlnCys: 0.349 ± 0.012
1.185GlnAsp: 1.185 ± 0.018
1.364GlnGlu: 1.364 ± 0.021
0.738GlnPhe: 0.738 ± 0.014
2.385GlnGly: 2.385 ± 0.031
0.567GlnHis: 0.567 ± 0.012
1.363GlnIle: 1.363 ± 0.019
1.093GlnLys: 1.093 ± 0.022
2.353GlnLeu: 2.353 ± 0.027
0.574GlnMet: 0.574 ± 0.012
0.653GlnAsn: 0.653 ± 0.015
1.606GlnPro: 1.606 ± 0.023
0.969GlnGln: 0.969 ± 0.023
2.399GlnArg: 2.399 ± 0.029
1.462GlnSer: 1.462 ± 0.021
1.351GlnThr: 1.351 ± 0.022
1.933GlnVal: 1.933 ± 0.029
0.378GlnTrp: 0.378 ± 0.012
0.521GlnTyr: 0.521 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
11.289ArgAla: 11.289 ± 0.09
0.803ArgCys: 0.803 ± 0.018
4.188ArgAsp: 4.188 ± 0.036
5.219ArgGlu: 5.219 ± 0.047
2.988ArgPhe: 2.988 ± 0.034
6.346ArgGly: 6.346 ± 0.054
1.588ArgHis: 1.588 ± 0.023
3.792ArgIle: 3.792 ± 0.039
2.328ArgLys: 2.328 ± 0.025
8.058ArgLeu: 8.058 ± 0.065
1.902ArgMet: 1.902 ± 0.026
1.357ArgAsn: 1.357 ± 0.019
4.352ArgPro: 4.352 ± 0.05
1.927ArgGln: 1.927 ± 0.026
7.19ArgArg: 7.19 ± 0.071
4.22ArgSer: 4.22 ± 0.044
3.769ArgThr: 3.769 ± 0.038
6.266ArgVal: 6.266 ± 0.055
1.228ArgTrp: 1.228 ± 0.021
1.834ArgTyr: 1.834 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
6.866SerAla: 6.866 ± 0.052
0.738SerCys: 0.738 ± 0.021
2.854SerAsp: 2.854 ± 0.029
2.901SerGlu: 2.901 ± 0.027
2.094SerPhe: 2.094 ± 0.024
5.516SerGly: 5.516 ± 0.05
0.971SerHis: 0.971 ± 0.017
2.275SerIle: 2.275 ± 0.024
1.535SerLys: 1.535 ± 0.023
5.357SerLeu: 5.357 ± 0.046
1.181SerMet: 1.181 ± 0.019
1.155SerAsn: 1.155 ± 0.021
3.887SerPro: 3.887 ± 0.041
1.314SerGln: 1.314 ± 0.02
3.911SerArg: 3.911 ± 0.041
3.68SerSer: 3.68 ± 0.044
2.985SerThr: 2.985 ± 0.03
3.929SerVal: 3.929 ± 0.03
0.689SerTrp: 0.689 ± 0.013
1.14SerTyr: 1.14 ± 0.017
0.0SerXaa: 0.0 ± 0.0
Thr
5.656ThrAla: 5.656 ± 0.042
0.752ThrCys: 0.752 ± 0.028
2.511ThrAsp: 2.511 ± 0.03
2.579ThrGlu: 2.579 ± 0.026
1.799ThrPhe: 1.799 ± 0.025
4.88ThrGly: 4.88 ± 0.044
0.955ThrHis: 0.955 ± 0.019
2.121ThrIle: 2.121 ± 0.028
1.401ThrLys: 1.401 ± 0.023
5.177ThrLeu: 5.177 ± 0.041
0.946ThrMet: 0.946 ± 0.016
1.218ThrAsn: 1.218 ± 0.022
3.584ThrPro: 3.584 ± 0.039
1.305ThrGln: 1.305 ± 0.019
3.44ThrArg: 3.44 ± 0.033
3.073ThrSer: 3.073 ± 0.032
2.899ThrThr: 2.899 ± 0.039
3.708ThrVal: 3.708 ± 0.036
0.752ThrTrp: 0.752 ± 0.016
1.11ThrTyr: 1.11 ± 0.019
0.0ThrXaa: 0.0 ± 0.0
Val
9.441ValAla: 9.441 ± 0.061
0.916ValCys: 0.916 ± 0.026
4.647ValAsp: 4.647 ± 0.038
5.158ValGlu: 5.158 ± 0.038
2.422ValPhe: 2.422 ± 0.025
6.012ValGly: 6.012 ± 0.047
1.72ValHis: 1.72 ± 0.024
2.917ValIle: 2.917 ± 0.03
2.148ValLys: 2.148 ± 0.029
7.873ValLeu: 7.873 ± 0.059
1.364ValMet: 1.364 ± 0.019
1.553ValAsn: 1.553 ± 0.024
4.435ValPro: 4.435 ± 0.041
2.004ValGln: 2.004 ± 0.024
6.362ValArg: 6.362 ± 0.052
4.058ValSer: 4.058 ± 0.031
4.295ValThr: 4.295 ± 0.043
6.589ValVal: 6.589 ± 0.053
0.957ValTrp: 0.957 ± 0.019
1.514ValTyr: 1.514 ± 0.02
0.0ValXaa: 0.0 ± 0.0
Trp
1.278TrpAla: 1.278 ± 0.019
0.114TrpCys: 0.114 ± 0.005
0.736TrpAsp: 0.736 ± 0.016
0.714TrpGlu: 0.714 ± 0.017
0.414TrpPhe: 0.414 ± 0.011
1.016TrpGly: 1.016 ± 0.02
0.281TrpHis: 0.281 ± 0.009
0.619TrpIle: 0.619 ± 0.015
0.449TrpLys: 0.449 ± 0.012
1.441TrpLeu: 1.441 ± 0.022
0.319TrpMet: 0.319 ± 0.009
0.385TrpAsn: 0.385 ± 0.014
0.619TrpPro: 0.619 ± 0.015
0.423TrpGln: 0.423 ± 0.01
0.926TrpArg: 0.926 ± 0.016
0.918TrpSer: 0.918 ± 0.021
0.773TrpThr: 0.773 ± 0.016
0.879TrpVal: 0.879 ± 0.017
0.166TrpTrp: 0.166 ± 0.008
0.268TrpTyr: 0.268 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.421TyrAla: 2.421 ± 0.027
0.25TyrCys: 0.25 ± 0.007
1.322TyrAsp: 1.322 ± 0.025
1.316TyrGlu: 1.316 ± 0.024
0.768TyrPhe: 0.768 ± 0.016
1.797TyrGly: 1.797 ± 0.025
0.427TyrHis: 0.427 ± 0.01
0.594TyrIle: 0.594 ± 0.013
0.55TyrLys: 0.55 ± 0.015
1.934TyrLeu: 1.934 ± 0.022
0.391TyrMet: 0.391 ± 0.01
0.476TyrAsn: 0.476 ± 0.012
1.033TyrPro: 1.033 ± 0.02
0.578TyrGln: 0.578 ± 0.014
1.779TyrArg: 1.779 ± 0.026
0.853TyrSer: 0.853 ± 0.016
0.998TyrThr: 0.998 ± 0.017
1.608TyrVal: 1.608 ± 0.023
0.288TyrTrp: 0.288 ± 0.01
0.534TyrTyr: 0.534 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9297 proteins (3626891 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski