Amino acid dipepetide frequency for Halobellus limi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.98AlaAla: 13.98 ± 0.193	0.66AlaCys: 0.66 ± 0.027	9.316AlaAsp: 9.316 ± 0.112	8.839AlaGlu: 8.839 ± 0.111	4.01AlaPhe: 4.01 ± 0.07	9.982AlaGly: 9.982 ± 0.115	1.787AlaHis: 1.787 ± 0.041	4.507AlaIle: 4.507 ± 0.075	1.757AlaLys: 1.757 ± 0.044	10.207AlaLeu: 10.207 ± 0.152	1.98AlaMet: 1.98 ± 0.051	2.257AlaAsn: 2.257 ± 0.054	4.051AlaPro: 4.051 ± 0.061	1.982AlaGln: 1.982 ± 0.042	6.231AlaArg: 6.231 ± 0.09	5.758AlaSer: 5.758 ± 0.095	6.873AlaThr: 6.873 ± 0.093	10.927AlaVal: 10.927 ± 0.138	1.169AlaTrp: 1.169 ± 0.039	2.721AlaTyr: 2.721 ± 0.052	0.001AlaXaa: 0.001 ± 0.001
Cys	0.544CysAla: 0.544 ± 0.025	0.07CysCys: 0.07 ± 0.008	0.472CysAsp: 0.472 ± 0.023	0.559CysGlu: 0.559 ± 0.025	0.17CysPhe: 0.17 ± 0.012	0.827CysGly: 0.827 ± 0.033	0.188CysHis: 0.188 ± 0.015	0.205CysIle: 0.205 ± 0.014	0.112CysLys: 0.112 ± 0.011	0.485CysLeu: 0.485 ± 0.024	0.104CysMet: 0.104 ± 0.009	0.168CysAsn: 0.168 ± 0.012	0.491CysPro: 0.491 ± 0.026	0.143CysGln: 0.143 ± 0.011	0.426CysArg: 0.426 ± 0.02	0.363CysSer: 0.363 ± 0.02	0.362CysThr: 0.362 ± 0.022	0.472CysVal: 0.472 ± 0.023	0.077CysTrp: 0.077 ± 0.008	0.164CysTyr: 0.164 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	10.472AspAla: 10.472 ± 0.132	0.529AspCys: 0.529 ± 0.023	7.673AspAsp: 7.673 ± 0.129	7.645AspGlu: 7.645 ± 0.119	2.154AspPhe: 2.154 ± 0.053	8.427AspGly: 8.427 ± 0.157	1.635AspHis: 1.635 ± 0.057	2.648AspIle: 2.648 ± 0.057	0.844AspLys: 0.844 ± 0.029	6.964AspLeu: 6.964 ± 0.092	0.981AspMet: 0.981 ± 0.032	1.162AspAsn: 1.162 ± 0.04	4.763AspPro: 4.763 ± 0.079	1.457AspGln: 1.457 ± 0.04	6.378AspArg: 6.378 ± 0.101	4.044AspSer: 4.044 ± 0.061	3.869AspThr: 3.869 ± 0.072	8.633AspVal: 8.633 ± 0.117	0.843AspTrp: 0.843 ± 0.033	1.788AspTyr: 1.788 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.786GluAla: 8.786 ± 0.115	0.458GluCys: 0.458 ± 0.022	5.479GluAsp: 5.479 ± 0.085	7.351GluGlu: 7.351 ± 0.12	2.873GluPhe: 2.873 ± 0.061	5.657GluGly: 5.657 ± 0.084	1.977GluHis: 1.977 ± 0.042	3.907GluIle: 3.907 ± 0.064	1.9GluLys: 1.9 ± 0.05	7.381GluLeu: 7.381 ± 0.081	1.994GluMet: 1.994 ± 0.046	2.309GluAsn: 2.309 ± 0.051	3.61GluPro: 3.61 ± 0.055	2.373GluGln: 2.373 ± 0.051	7.92GluArg: 7.92 ± 0.111	5.661GluSer: 5.661 ± 0.08	6.452GluThr: 6.452 ± 0.087	5.832GluVal: 5.832 ± 0.088	1.255GluTrp: 1.255 ± 0.035	2.735GluTyr: 2.735 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.735PheAla: 3.735 ± 0.066	0.253PheCys: 0.253 ± 0.015	3.188PheAsp: 3.188 ± 0.061	3.236PheGlu: 3.236 ± 0.06	1.142PhePhe: 1.142 ± 0.041	3.321PheGly: 3.321 ± 0.07	0.613PheHis: 0.613 ± 0.023	1.036PheIle: 1.036 ± 0.036	0.466PheLys: 0.466 ± 0.019	3.09PheLeu: 3.09 ± 0.074	0.451PheMet: 0.451 ± 0.022	0.668PheAsn: 0.668 ± 0.028	1.415PhePro: 1.415 ± 0.038	0.776PheGln: 0.776 ± 0.029	1.812PheArg: 1.812 ± 0.043	1.782PheSer: 1.782 ± 0.043	1.826PheThr: 1.826 ± 0.051	3.482PheVal: 3.482 ± 0.062	0.415PheTrp: 0.415 ± 0.023	0.897PheTyr: 0.897 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.305GlyAla: 8.305 ± 0.106	0.627GlyCys: 0.627 ± 0.025	7.395GlyAsp: 7.395 ± 0.12	7.433GlyGlu: 7.433 ± 0.095	3.204GlyPhe: 3.204 ± 0.052	8.39GlyGly: 8.39 ± 0.121	1.589GlyHis: 1.589 ± 0.041	4.244GlyIle: 4.244 ± 0.069	1.772GlyLys: 1.772 ± 0.046	7.465GlyLeu: 7.465 ± 0.107	1.695GlyMet: 1.695 ± 0.039	1.883GlyAsn: 1.883 ± 0.045	3.542GlyPro: 3.542 ± 0.061	1.822GlyGln: 1.822 ± 0.046	5.248GlyArg: 5.248 ± 0.078	5.803GlySer: 5.803 ± 0.093	5.94GlyThr: 5.94 ± 0.103	8.113GlyVal: 8.113 ± 0.103	1.119GlyTrp: 1.119 ± 0.033	2.75GlyTyr: 2.75 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.921HisAla: 1.921 ± 0.045	0.18HisCys: 0.18 ± 0.016	1.672HisAsp: 1.672 ± 0.053	1.587HisGlu: 1.587 ± 0.044	0.541HisPhe: 0.541 ± 0.026	1.8HisGly: 1.8 ± 0.048	0.478HisHis: 0.478 ± 0.024	0.621HisIle: 0.621 ± 0.027	0.279HisLys: 0.279 ± 0.017	1.694HisLeu: 1.694 ± 0.039	0.238HisMet: 0.238 ± 0.016	0.437HisAsn: 0.437 ± 0.022	1.174HisPro: 1.174 ± 0.036	0.424HisGln: 0.424 ± 0.022	1.35HisArg: 1.35 ± 0.033	0.868HisSer: 0.868 ± 0.029	0.984HisThr: 0.984 ± 0.031	1.851HisVal: 1.851 ± 0.042	0.226HisTrp: 0.226 ± 0.015	0.577HisTyr: 0.577 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.6IleAla: 4.6 ± 0.067	0.225IleCys: 0.225 ± 0.014	3.87IleAsp: 3.87 ± 0.07	4.103IleGlu: 4.103 ± 0.073	1.009IlePhe: 1.009 ± 0.035	3.791IleGly: 3.791 ± 0.072	0.763IleHis: 0.763 ± 0.025	1.273IleIle: 1.273 ± 0.043	0.714IleLys: 0.714 ± 0.027	3.011IleLeu: 3.011 ± 0.06	0.457IleMet: 0.457 ± 0.023	0.921IleAsn: 0.921 ± 0.03	2.053IlePro: 2.053 ± 0.047	1.041IleGln: 1.041 ± 0.037	2.608IleArg: 2.608 ± 0.051	2.074IleSer: 2.074 ± 0.05	2.293IleThr: 2.293 ± 0.049	3.67IleVal: 3.67 ± 0.071	0.332IleTrp: 0.332 ± 0.018	0.88IleTyr: 0.88 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.624LysAla: 1.624 ± 0.038	0.12LysCys: 0.12 ± 0.01	0.991LysAsp: 0.991 ± 0.038	1.333LysGlu: 1.333 ± 0.036	0.543LysPhe: 0.543 ± 0.026	1.263LysGly: 1.263 ± 0.037	0.425LysHis: 0.425 ± 0.02	0.829LysIle: 0.829 ± 0.03	0.531LysLys: 0.531 ± 0.029	1.608LysLeu: 1.608 ± 0.042	0.389LysMet: 0.389 ± 0.02	0.541LysAsn: 0.541 ± 0.022	0.886LysPro: 0.886 ± 0.03	0.699LysGln: 0.699 ± 0.028	1.591LysArg: 1.591 ± 0.041	1.23LysSer: 1.23 ± 0.036	1.317LysThr: 1.317 ± 0.037	1.151LysVal: 1.151 ± 0.036	0.223LysTrp: 0.223 ± 0.014	0.594LysTyr: 0.594 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	10.591LeuAla: 10.591 ± 0.148	0.547LeuCys: 0.547 ± 0.023	7.498LeuAsp: 7.498 ± 0.1	6.387LeuGlu: 6.387 ± 0.074	3.294LeuPhe: 3.294 ± 0.074	7.874LeuGly: 7.874 ± 0.121	1.435LeuHis: 1.435 ± 0.04	2.89LeuIle: 2.89 ± 0.064	1.54LeuLys: 1.54 ± 0.042	8.856LeuLeu: 8.856 ± 0.163	1.27LeuMet: 1.27 ± 0.038	1.852LeuAsn: 1.852 ± 0.046	4.224LeuPro: 4.224 ± 0.076	2.045LeuGln: 2.045 ± 0.046	5.863LeuArg: 5.863 ± 0.068	5.972LeuSer: 5.972 ± 0.085	5.192LeuThr: 5.192 ± 0.089	8.612LeuVal: 8.612 ± 0.134	0.97LeuTrp: 0.97 ± 0.031	2.19LeuTyr: 2.19 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.661MetAla: 1.661 ± 0.045	0.111MetCys: 0.111 ± 0.011	1.168MetAsp: 1.168 ± 0.037	1.066MetGlu: 1.066 ± 0.027	0.477MetPhe: 0.477 ± 0.022	1.331MetGly: 1.331 ± 0.039	0.322MetHis: 0.322 ± 0.019	0.728MetIle: 0.728 ± 0.024	0.45MetLys: 0.45 ± 0.02	1.462MetLeu: 1.462 ± 0.04	0.304MetMet: 0.304 ± 0.017	0.59MetAsn: 0.59 ± 0.022	0.785MetPro: 0.785 ± 0.027	0.479MetGln: 0.479 ± 0.023	1.143MetArg: 1.143 ± 0.031	1.513MetSer: 1.513 ± 0.036	1.44MetThr: 1.44 ± 0.04	1.133MetVal: 1.133 ± 0.04	0.169MetTrp: 0.169 ± 0.012	0.381MetTyr: 0.381 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.488AsnAla: 2.488 ± 0.05	0.185AsnCys: 0.185 ± 0.014	1.622AsnAsp: 1.622 ± 0.047	1.736AsnGlu: 1.736 ± 0.044	0.746AsnPhe: 0.746 ± 0.024	1.972AsnGly: 1.972 ± 0.053	0.474AsnHis: 0.474 ± 0.021	0.869AsnIle: 0.869 ± 0.033	0.44AsnLys: 0.44 ± 0.022	1.963AsnLeu: 1.963 ± 0.048	0.36AsnMet: 0.36 ± 0.018	0.526AsnAsn: 0.526 ± 0.027	1.496AsnPro: 1.496 ± 0.042	0.569AsnGln: 0.569 ± 0.024	1.617AsnArg: 1.617 ± 0.042	0.99AsnSer: 0.99 ± 0.032	1.247AsnThr: 1.247 ± 0.038	2.296AsnVal: 2.296 ± 0.053	0.323AsnTrp: 0.323 ± 0.02	0.653AsnTyr: 0.653 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.692ProAla: 4.692 ± 0.075	0.209ProCys: 0.209 ± 0.014	4.722ProAsp: 4.722 ± 0.088	4.858ProGlu: 4.858 ± 0.07	1.608ProPhe: 1.608 ± 0.039	3.92ProGly: 3.92 ± 0.062	0.901ProHis: 0.901 ± 0.028	2.035ProIle: 2.035 ± 0.043	0.859ProLys: 0.859 ± 0.027	3.729ProLeu: 3.729 ± 0.067	0.796ProMet: 0.796 ± 0.028	1.187ProAsn: 1.187 ± 0.033	2.189ProPro: 2.189 ± 0.053	0.996ProGln: 0.996 ± 0.028	2.377ProArg: 2.377 ± 0.053	2.88ProSer: 2.88 ± 0.053	3.235ProThr: 3.235 ± 0.058	4.076ProVal: 4.076 ± 0.06	0.536ProTrp: 0.536 ± 0.022	1.103ProTyr: 1.103 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.184GlnAla: 2.184 ± 0.042	0.151GlnCys: 0.151 ± 0.012	1.13GlnAsp: 1.13 ± 0.029	1.638GlnGlu: 1.638 ± 0.04	1.022GlnPhe: 1.022 ± 0.03	1.48GlnGly: 1.48 ± 0.041	0.496GlnHis: 0.496 ± 0.022	1.134GlnIle: 1.134 ± 0.036	0.57GlnLys: 0.57 ± 0.024	2.115GlnLeu: 2.115 ± 0.048	0.518GlnMet: 0.518 ± 0.022	0.67GlnAsn: 0.67 ± 0.029	1.017GlnPro: 1.017 ± 0.039	0.861GlnGln: 0.861 ± 0.038	1.893GlnArg: 1.893 ± 0.045	1.659GlnSer: 1.659 ± 0.038	1.631GlnThr: 1.631 ± 0.043	1.632GlnVal: 1.632 ± 0.049	0.322GlnTrp: 0.322 ± 0.017	0.811GlnTyr: 0.811 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.559ArgAla: 6.559 ± 0.098	0.415ArgCys: 0.415 ± 0.023	5.135ArgAsp: 5.135 ± 0.077	6.844ArgGlu: 6.844 ± 0.098	2.299ArgPhe: 2.299 ± 0.051	4.829ArgGly: 4.829 ± 0.068	1.187ArgHis: 1.187 ± 0.035	3.161ArgIle: 3.161 ± 0.056	1.318ArgLys: 1.318 ± 0.041	6.177ArgLeu: 6.177 ± 0.086	1.335ArgMet: 1.335 ± 0.036	1.622ArgAsn: 1.622 ± 0.035	2.824ArgPro: 2.824 ± 0.052	1.693ArgGln: 1.693 ± 0.041	5.396ArgArg: 5.396 ± 0.1	3.948ArgSer: 3.948 ± 0.072	4.0ArgThr: 4.0 ± 0.069	5.543ArgVal: 5.543 ± 0.086	0.828ArgTrp: 0.828 ± 0.029	1.941ArgTyr: 1.941 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.752SerAla: 5.752 ± 0.078	0.305SerCys: 0.305 ± 0.019	4.68SerAsp: 4.68 ± 0.089	4.953SerGlu: 4.953 ± 0.071	1.96SerPhe: 1.96 ± 0.049	5.922SerGly: 5.922 ± 0.097	1.026SerHis: 1.026 ± 0.03	2.655SerIle: 2.655 ± 0.055	1.218SerLys: 1.218 ± 0.04	5.26SerLeu: 5.26 ± 0.071	1.04SerMet: 1.04 ± 0.029	1.397SerAsn: 1.397 ± 0.037	2.828SerPro: 2.828 ± 0.056	1.354SerGln: 1.354 ± 0.042	3.345SerArg: 3.345 ± 0.062	3.102SerSer: 3.102 ± 0.063	3.805SerThr: 3.805 ± 0.08	5.251SerVal: 5.251 ± 0.087	0.625SerTrp: 0.625 ± 0.025	1.454SerTyr: 1.454 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.79ThrAla: 6.79 ± 0.09	0.349ThrCys: 0.349 ± 0.018	5.356ThrAsp: 5.356 ± 0.093	4.586ThrGlu: 4.586 ± 0.068	2.127ThrPhe: 2.127 ± 0.05	5.861ThrGly: 5.861 ± 0.084	1.168ThrHis: 1.168 ± 0.034	2.641ThrIle: 2.641 ± 0.065	1.056ThrLys: 1.056 ± 0.032	5.651ThrLeu: 5.651 ± 0.072	0.941ThrMet: 0.941 ± 0.032	1.436ThrAsn: 1.436 ± 0.045	3.346ThrPro: 3.346 ± 0.059	1.309ThrGln: 1.309 ± 0.039	3.408ThrArg: 3.408 ± 0.065	3.044ThrSer: 3.044 ± 0.066	4.121ThrThr: 4.121 ± 0.102	7.103ThrVal: 7.103 ± 0.148	0.672ThrTrp: 0.672 ± 0.026	1.82ThrTyr: 1.82 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	10.642ValAla: 10.642 ± 0.141	0.673ValCys: 0.673 ± 0.026	8.129ValAsp: 8.129 ± 0.113	8.326ValGlu: 8.326 ± 0.115	3.064ValPhe: 3.064 ± 0.067	8.441ValGly: 8.441 ± 0.106	1.578ValHis: 1.578 ± 0.039	3.065ValIle: 3.065 ± 0.061	1.367ValLys: 1.367 ± 0.037	8.135ValLeu: 8.135 ± 0.129	1.266ValMet: 1.266 ± 0.04	1.942ValAsn: 1.942 ± 0.05	4.405ValPro: 4.405 ± 0.07	1.796ValGln: 1.796 ± 0.041	5.667ValArg: 5.667 ± 0.086	5.427ValSer: 5.427 ± 0.077	5.998ValThr: 5.998 ± 0.119	9.97ValVal: 9.97 ± 0.136	0.878ValTrp: 0.878 ± 0.033	2.184ValTyr: 2.184 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.945TrpAla: 0.945 ± 0.028	0.101TrpCys: 0.101 ± 0.011	0.8TrpAsp: 0.8 ± 0.028	0.901TrpGlu: 0.901 ± 0.026	0.469TrpPhe: 0.469 ± 0.022	0.891TrpGly: 0.891 ± 0.026	0.236TrpHis: 0.236 ± 0.015	0.528TrpIle: 0.528 ± 0.025	0.259TrpLys: 0.259 ± 0.017	1.21TrpLeu: 1.21 ± 0.038	0.236TrpMet: 0.236 ± 0.016	0.371TrpAsn: 0.371 ± 0.019	0.497TrpPro: 0.497 ± 0.022	0.36TrpGln: 0.36 ± 0.019	0.879TrpArg: 0.879 ± 0.032	0.62TrpSer: 0.62 ± 0.023	0.776TrpThr: 0.776 ± 0.029	0.829TrpVal: 0.829 ± 0.032	0.203TrpTrp: 0.203 ± 0.016	0.406TrpTyr: 0.406 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.724TyrAla: 2.724 ± 0.051	0.233TyrCys: 0.233 ± 0.015	2.613TyrAsp: 2.613 ± 0.057	2.527TyrGlu: 2.527 ± 0.051	0.892TyrPhe: 0.892 ± 0.031	2.361TyrGly: 2.361 ± 0.048	0.627TyrHis: 0.627 ± 0.024	0.713TyrIle: 0.713 ± 0.03	0.435TyrLys: 0.435 ± 0.019	2.638TyrLeu: 2.638 ± 0.055	0.356TyrMet: 0.356 ± 0.021	0.632TyrAsn: 0.632 ± 0.023	1.313TyrPro: 1.313 ± 0.038	0.756TyrGln: 0.756 ± 0.029	1.9TyrArg: 1.9 ± 0.045	1.195TyrSer: 1.195 ± 0.033	1.426TyrThr: 1.426 ± 0.041	2.374TyrVal: 2.374 ± 0.05	0.334TyrTrp: 0.334 ± 0.019	0.843TyrTyr: 0.843 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3637 proteins (1069361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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