Amino acid dipepetide frequency for Mizugakiibacter sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.733AlaAla: 24.733 ± 0.292	1.451AlaCys: 1.451 ± 0.05	8.155AlaAsp: 8.155 ± 0.099	8.52AlaGlu: 8.52 ± 0.124	4.617AlaPhe: 4.617 ± 0.082	12.36AlaGly: 12.36 ± 0.138	3.362AlaHis: 3.362 ± 0.066	5.443AlaIle: 5.443 ± 0.089	3.444AlaLys: 3.444 ± 0.09	19.131AlaLeu: 19.131 ± 0.197	3.442AlaMet: 3.442 ± 0.058	2.464AlaAsn: 2.464 ± 0.062	7.96AlaPro: 7.96 ± 0.136	5.353AlaGln: 5.353 ± 0.087	13.243AlaArg: 13.243 ± 0.178	5.616AlaSer: 5.616 ± 0.084	5.792AlaThr: 5.792 ± 0.086	9.703AlaVal: 9.703 ± 0.104	2.401AlaTrp: 2.401 ± 0.063	2.881AlaTyr: 2.881 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.432CysAla: 1.432 ± 0.046	0.117CysCys: 0.117 ± 0.013	0.51CysAsp: 0.51 ± 0.024	0.48CysGlu: 0.48 ± 0.025	0.319CysPhe: 0.319 ± 0.019	0.958CysGly: 0.958 ± 0.037	0.238CysHis: 0.238 ± 0.019	0.306CysIle: 0.306 ± 0.018	0.171CysLys: 0.171 ± 0.013	0.829CysLeu: 0.829 ± 0.032	0.154CysMet: 0.154 ± 0.014	0.188CysAsn: 0.188 ± 0.016	0.461CysPro: 0.461 ± 0.025	0.193CysGln: 0.193 ± 0.013	0.724CysArg: 0.724 ± 0.032	0.38CysSer: 0.38 ± 0.02	0.43CysThr: 0.43 ± 0.024	0.755CysVal: 0.755 ± 0.028	0.104CysTrp: 0.104 ± 0.01	0.254CysTyr: 0.254 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	9.739AspAla: 9.739 ± 0.128	0.473AspCys: 0.473 ± 0.023	3.168AspAsp: 3.168 ± 0.075	3.066AspGlu: 3.066 ± 0.069	2.05AspPhe: 2.05 ± 0.05	5.763AspGly: 5.763 ± 0.096	1.103AspHis: 1.103 ± 0.032	2.091AspIle: 2.091 ± 0.05	1.36AspLys: 1.36 ± 0.044	5.717AspLeu: 5.717 ± 0.081	1.004AspMet: 1.004 ± 0.036	1.013AspAsn: 1.013 ± 0.037	3.571AspPro: 3.571 ± 0.059	1.306AspGln: 1.306 ± 0.042	3.968AspArg: 3.968 ± 0.072	1.861AspSer: 1.861 ± 0.049	2.466AspThr: 2.466 ± 0.051	4.085AspVal: 4.085 ± 0.069	1.0AspTrp: 1.0 ± 0.034	1.698AspTyr: 1.698 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	8.139GluAla: 8.139 ± 0.104	0.402GluCys: 0.402 ± 0.023	2.466GluAsp: 2.466 ± 0.048	2.528GluGlu: 2.528 ± 0.058	1.714GluPhe: 1.714 ± 0.046	3.693GluGly: 3.693 ± 0.072	1.556GluHis: 1.556 ± 0.045	2.367GluIle: 2.367 ± 0.057	1.42GluLys: 1.42 ± 0.046	6.456GluLeu: 6.456 ± 0.094	0.955GluMet: 0.955 ± 0.036	1.015GluAsn: 1.015 ± 0.039	2.616GluPro: 2.616 ± 0.061	2.349GluGln: 2.349 ± 0.061	6.322GluArg: 6.322 ± 0.101	2.005GluSer: 2.005 ± 0.049	2.539GluThr: 2.539 ± 0.049	4.048GluVal: 4.048 ± 0.079	0.624GluTrp: 0.624 ± 0.027	1.028GluTyr: 1.028 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	5.06PheAla: 5.06 ± 0.084	0.345PheCys: 0.345 ± 0.02	2.464PheAsp: 2.464 ± 0.051	1.998PheGlu: 1.998 ± 0.052	1.145PhePhe: 1.145 ± 0.04	3.415PheGly: 3.415 ± 0.078	0.739PheHis: 0.739 ± 0.028	1.004PheIle: 1.004 ± 0.04	0.756PheLys: 0.756 ± 0.035	3.108PheLeu: 3.108 ± 0.066	0.567PheMet: 0.567 ± 0.026	0.834PheAsn: 0.834 ± 0.034	1.469PhePro: 1.469 ± 0.036	0.808PheGln: 0.808 ± 0.03	2.516PheArg: 2.516 ± 0.051	1.471PheSer: 1.471 ± 0.041	1.527PheThr: 1.527 ± 0.044	2.761PheVal: 2.761 ± 0.064	0.421PheTrp: 0.421 ± 0.023	0.772PheTyr: 0.772 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	11.209GlyAla: 11.209 ± 0.114	0.886GlyCys: 0.886 ± 0.033	4.663GlyAsp: 4.663 ± 0.081	5.015GlyGlu: 5.015 ± 0.075	3.352GlyPhe: 3.352 ± 0.063	7.456GlyGly: 7.456 ± 0.117	1.955GlyHis: 1.955 ± 0.045	3.7GlyIle: 3.7 ± 0.064	2.889GlyLys: 2.889 ± 0.07	8.483GlyLeu: 8.483 ± 0.109	2.278GlyMet: 2.278 ± 0.055	1.849GlyAsn: 1.849 ± 0.056	3.095GlyPro: 3.095 ± 0.063	2.441GlyGln: 2.441 ± 0.055	6.974GlyArg: 6.974 ± 0.087	3.951GlySer: 3.951 ± 0.076	4.219GlyThr: 4.219 ± 0.071	6.7GlyVal: 6.7 ± 0.078	1.632GlyTrp: 1.632 ± 0.054	2.511GlyTyr: 2.511 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	3.693HisAla: 3.693 ± 0.072	0.285HisCys: 0.285 ± 0.02	1.294HisAsp: 1.294 ± 0.039	1.116HisGlu: 1.116 ± 0.04	0.831HisPhe: 0.831 ± 0.029	2.417HisGly: 2.417 ± 0.048	0.547HisHis: 0.547 ± 0.029	0.695HisIle: 0.695 ± 0.029	0.468HisLys: 0.468 ± 0.026	2.331HisLeu: 2.331 ± 0.046	0.428HisMet: 0.428 ± 0.02	0.408HisAsn: 0.408 ± 0.019	1.607HisPro: 1.607 ± 0.044	0.557HisGln: 0.557 ± 0.02	1.77HisArg: 1.77 ± 0.048	0.718HisSer: 0.718 ± 0.027	0.844HisThr: 0.844 ± 0.032	1.751HisVal: 1.751 ± 0.051	0.399HisTrp: 0.399 ± 0.021	0.68HisTyr: 0.68 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.425IleAla: 6.425 ± 0.108	0.328IleCys: 0.328 ± 0.02	2.96IleAsp: 2.96 ± 0.065	2.929IleGlu: 2.929 ± 0.064	0.943IlePhe: 0.943 ± 0.034	3.933IleGly: 3.933 ± 0.063	0.709IleHis: 0.709 ± 0.027	0.975IleIle: 0.975 ± 0.042	1.012IleLys: 1.012 ± 0.037	2.824IleLeu: 2.824 ± 0.062	0.484IleMet: 0.484 ± 0.023	0.999IleAsn: 0.999 ± 0.031	1.842IlePro: 1.842 ± 0.05	0.886IleGln: 0.886 ± 0.04	2.648IleArg: 2.648 ± 0.056	1.52IleSer: 1.52 ± 0.047	1.848IleThr: 1.848 ± 0.045	3.316IleVal: 3.316 ± 0.064	0.38IleTrp: 0.38 ± 0.021	0.827IleTyr: 0.827 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.358LysAla: 3.358 ± 0.085	0.156LysCys: 0.156 ± 0.014	1.318LysAsp: 1.318 ± 0.046	1.104LysGlu: 1.104 ± 0.042	0.699LysPhe: 0.699 ± 0.032	1.922LysGly: 1.922 ± 0.058	0.567LysHis: 0.567 ± 0.026	1.014LysIle: 1.014 ± 0.04	0.927LysLys: 0.927 ± 0.039	2.953LysLeu: 2.953 ± 0.068	0.491LysMet: 0.491 ± 0.027	0.615LysAsn: 0.615 ± 0.031	1.891LysPro: 1.891 ± 0.052	0.987LysGln: 0.987 ± 0.04	2.318LysArg: 2.318 ± 0.057	1.17LysSer: 1.17 ± 0.039	1.411LysThr: 1.411 ± 0.045	1.919LysVal: 1.919 ± 0.055	0.28LysTrp: 0.28 ± 0.019	0.584LysTyr: 0.584 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	18.601LeuAla: 18.601 ± 0.197	1.016LeuCys: 1.016 ± 0.037	7.049LeuAsp: 7.049 ± 0.094	5.799LeuGlu: 5.799 ± 0.083	3.341LeuPhe: 3.341 ± 0.068	9.481LeuGly: 9.481 ± 0.104	2.386LeuHis: 2.386 ± 0.058	3.791LeuIle: 3.791 ± 0.067	3.214LeuLys: 3.214 ± 0.078	12.529LeuLeu: 12.529 ± 0.156	1.839LeuMet: 1.839 ± 0.045	2.09LeuAsn: 2.09 ± 0.052	6.838LeuPro: 6.838 ± 0.1	3.289LeuGln: 3.289 ± 0.064	9.85LeuArg: 9.85 ± 0.123	4.593LeuSer: 4.593 ± 0.081	4.91LeuThr: 4.91 ± 0.082	7.429LeuVal: 7.429 ± 0.098	1.427LeuTrp: 1.427 ± 0.045	2.33LeuTyr: 2.33 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.437MetAla: 2.437 ± 0.053	0.133MetCys: 0.133 ± 0.011	0.977MetAsp: 0.977 ± 0.03	0.834MetGlu: 0.834 ± 0.035	0.634MetPhe: 0.634 ± 0.028	1.362MetGly: 1.362 ± 0.039	0.452MetHis: 0.452 ± 0.021	0.765MetIle: 0.765 ± 0.033	0.673MetLys: 0.673 ± 0.028	2.373MetLeu: 2.373 ± 0.052	0.343MetMet: 0.343 ± 0.019	0.648MetAsn: 0.648 ± 0.03	1.372MetPro: 1.372 ± 0.037	0.812MetGln: 0.812 ± 0.031	1.997MetArg: 1.997 ± 0.049	1.238MetSer: 1.238 ± 0.035	1.196MetThr: 1.196 ± 0.032	1.32MetVal: 1.32 ± 0.036	0.175MetTrp: 0.175 ± 0.015	0.349MetTyr: 0.349 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.992AsnAla: 2.992 ± 0.063	0.192AsnCys: 0.192 ± 0.015	1.097AsnAsp: 1.097 ± 0.036	0.923AsnGlu: 0.923 ± 0.037	0.738AsnPhe: 0.738 ± 0.029	1.938AsnGly: 1.938 ± 0.066	0.398AsnHis: 0.398 ± 0.02	0.801AsnIle: 0.801 ± 0.029	0.43AsnLys: 0.43 ± 0.025	2.214AsnLeu: 2.214 ± 0.052	0.338AsnMet: 0.338 ± 0.018	0.478AsnAsn: 0.478 ± 0.029	1.522AsnPro: 1.522 ± 0.048	0.565AsnGln: 0.565 ± 0.029	1.54AsnArg: 1.54 ± 0.041	0.733AsnSer: 0.733 ± 0.034	1.02AsnThr: 1.02 ± 0.037	1.666AsnVal: 1.666 ± 0.044	0.301AsnTrp: 0.301 ± 0.02	0.556AsnTyr: 0.556 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	8.653ProAla: 8.653 ± 0.126	0.411ProCys: 0.411 ± 0.024	3.399ProAsp: 3.399 ± 0.066	3.23ProGlu: 3.23 ± 0.064	1.782ProPhe: 1.782 ± 0.048	4.841ProGly: 4.841 ± 0.075	1.246ProHis: 1.246 ± 0.035	1.787ProIle: 1.787 ± 0.045	1.343ProLys: 1.343 ± 0.042	5.796ProLeu: 5.796 ± 0.101	1.132ProMet: 1.132 ± 0.034	1.126ProAsn: 1.126 ± 0.039	3.482ProPro: 3.482 ± 0.091	2.162ProGln: 2.162 ± 0.049	4.3ProArg: 4.3 ± 0.081	2.402ProSer: 2.402 ± 0.053	2.342ProThr: 2.342 ± 0.047	3.882ProVal: 3.882 ± 0.071	0.893ProTrp: 0.893 ± 0.032	1.32ProTyr: 1.32 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.085GlnAla: 5.085 ± 0.08	0.201GlnCys: 0.201 ± 0.016	1.364GlnAsp: 1.364 ± 0.046	1.2GlnGlu: 1.2 ± 0.04	0.975GlnPhe: 0.975 ± 0.03	2.463GlnGly: 2.463 ± 0.051	0.791GlnHis: 0.791 ± 0.03	1.292GlnIle: 1.292 ± 0.04	0.792GlnLys: 0.792 ± 0.032	3.357GlnLeu: 3.357 ± 0.062	0.655GlnMet: 0.655 ± 0.027	0.627GlnAsn: 0.627 ± 0.028	2.079GlnPro: 2.079 ± 0.049	1.499GlnGln: 1.499 ± 0.046	3.503GlnArg: 3.503 ± 0.068	1.315GlnSer: 1.315 ± 0.038	1.435GlnThr: 1.435 ± 0.045	2.363GlnVal: 2.363 ± 0.058	0.447GlnTrp: 0.447 ± 0.022	0.666GlnTyr: 0.666 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	11.964ArgAla: 11.964 ± 0.159	0.751ArgCys: 0.751 ± 0.032	4.782ArgAsp: 4.782 ± 0.077	5.42ArgGlu: 5.42 ± 0.097	3.143ArgPhe: 3.143 ± 0.061	6.349ArgGly: 6.349 ± 0.086	2.251ArgHis: 2.251 ± 0.061	3.907ArgIle: 3.907 ± 0.074	1.985ArgLys: 1.985 ± 0.054	9.989ArgLeu: 9.989 ± 0.136	2.086ArgMet: 2.086 ± 0.048	1.606ArgAsn: 1.606 ± 0.047	4.069ArgPro: 4.069 ± 0.07	2.664ArgGln: 2.664 ± 0.055	8.184ArgArg: 8.184 ± 0.124	3.236ArgSer: 3.236 ± 0.063	3.473ArgThr: 3.473 ± 0.058	6.592ArgVal: 6.592 ± 0.092	1.52ArgTrp: 1.52 ± 0.042	2.559ArgTyr: 2.559 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.73SerAla: 5.73 ± 0.089	0.347SerCys: 0.347 ± 0.02	2.148SerAsp: 2.148 ± 0.048	1.95SerGlu: 1.95 ± 0.047	1.522SerPhe: 1.522 ± 0.045	4.37SerGly: 4.37 ± 0.079	0.885SerHis: 0.885 ± 0.033	1.719SerIle: 1.719 ± 0.046	1.075SerLys: 1.075 ± 0.038	4.272SerLeu: 4.272 ± 0.085	0.913SerMet: 0.913 ± 0.028	1.005SerAsn: 1.005 ± 0.035	2.294SerPro: 2.294 ± 0.05	1.158SerGln: 1.158 ± 0.039	2.979SerArg: 2.979 ± 0.056	1.951SerSer: 1.951 ± 0.058	2.079SerThr: 2.079 ± 0.053	3.099SerVal: 3.099 ± 0.063	0.559SerTrp: 0.559 ± 0.026	1.123SerTyr: 1.123 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.627ThrAla: 5.627 ± 0.084	0.379ThrCys: 0.379 ± 0.019	2.177ThrAsp: 2.177 ± 0.057	2.005ThrGlu: 2.005 ± 0.054	1.476ThrPhe: 1.476 ± 0.038	3.932ThrGly: 3.932 ± 0.078	1.067ThrHis: 1.067 ± 0.037	1.745ThrIle: 1.745 ± 0.048	0.901ThrLys: 0.901 ± 0.032	6.345ThrLeu: 6.345 ± 0.09	0.88ThrMet: 0.88 ± 0.033	0.779ThrAsn: 0.779 ± 0.033	3.378ThrPro: 3.378 ± 0.058	1.347ThrGln: 1.347 ± 0.041	3.695ThrArg: 3.695 ± 0.066	1.851ThrSer: 1.851 ± 0.058	2.162ThrThr: 2.162 ± 0.068	3.742ThrVal: 3.742 ± 0.069	0.64ThrTrp: 0.64 ± 0.029	1.069ThrTyr: 1.069 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	10.133ValAla: 10.133 ± 0.116	0.73ValCys: 0.73 ± 0.029	4.416ValAsp: 4.416 ± 0.074	4.45ValGlu: 4.45 ± 0.071	2.412ValPhe: 2.412 ± 0.056	5.609ValGly: 5.609 ± 0.087	1.676ValHis: 1.676 ± 0.051	3.087ValIle: 3.087 ± 0.062	1.879ValLys: 1.879 ± 0.05	8.33ValLeu: 8.33 ± 0.102	1.349ValMet: 1.349 ± 0.039	1.772ValAsn: 1.772 ± 0.053	4.042ValPro: 4.042 ± 0.069	2.26ValGln: 2.26 ± 0.06	6.091ValArg: 6.091 ± 0.081	3.391ValSer: 3.391 ± 0.061	3.544ValThr: 3.544 ± 0.065	5.866ValVal: 5.866 ± 0.1	0.953ValTrp: 0.953 ± 0.037	1.749ValTyr: 1.749 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.406TrpAla: 1.406 ± 0.045	0.165TrpCys: 0.165 ± 0.015	0.664TrpAsp: 0.664 ± 0.026	0.573TrpGlu: 0.573 ± 0.025	0.548TrpPhe: 0.548 ± 0.029	0.861TrpGly: 0.861 ± 0.036	0.391TrpHis: 0.391 ± 0.02	0.644TrpIle: 0.644 ± 0.029	0.403TrpLys: 0.403 ± 0.02	2.173TrpLeu: 2.173 ± 0.048	0.391TrpMet: 0.391 ± 0.02	0.431TrpAsn: 0.431 ± 0.02	0.743TrpPro: 0.743 ± 0.03	0.715TrpGln: 0.715 ± 0.029	1.556TrpArg: 1.556 ± 0.044	0.815TrpSer: 0.815 ± 0.033	0.779TrpThr: 0.779 ± 0.032	0.893TrpVal: 0.893 ± 0.03	0.284TrpTrp: 0.284 ± 0.016	0.364TrpTyr: 0.364 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.652TyrAla: 3.652 ± 0.058	0.237TyrCys: 0.237 ± 0.015	1.43TyrAsp: 1.43 ± 0.048	1.103TyrGlu: 1.103 ± 0.036	0.94TyrPhe: 0.94 ± 0.036	2.134TyrGly: 2.134 ± 0.045	0.519TyrHis: 0.519 ± 0.026	0.652TyrIle: 0.652 ± 0.026	0.546TyrLys: 0.546 ± 0.028	2.59TyrLeu: 2.59 ± 0.057	0.359TyrMet: 0.359 ± 0.021	0.496TyrAsn: 0.496 ± 0.03	1.196TyrPro: 1.196 ± 0.038	0.758TyrGln: 0.758 ± 0.027	2.354TyrArg: 2.354 ± 0.051	0.96TyrSer: 0.96 ± 0.039	1.18TyrThr: 1.18 ± 0.046	1.85TyrVal: 1.85 ± 0.048	0.364TyrTrp: 0.364 ± 0.021	0.69TyrTyr: 0.69 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2837 proteins (897279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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