Amino acid dipepetide frequency for Alienimonas californiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	26.375AlaAla: 26.375 ± 0.288	1.334AlaCys: 1.334 ± 0.033	9.76AlaAsp: 9.76 ± 0.098	10.022AlaGlu: 10.022 ± 0.093	4.371AlaPhe: 4.371 ± 0.056	13.695AlaGly: 13.695 ± 0.129	1.885AlaHis: 1.885 ± 0.035	3.674AlaIle: 3.674 ± 0.053	3.236AlaLys: 3.236 ± 0.055	13.225AlaLeu: 13.225 ± 0.132	2.17AlaMet: 2.17 ± 0.037	2.558AlaAsn: 2.558 ± 0.043	8.413AlaPro: 8.413 ± 0.122	2.648AlaGln: 2.648 ± 0.045	8.445AlaArg: 8.445 ± 0.077	5.354AlaSer: 5.354 ± 0.072	6.276AlaThr: 6.276 ± 0.071	11.569AlaVal: 11.569 ± 0.119	1.729AlaTrp: 1.729 ± 0.032	1.995AlaTyr: 1.995 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.91CysAla: 0.91 ± 0.03	0.218CysCys: 0.218 ± 0.017	0.737CysAsp: 0.737 ± 0.025	0.65CysGlu: 0.65 ± 0.024	0.292CysPhe: 0.292 ± 0.012	1.402CysGly: 1.402 ± 0.033	0.316CysHis: 0.316 ± 0.016	0.197CysIle: 0.197 ± 0.012	0.185CysLys: 0.185 ± 0.012	0.971CysLeu: 0.971 ± 0.029	0.113CysMet: 0.113 ± 0.008	0.161CysAsn: 0.161 ± 0.01	0.659CysPro: 0.659 ± 0.023	0.219CysGln: 0.219 ± 0.013	0.834CysArg: 0.834 ± 0.023	0.454CysSer: 0.454 ± 0.02	0.498CysThr: 0.498 ± 0.02	0.85CysVal: 0.85 ± 0.022	0.136CysTrp: 0.136 ± 0.01	0.209CysTyr: 0.209 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	9.534AspAla: 9.534 ± 0.108	0.513AspCys: 0.513 ± 0.022	4.246AspAsp: 4.246 ± 0.066	4.13AspGlu: 4.13 ± 0.061	1.922AspPhe: 1.922 ± 0.034	7.105AspGly: 7.105 ± 0.093	1.115AspHis: 1.115 ± 0.031	0.992AspIle: 0.992 ± 0.032	1.02AspLys: 1.02 ± 0.028	6.766AspLeu: 6.766 ± 0.065	0.737AspMet: 0.737 ± 0.024	0.867AspAsn: 0.867 ± 0.027	5.276AspPro: 5.276 ± 0.065	1.375AspGln: 1.375 ± 0.034	6.117AspArg: 6.117 ± 0.08	2.505AspSer: 2.505 ± 0.04	2.033AspThr: 2.033 ± 0.037	4.74AspVal: 4.74 ± 0.053	1.131AspTrp: 1.131 ± 0.029	1.307AspTyr: 1.307 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	8.166GluAla: 8.166 ± 0.082	0.426GluCys: 0.426 ± 0.018	3.328GluAsp: 3.328 ± 0.045	4.31GluGlu: 4.31 ± 0.068	1.99GluPhe: 1.99 ± 0.037	4.789GluGly: 4.789 ± 0.056	1.213GluHis: 1.213 ± 0.028	2.374GluIle: 2.374 ± 0.041	1.766GluLys: 1.766 ± 0.041	6.558GluLeu: 6.558 ± 0.068	1.142GluMet: 1.142 ± 0.028	1.586GluAsn: 1.586 ± 0.034	4.498GluPro: 4.498 ± 0.067	2.119GluGln: 2.119 ± 0.042	5.84GluArg: 5.84 ± 0.079	2.895GluSer: 2.895 ± 0.044	3.654GluThr: 3.654 ± 0.051	4.239GluVal: 4.239 ± 0.062	0.822GluTrp: 0.822 ± 0.026	1.19GluTyr: 1.19 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.735PheAla: 4.735 ± 0.057	0.398PheCys: 0.398 ± 0.018	2.534PheAsp: 2.534 ± 0.043	2.123PheGlu: 2.123 ± 0.036	1.066PhePhe: 1.066 ± 0.032	3.378PheGly: 3.378 ± 0.047	0.64PheHis: 0.64 ± 0.018	0.709PheIle: 0.709 ± 0.023	0.754PheLys: 0.754 ± 0.024	3.381PheLeu: 3.381 ± 0.053	0.424PheMet: 0.424 ± 0.016	0.775PheAsn: 0.775 ± 0.022	1.838PhePro: 1.838 ± 0.034	0.804PheGln: 0.804 ± 0.025	2.427PheArg: 2.427 ± 0.042	1.57PheSer: 1.57 ± 0.029	1.848PheThr: 1.848 ± 0.038	2.576PheVal: 2.576 ± 0.042	0.474PheTrp: 0.474 ± 0.019	0.772PheTyr: 0.772 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.363GlyAla: 10.363 ± 0.122	1.056GlyCys: 1.056 ± 0.033	5.888GlyAsp: 5.888 ± 0.079	6.549GlyGlu: 6.549 ± 0.083	3.16GlyPhe: 3.16 ± 0.049	10.19GlyGly: 10.19 ± 0.145	1.589GlyHis: 1.589 ± 0.034	2.307GlyIle: 2.307 ± 0.05	2.504GlyLys: 2.504 ± 0.049	9.227GlyLeu: 9.227 ± 0.094	1.738GlyMet: 1.738 ± 0.035	1.925GlyAsn: 1.925 ± 0.042	5.75GlyPro: 5.75 ± 0.079	2.349GlyGln: 2.349 ± 0.04	7.731GlyArg: 7.731 ± 0.078	4.928GlySer: 4.928 ± 0.061	5.021GlyThr: 5.021 ± 0.079	7.413GlyVal: 7.413 ± 0.071	1.713GlyTrp: 1.713 ± 0.038	2.09GlyTyr: 2.09 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.498HisAla: 2.498 ± 0.044	0.237HisCys: 0.237 ± 0.013	1.176HisAsp: 1.176 ± 0.033	1.045HisGlu: 1.045 ± 0.028	0.684HisPhe: 0.684 ± 0.02	1.977HisGly: 1.977 ± 0.042	0.54HisHis: 0.54 ± 0.02	0.464HisIle: 0.464 ± 0.02	0.363HisLys: 0.363 ± 0.017	1.996HisLeu: 1.996 ± 0.035	0.26HisMet: 0.26 ± 0.013	0.437HisAsn: 0.437 ± 0.018	1.408HisPro: 1.408 ± 0.034	0.409HisGln: 0.409 ± 0.015	1.571HisArg: 1.571 ± 0.036	0.848HisSer: 0.848 ± 0.025	0.854HisThr: 0.854 ± 0.026	1.426HisVal: 1.426 ± 0.031	0.347HisTrp: 0.347 ± 0.016	0.449HisTyr: 0.449 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.345IleAla: 4.345 ± 0.055	0.347IleCys: 0.347 ± 0.016	2.342IleAsp: 2.342 ± 0.041	2.186IleGlu: 2.186 ± 0.039	0.849IlePhe: 0.849 ± 0.025	2.854IleGly: 2.854 ± 0.052	0.572IleHis: 0.572 ± 0.021	0.66IleIle: 0.66 ± 0.026	0.644IleLys: 0.644 ± 0.021	2.69IleLeu: 2.69 ± 0.045	0.318IleMet: 0.318 ± 0.016	0.659IleAsn: 0.659 ± 0.021	1.779IlePro: 1.779 ± 0.037	0.669IleGln: 0.669 ± 0.021	2.166IleArg: 2.166 ± 0.04	1.386IleSer: 1.386 ± 0.032	1.427IleThr: 1.427 ± 0.033	2.583IleVal: 2.583 ± 0.043	0.34IleTrp: 0.34 ± 0.016	0.677IleTyr: 0.677 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.971LysAla: 2.971 ± 0.052	0.193LysCys: 0.193 ± 0.012	1.296LysAsp: 1.296 ± 0.035	1.467LysGlu: 1.467 ± 0.038	0.745LysPhe: 0.745 ± 0.019	1.696LysGly: 1.696 ± 0.042	0.506LysHis: 0.506 ± 0.019	0.95LysIle: 0.95 ± 0.026	1.07LysLys: 1.07 ± 0.038	2.613LysLeu: 2.613 ± 0.052	0.471LysMet: 0.471 ± 0.017	0.643LysAsn: 0.643 ± 0.023	1.747LysPro: 1.747 ± 0.038	0.876LysGln: 0.876 ± 0.025	1.929LysArg: 1.929 ± 0.039	1.34LysSer: 1.34 ± 0.033	1.644LysThr: 1.644 ± 0.036	1.671LysVal: 1.671 ± 0.036	0.362LysTrp: 0.362 ± 0.016	0.599LysTyr: 0.599 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.521LeuAla: 14.521 ± 0.129	1.263LeuCys: 1.263 ± 0.031	5.977LeuAsp: 5.977 ± 0.064	5.308LeuGlu: 5.308 ± 0.065	3.431LeuPhe: 3.431 ± 0.056	8.163LeuGly: 8.163 ± 0.095	2.001LeuHis: 2.001 ± 0.043	3.774LeuIle: 3.774 ± 0.06	3.029LeuLys: 3.029 ± 0.049	10.775LeuLeu: 10.775 ± 0.128	1.614LeuMet: 1.614 ± 0.035	2.54LeuAsn: 2.54 ± 0.042	6.968LeuPro: 6.968 ± 0.068	2.103LeuGln: 2.103 ± 0.031	8.034LeuArg: 8.034 ± 0.08	5.741LeuSer: 5.741 ± 0.071	6.671LeuThr: 6.671 ± 0.079	6.361LeuVal: 6.361 ± 0.077	1.489LeuTrp: 1.489 ± 0.036	1.885LeuTyr: 1.885 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.728MetAla: 1.728 ± 0.037	0.129MetCys: 0.129 ± 0.01	0.728MetAsp: 0.728 ± 0.021	0.68MetGlu: 0.68 ± 0.022	0.505MetPhe: 0.505 ± 0.017	1.094MetGly: 1.094 ± 0.027	0.352MetHis: 0.352 ± 0.014	0.667MetIle: 0.667 ± 0.022	0.56MetLys: 0.56 ± 0.019	1.574MetLeu: 1.574 ± 0.035	0.28MetMet: 0.28 ± 0.015	0.585MetAsn: 0.585 ± 0.022	1.24MetPro: 1.24 ± 0.03	0.456MetGln: 0.456 ± 0.016	1.13MetArg: 1.13 ± 0.028	1.216MetSer: 1.216 ± 0.03	1.337MetThr: 1.337 ± 0.033	0.873MetVal: 0.873 ± 0.027	0.18MetTrp: 0.18 ± 0.01	0.246MetTyr: 0.246 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.815AsnAla: 2.815 ± 0.047	0.242AsnCys: 0.242 ± 0.015	1.356AsnAsp: 1.356 ± 0.034	1.17AsnGlu: 1.17 ± 0.03	0.728AsnPhe: 0.728 ± 0.023	2.285AsnGly: 2.285 ± 0.041	0.431AsnHis: 0.431 ± 0.018	0.47AsnIle: 0.47 ± 0.019	0.426AsnLys: 0.426 ± 0.016	2.374AsnLeu: 2.374 ± 0.045	0.337AsnMet: 0.337 ± 0.016	0.512AsnAsn: 0.512 ± 0.023	1.827AsnPro: 1.827 ± 0.039	0.53AsnGln: 0.53 ± 0.019	1.862AsnArg: 1.862 ± 0.038	1.013AsnSer: 1.013 ± 0.028	0.959AsnThr: 0.959 ± 0.029	1.87AsnVal: 1.87 ± 0.04	0.366AsnTrp: 0.366 ± 0.014	0.635AsnTyr: 0.635 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	10.983ProAla: 10.983 ± 0.118	0.381ProCys: 0.381 ± 0.02	5.085ProAsp: 5.085 ± 0.069	4.554ProGlu: 4.554 ± 0.058	2.044ProPhe: 2.044 ± 0.038	6.596ProGly: 6.596 ± 0.081	1.48ProHis: 1.48 ± 0.03	1.887ProIle: 1.887 ± 0.031	1.558ProLys: 1.558 ± 0.033	5.979ProLeu: 5.979 ± 0.069	0.866ProMet: 0.866 ± 0.024	1.62ProAsn: 1.62 ± 0.032	6.095ProPro: 6.095 ± 0.104	1.773ProGln: 1.773 ± 0.032	4.315ProArg: 4.315 ± 0.064	3.278ProSer: 3.278 ± 0.05	3.805ProThr: 3.805 ± 0.062	5.053ProVal: 5.053 ± 0.061	0.831ProTrp: 0.831 ± 0.023	1.063ProTyr: 1.063 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.11GlnAla: 3.11 ± 0.051	0.25GlnCys: 0.25 ± 0.013	1.164GlnAsp: 1.164 ± 0.027	1.328GlnGlu: 1.328 ± 0.031	1.067GlnPhe: 1.067 ± 0.029	1.673GlnGly: 1.673 ± 0.036	0.481GlnHis: 0.481 ± 0.019	1.227GlnIle: 1.227 ± 0.029	0.749GlnLys: 0.749 ± 0.021	2.277GlnLeu: 2.277 ± 0.045	0.531GlnMet: 0.531 ± 0.017	0.702GlnAsn: 0.702 ± 0.024	1.646GlnPro: 1.646 ± 0.044	0.905GlnGln: 0.905 ± 0.027	1.971GlnArg: 1.971 ± 0.034	1.363GlnSer: 1.363 ± 0.031	1.64GlnThr: 1.64 ± 0.033	1.798GlnVal: 1.798 ± 0.039	0.412GlnTrp: 0.412 ± 0.015	0.614GlnTyr: 0.614 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.203ArgAla: 8.203 ± 0.079	0.811ArgCys: 0.811 ± 0.023	4.755ArgAsp: 4.755 ± 0.06	4.882ArgGlu: 4.882 ± 0.062	3.303ArgPhe: 3.303 ± 0.048	6.296ArgGly: 6.296 ± 0.071	1.529ArgHis: 1.529 ± 0.033	2.678ArgIle: 2.678 ± 0.04	1.818ArgLys: 1.818 ± 0.04	8.761ArgLeu: 8.761 ± 0.089	1.428ArgMet: 1.428 ± 0.028	1.663ArgAsn: 1.663 ± 0.035	5.503ArgPro: 5.503 ± 0.08	2.24ArgGln: 2.24 ± 0.042	7.686ArgArg: 7.686 ± 0.089	4.1ArgSer: 4.1 ± 0.059	4.713ArgThr: 4.713 ± 0.06	5.637ArgVal: 5.637 ± 0.058	1.428ArgTrp: 1.428 ± 0.031	1.678ArgTyr: 1.678 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.131SerAla: 6.131 ± 0.078	0.419SerCys: 0.419 ± 0.019	3.036SerAsp: 3.036 ± 0.046	2.741SerGlu: 2.741 ± 0.039	1.631SerPhe: 1.631 ± 0.034	5.204SerGly: 5.204 ± 0.063	0.995SerHis: 0.995 ± 0.026	1.355SerIle: 1.355 ± 0.034	1.167SerLys: 1.167 ± 0.031	5.004SerLeu: 5.004 ± 0.065	0.735SerMet: 0.735 ± 0.024	1.097SerAsn: 1.097 ± 0.027	3.776SerPro: 3.776 ± 0.057	1.161SerGln: 1.161 ± 0.03	3.506SerArg: 3.506 ± 0.049	2.517SerSer: 2.517 ± 0.051	2.188SerThr: 2.188 ± 0.038	3.733SerVal: 3.733 ± 0.052	0.621SerTrp: 0.621 ± 0.02	0.995SerTyr: 0.995 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	7.65ThrAla: 7.65 ± 0.08	0.448ThrCys: 0.448 ± 0.022	3.375ThrAsp: 3.375 ± 0.051	2.924ThrGlu: 2.924 ± 0.043	2.019ThrPhe: 2.019 ± 0.043	5.364ThrGly: 5.364 ± 0.082	1.043ThrHis: 1.043 ± 0.029	1.788ThrIle: 1.788 ± 0.034	1.142ThrLys: 1.142 ± 0.03	6.279ThrLeu: 6.279 ± 0.07	0.72ThrMet: 0.72 ± 0.026	1.231ThrAsn: 1.231 ± 0.032	4.107ThrPro: 4.107 ± 0.06	1.122ThrGln: 1.122 ± 0.027	3.374ThrArg: 3.374 ± 0.05	2.017ThrSer: 2.017 ± 0.041	2.601ThrThr: 2.601 ± 0.051	5.065ThrVal: 5.065 ± 0.075	0.645ThrTrp: 0.645 ± 0.022	1.025ThrTyr: 1.025 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.772ValAla: 9.772 ± 0.097	0.945ValCys: 0.945 ± 0.034	4.299ValAsp: 4.299 ± 0.055	4.645ValGlu: 4.645 ± 0.054	2.143ValPhe: 2.143 ± 0.043	6.547ValGly: 6.547 ± 0.081	1.437ValHis: 1.437 ± 0.033	2.355ValIle: 2.355 ± 0.039	1.93ValLys: 1.93 ± 0.039	7.567ValLeu: 7.567 ± 0.087	1.164ValMet: 1.164 ± 0.024	1.73ValAsn: 1.73 ± 0.037	4.909ValPro: 4.909 ± 0.059	2.017ValGln: 2.017 ± 0.042	7.065ValArg: 7.065 ± 0.074	3.803ValSer: 3.803 ± 0.05	4.876ValThr: 4.876 ± 0.069	6.008ValVal: 6.008 ± 0.07	1.209ValTrp: 1.209 ± 0.03	1.376ValTyr: 1.376 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.716TrpAla: 1.716 ± 0.036	0.172TrpCys: 0.172 ± 0.011	0.895TrpAsp: 0.895 ± 0.025	0.883TrpGlu: 0.883 ± 0.024	0.555TrpPhe: 0.555 ± 0.02	1.134TrpGly: 1.134 ± 0.029	0.362TrpHis: 0.362 ± 0.016	0.554TrpIle: 0.554 ± 0.022	0.407TrpLys: 0.407 ± 0.016	1.596TrpLeu: 1.596 ± 0.036	0.243TrpMet: 0.243 ± 0.012	0.451TrpAsn: 0.451 ± 0.019	0.804TrpPro: 0.804 ± 0.026	0.473TrpGln: 0.473 ± 0.015	1.301TrpArg: 1.301 ± 0.031	0.764TrpSer: 0.764 ± 0.023	0.981TrpThr: 0.981 ± 0.024	0.975TrpVal: 0.975 ± 0.027	0.314TrpTrp: 0.314 ± 0.014	0.282TrpTyr: 0.282 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.209TyrAla: 2.209 ± 0.045	0.232TyrCys: 0.232 ± 0.011	1.453TyrAsp: 1.453 ± 0.04	1.305TyrGlu: 1.305 ± 0.031	0.721TyrPhe: 0.721 ± 0.021	2.053TyrGly: 2.053 ± 0.049	0.502TyrHis: 0.502 ± 0.02	0.413TyrIle: 0.413 ± 0.016	0.46TyrLys: 0.46 ± 0.017	2.039TyrLeu: 2.039 ± 0.039	0.267TyrMet: 0.267 ± 0.013	0.466TyrAsn: 0.466 ± 0.019	1.005TyrPro: 1.005 ± 0.027	0.66TyrGln: 0.66 ± 0.021	1.804TyrArg: 1.804 ± 0.035	0.919TyrSer: 0.919 ± 0.026	0.912TyrThr: 0.912 ± 0.026	1.355TyrVal: 1.355 ± 0.03	0.312TyrTrp: 0.312 ± 0.016	0.543TyrTyr: 0.543 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4303 proteins (1597559 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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