Amino acid dipepetide frequency for Methylotenera mobilis (strain JLW8 / ATCC BAA-1282 / DSM 17540)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.487AlaAla: 10.487 ± 0.172
0.925AlaCys: 0.925 ± 0.039
5.54AlaAsp: 5.54 ± 0.098
6.235AlaGlu: 6.235 ± 0.106
3.437AlaPhe: 3.437 ± 0.072
6.912AlaGly: 6.912 ± 0.112
2.243AlaHis: 2.243 ± 0.054
6.4AlaIle: 6.4 ± 0.092
6.002AlaLys: 6.002 ± 0.1
11.012AlaLeu: 11.012 ± 0.149
2.913AlaMet: 2.913 ± 0.07
4.359AlaAsn: 4.359 ± 0.078
3.47AlaPro: 3.47 ± 0.077
4.534AlaGln: 4.534 ± 0.089
4.468AlaArg: 4.468 ± 0.086
6.054AlaSer: 6.054 ± 0.101
5.389AlaThr: 5.389 ± 0.098
6.934AlaVal: 6.934 ± 0.111
1.175AlaTrp: 1.175 ± 0.039
2.71AlaTyr: 2.71 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.792CysAla: 0.792 ± 0.038
0.124CysCys: 0.124 ± 0.014
0.442CysAsp: 0.442 ± 0.022
0.473CysGlu: 0.473 ± 0.022
0.304CysPhe: 0.304 ± 0.025
0.792CysGly: 0.792 ± 0.034
0.271CysHis: 0.271 ± 0.022
0.51CysIle: 0.51 ± 0.026
0.411CysLys: 0.411 ± 0.024
0.825CysLeu: 0.825 ± 0.034
0.232CysMet: 0.232 ± 0.017
0.351CysAsn: 0.351 ± 0.022
0.469CysPro: 0.469 ± 0.027
0.323CysGln: 0.323 ± 0.021
0.366CysArg: 0.366 ± 0.024
0.548CysSer: 0.548 ± 0.028
0.478CysThr: 0.478 ± 0.025
0.647CysVal: 0.647 ± 0.033
0.074CysTrp: 0.074 ± 0.009
0.255CysTyr: 0.255 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.894AspAla: 5.894 ± 0.085
0.486AspCys: 0.486 ± 0.025
2.742AspAsp: 2.742 ± 0.066
3.25AspGlu: 3.25 ± 0.081
2.35AspPhe: 2.35 ± 0.055
3.818AspGly: 3.818 ± 0.103
0.999AspHis: 0.999 ± 0.039
3.737AspIle: 3.737 ± 0.082
2.884AspLys: 2.884 ± 0.065
5.151AspLeu: 5.151 ± 0.081
1.343AspMet: 1.343 ± 0.039
2.017AspAsn: 2.017 ± 0.051
1.877AspPro: 1.877 ± 0.06
1.637AspGln: 1.637 ± 0.046
2.249AspArg: 2.249 ± 0.057
2.851AspSer: 2.851 ± 0.065
2.805AspThr: 2.805 ± 0.085
3.967AspVal: 3.967 ± 0.075
0.8AspTrp: 0.8 ± 0.033
1.872AspTyr: 1.872 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.997GluAla: 5.997 ± 0.099
0.374GluCys: 0.374 ± 0.025
2.49GluAsp: 2.49 ± 0.058
2.87GluGlu: 2.87 ± 0.074
2.166GluPhe: 2.166 ± 0.061
3.168GluGly: 3.168 ± 0.067
1.534GluHis: 1.534 ± 0.049
4.028GluIle: 4.028 ± 0.085
3.23GluLys: 3.23 ± 0.059
6.083GluLeu: 6.083 ± 0.096
1.497GluMet: 1.497 ± 0.052
2.286GluAsn: 2.286 ± 0.052
1.908GluPro: 1.908 ± 0.064
3.093GluGln: 3.093 ± 0.074
3.218GluArg: 3.218 ± 0.073
3.32GluSer: 3.32 ± 0.068
2.876GluThr: 2.876 ± 0.068
4.29GluVal: 4.29 ± 0.086
0.622GluTrp: 0.622 ± 0.026
1.543GluTyr: 1.543 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.612PheAla: 3.612 ± 0.069
0.401PheCys: 0.401 ± 0.026
2.4PheAsp: 2.4 ± 0.059
2.223PheGlu: 2.223 ± 0.057
1.604PhePhe: 1.604 ± 0.053
3.148PheGly: 3.148 ± 0.069
0.702PheHis: 0.702 ± 0.03
2.413PheIle: 2.413 ± 0.064
1.992PheLys: 1.992 ± 0.052
3.357PheLeu: 3.357 ± 0.08
0.927PheMet: 0.927 ± 0.04
2.04PheAsn: 2.04 ± 0.063
1.313PhePro: 1.313 ± 0.043
1.086PheGln: 1.086 ± 0.033
1.407PheArg: 1.407 ± 0.046
2.87PheSer: 2.87 ± 0.061
2.199PheThr: 2.199 ± 0.058
2.682PheVal: 2.682 ± 0.054
0.469PheTrp: 0.469 ± 0.026
1.241PheTyr: 1.241 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
6.22GlyAla: 6.22 ± 0.115
0.729GlyCys: 0.729 ± 0.034
3.515GlyAsp: 3.515 ± 0.076
3.925GlyGlu: 3.925 ± 0.075
3.07GlyPhe: 3.07 ± 0.072
4.899GlyGly: 4.899 ± 0.098
1.592GlyHis: 1.592 ± 0.047
4.442GlyIle: 4.442 ± 0.089
4.194GlyLys: 4.194 ± 0.075
7.278GlyLeu: 7.278 ± 0.108
2.007GlyMet: 2.007 ± 0.056
2.908GlyAsn: 2.908 ± 0.103
1.485GlyPro: 1.485 ± 0.039
2.38GlyGln: 2.38 ± 0.07
3.221GlyArg: 3.221 ± 0.076
3.942GlySer: 3.942 ± 0.083
3.567GlyThr: 3.567 ± 0.089
5.571GlyVal: 5.571 ± 0.097
0.89GlyTrp: 0.89 ± 0.04
2.37GlyTyr: 2.37 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.43HisAla: 2.43 ± 0.062
0.26HisCys: 0.26 ± 0.021
1.232HisAsp: 1.232 ± 0.042
1.295HisGlu: 1.295 ± 0.042
0.945HisPhe: 0.945 ± 0.034
1.632HisGly: 1.632 ± 0.05
0.841HisHis: 0.841 ± 0.039
1.444HisIle: 1.444 ± 0.046
0.958HisLys: 0.958 ± 0.034
2.379HisLeu: 2.379 ± 0.064
0.582HisMet: 0.582 ± 0.024
0.869HisAsn: 0.869 ± 0.033
1.25HisPro: 1.25 ± 0.044
1.167HisGln: 1.167 ± 0.042
0.986HisArg: 0.986 ± 0.037
1.181HisSer: 1.181 ± 0.037
1.196HisThr: 1.196 ± 0.035
1.468HisVal: 1.468 ± 0.047
0.322HisTrp: 0.322 ± 0.02
0.855HisTyr: 0.855 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.874IleAla: 6.874 ± 0.091
0.564IleCys: 0.564 ± 0.029
3.791IleAsp: 3.791 ± 0.078
4.215IleGlu: 4.215 ± 0.086
2.161IlePhe: 2.161 ± 0.065
4.725IleGly: 4.725 ± 0.084
1.27IleHis: 1.27 ± 0.044
3.515IleIle: 3.515 ± 0.067
3.851IleLys: 3.851 ± 0.077
5.366IleLeu: 5.366 ± 0.091
1.307IleMet: 1.307 ± 0.045
3.085IleAsn: 3.085 ± 0.068
2.655IlePro: 2.655 ± 0.069
2.236IleGln: 2.236 ± 0.06
2.606IleArg: 2.606 ± 0.057
4.439IleSer: 4.439 ± 0.097
3.898IleThr: 3.898 ± 0.084
4.227IleVal: 4.227 ± 0.085
0.569IleTrp: 0.569 ± 0.032
1.651IleTyr: 1.651 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
5.275LysAla: 5.275 ± 0.09
0.268LysCys: 0.268 ± 0.021
2.591LysAsp: 2.591 ± 0.071
2.737LysGlu: 2.737 ± 0.062
1.768LysPhe: 1.768 ± 0.047
2.999LysGly: 2.999 ± 0.068
1.336LysHis: 1.336 ± 0.046
3.455LysIle: 3.455 ± 0.075
2.975LysLys: 2.975 ± 0.079
6.056LysLeu: 6.056 ± 0.085
1.397LysMet: 1.397 ± 0.044
2.439LysAsn: 2.439 ± 0.063
2.674LysPro: 2.674 ± 0.071
2.808LysGln: 2.808 ± 0.062
2.644LysArg: 2.644 ± 0.063
3.401LysSer: 3.401 ± 0.069
3.163LysThr: 3.163 ± 0.066
3.938LysVal: 3.938 ± 0.07
0.469LysTrp: 0.469 ± 0.023
1.356LysTyr: 1.356 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
10.768LeuAla: 10.768 ± 0.141
0.935LeuCys: 0.935 ± 0.036
5.594LeuAsp: 5.594 ± 0.086
5.696LeuGlu: 5.696 ± 0.081
3.762LeuPhe: 3.762 ± 0.082
7.212LeuGly: 7.212 ± 0.116
2.277LeuHis: 2.277 ± 0.06
6.45LeuIle: 6.45 ± 0.102
5.733LeuLys: 5.733 ± 0.092
10.995LeuLeu: 10.995 ± 0.176
2.705LeuMet: 2.705 ± 0.063
4.87LeuAsn: 4.87 ± 0.105
4.994LeuPro: 4.994 ± 0.085
4.344LeuGln: 4.344 ± 0.083
4.977LeuArg: 4.977 ± 0.094
7.551LeuSer: 7.551 ± 0.113
5.79LeuThr: 5.79 ± 0.099
6.944LeuVal: 6.944 ± 0.091
1.012LeuTrp: 1.012 ± 0.04
2.453LeuTyr: 2.453 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.574MetAla: 2.574 ± 0.057
0.176MetCys: 0.176 ± 0.015
1.166MetAsp: 1.166 ± 0.039
1.117MetGlu: 1.117 ± 0.038
0.863MetPhe: 0.863 ± 0.038
1.659MetGly: 1.659 ± 0.05
0.692MetHis: 0.692 ± 0.028
1.403MetIle: 1.403 ± 0.042
1.267MetLys: 1.267 ± 0.045
3.043MetLeu: 3.043 ± 0.067
0.821MetMet: 0.821 ± 0.036
1.084MetAsn: 1.084 ± 0.035
1.329MetPro: 1.329 ± 0.047
1.613MetGln: 1.613 ± 0.048
1.508MetArg: 1.508 ± 0.042
1.756MetSer: 1.756 ± 0.05
1.592MetThr: 1.592 ± 0.048
1.77MetVal: 1.77 ± 0.058
0.218MetTrp: 0.218 ± 0.016
0.528MetTyr: 0.528 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
4.402AsnAla: 4.402 ± 0.095
0.392AsnCys: 0.392 ± 0.026
2.183AsnAsp: 2.183 ± 0.061
2.271AsnGlu: 2.271 ± 0.057
1.548AsnPhe: 1.548 ± 0.047
2.974AsnGly: 2.974 ± 0.087
0.99AsnHis: 0.99 ± 0.036
2.968AsnIle: 2.968 ± 0.071
2.313AsnLys: 2.313 ± 0.059
4.323AsnLeu: 4.323 ± 0.081
1.053AsnMet: 1.053 ± 0.041
2.037AsnAsn: 2.037 ± 0.072
2.158AsnPro: 2.158 ± 0.054
2.214AsnGln: 2.214 ± 0.057
1.962AsnArg: 1.962 ± 0.049
2.355AsnSer: 2.355 ± 0.062
2.793AsnThr: 2.793 ± 0.073
2.876AsnVal: 2.876 ± 0.059
0.543AsnTrp: 0.543 ± 0.031
1.171AsnTyr: 1.171 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.09ProAla: 4.09 ± 0.095
0.302ProCys: 0.302 ± 0.02
2.443ProAsp: 2.443 ± 0.057
2.813ProGlu: 2.813 ± 0.07
1.493ProPhe: 1.493 ± 0.045
2.282ProGly: 2.282 ± 0.064
0.982ProHis: 0.982 ± 0.033
2.492ProIle: 2.492 ± 0.06
2.078ProLys: 2.078 ± 0.061
4.062ProLeu: 4.062 ± 0.083
1.031ProMet: 1.031 ± 0.042
1.984ProAsn: 1.984 ± 0.048
1.407ProPro: 1.407 ± 0.052
1.663ProGln: 1.663 ± 0.048
1.521ProArg: 1.521 ± 0.052
2.515ProSer: 2.515 ± 0.059
2.199ProThr: 2.199 ± 0.057
3.279ProVal: 3.279 ± 0.073
0.451ProTrp: 0.451 ± 0.025
1.242ProTyr: 1.242 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.85GlnAla: 4.85 ± 0.083
0.294GlnCys: 0.294 ± 0.018
2.043GlnAsp: 2.043 ± 0.053
2.071GlnGlu: 2.071 ± 0.055
1.603GlnPhe: 1.603 ± 0.043
2.523GlnGly: 2.523 ± 0.067
1.382GlnHis: 1.382 ± 0.042
2.579GlnIle: 2.579 ± 0.066
2.09GlnLys: 2.09 ± 0.059
4.901GlnLeu: 4.901 ± 0.092
1.13GlnMet: 1.13 ± 0.036
1.588GlnAsn: 1.588 ± 0.047
1.76GlnPro: 1.76 ± 0.047
2.602GlnGln: 2.602 ± 0.077
2.358GlnArg: 2.358 ± 0.066
2.722GlnSer: 2.722 ± 0.07
2.282GlnThr: 2.282 ± 0.062
3.162GlnVal: 3.162 ± 0.067
0.491GlnTrp: 0.491 ± 0.026
1.28GlnTyr: 1.28 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
4.154ArgAla: 4.154 ± 0.075
0.354ArgCys: 0.354 ± 0.022
2.582ArgAsp: 2.582 ± 0.07
2.946ArgGlu: 2.946 ± 0.066
2.095ArgPhe: 2.095 ± 0.055
2.923ArgGly: 2.923 ± 0.067
1.1ArgHis: 1.1 ± 0.037
3.142ArgIle: 3.142 ± 0.066
2.333ArgLys: 2.333 ± 0.061
5.012ArgLeu: 5.012 ± 0.079
1.379ArgMet: 1.379 ± 0.049
1.972ArgAsn: 1.972 ± 0.058
1.687ArgPro: 1.687 ± 0.046
1.997ArgGln: 1.997 ± 0.047
2.261ArgArg: 2.261 ± 0.067
2.47ArgSer: 2.47 ± 0.054
2.235ArgThr: 2.235 ± 0.051
3.445ArgVal: 3.445 ± 0.08
0.591ArgTrp: 0.591 ± 0.03
1.671ArgTyr: 1.671 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.315SerAla: 6.315 ± 0.112
0.532SerCys: 0.532 ± 0.031
3.202SerAsp: 3.202 ± 0.082
3.253SerGlu: 3.253 ± 0.073
2.564SerPhe: 2.564 ± 0.064
4.702SerGly: 4.702 ± 0.084
1.428SerHis: 1.428 ± 0.041
3.894SerIle: 3.894 ± 0.071
3.167SerLys: 3.167 ± 0.077
6.686SerLeu: 6.686 ± 0.09
1.675SerMet: 1.675 ± 0.043
2.805SerAsn: 2.805 ± 0.068
2.425SerPro: 2.425 ± 0.058
2.578SerGln: 2.578 ± 0.062
2.8SerArg: 2.8 ± 0.06
3.849SerSer: 3.849 ± 0.104
3.424SerThr: 3.424 ± 0.075
4.392SerVal: 4.392 ± 0.081
0.704SerTrp: 0.704 ± 0.031
1.801SerTyr: 1.801 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.245ThrAla: 5.245 ± 0.087
0.454ThrCys: 0.454 ± 0.024
2.874ThrAsp: 2.874 ± 0.063
3.015ThrGlu: 3.015 ± 0.069
1.98ThrPhe: 1.98 ± 0.058
4.282ThrGly: 4.282 ± 0.095
1.316ThrHis: 1.316 ± 0.049
3.299ThrIle: 3.299 ± 0.076
2.509ThrLys: 2.509 ± 0.056
6.326ThrLeu: 6.326 ± 0.124
1.184ThrMet: 1.184 ± 0.036
2.277ThrAsn: 2.277 ± 0.063
3.051ThrPro: 3.051 ± 0.061
2.532ThrGln: 2.532 ± 0.061
2.347ThrArg: 2.347 ± 0.058
3.327ThrSer: 3.327 ± 0.079
3.201ThrThr: 3.201 ± 0.081
3.849ThrVal: 3.849 ± 0.093
0.524ThrTrp: 0.524 ± 0.028
1.579ThrTyr: 1.579 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
7.594ValAla: 7.594 ± 0.119
0.664ValCys: 0.664 ± 0.034
3.849ValAsp: 3.849 ± 0.075
4.16ValGlu: 4.16 ± 0.077
2.618ValPhe: 2.618 ± 0.072
4.85ValGly: 4.85 ± 0.103
1.333ValHis: 1.333 ± 0.043
4.701ValIle: 4.701 ± 0.093
3.856ValLys: 3.856 ± 0.079
7.396ValLeu: 7.396 ± 0.102
2.058ValMet: 2.058 ± 0.061
3.129ValAsn: 3.129 ± 0.069
2.789ValPro: 2.789 ± 0.061
2.579ValGln: 2.579 ± 0.062
3.251ValArg: 3.251 ± 0.061
4.744ValSer: 4.744 ± 0.08
4.119ValThr: 4.119 ± 0.082
5.757ValVal: 5.757 ± 0.113
0.776ValTrp: 0.776 ± 0.034
1.797ValTyr: 1.797 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.841TrpAla: 0.841 ± 0.038
0.139TrpCys: 0.139 ± 0.013
0.533TrpAsp: 0.533 ± 0.03
0.528TrpGlu: 0.528 ± 0.026
0.448TrpPhe: 0.448 ± 0.027
0.636TrpGly: 0.636 ± 0.033
0.315TrpHis: 0.315 ± 0.019
0.655TrpIle: 0.655 ± 0.03
0.535TrpLys: 0.535 ± 0.029
1.744TrpLeu: 1.744 ± 0.054
0.309TrpMet: 0.309 ± 0.021
0.348TrpAsn: 0.348 ± 0.024
0.367TrpPro: 0.367 ± 0.022
0.778TrpGln: 0.778 ± 0.039
0.685TrpArg: 0.685 ± 0.029
0.581TrpSer: 0.581 ± 0.031
0.437TrpThr: 0.437 ± 0.022
0.904TrpVal: 0.904 ± 0.039
0.181TrpTrp: 0.181 ± 0.017
0.312TrpTyr: 0.312 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.787TyrAla: 2.787 ± 0.058
0.313TyrCys: 0.313 ± 0.021
1.514TyrAsp: 1.514 ± 0.047
1.502TyrGlu: 1.502 ± 0.046
1.308TyrPhe: 1.308 ± 0.041
2.067TyrGly: 2.067 ± 0.057
0.689TyrHis: 0.689 ± 0.031
1.478TyrIle: 1.478 ± 0.042
1.37TyrLys: 1.37 ± 0.045
3.065TyrLeu: 3.065 ± 0.063
0.627TyrMet: 0.627 ± 0.028
1.08TyrAsn: 1.08 ± 0.046
1.262TyrPro: 1.262 ± 0.043
1.546TyrGln: 1.546 ± 0.044
1.515TyrArg: 1.515 ± 0.043
1.721TyrSer: 1.721 ± 0.05
1.527TyrThr: 1.527 ± 0.046
1.918TyrVal: 1.918 ± 0.053
0.395TyrTrp: 0.395 ± 0.023
0.952TyrTyr: 0.952 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2334 proteins (757536 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski