Amino acid dipepetide frequency for Jhaorihella thermophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.15AlaAla: 18.15 ± 0.171	1.156AlaCys: 1.156 ± 0.035	7.098AlaAsp: 7.098 ± 0.087	9.039AlaGlu: 9.039 ± 0.118	4.272AlaPhe: 4.272 ± 0.053	11.071AlaGly: 11.071 ± 0.109	2.477AlaHis: 2.477 ± 0.045	5.744AlaIle: 5.744 ± 0.072	3.194AlaLys: 3.194 ± 0.064	13.789AlaLeu: 13.789 ± 0.148	3.781AlaMet: 3.781 ± 0.059	2.527AlaAsn: 2.527 ± 0.041	6.269AlaPro: 6.269 ± 0.086	4.176AlaGln: 4.176 ± 0.061	11.267AlaArg: 11.267 ± 0.137	4.807AlaSer: 4.807 ± 0.07	5.654AlaThr: 5.654 ± 0.08	8.859AlaVal: 8.859 ± 0.119	1.609AlaTrp: 1.609 ± 0.042	2.44AlaTyr: 2.44 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.188CysAla: 1.188 ± 0.038	0.1CysCys: 0.1 ± 0.009	0.646CysAsp: 0.646 ± 0.024	0.48CysGlu: 0.48 ± 0.021	0.321CysPhe: 0.321 ± 0.015	0.977CysGly: 0.977 ± 0.032	0.284CysHis: 0.284 ± 0.018	0.409CysIle: 0.409 ± 0.018	0.21CysLys: 0.21 ± 0.014	0.839CysLeu: 0.839 ± 0.027	0.179CysMet: 0.179 ± 0.013	0.216CysAsn: 0.216 ± 0.013	0.55CysPro: 0.55 ± 0.025	0.199CysGln: 0.199 ± 0.014	0.68CysArg: 0.68 ± 0.024	0.417CysSer: 0.417 ± 0.021	0.422CysThr: 0.422 ± 0.019	0.609CysVal: 0.609 ± 0.028	0.126CysTrp: 0.126 ± 0.01	0.209CysTyr: 0.209 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.051AspAla: 7.051 ± 0.08	0.58AspCys: 0.58 ± 0.024	3.392AspAsp: 3.392 ± 0.065	3.657AspGlu: 3.657 ± 0.061	2.248AspPhe: 2.248 ± 0.042	5.498AspGly: 5.498 ± 0.084	1.421AspHis: 1.421 ± 0.041	2.86AspIle: 2.86 ± 0.049	1.577AspLys: 1.577 ± 0.041	6.539AspLeu: 6.539 ± 0.079	1.629AspMet: 1.629 ± 0.034	1.148AspAsn: 1.148 ± 0.034	4.099AspPro: 4.099 ± 0.063	1.632AspGln: 1.632 ± 0.04	5.442AspArg: 5.442 ± 0.076	1.989AspSer: 1.989 ± 0.043	2.759AspThr: 2.759 ± 0.052	3.997AspVal: 3.997 ± 0.063	1.295AspTrp: 1.295 ± 0.033	1.541AspTyr: 1.541 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.527GluAla: 8.527 ± 0.127	0.399GluCys: 0.399 ± 0.019	3.352GluAsp: 3.352 ± 0.062	4.072GluGlu: 4.072 ± 0.08	1.79GluPhe: 1.79 ± 0.042	4.948GluGly: 4.948 ± 0.074	1.169GluHis: 1.169 ± 0.037	4.026GluIle: 4.026 ± 0.065	2.162GluLys: 2.162 ± 0.051	5.572GluLeu: 5.572 ± 0.08	1.836GluMet: 1.836 ± 0.043	1.671GluAsn: 1.671 ± 0.036	2.922GluPro: 2.922 ± 0.059	2.038GluGln: 2.038 ± 0.046	5.073GluArg: 5.073 ± 0.073	2.194GluSer: 2.194 ± 0.051	3.782GluThr: 3.782 ± 0.066	4.383GluVal: 4.383 ± 0.057	0.79GluTrp: 0.79 ± 0.028	1.07GluTyr: 1.07 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.378PheAla: 4.378 ± 0.058	0.412PheCys: 0.412 ± 0.021	2.854PheAsp: 2.854 ± 0.046	2.123PheGlu: 2.123 ± 0.046	1.299PhePhe: 1.299 ± 0.04	3.598PheGly: 3.598 ± 0.061	0.813PheHis: 0.813 ± 0.028	1.496PheIle: 1.496 ± 0.04	0.837PheLys: 0.837 ± 0.026	3.407PheLeu: 3.407 ± 0.07	0.843PheMet: 0.843 ± 0.026	0.963PheAsn: 0.963 ± 0.028	1.535PhePro: 1.535 ± 0.036	0.911PheGln: 0.911 ± 0.026	2.517PheArg: 2.517 ± 0.048	1.943PheSer: 1.943 ± 0.046	1.878PheThr: 1.878 ± 0.042	2.695PheVal: 2.695 ± 0.054	0.586PheTrp: 0.586 ± 0.024	0.911PheTyr: 0.911 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.18GlyAla: 10.18 ± 0.112	0.909GlyCys: 0.909 ± 0.031	4.791GlyAsp: 4.791 ± 0.073	4.872GlyGlu: 4.872 ± 0.065	3.657GlyPhe: 3.657 ± 0.058	7.825GlyGly: 7.825 ± 0.115	2.03GlyHis: 2.03 ± 0.046	4.383GlyIle: 4.383 ± 0.063	2.906GlyLys: 2.906 ± 0.062	9.066GlyLeu: 9.066 ± 0.091	2.671GlyMet: 2.671 ± 0.083	1.981GlyAsn: 1.981 ± 0.055	4.006GlyPro: 4.006 ± 0.065	2.987GlyGln: 2.987 ± 0.057	6.982GlyArg: 6.982 ± 0.081	3.837GlySer: 3.837 ± 0.075	4.454GlyThr: 4.454 ± 0.074	6.348GlyVal: 6.348 ± 0.075	1.6GlyTrp: 1.6 ± 0.036	2.252GlyTyr: 2.252 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.491HisAla: 2.491 ± 0.051	0.235HisCys: 0.235 ± 0.013	1.445HisAsp: 1.445 ± 0.037	1.177HisGlu: 1.177 ± 0.033	0.81HisPhe: 0.81 ± 0.027	2.052HisGly: 2.052 ± 0.046	0.596HisHis: 0.596 ± 0.027	0.878HisIle: 0.878 ± 0.031	0.488HisLys: 0.488 ± 0.023	2.165HisLeu: 2.165 ± 0.045	0.547HisMet: 0.547 ± 0.02	0.411HisAsn: 0.411 ± 0.02	1.476HisPro: 1.476 ± 0.036	0.535HisGln: 0.535 ± 0.024	1.573HisArg: 1.573 ± 0.04	0.821HisSer: 0.821 ± 0.025	0.752HisThr: 0.752 ± 0.024	1.701HisVal: 1.701 ± 0.036	0.345HisTrp: 0.345 ± 0.016	0.598HisTyr: 0.598 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.882IleAla: 6.882 ± 0.082	0.594IleCys: 0.594 ± 0.022	3.456IleAsp: 3.456 ± 0.055	3.634IleGlu: 3.634 ± 0.057	1.581IlePhe: 1.581 ± 0.045	4.614IleGly: 4.614 ± 0.065	0.98IleHis: 0.98 ± 0.03	1.846IleIle: 1.846 ± 0.049	1.232IleLys: 1.232 ± 0.036	4.745IleLeu: 4.745 ± 0.078	0.971IleMet: 0.971 ± 0.03	1.174IleAsn: 1.174 ± 0.037	2.384IlePro: 2.384 ± 0.05	1.007IleGln: 1.007 ± 0.027	3.867IleArg: 3.867 ± 0.065	2.481IleSer: 2.481 ± 0.052	2.53IleThr: 2.53 ± 0.048	3.62IleVal: 3.62 ± 0.069	0.742IleTrp: 0.742 ± 0.027	1.059IleTyr: 1.059 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.686LysAla: 3.686 ± 0.068	0.185LysCys: 0.185 ± 0.013	1.549LysAsp: 1.549 ± 0.043	1.562LysGlu: 1.562 ± 0.047	0.867LysPhe: 0.867 ± 0.028	2.615LysGly: 2.615 ± 0.053	0.493LysHis: 0.493 ± 0.019	1.415LysIle: 1.415 ± 0.041	1.188LysLys: 1.188 ± 0.047	2.735LysLeu: 2.735 ± 0.053	0.774LysMet: 0.774 ± 0.024	0.702LysAsn: 0.702 ± 0.027	1.826LysPro: 1.826 ± 0.047	0.771LysGln: 0.771 ± 0.027	2.21LysArg: 2.21 ± 0.043	1.546LysSer: 1.546 ± 0.039	1.695LysThr: 1.695 ± 0.037	2.305LysVal: 2.305 ± 0.051	0.407LysTrp: 0.407 ± 0.017	0.654LysTyr: 0.654 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.28LeuAla: 13.28 ± 0.145	0.926LeuCys: 0.926 ± 0.032	6.062LeuAsp: 6.062 ± 0.077	5.606LeuGlu: 5.606 ± 0.083	3.502LeuPhe: 3.502 ± 0.063	8.291LeuGly: 8.291 ± 0.098	1.919LeuHis: 1.919 ± 0.041	5.026LeuIle: 5.026 ± 0.081	3.147LeuLys: 3.147 ± 0.051	8.557LeuLeu: 8.557 ± 0.129	2.594LeuMet: 2.594 ± 0.047	2.483LeuAsn: 2.483 ± 0.049	5.703LeuPro: 5.703 ± 0.082	2.571LeuGln: 2.571 ± 0.05	7.92LeuArg: 7.92 ± 0.097	5.698LeuSer: 5.698 ± 0.086	5.731LeuThr: 5.731 ± 0.073	7.057LeuVal: 7.057 ± 0.101	1.417LeuTrp: 1.417 ± 0.039	1.907LeuTyr: 1.907 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.555MetAla: 3.555 ± 0.051	0.183MetCys: 0.183 ± 0.01	1.369MetAsp: 1.369 ± 0.039	1.416MetGlu: 1.416 ± 0.035	0.795MetPhe: 0.795 ± 0.027	2.244MetGly: 2.244 ± 0.055	0.47MetHis: 0.47 ± 0.021	1.415MetIle: 1.415 ± 0.034	1.071MetLys: 1.071 ± 0.031	2.476MetLeu: 2.476 ± 0.045	0.703MetMet: 0.703 ± 0.029	0.793MetAsn: 0.793 ± 0.025	1.53MetPro: 1.53 ± 0.037	0.917MetGln: 0.917 ± 0.03	2.065MetArg: 2.065 ± 0.043	1.533MetSer: 1.533 ± 0.052	2.022MetThr: 2.022 ± 0.041	1.832MetVal: 1.832 ± 0.039	0.25MetTrp: 0.25 ± 0.015	0.314MetTyr: 0.314 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.924AsnAla: 2.924 ± 0.049	0.25AsnCys: 0.25 ± 0.016	1.323AsnAsp: 1.323 ± 0.042	1.065AsnGlu: 1.065 ± 0.031	0.812AsnPhe: 0.812 ± 0.026	2.175AsnGly: 2.175 ± 0.049	0.479AsnHis: 0.479 ± 0.021	1.161AsnIle: 1.161 ± 0.032	0.608AsnLys: 0.608 ± 0.024	2.282AsnLeu: 2.282 ± 0.04	0.601AsnMet: 0.601 ± 0.025	0.53AsnAsn: 0.53 ± 0.022	1.876AsnPro: 1.876 ± 0.041	0.584AsnGln: 0.584 ± 0.023	1.937AsnArg: 1.937 ± 0.041	0.911AsnSer: 0.911 ± 0.028	1.117AsnThr: 1.117 ± 0.031	1.749AsnVal: 1.749 ± 0.043	0.424AsnTrp: 0.424 ± 0.022	0.561AsnTyr: 0.561 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.535ProAla: 6.535 ± 0.095	0.417ProCys: 0.417 ± 0.022	4.392ProAsp: 4.392 ± 0.062	4.551ProGlu: 4.551 ± 0.069	2.003ProPhe: 2.003 ± 0.039	5.095ProGly: 5.095 ± 0.072	1.149ProHis: 1.149 ± 0.031	2.185ProIle: 2.185 ± 0.045	1.552ProLys: 1.552 ± 0.04	4.786ProLeu: 4.786 ± 0.074	1.325ProMet: 1.325 ± 0.037	1.192ProAsn: 1.192 ± 0.035	2.887ProPro: 2.887 ± 0.059	1.637ProGln: 1.637 ± 0.037	3.626ProArg: 3.626 ± 0.068	2.291ProSer: 2.291 ± 0.043	2.33ProThr: 2.33 ± 0.044	4.615ProVal: 4.615 ± 0.068	0.764ProTrp: 0.764 ± 0.027	1.118ProTyr: 1.118 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.086GlnAla: 4.086 ± 0.066	0.205GlnCys: 0.205 ± 0.014	1.462GlnAsp: 1.462 ± 0.035	1.542GlnGlu: 1.542 ± 0.034	0.994GlnPhe: 0.994 ± 0.028	2.499GlnGly: 2.499 ± 0.046	0.483GlnHis: 0.483 ± 0.023	1.734GlnIle: 1.734 ± 0.034	1.035GlnLys: 1.035 ± 0.031	2.623GlnLeu: 2.623 ± 0.057	1.011GlnMet: 1.011 ± 0.03	0.698GlnAsn: 0.698 ± 0.024	1.586GlnPro: 1.586 ± 0.036	0.925GlnGln: 0.925 ± 0.027	2.162GlnArg: 2.162 ± 0.049	1.41GlnSer: 1.41 ± 0.036	1.484GlnThr: 1.484 ± 0.04	2.294GlnVal: 2.294 ± 0.04	0.367GlnTrp: 0.367 ± 0.018	0.508GlnTyr: 0.508 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.208ArgAla: 10.208 ± 0.122	0.587ArgCys: 0.587 ± 0.024	5.011ArgAsp: 5.011 ± 0.069	4.616ArgGlu: 4.616 ± 0.063	3.054ArgPhe: 3.054 ± 0.05	5.637ArgGly: 5.637 ± 0.079	1.911ArgHis: 1.911 ± 0.04	4.513ArgIle: 4.513 ± 0.067	2.541ArgLys: 2.541 ± 0.05	8.8ArgLeu: 8.8 ± 0.118	2.313ArgMet: 2.313 ± 0.048	1.9ArgAsn: 1.9 ± 0.044	4.307ArgPro: 4.307 ± 0.07	2.475ArgGln: 2.475 ± 0.045	6.823ArgArg: 6.823 ± 0.105	3.206ArgSer: 3.206 ± 0.051	3.401ArgThr: 3.401 ± 0.053	5.515ArgVal: 5.515 ± 0.065	1.131ArgTrp: 1.131 ± 0.033	1.6ArgTyr: 1.6 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.137SerAla: 5.137 ± 0.07	0.424SerCys: 0.424 ± 0.019	2.839SerAsp: 2.839 ± 0.049	2.446SerGlu: 2.446 ± 0.051	1.969SerPhe: 1.969 ± 0.04	4.882SerGly: 4.882 ± 0.082	0.979SerHis: 0.979 ± 0.027	2.041SerIle: 2.041 ± 0.046	1.223SerLys: 1.223 ± 0.034	4.246SerLeu: 4.246 ± 0.065	1.145SerMet: 1.145 ± 0.03	1.073SerAsn: 1.073 ± 0.03	2.503SerPro: 2.503 ± 0.052	1.236SerGln: 1.236 ± 0.034	3.406SerArg: 3.406 ± 0.06	2.046SerSer: 2.046 ± 0.048	2.107SerThr: 2.107 ± 0.04	3.346SerVal: 3.346 ± 0.056	0.659SerTrp: 0.659 ± 0.025	1.081SerTyr: 1.081 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.974ThrAla: 5.974 ± 0.074	0.469ThrCys: 0.469 ± 0.022	3.014ThrAsp: 3.014 ± 0.052	2.941ThrGlu: 2.941 ± 0.059	1.788ThrPhe: 1.788 ± 0.045	5.323ThrGly: 5.323 ± 0.071	1.057ThrHis: 1.057 ± 0.027	2.505ThrIle: 2.505 ± 0.054	1.106ThrLys: 1.106 ± 0.038	5.421ThrLeu: 5.421 ± 0.067	1.112ThrMet: 1.112 ± 0.028	1.095ThrAsn: 1.095 ± 0.029	3.311ThrPro: 3.311 ± 0.063	1.358ThrGln: 1.358 ± 0.036	3.892ThrArg: 3.892 ± 0.069	2.094ThrSer: 2.094 ± 0.045	2.544ThrThr: 2.544 ± 0.053	4.203ThrVal: 4.203 ± 0.061	0.731ThrTrp: 0.731 ± 0.025	1.088ThrTyr: 1.088 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.215ValAla: 9.215 ± 0.1	0.65ValCys: 0.65 ± 0.025	3.935ValAsp: 3.935 ± 0.061	4.97ValGlu: 4.97 ± 0.078	2.792ValPhe: 2.792 ± 0.057	5.297ValGly: 5.297 ± 0.075	1.486ValHis: 1.486 ± 0.036	4.216ValIle: 4.216 ± 0.071	2.048ValLys: 2.048 ± 0.041	7.442ValLeu: 7.442 ± 0.089	2.018ValMet: 2.018 ± 0.043	1.874ValAsn: 1.874 ± 0.046	3.85ValPro: 3.85 ± 0.061	2.014ValGln: 2.014 ± 0.04	5.03ValArg: 5.03 ± 0.065	3.791ValSer: 3.791 ± 0.063	4.595ValThr: 4.595 ± 0.07	5.698ValVal: 5.698 ± 0.082	1.019ValTrp: 1.019 ± 0.031	1.406ValTyr: 1.406 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.545TrpAla: 1.545 ± 0.04	0.149TrpCys: 0.149 ± 0.011	0.797TrpAsp: 0.797 ± 0.029	0.764TrpGlu: 0.764 ± 0.028	0.609TrpPhe: 0.609 ± 0.023	1.037TrpGly: 1.037 ± 0.032	0.369TrpHis: 0.369 ± 0.016	0.749TrpIle: 0.749 ± 0.024	0.503TrpLys: 0.503 ± 0.021	1.731TrpLeu: 1.731 ± 0.042	0.417TrpMet: 0.417 ± 0.02	0.416TrpAsn: 0.416 ± 0.021	0.777TrpPro: 0.777 ± 0.027	0.547TrpGln: 0.547 ± 0.023	1.398TrpArg: 1.398 ± 0.041	0.778TrpSer: 0.778 ± 0.026	0.793TrpThr: 0.793 ± 0.025	0.96TrpVal: 0.96 ± 0.031	0.244TrpTrp: 0.244 ± 0.016	0.283TrpTyr: 0.283 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.387TyrAla: 2.387 ± 0.047	0.232TyrCys: 0.232 ± 0.014	1.57TyrAsp: 1.57 ± 0.038	1.24TyrGlu: 1.24 ± 0.042	0.838TyrPhe: 0.838 ± 0.027	2.061TyrGly: 2.061 ± 0.042	0.531TyrHis: 0.531 ± 0.023	0.797TyrIle: 0.797 ± 0.028	0.559TyrLys: 0.559 ± 0.024	2.173TyrLeu: 2.173 ± 0.046	0.484TyrMet: 0.484 ± 0.021	0.522TyrAsn: 0.522 ± 0.025	1.052TyrPro: 1.052 ± 0.033	0.59TyrGln: 0.59 ± 0.021	1.679TyrArg: 1.679 ± 0.039	0.994TyrSer: 0.994 ± 0.033	0.975TyrThr: 0.975 ± 0.029	1.561TyrVal: 1.561 ± 0.037	0.354TyrTrp: 0.354 ± 0.018	0.57TyrTyr: 0.57 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3696 proteins (1135509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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