Amino acid dipepetide frequency for Macaca mulatta papillomavirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.378AlaAla: 7.378 ± 1.764
3.038AlaCys: 3.038 ± 1.139
6.076AlaAsp: 6.076 ± 1.676
2.604AlaGlu: 2.604 ± 0.69
2.604AlaPhe: 2.604 ± 1.723
6.076AlaGly: 6.076 ± 1.283
1.302AlaHis: 1.302 ± 0.765
2.17AlaIle: 2.17 ± 0.402
3.906AlaLys: 3.906 ± 1.386
4.34AlaLeu: 4.34 ± 0.871
3.038AlaMet: 3.038 ± 1.173
3.472AlaAsn: 3.472 ± 1.378
6.076AlaPro: 6.076 ± 1.624
1.736AlaGln: 1.736 ± 0.609
6.944AlaArg: 6.944 ± 1.563
6.076AlaSer: 6.076 ± 1.663
5.208AlaThr: 5.208 ± 1.004
4.34AlaVal: 4.34 ± 1.266
0.434AlaTrp: 0.434 ± 0.52
2.17AlaTyr: 2.17 ± 0.682
0.0AlaXaa: 0.0 ± 0.0
Cys
2.604CysAla: 2.604 ± 1.054
0.434CysCys: 0.434 ± 0.489
0.868CysAsp: 0.868 ± 1.039
0.868CysGlu: 0.868 ± 0.727
0.868CysPhe: 0.868 ± 0.432
1.736CysGly: 1.736 ± 0.966
0.868CysHis: 0.868 ± 0.972
1.736CysIle: 1.736 ± 0.75
2.17CysLys: 2.17 ± 0.925
2.604CysLeu: 2.604 ± 1.809
1.736CysMet: 1.736 ± 1.382
1.736CysAsn: 1.736 ± 1.047
1.736CysPro: 1.736 ± 0.5
3.038CysGln: 3.038 ± 1.142
0.434CysArg: 0.434 ± 0.364
0.868CysSer: 0.868 ± 0.53
3.038CysThr: 3.038 ± 2.074
1.302CysVal: 1.302 ± 0.746
1.302CysTrp: 1.302 ± 0.516
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.208AspAla: 5.208 ± 1.944
1.736AspCys: 1.736 ± 0.983
4.774AspAsp: 4.774 ± 2.391
1.736AspGlu: 1.736 ± 0.558
3.472AspPhe: 3.472 ± 0.698
3.472AspGly: 3.472 ± 1.047
0.868AspHis: 0.868 ± 0.457
3.038AspIle: 3.038 ± 1.399
1.736AspLys: 1.736 ± 0.609
4.34AspLeu: 4.34 ± 0.864
1.302AspMet: 1.302 ± 0.349
3.472AspAsn: 3.472 ± 1.553
4.774AspPro: 4.774 ± 2.09
2.604AspGln: 2.604 ± 0.674
2.17AspArg: 2.17 ± 0.875
2.604AspSer: 2.604 ± 0.811
3.472AspThr: 3.472 ± 0.617
4.774AspVal: 4.774 ± 1.166
1.302AspTrp: 1.302 ± 0.657
1.736AspTyr: 1.736 ± 0.471
0.0AspXaa: 0.0 ± 0.0
Glu
4.34GluAla: 4.34 ± 1.668
0.434GluCys: 0.434 ± 0.52
5.208GluAsp: 5.208 ± 0.832
5.208GluGlu: 5.208 ± 1.586
0.0GluPhe: 0.0 ± 0.0
4.34GluGly: 4.34 ± 1.459
2.604GluHis: 2.604 ± 0.614
2.17GluIle: 2.17 ± 0.717
0.868GluLys: 0.868 ± 0.647
3.472GluLeu: 3.472 ± 0.832
0.434GluMet: 0.434 ± 0.377
1.736GluAsn: 1.736 ± 0.738
3.906GluPro: 3.906 ± 1.215
2.17GluGln: 2.17 ± 0.786
1.302GluArg: 1.302 ± 0.709
2.17GluSer: 2.17 ± 0.493
3.906GluThr: 3.906 ± 0.672
3.906GluVal: 3.906 ± 1.174
0.868GluTrp: 0.868 ± 0.53
3.472GluTyr: 3.472 ± 1.08
0.0GluXaa: 0.0 ± 0.0
Phe
1.736PheAla: 1.736 ± 0.648
0.868PheCys: 0.868 ± 0.53
2.17PheAsp: 2.17 ± 1.38
1.302PheGlu: 1.302 ± 0.769
2.17PhePhe: 2.17 ± 0.709
3.472PheGly: 3.472 ± 1.116
0.434PheHis: 0.434 ± 0.52
2.17PheIle: 2.17 ± 0.639
3.472PheLys: 3.472 ± 1.675
3.906PheLeu: 3.906 ± 1.051
1.302PheMet: 1.302 ± 0.733
0.434PheAsn: 0.434 ± 0.392
1.302PhePro: 1.302 ± 0.657
1.736PheGln: 1.736 ± 0.747
2.17PheArg: 2.17 ± 0.745
1.302PheSer: 1.302 ± 0.472
0.868PheThr: 0.868 ± 0.454
2.604PheVal: 2.604 ± 1.002
0.868PheTrp: 0.868 ± 0.4
2.604PheTyr: 2.604 ± 1.33
0.0PheXaa: 0.0 ± 0.0
Gly
5.642GlyAla: 5.642 ± 0.933
2.17GlyCys: 2.17 ± 0.87
4.34GlyAsp: 4.34 ± 1.221
2.604GlyGlu: 2.604 ± 1.083
1.736GlyPhe: 1.736 ± 0.908
5.208GlyGly: 5.208 ± 2.491
2.604GlyHis: 2.604 ± 0.871
3.038GlyIle: 3.038 ± 0.543
3.906GlyLys: 3.906 ± 1.321
6.51GlyLeu: 6.51 ± 1.671
0.868GlyMet: 0.868 ± 0.4
2.604GlyAsn: 2.604 ± 1.237
3.906GlyPro: 3.906 ± 2.136
2.604GlyGln: 2.604 ± 0.79
4.774GlyArg: 4.774 ± 1.957
3.038GlySer: 3.038 ± 0.969
4.774GlyThr: 4.774 ± 1.179
4.34GlyVal: 4.34 ± 0.825
0.434GlyTrp: 0.434 ± 0.364
1.736GlyTyr: 1.736 ± 0.886
0.0GlyXaa: 0.0 ± 0.0
His
1.736HisAla: 1.736 ± 0.698
0.434HisCys: 0.434 ± 0.364
0.868HisAsp: 0.868 ± 0.609
0.0HisGlu: 0.0 ± 0.0
2.17HisPhe: 2.17 ± 0.782
1.736HisGly: 1.736 ± 0.5
0.868HisHis: 0.868 ± 0.432
0.0HisIle: 0.0 ± 0.0
2.17HisLys: 2.17 ± 1.005
0.868HisLeu: 0.868 ± 0.432
1.302HisMet: 1.302 ± 0.654
1.736HisAsn: 1.736 ± 0.672
1.736HisPro: 1.736 ± 0.886
0.434HisGln: 0.434 ± 0.377
1.302HisArg: 1.302 ± 0.693
2.604HisSer: 2.604 ± 0.981
0.434HisThr: 0.434 ± 0.377
3.472HisVal: 3.472 ± 1.064
1.302HisTrp: 1.302 ± 0.818
0.434HisTyr: 0.434 ± 0.364
0.0HisXaa: 0.0 ± 0.0
Ile
3.472IleAla: 3.472 ± 1.291
0.868IleCys: 0.868 ± 0.617
2.17IleAsp: 2.17 ± 1.15
3.472IleGlu: 3.472 ± 1.261
1.302IlePhe: 1.302 ± 0.838
1.736IleGly: 1.736 ± 0.738
1.302IleHis: 1.302 ± 0.349
1.302IleIle: 1.302 ± 0.781
0.434IleLys: 0.434 ± 0.392
3.472IleLeu: 3.472 ± 0.734
0.868IleMet: 0.868 ± 0.454
0.434IleAsn: 0.434 ± 0.392
3.472IlePro: 3.472 ± 1.183
3.038IleGln: 3.038 ± 1.09
3.038IleArg: 3.038 ± 0.995
3.038IleSer: 3.038 ± 1.302
2.17IleThr: 2.17 ± 0.506
2.604IleVal: 2.604 ± 0.884
0.434IleTrp: 0.434 ± 0.377
0.868IleTyr: 0.868 ± 0.519
0.0IleXaa: 0.0 ± 0.0
Lys
5.642LysAla: 5.642 ± 1.824
2.17LysCys: 2.17 ± 1.088
2.604LysAsp: 2.604 ± 1.071
3.472LysGlu: 3.472 ± 1.415
1.302LysPhe: 1.302 ± 0.657
1.736LysGly: 1.736 ± 1.509
1.736LysHis: 1.736 ± 0.727
1.736LysIle: 1.736 ± 0.865
1.302LysLys: 1.302 ± 0.434
2.17LysLeu: 2.17 ± 0.885
1.302LysMet: 1.302 ± 0.657
2.17LysAsn: 2.17 ± 1.38
2.604LysPro: 2.604 ± 1.85
2.17LysGln: 2.17 ± 1.261
4.774LysArg: 4.774 ± 1.179
3.038LysSer: 3.038 ± 0.859
1.736LysThr: 1.736 ± 0.747
3.472LysVal: 3.472 ± 1.51
0.434LysTrp: 0.434 ± 0.364
1.736LysTyr: 1.736 ± 0.705
0.0LysXaa: 0.0 ± 0.0
Leu
2.604LeuAla: 2.604 ± 1.237
3.906LeuCys: 3.906 ± 2.524
5.208LeuAsp: 5.208 ± 0.936
4.774LeuGlu: 4.774 ± 1.885
3.472LeuPhe: 3.472 ± 0.852
5.208LeuGly: 5.208 ± 1.975
3.906LeuHis: 3.906 ± 1.898
1.736LeuIle: 1.736 ± 1.102
3.906LeuLys: 3.906 ± 1.721
6.076LeuLeu: 6.076 ± 1.24
2.604LeuMet: 2.604 ± 1.104
3.906LeuAsn: 3.906 ± 1.013
3.038LeuPro: 3.038 ± 1.376
7.378LeuGln: 7.378 ± 0.754
2.604LeuArg: 2.604 ± 0.482
5.642LeuSer: 5.642 ± 0.99
3.906LeuThr: 3.906 ± 1.418
5.208LeuVal: 5.208 ± 1.422
0.0LeuTrp: 0.0 ± 0.0
3.906LeuTyr: 3.906 ± 1.193
0.0LeuXaa: 0.0 ± 0.0
Met
3.038MetAla: 3.038 ± 1.154
1.736MetCys: 1.736 ± 1.12
2.604MetAsp: 2.604 ± 0.902
1.302MetGlu: 1.302 ± 0.739
0.868MetPhe: 0.868 ± 0.443
1.736MetGly: 1.736 ± 0.745
0.434MetHis: 0.434 ± 0.489
1.302MetIle: 1.302 ± 1.091
0.434MetLys: 0.434 ± 0.364
1.736MetLeu: 1.736 ± 0.75
0.0MetMet: 0.0 ± 0.0
0.434MetAsn: 0.434 ± 0.687
0.868MetPro: 0.868 ± 0.457
1.736MetGln: 1.736 ± 2.095
1.302MetArg: 1.302 ± 0.759
2.17MetSer: 2.17 ± 0.601
0.434MetThr: 0.434 ± 0.687
3.038MetVal: 3.038 ± 0.926
1.302MetTrp: 1.302 ± 0.852
0.868MetTyr: 0.868 ± 0.457
0.0MetXaa: 0.0 ± 0.0
Asn
3.038AsnAla: 3.038 ± 1.076
1.302AsnCys: 1.302 ± 0.703
2.604AsnAsp: 2.604 ± 1.734
0.434AsnGlu: 0.434 ± 0.377
1.736AsnPhe: 1.736 ± 0.587
2.17AsnGly: 2.17 ± 0.662
0.0AsnHis: 0.0 ± 0.0
2.17AsnIle: 2.17 ± 0.682
3.906AsnLys: 3.906 ± 1.848
3.038AsnLeu: 3.038 ± 1.307
0.868AsnMet: 0.868 ± 0.432
2.604AsnAsn: 2.604 ± 1.454
3.472AsnPro: 3.472 ± 0.937
1.302AsnGln: 1.302 ± 0.349
3.038AsnArg: 3.038 ± 0.781
2.604AsnSer: 2.604 ± 0.936
2.604AsnThr: 2.604 ± 0.827
2.17AsnVal: 2.17 ± 0.911
0.434AsnTrp: 0.434 ± 0.364
0.434AsnTyr: 0.434 ± 0.364
0.0AsnXaa: 0.0 ± 0.0
Pro
5.208ProAla: 5.208 ± 3.85
0.434ProCys: 0.434 ± 0.364
3.906ProAsp: 3.906 ± 1.565
2.17ProGlu: 2.17 ± 0.601
1.736ProPhe: 1.736 ± 0.558
3.038ProGly: 3.038 ± 1.348
1.302ProHis: 1.302 ± 0.413
2.17ProIle: 2.17 ± 1.031
4.774ProLys: 4.774 ± 1.461
5.642ProLeu: 5.642 ± 1.278
2.17ProMet: 2.17 ± 1.515
1.736ProAsn: 1.736 ± 0.245
8.247ProPro: 8.247 ± 1.87
0.868ProGln: 0.868 ± 0.457
2.17ProArg: 2.17 ± 0.884
7.812ProSer: 7.812 ± 3.218
5.208ProThr: 5.208 ± 2.034
3.472ProVal: 3.472 ± 1.273
0.434ProTrp: 0.434 ± 0.377
2.17ProTyr: 2.17 ± 0.752
0.0ProXaa: 0.0 ± 0.0
Gln
3.472GlnAla: 3.472 ± 1.453
1.736GlnCys: 1.736 ± 1.073
3.038GlnAsp: 3.038 ± 0.884
2.604GlnGlu: 2.604 ± 0.811
1.736GlnPhe: 1.736 ± 0.705
3.038GlnGly: 3.038 ± 0.587
0.0GlnHis: 0.0 ± 0.0
2.17GlnIle: 2.17 ± 0.977
1.736GlnLys: 1.736 ± 0.833
3.906GlnLeu: 3.906 ± 1.073
0.868GlnMet: 0.868 ± 0.4
1.302GlnAsn: 1.302 ± 0.657
3.472GlnPro: 3.472 ± 1.121
3.906GlnGln: 3.906 ± 1.166
3.472GlnArg: 3.472 ± 1.804
2.604GlnSer: 2.604 ± 0.482
3.038GlnThr: 3.038 ± 0.735
2.604GlnVal: 2.604 ± 0.811
1.302GlnTrp: 1.302 ± 0.703
1.736GlnTyr: 1.736 ± 1.233
0.0GlnXaa: 0.0 ± 0.0
Arg
6.076ArgAla: 6.076 ± 1.627
2.604ArgCys: 2.604 ± 1.418
0.0ArgAsp: 0.0 ± 0.0
2.17ArgGlu: 2.17 ± 0.786
3.038ArgPhe: 3.038 ± 0.883
3.038ArgGly: 3.038 ± 1.282
2.17ArgHis: 2.17 ± 1.077
0.0ArgIle: 0.0 ± 0.0
3.906ArgLys: 3.906 ± 0.864
7.812ArgLeu: 7.812 ± 1.135
0.434ArgMet: 0.434 ± 0.571
2.17ArgAsn: 2.17 ± 1.147
3.906ArgPro: 3.906 ± 1.784
1.736ArgGln: 1.736 ± 0.71
5.642ArgArg: 5.642 ± 2.927
3.038ArgSer: 3.038 ± 0.493
3.472ArgThr: 3.472 ± 1.462
4.34ArgVal: 4.34 ± 1.568
1.302ArgTrp: 1.302 ± 0.413
1.736ArgTyr: 1.736 ± 0.645
0.0ArgXaa: 0.0 ± 0.0
Ser
3.472SerAla: 3.472 ± 1.027
0.868SerCys: 0.868 ± 0.647
3.038SerAsp: 3.038 ± 0.543
3.906SerGlu: 3.906 ± 1.029
2.604SerPhe: 2.604 ± 1.218
4.774SerGly: 4.774 ± 1.129
1.302SerHis: 1.302 ± 0.724
2.604SerIle: 2.604 ± 0.871
2.604SerLys: 2.604 ± 1.13
4.774SerLeu: 4.774 ± 1.514
2.604SerMet: 2.604 ± 0.819
2.604SerAsn: 2.604 ± 1.683
4.34SerPro: 4.34 ± 0.792
3.472SerGln: 3.472 ± 1.151
2.17SerArg: 2.17 ± 0.917
7.378SerSer: 7.378 ± 0.836
8.681SerThr: 8.681 ± 1.484
3.906SerVal: 3.906 ± 1.4
0.434SerTrp: 0.434 ± 0.364
2.17SerTyr: 2.17 ± 0.408
0.0SerXaa: 0.0 ± 0.0
Thr
5.642ThrAla: 5.642 ± 1.256
3.472ThrCys: 3.472 ± 0.796
2.17ThrAsp: 2.17 ± 0.493
4.774ThrGlu: 4.774 ± 1.084
2.604ThrPhe: 2.604 ± 0.87
4.34ThrGly: 4.34 ± 1.799
0.868ThrHis: 0.868 ± 0.647
3.038ThrIle: 3.038 ± 1.242
2.17ThrLys: 2.17 ± 0.833
5.642ThrLeu: 5.642 ± 1.331
2.17ThrMet: 2.17 ± 2.683
1.736ThrAsn: 1.736 ± 1.202
3.472ThrPro: 3.472 ± 1.508
3.472ThrGln: 3.472 ± 1.165
3.906ThrArg: 3.906 ± 1.436
5.208ThrSer: 5.208 ± 0.866
5.208ThrThr: 5.208 ± 1.462
3.906ThrVal: 3.906 ± 0.774
0.434ThrTrp: 0.434 ± 0.377
0.868ThrTyr: 0.868 ± 0.817
0.0ThrXaa: 0.0 ± 0.0
Val
4.774ValAla: 4.774 ± 1.803
1.302ValCys: 1.302 ± 0.929
5.208ValAsp: 5.208 ± 0.98
6.076ValGlu: 6.076 ± 1.706
2.604ValPhe: 2.604 ± 0.69
4.774ValGly: 4.774 ± 1.422
2.17ValHis: 2.17 ± 0.977
2.604ValIle: 2.604 ± 0.797
0.868ValLys: 0.868 ± 0.727
4.34ValLeu: 4.34 ± 1.117
2.17ValMet: 2.17 ± 0.973
2.17ValAsn: 2.17 ± 0.926
3.906ValPro: 3.906 ± 1.153
3.038ValGln: 3.038 ± 1.21
3.038ValArg: 3.038 ± 0.71
4.34ValSer: 4.34 ± 1.005
4.774ValThr: 4.774 ± 0.952
2.604ValVal: 2.604 ± 0.8
0.434ValTrp: 0.434 ± 0.392
3.906ValTyr: 3.906 ± 1.163
0.0ValXaa: 0.0 ± 0.0
Trp
1.736TrpAla: 1.736 ± 0.714
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.302TrpGlu: 1.302 ± 0.818
0.434TrpPhe: 0.434 ± 0.364
1.302TrpGly: 1.302 ± 0.349
0.434TrpHis: 0.434 ± 0.377
0.868TrpIle: 0.868 ± 0.727
1.302TrpLys: 1.302 ± 0.584
1.736TrpLeu: 1.736 ± 0.983
0.0TrpMet: 0.0 ± 0.0
1.302TrpAsn: 1.302 ± 0.704
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
2.17TrpArg: 2.17 ± 0.97
0.434TrpSer: 0.434 ± 0.377
0.868TrpThr: 0.868 ± 0.754
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.434TrpTyr: 0.434 ± 0.364
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.17TyrAla: 2.17 ± 0.752
0.434TyrCys: 0.434 ± 0.52
1.736TyrAsp: 1.736 ± 0.245
1.736TyrGlu: 1.736 ± 0.648
0.434TyrPhe: 0.434 ± 0.392
3.906TyrGly: 3.906 ± 1.71
0.434TyrHis: 0.434 ± 0.392
3.472TyrIle: 3.472 ± 1.243
1.736TyrLys: 1.736 ± 0.747
2.604TyrLeu: 2.604 ± 0.96
0.868TyrMet: 0.868 ± 0.727
2.17TyrAsn: 2.17 ± 0.506
0.434TyrPro: 0.434 ± 0.392
1.302TyrGln: 1.302 ± 0.742
2.604TyrArg: 2.604 ± 0.708
1.736TyrSer: 1.736 ± 0.723
1.302TyrThr: 1.302 ± 0.724
3.038TyrVal: 3.038 ± 0.556
0.868TyrTrp: 0.868 ± 0.4
1.302TyrTyr: 1.302 ± 0.923
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2305 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski