Amino acid dipepetide frequency for Paracoccus sp. 228

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.627AlaAla: 19.627 ± 0.236	1.043AlaCys: 1.043 ± 0.04	8.253AlaAsp: 8.253 ± 0.091	7.618AlaGlu: 7.618 ± 0.113	4.227AlaPhe: 4.227 ± 0.059	11.735AlaGly: 11.735 ± 0.124	2.592AlaHis: 2.592 ± 0.048	6.243AlaIle: 6.243 ± 0.083	2.847AlaLys: 2.847 ± 0.063	15.182AlaLeu: 15.182 ± 0.154	4.41AlaMet: 4.41 ± 0.08	2.403AlaAsn: 2.403 ± 0.054	6.598AlaPro: 6.598 ± 0.113	5.568AlaGln: 5.568 ± 0.088	10.894AlaArg: 10.894 ± 0.116	5.489AlaSer: 5.489 ± 0.072	6.606AlaThr: 6.606 ± 0.067	9.294AlaVal: 9.294 ± 0.1	1.722AlaTrp: 1.722 ± 0.04	2.307AlaTyr: 2.307 ± 0.045	0.01AlaXaa: 0.01 ± 0.003
Cys	1.059CysAla: 1.059 ± 0.032	0.101CysCys: 0.101 ± 0.01	0.592CysAsp: 0.592 ± 0.023	0.32CysGlu: 0.32 ± 0.018	0.27CysPhe: 0.27 ± 0.016	0.911CysGly: 0.911 ± 0.035	0.265CysHis: 0.265 ± 0.015	0.379CysIle: 0.379 ± 0.019	0.15CysLys: 0.15 ± 0.012	0.814CysLeu: 0.814 ± 0.028	0.173CysMet: 0.173 ± 0.013	0.157CysAsn: 0.157 ± 0.014	0.492CysPro: 0.492 ± 0.023	0.205CysGln: 0.205 ± 0.015	0.578CysArg: 0.578 ± 0.027	0.379CysSer: 0.379 ± 0.019	0.381CysThr: 0.381 ± 0.021	0.53CysVal: 0.53 ± 0.026	0.115CysTrp: 0.115 ± 0.01	0.155CysTyr: 0.155 ± 0.012	0.002CysXaa: 0.002 ± 0.001
Asp	8.512AspAla: 8.512 ± 0.117	0.5AspCys: 0.5 ± 0.023	3.95AspAsp: 3.95 ± 0.068	2.99AspGlu: 2.99 ± 0.068	2.232AspPhe: 2.232 ± 0.049	5.8AspGly: 5.8 ± 0.085	1.705AspHis: 1.705 ± 0.047	2.806AspIle: 2.806 ± 0.05	1.361AspLys: 1.361 ± 0.043	7.476AspLeu: 7.476 ± 0.092	1.722AspMet: 1.722 ± 0.04	1.084AspAsn: 1.084 ± 0.034	4.252AspPro: 4.252 ± 0.065	2.498AspGln: 2.498 ± 0.045	5.826AspArg: 5.826 ± 0.084	2.291AspSer: 2.291 ± 0.045	2.778AspThr: 2.778 ± 0.067	3.89AspVal: 3.89 ± 0.059	1.352AspTrp: 1.352 ± 0.037	1.464AspTyr: 1.464 ± 0.039	0.004AspXaa: 0.004 ± 0.002
Glu	7.299GluAla: 7.299 ± 0.096	0.324GluCys: 0.324 ± 0.017	2.707GluAsp: 2.707 ± 0.059	2.589GluGlu: 2.589 ± 0.058	1.528GluPhe: 1.528 ± 0.043	4.406GluGly: 4.406 ± 0.067	0.957GluHis: 0.957 ± 0.031	2.794GluIle: 2.794 ± 0.058	1.342GluLys: 1.342 ± 0.047	4.251GluLeu: 4.251 ± 0.074	1.552GluMet: 1.552 ± 0.038	1.249GluAsn: 1.249 ± 0.037	2.258GluPro: 2.258 ± 0.047	1.831GluGln: 1.831 ± 0.052	3.871GluArg: 3.871 ± 0.067	1.804GluSer: 1.804 ± 0.046	2.955GluThr: 2.955 ± 0.057	3.652GluVal: 3.652 ± 0.065	0.699GluTrp: 0.699 ± 0.028	0.967GluTyr: 0.967 ± 0.034	0.004GluXaa: 0.004 ± 0.002
Phe	4.5PheAla: 4.5 ± 0.072	0.354PheCys: 0.354 ± 0.019	2.737PheAsp: 2.737 ± 0.05	1.652PheGlu: 1.652 ± 0.038	1.24PhePhe: 1.24 ± 0.038	3.536PheGly: 3.536 ± 0.068	0.717PheHis: 0.717 ± 0.028	1.482PheIle: 1.482 ± 0.044	0.681PheLys: 0.681 ± 0.029	3.283PheLeu: 3.283 ± 0.062	0.809PheMet: 0.809 ± 0.024	0.839PheAsn: 0.839 ± 0.032	1.473PhePro: 1.473 ± 0.038	1.029PheGln: 1.029 ± 0.031	2.256PheArg: 2.256 ± 0.046	1.743PheSer: 1.743 ± 0.037	1.839PheThr: 1.839 ± 0.041	2.507PheVal: 2.507 ± 0.055	0.598PheTrp: 0.598 ± 0.025	0.743PheTyr: 0.743 ± 0.026	0.002PheXaa: 0.002 ± 0.001
Gly	10.498GlyAla: 10.498 ± 0.129	0.797GlyCys: 0.797 ± 0.032	4.956GlyAsp: 4.956 ± 0.081	3.791GlyGlu: 3.791 ± 0.069	3.588GlyPhe: 3.588 ± 0.052	7.513GlyGly: 7.513 ± 0.124	2.156GlyHis: 2.156 ± 0.049	4.488GlyIle: 4.488 ± 0.071	2.452GlyLys: 2.452 ± 0.055	9.89GlyLeu: 9.89 ± 0.098	2.789GlyMet: 2.789 ± 0.048	1.995GlyAsn: 1.995 ± 0.06	4.152GlyPro: 4.152 ± 0.074	3.714GlyGln: 3.714 ± 0.067	6.752GlyArg: 6.752 ± 0.092	4.111GlySer: 4.111 ± 0.065	4.842GlyThr: 4.842 ± 0.068	6.48GlyVal: 6.48 ± 0.075	1.611GlyTrp: 1.611 ± 0.041	2.032GlyTyr: 2.032 ± 0.046	0.003GlyXaa: 0.003 ± 0.002
His	2.69HisAla: 2.69 ± 0.056	0.212HisCys: 0.212 ± 0.014	1.546HisAsp: 1.546 ± 0.042	0.907HisGlu: 0.907 ± 0.031	0.698HisPhe: 0.698 ± 0.026	2.132HisGly: 2.132 ± 0.047	0.603HisHis: 0.603 ± 0.027	0.792HisIle: 0.792 ± 0.028	0.43HisLys: 0.43 ± 0.021	2.331HisLeu: 2.331 ± 0.05	0.551HisMet: 0.551 ± 0.024	0.409HisAsn: 0.409 ± 0.021	1.547HisPro: 1.547 ± 0.038	0.664HisGln: 0.664 ± 0.024	1.585HisArg: 1.585 ± 0.035	0.82HisSer: 0.82 ± 0.026	0.708HisThr: 0.708 ± 0.024	1.618HisVal: 1.618 ± 0.041	0.316HisTrp: 0.316 ± 0.016	0.501HisTyr: 0.501 ± 0.018	0.002HisXaa: 0.002 ± 0.001
Ile	7.507IleAla: 7.507 ± 0.091	0.547IleCys: 0.547 ± 0.021	3.587IleAsp: 3.587 ± 0.057	2.955IleGlu: 2.955 ± 0.055	1.684IlePhe: 1.684 ± 0.046	4.891IleGly: 4.891 ± 0.071	0.946IleHis: 0.946 ± 0.032	2.19IleIle: 2.19 ± 0.052	1.029IleLys: 1.029 ± 0.035	4.796IleLeu: 4.796 ± 0.067	1.128IleMet: 1.128 ± 0.036	1.15IleAsn: 1.15 ± 0.035	2.411IlePro: 2.411 ± 0.048	1.252IleGln: 1.252 ± 0.032	3.621IleArg: 3.621 ± 0.062	2.413IleSer: 2.413 ± 0.047	2.834IleThr: 2.834 ± 0.047	3.707IleVal: 3.707 ± 0.06	0.716IleTrp: 0.716 ± 0.029	0.985IleTyr: 0.985 ± 0.032	0.002IleXaa: 0.002 ± 0.001
Lys	3.028LysAla: 3.028 ± 0.058	0.137LysCys: 0.137 ± 0.011	1.273LysAsp: 1.273 ± 0.044	0.977LysGlu: 0.977 ± 0.037	0.617LysPhe: 0.617 ± 0.027	2.162LysGly: 2.162 ± 0.045	0.421LysHis: 0.421 ± 0.023	1.234LysIle: 1.234 ± 0.038	0.783LysLys: 0.783 ± 0.032	2.151LysLeu: 2.151 ± 0.057	0.627LysMet: 0.627 ± 0.026	0.53LysAsn: 0.53 ± 0.022	1.373LysPro: 1.373 ± 0.044	0.649LysGln: 0.649 ± 0.028	1.681LysArg: 1.681 ± 0.054	1.303LysSer: 1.303 ± 0.035	1.442LysThr: 1.442 ± 0.038	1.741LysVal: 1.741 ± 0.047	0.278LysTrp: 0.278 ± 0.018	0.47LysTyr: 0.47 ± 0.022	0.001LysXaa: 0.001 ± 0.001
Leu	14.753LeuAla: 14.753 ± 0.153	0.845LeuCys: 0.845 ± 0.029	6.768LeuAsp: 6.768 ± 0.08	4.605LeuGlu: 4.605 ± 0.069	3.273LeuPhe: 3.273 ± 0.059	8.517LeuGly: 8.517 ± 0.101	1.904LeuHis: 1.904 ± 0.044	5.609LeuIle: 5.609 ± 0.087	2.35LeuLys: 2.35 ± 0.058	8.934LeuLeu: 8.934 ± 0.142	2.832LeuMet: 2.832 ± 0.054	2.418LeuAsn: 2.418 ± 0.049	6.153LeuPro: 6.153 ± 0.087	2.962LeuGln: 2.962 ± 0.049	8.073LeuArg: 8.073 ± 0.105	6.787LeuSer: 6.787 ± 0.08	6.779LeuThr: 6.779 ± 0.077	6.967LeuVal: 6.967 ± 0.091	1.358LeuTrp: 1.358 ± 0.039	1.83LeuTyr: 1.83 ± 0.04	0.005LeuXaa: 0.005 ± 0.003
Met	4.059MetAla: 4.059 ± 0.066	0.171MetCys: 0.171 ± 0.012	1.576MetAsp: 1.576 ± 0.037	1.104MetGlu: 1.104 ± 0.033	0.777MetPhe: 0.777 ± 0.027	2.47MetGly: 2.47 ± 0.05	0.444MetHis: 0.444 ± 0.022	1.67MetIle: 1.67 ± 0.045	0.781MetLys: 0.781 ± 0.027	2.9MetLeu: 2.9 ± 0.057	0.814MetMet: 0.814 ± 0.03	0.806MetAsn: 0.806 ± 0.027	1.683MetPro: 1.683 ± 0.038	1.015MetGln: 1.015 ± 0.027	2.101MetArg: 2.101 ± 0.045	1.615MetSer: 1.615 ± 0.035	2.311MetThr: 2.311 ± 0.047	1.955MetVal: 1.955 ± 0.046	0.264MetTrp: 0.264 ± 0.015	0.302MetTyr: 0.302 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.831AsnAla: 2.831 ± 0.047	0.215AsnCys: 0.215 ± 0.015	1.302AsnAsp: 1.302 ± 0.047	0.903AsnGlu: 0.903 ± 0.031	0.796AsnPhe: 0.796 ± 0.028	1.92AsnGly: 1.92 ± 0.048	0.455AsnHis: 0.455 ± 0.022	1.172AsnIle: 1.172 ± 0.036	0.446AsnLys: 0.446 ± 0.023	2.322AsnLeu: 2.322 ± 0.049	0.624AsnMet: 0.624 ± 0.025	0.531AsnAsn: 0.531 ± 0.024	1.726AsnPro: 1.726 ± 0.043	0.693AsnGln: 0.693 ± 0.026	1.706AsnArg: 1.706 ± 0.041	0.983AsnSer: 0.983 ± 0.037	0.999AsnThr: 0.999 ± 0.032	1.54AsnVal: 1.54 ± 0.04	0.373AsnTrp: 0.373 ± 0.021	0.517AsnTyr: 0.517 ± 0.024	0.002AsnXaa: 0.002 ± 0.001
Pro	7.202ProAla: 7.202 ± 0.11	0.375ProCys: 0.375 ± 0.02	4.789ProAsp: 4.789 ± 0.072	3.476ProGlu: 3.476 ± 0.066	1.864ProPhe: 1.864 ± 0.039	5.012ProGly: 5.012 ± 0.074	1.136ProHis: 1.136 ± 0.036	2.256ProIle: 2.256 ± 0.057	1.206ProLys: 1.206 ± 0.034	5.024ProLeu: 5.024 ± 0.077	1.487ProMet: 1.487 ± 0.041	1.075ProAsn: 1.075 ± 0.033	2.447ProPro: 2.447 ± 0.06	2.064ProGln: 2.064 ± 0.04	3.373ProArg: 3.373 ± 0.063	2.303ProSer: 2.303 ± 0.047	2.503ProThr: 2.503 ± 0.056	4.807ProVal: 4.807 ± 0.066	0.783ProTrp: 0.783 ± 0.03	1.025ProTyr: 1.025 ± 0.034	0.002ProXaa: 0.002 ± 0.001
Gln	5.399GlnAla: 5.399 ± 0.082	0.191GlnCys: 0.191 ± 0.013	2.122GlnAsp: 2.122 ± 0.047	1.373GlnGlu: 1.373 ± 0.041	1.046GlnPhe: 1.046 ± 0.03	3.476GlnGly: 3.476 ± 0.061	0.566GlnHis: 0.566 ± 0.025	2.245GlnIle: 2.245 ± 0.044	0.779GlnLys: 0.779 ± 0.027	3.07GlnLeu: 3.07 ± 0.051	1.272GlnMet: 1.272 ± 0.033	0.847GlnAsn: 0.847 ± 0.032	2.014GlnPro: 2.014 ± 0.05	1.226GlnGln: 1.226 ± 0.042	2.274GlnArg: 2.274 ± 0.043	1.595GlnSer: 1.595 ± 0.039	1.974GlnThr: 1.974 ± 0.042	2.932GlnVal: 2.932 ± 0.056	0.394GlnTrp: 0.394 ± 0.02	0.499GlnTyr: 0.499 ± 0.021	0.003GlnXaa: 0.003 ± 0.002
Arg	9.854ArgAla: 9.854 ± 0.113	0.488ArgCys: 0.488 ± 0.021	5.459ArgAsp: 5.459 ± 0.08	3.471ArgGlu: 3.471 ± 0.062	2.72ArgPhe: 2.72 ± 0.053	5.154ArgGly: 5.154 ± 0.073	1.941ArgHis: 1.941 ± 0.043	4.436ArgIle: 4.436 ± 0.067	1.777ArgLys: 1.777 ± 0.047	8.528ArgLeu: 8.528 ± 0.106	2.397ArgMet: 2.397 ± 0.048	1.684ArgAsn: 1.684 ± 0.041	4.13ArgPro: 4.13 ± 0.063	2.904ArgGln: 2.904 ± 0.053	5.955ArgArg: 5.955 ± 0.086	3.228ArgSer: 3.228 ± 0.055	3.353ArgThr: 3.353 ± 0.059	5.143ArgVal: 5.143 ± 0.073	1.053ArgTrp: 1.053 ± 0.032	1.455ArgTyr: 1.455 ± 0.04	0.003ArgXaa: 0.003 ± 0.002
Ser	5.484SerAla: 5.484 ± 0.08	0.389SerCys: 0.389 ± 0.021	3.127SerAsp: 3.127 ± 0.054	2.246SerGlu: 2.246 ± 0.049	1.894SerPhe: 1.894 ± 0.04	5.068SerGly: 5.068 ± 0.068	1.034SerHis: 1.034 ± 0.028	2.175SerIle: 2.175 ± 0.046	0.997SerLys: 0.997 ± 0.034	4.826SerLeu: 4.826 ± 0.066	1.204SerMet: 1.204 ± 0.033	1.086SerAsn: 1.086 ± 0.031	2.468SerPro: 2.468 ± 0.042	1.529SerGln: 1.529 ± 0.04	3.381SerArg: 3.381 ± 0.055	2.182SerSer: 2.182 ± 0.05	2.283SerThr: 2.283 ± 0.046	3.602SerVal: 3.602 ± 0.062	0.698SerTrp: 0.698 ± 0.024	1.068SerTyr: 1.068 ± 0.032	0.005SerXaa: 0.005 ± 0.003
Thr	6.669ThrAla: 6.669 ± 0.079	0.446ThrCys: 0.446 ± 0.021	3.516ThrAsp: 3.516 ± 0.057	2.752ThrGlu: 2.752 ± 0.053	1.674ThrPhe: 1.674 ± 0.038	5.525ThrGly: 5.525 ± 0.075	1.136ThrHis: 1.136 ± 0.036	2.731ThrIle: 2.731 ± 0.052	1.072ThrLys: 1.072 ± 0.037	6.064ThrLeu: 6.064 ± 0.076	1.26ThrMet: 1.26 ± 0.034	1.191ThrAsn: 1.191 ± 0.031	3.549ThrPro: 3.549 ± 0.069	1.693ThrGln: 1.693 ± 0.039	3.956ThrArg: 3.956 ± 0.067	2.266ThrSer: 2.266 ± 0.051	2.872ThrThr: 2.872 ± 0.061	4.267ThrVal: 4.267 ± 0.072	0.649ThrTrp: 0.649 ± 0.026	1.052ThrTyr: 1.052 ± 0.03	0.001ThrXaa: 0.001 ± 0.001
Val	9.726ValAla: 9.726 ± 0.114	0.578ValCys: 0.578 ± 0.023	3.938ValAsp: 3.938 ± 0.061	3.853ValGlu: 3.853 ± 0.063	2.572ValPhe: 2.572 ± 0.052	5.413ValGly: 5.413 ± 0.082	1.298ValHis: 1.298 ± 0.034	4.23ValIle: 4.23 ± 0.063	1.64ValLys: 1.64 ± 0.046	7.93ValLeu: 7.93 ± 0.11	2.31ValMet: 2.31 ± 0.046	1.747ValAsn: 1.747 ± 0.045	3.737ValPro: 3.737 ± 0.057	2.372ValGln: 2.372 ± 0.047	4.505ValArg: 4.505 ± 0.071	3.663ValSer: 3.663 ± 0.065	5.15ValThr: 5.15 ± 0.081	5.652ValVal: 5.652 ± 0.088	1.007ValTrp: 1.007 ± 0.038	1.248ValTyr: 1.248 ± 0.042	0.003ValXaa: 0.003 ± 0.001
Trp	1.503TrpAla: 1.503 ± 0.041	0.136TrpCys: 0.136 ± 0.011	0.812TrpAsp: 0.812 ± 0.026	0.521TrpGlu: 0.521 ± 0.022	0.599TrpPhe: 0.599 ± 0.025	1.071TrpGly: 1.071 ± 0.034	0.338TrpHis: 0.338 ± 0.018	0.702TrpIle: 0.702 ± 0.026	0.347TrpLys: 0.347 ± 0.02	1.835TrpLeu: 1.835 ± 0.046	0.442TrpMet: 0.442 ± 0.017	0.383TrpAsn: 0.383 ± 0.019	0.788TrpPro: 0.788 ± 0.033	0.763TrpGln: 0.763 ± 0.026	1.275TrpArg: 1.275 ± 0.036	0.805TrpSer: 0.805 ± 0.028	0.853TrpThr: 0.853 ± 0.028	0.891TrpVal: 0.891 ± 0.03	0.251TrpTrp: 0.251 ± 0.016	0.251TrpTyr: 0.251 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.458TyrAla: 2.458 ± 0.05	0.18TyrCys: 0.18 ± 0.014	1.479TyrAsp: 1.479 ± 0.036	0.932TyrGlu: 0.932 ± 0.035	0.721TyrPhe: 0.721 ± 0.028	1.892TyrGly: 1.892 ± 0.045	0.449TyrHis: 0.449 ± 0.019	0.713TyrIle: 0.713 ± 0.027	0.406TyrLys: 0.406 ± 0.023	2.112TyrLeu: 2.112 ± 0.046	0.41TyrMet: 0.41 ± 0.018	0.47TyrAsn: 0.47 ± 0.022	0.958TyrPro: 0.958 ± 0.03	0.66TyrGln: 0.66 ± 0.026	1.47TyrArg: 1.47 ± 0.036	0.963TyrSer: 0.963 ± 0.034	0.874TyrThr: 0.874 ± 0.032	1.397TyrVal: 1.397 ± 0.034	0.327TyrTrp: 0.327 ± 0.019	0.463TyrTyr: 0.463 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.011XaaAla: 0.011 ± 0.004	0.0XaaCys: 0.0 ± 0.0	0.004XaaAsp: 0.004 ± 0.002	0.005XaaGlu: 0.005 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.005XaaGly: 0.005 ± 0.003	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.005XaaLeu: 0.005 ± 0.002	0.002XaaMet: 0.002 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.005XaaGln: 0.005 ± 0.002	0.003XaaArg: 0.003 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.005XaaThr: 0.005 ± 0.002	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.003

Statistics based on 3463 proteins (1070115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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