Amino acid dipepetide frequency for Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.98AlaAla: 6.98 ± 0.108	1.111AlaCys: 1.111 ± 0.025	3.462AlaAsp: 3.462 ± 0.04	4.5AlaGlu: 4.5 ± 0.054	3.281AlaPhe: 3.281 ± 0.045	3.636AlaGly: 3.636 ± 0.045	1.544AlaHis: 1.544 ± 0.028	3.941AlaIle: 3.941 ± 0.044	4.119AlaLys: 4.119 ± 0.043	7.07AlaLeu: 7.07 ± 0.057	1.662AlaMet: 1.662 ± 0.03	3.058AlaAsn: 3.058 ± 0.038	3.63AlaPro: 3.63 ± 0.069	2.744AlaGln: 2.744 ± 0.04	3.642AlaArg: 3.642 ± 0.047	6.719AlaSer: 6.719 ± 0.076	4.169AlaThr: 4.169 ± 0.053	4.824AlaVal: 4.824 ± 0.052	0.765AlaTrp: 0.765 ± 0.029	2.189AlaTyr: 2.189 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.972CysAla: 0.972 ± 0.021	0.34CysCys: 0.34 ± 0.015	0.724CysAsp: 0.724 ± 0.02	0.766CysGlu: 0.766 ± 0.02	0.796CysPhe: 0.796 ± 0.022	0.881CysGly: 0.881 ± 0.025	0.371CysHis: 0.371 ± 0.013	0.995CysIle: 0.995 ± 0.023	0.769CysLys: 0.769 ± 0.026	1.669CysLeu: 1.669 ± 0.032	0.359CysMet: 0.359 ± 0.013	0.652CysAsn: 0.652 ± 0.018	0.667CysPro: 0.667 ± 0.018	0.546CysGln: 0.546 ± 0.017	0.792CysArg: 0.792 ± 0.02	1.345CysSer: 1.345 ± 0.029	0.857CysThr: 0.857 ± 0.021	1.061CysVal: 1.061 ± 0.023	0.203CysTrp: 0.203 ± 0.01	0.528CysTyr: 0.528 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.188AspAla: 4.188 ± 0.044	0.729AspCys: 0.729 ± 0.019	3.592AspAsp: 3.592 ± 0.052	4.679AspGlu: 4.679 ± 0.061	2.418AspPhe: 2.418 ± 0.036	2.796AspGly: 2.796 ± 0.044	0.971AspHis: 0.971 ± 0.022	3.152AspIle: 3.152 ± 0.038	2.627AspLys: 2.627 ± 0.036	4.87AspLeu: 4.87 ± 0.049	1.252AspMet: 1.252 ± 0.024	2.196AspAsn: 2.196 ± 0.027	2.383AspPro: 2.383 ± 0.033	1.509AspGln: 1.509 ± 0.028	2.246AspArg: 2.246 ± 0.033	4.196AspSer: 4.196 ± 0.048	2.924AspThr: 2.924 ± 0.034	3.89AspVal: 3.89 ± 0.045	0.654AspTrp: 0.654 ± 0.018	1.866AspTyr: 1.866 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	4.622GluAla: 4.622 ± 0.057	0.838GluCys: 0.838 ± 0.021	3.927GluAsp: 3.927 ± 0.059	5.767GluGlu: 5.767 ± 0.095	2.481GluPhe: 2.481 ± 0.035	2.766GluGly: 2.766 ± 0.039	1.566GluHis: 1.566 ± 0.034	3.109GluIle: 3.109 ± 0.039	4.719GluLys: 4.719 ± 0.057	6.462GluLeu: 6.462 ± 0.071	1.435GluMet: 1.435 ± 0.027	3.339GluAsn: 3.339 ± 0.037	2.438GluPro: 2.438 ± 0.038	3.19GluGln: 3.19 ± 0.047	3.685GluArg: 3.685 ± 0.047	4.692GluSer: 4.692 ± 0.055	3.977GluThr: 3.977 ± 0.049	3.475GluVal: 3.475 ± 0.046	0.741GluTrp: 0.741 ± 0.018	1.984GluTyr: 1.984 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	2.993PheAla: 2.993 ± 0.04	0.781PheCys: 0.781 ± 0.019	2.458PheAsp: 2.458 ± 0.034	2.618PheGlu: 2.618 ± 0.036	2.071PhePhe: 2.071 ± 0.041	2.641PheGly: 2.641 ± 0.049	1.113PheHis: 1.113 ± 0.022	2.247PheIle: 2.247 ± 0.041	1.88PheLys: 1.88 ± 0.033	4.436PheLeu: 4.436 ± 0.06	0.925PheMet: 0.925 ± 0.022	1.729PheAsn: 1.729 ± 0.025	1.981PhePro: 1.981 ± 0.031	1.742PheGln: 1.742 ± 0.028	2.216PheArg: 2.216 ± 0.032	3.946PheSer: 3.946 ± 0.049	2.437PheThr: 2.437 ± 0.04	3.08PheVal: 3.08 ± 0.042	0.54PheTrp: 0.54 ± 0.016	1.445PheTyr: 1.445 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	3.41GlyAla: 3.41 ± 0.047	0.762GlyCys: 0.762 ± 0.017	2.523GlyAsp: 2.523 ± 0.036	2.691GlyGlu: 2.691 ± 0.036	2.516GlyPhe: 2.516 ± 0.036	2.895GlyGly: 2.895 ± 0.051	1.246GlyHis: 1.246 ± 0.031	3.135GlyIle: 3.135 ± 0.043	3.184GlyLys: 3.184 ± 0.043	4.69GlyLeu: 4.69 ± 0.047	1.185GlyMet: 1.185 ± 0.029	2.354GlyAsn: 2.354 ± 0.036	1.892GlyPro: 1.892 ± 0.031	1.65GlyGln: 1.65 ± 0.03	2.756GlyArg: 2.756 ± 0.041	4.346GlySer: 4.346 ± 0.057	3.113GlyThr: 3.113 ± 0.043	3.352GlyVal: 3.352 ± 0.05	0.632GlyTrp: 0.632 ± 0.02	1.813GlyTyr: 1.813 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	1.565HisAla: 1.565 ± 0.029	0.413HisCys: 0.413 ± 0.012	1.138HisAsp: 1.138 ± 0.024	1.441HisGlu: 1.441 ± 0.027	1.036HisPhe: 1.036 ± 0.023	1.264HisGly: 1.264 ± 0.027	0.678HisHis: 0.678 ± 0.019	1.307HisIle: 1.307 ± 0.023	1.234HisLys: 1.234 ± 0.039	2.303HisLeu: 2.303 ± 0.032	0.545HisMet: 0.545 ± 0.015	0.951HisAsn: 0.951 ± 0.021	1.423HisPro: 1.423 ± 0.027	0.859HisGln: 0.859 ± 0.021	1.355HisArg: 1.355 ± 0.026	2.094HisSer: 2.094 ± 0.034	1.27HisThr: 1.27 ± 0.025	1.578HisVal: 1.578 ± 0.026	0.32HisTrp: 0.32 ± 0.012	0.799HisTyr: 0.799 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	3.927IleAla: 3.927 ± 0.041	0.948IleCys: 0.948 ± 0.021	3.077IleAsp: 3.077 ± 0.038	3.204IleGlu: 3.204 ± 0.044	2.145IlePhe: 2.145 ± 0.035	2.664IleGly: 2.664 ± 0.038	1.393IleHis: 1.393 ± 0.028	2.743IleIle: 2.743 ± 0.044	2.627IleLys: 2.627 ± 0.035	5.053IleLeu: 5.053 ± 0.062	1.079IleMet: 1.079 ± 0.023	2.133IleAsn: 2.133 ± 0.031	2.999IlePro: 2.999 ± 0.035	2.273IleGln: 2.273 ± 0.033	2.984IleArg: 2.984 ± 0.041	4.222IleSer: 4.222 ± 0.049	3.002IleThr: 3.002 ± 0.044	3.653IleVal: 3.653 ± 0.045	0.601IleTrp: 0.601 ± 0.019	1.595IleTyr: 1.595 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.003LysAla: 4.003 ± 0.051	0.797LysCys: 0.797 ± 0.02	3.05LysAsp: 3.05 ± 0.041	4.094LysGlu: 4.094 ± 0.058	2.016LysPhe: 2.016 ± 0.029	2.499LysGly: 2.499 ± 0.039	1.58LysHis: 1.58 ± 0.03	2.735LysIle: 2.735 ± 0.041	4.668LysLys: 4.668 ± 0.07	5.745LysLeu: 5.745 ± 0.065	1.182LysMet: 1.182 ± 0.023	3.007LysAsn: 3.007 ± 0.035	2.925LysPro: 2.925 ± 0.045	2.883LysGln: 2.883 ± 0.036	4.034LysArg: 4.034 ± 0.052	4.43LysSer: 4.43 ± 0.053	3.688LysThr: 3.688 ± 0.045	3.268LysVal: 3.268 ± 0.042	0.615LysTrp: 0.615 ± 0.017	1.771LysTyr: 1.771 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	6.866LeuAla: 6.866 ± 0.062	1.735LeuCys: 1.735 ± 0.029	5.365LeuAsp: 5.365 ± 0.049	6.302LeuGlu: 6.302 ± 0.071	4.267LeuPhe: 4.267 ± 0.06	4.783LeuGly: 4.783 ± 0.055	2.522LeuHis: 2.522 ± 0.03	4.397LeuIle: 4.397 ± 0.048	5.904LeuLys: 5.904 ± 0.059	10.324LeuLeu: 10.324 ± 0.105	1.963LeuMet: 1.963 ± 0.03	4.465LeuAsn: 4.465 ± 0.044	5.101LeuPro: 5.101 ± 0.051	4.789LeuGln: 4.789 ± 0.065	5.949LeuArg: 5.949 ± 0.057	8.776LeuSer: 8.776 ± 0.068	5.1LeuThr: 5.1 ± 0.052	5.771LeuVal: 5.771 ± 0.057	1.046LeuTrp: 1.046 ± 0.027	3.121LeuTyr: 3.121 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.623MetAla: 1.623 ± 0.028	0.3MetCys: 0.3 ± 0.012	1.32MetAsp: 1.32 ± 0.023	1.422MetGlu: 1.422 ± 0.025	0.932MetPhe: 0.932 ± 0.023	1.106MetGly: 1.106 ± 0.025	0.533MetHis: 0.533 ± 0.014	0.963MetIle: 0.963 ± 0.023	1.336MetLys: 1.336 ± 0.025	2.205MetLeu: 2.205 ± 0.034	0.456MetMet: 0.456 ± 0.016	1.176MetAsn: 1.176 ± 0.023	1.017MetPro: 1.017 ± 0.028	1.002MetGln: 1.002 ± 0.026	1.058MetArg: 1.058 ± 0.021	2.075MetSer: 2.075 ± 0.032	1.16MetThr: 1.16 ± 0.021	1.13MetVal: 1.13 ± 0.023	0.179MetTrp: 0.179 ± 0.009	0.666MetTyr: 0.666 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.698AsnAla: 3.698 ± 0.038	0.66AsnCys: 0.66 ± 0.018	2.61AsnAsp: 2.61 ± 0.034	3.241AsnGlu: 3.241 ± 0.046	1.724AsnPhe: 1.724 ± 0.033	2.822AsnGly: 2.822 ± 0.042	0.935AsnHis: 0.935 ± 0.022	2.587AsnIle: 2.587 ± 0.033	2.33AsnLys: 2.33 ± 0.033	3.909AsnLeu: 3.909 ± 0.055	1.054AsnMet: 1.054 ± 0.019	2.088AsnAsn: 2.088 ± 0.037	2.215AsnPro: 2.215 ± 0.035	1.524AsnGln: 1.524 ± 0.026	2.046AsnArg: 2.046 ± 0.033	3.776AsnSer: 3.776 ± 0.047	2.718AsnThr: 2.718 ± 0.044	3.389AsnVal: 3.389 ± 0.044	0.567AsnTrp: 0.567 ± 0.015	1.444AsnTyr: 1.444 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	3.638ProAla: 3.638 ± 0.06	0.568ProCys: 0.568 ± 0.021	2.251ProAsp: 2.251 ± 0.039	3.314ProGlu: 3.314 ± 0.053	2.165ProPhe: 2.165 ± 0.036	2.24ProGly: 2.24 ± 0.04	0.981ProHis: 0.981 ± 0.021	2.432ProIle: 2.432 ± 0.034	2.829ProLys: 2.829 ± 0.036	4.409ProLeu: 4.409 ± 0.05	0.978ProMet: 0.978 ± 0.028	2.208ProAsn: 2.208 ± 0.035	2.918ProPro: 2.918 ± 0.072	1.752ProGln: 1.752 ± 0.035	2.219ProArg: 2.219 ± 0.03	5.2ProSer: 5.2 ± 0.064	3.2ProThr: 3.2 ± 0.053	3.618ProVal: 3.618 ± 0.065	0.517ProTrp: 0.517 ± 0.015	1.485ProTyr: 1.485 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	2.837GlnAla: 2.837 ± 0.041	0.565GlnCys: 0.565 ± 0.017	1.787GlnAsp: 1.787 ± 0.028	2.534GlnGlu: 2.534 ± 0.039	1.61GlnPhe: 1.61 ± 0.029	1.665GlnGly: 1.665 ± 0.029	1.057GlnHis: 1.057 ± 0.025	1.905GlnIle: 1.905 ± 0.03	2.827GlnLys: 2.827 ± 0.036	4.601GlnLeu: 4.601 ± 0.051	0.94GlnMet: 0.94 ± 0.022	2.034GlnAsn: 2.034 ± 0.028	1.906GlnPro: 1.906 ± 0.038	2.706GlnGln: 2.706 ± 0.076	2.55GlnArg: 2.55 ± 0.034	3.139GlnSer: 3.139 ± 0.043	2.408GlnThr: 2.408 ± 0.035	2.277GlnVal: 2.277 ± 0.033	0.47GlnTrp: 0.47 ± 0.014	1.275GlnTyr: 1.275 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	3.472ArgAla: 3.472 ± 0.046	0.806ArgCys: 0.806 ± 0.021	2.649ArgAsp: 2.649 ± 0.037	3.426ArgGlu: 3.426 ± 0.049	2.382ArgPhe: 2.382 ± 0.031	2.467ArgGly: 2.467 ± 0.043	1.253ArgHis: 1.253 ± 0.027	3.103ArgIle: 3.103 ± 0.041	3.76ArgLys: 3.76 ± 0.047	5.718ArgLeu: 5.718 ± 0.059	1.239ArgMet: 1.239 ± 0.023	2.535ArgAsn: 2.535 ± 0.034	2.419ArgPro: 2.419 ± 0.038	2.263ArgGln: 2.263 ± 0.037	3.899ArgArg: 3.899 ± 0.058	4.316ArgSer: 4.316 ± 0.056	2.883ArgThr: 2.883 ± 0.038	3.454ArgVal: 3.454 ± 0.045	0.623ArgTrp: 0.623 ± 0.019	1.8ArgTyr: 1.8 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.397SerAla: 6.397 ± 0.084	1.171SerCys: 1.171 ± 0.026	4.127SerAsp: 4.127 ± 0.053	4.937SerGlu: 4.937 ± 0.055	3.978SerPhe: 3.978 ± 0.048	4.222SerGly: 4.222 ± 0.064	1.867SerHis: 1.867 ± 0.029	4.773SerIle: 4.773 ± 0.053	4.879SerLys: 4.879 ± 0.052	8.708SerLeu: 8.708 ± 0.071	1.945SerMet: 1.945 ± 0.031	3.839SerAsn: 3.839 ± 0.043	4.358SerPro: 4.358 ± 0.063	3.231SerGln: 3.231 ± 0.044	4.45SerArg: 4.45 ± 0.048	10.26SerSer: 10.26 ± 0.165	5.643SerThr: 5.643 ± 0.073	5.894SerVal: 5.894 ± 0.072	0.967SerTrp: 0.967 ± 0.024	2.455SerTyr: 2.455 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	4.404ThrAla: 4.404 ± 0.046	0.839ThrCys: 0.839 ± 0.022	2.889ThrAsp: 2.889 ± 0.038	3.678ThrGlu: 3.678 ± 0.053	2.491ThrPhe: 2.491 ± 0.04	3.219ThrGly: 3.219 ± 0.051	1.291ThrHis: 1.291 ± 0.025	3.18ThrIle: 3.18 ± 0.046	3.375ThrLys: 3.375 ± 0.04	5.543ThrLeu: 5.543 ± 0.049	1.1ThrMet: 1.1 ± 0.021	2.667ThrAsn: 2.667 ± 0.037	3.281ThrPro: 3.281 ± 0.055	2.136ThrGln: 2.136 ± 0.032	2.805ThrArg: 2.805 ± 0.038	5.288ThrSer: 5.288 ± 0.078	3.96ThrThr: 3.96 ± 0.084	4.267ThrVal: 4.267 ± 0.088	0.566ThrTrp: 0.566 ± 0.016	1.657ThrTyr: 1.657 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	4.498ValAla: 4.498 ± 0.054	1.168ValCys: 1.168 ± 0.024	3.663ValAsp: 3.663 ± 0.037	3.958ValGlu: 3.958 ± 0.049	3.084ValPhe: 3.084 ± 0.04	3.113ValGly: 3.113 ± 0.046	1.647ValHis: 1.647 ± 0.029	3.29ValIle: 3.29 ± 0.043	3.476ValLys: 3.476 ± 0.042	6.579ValLeu: 6.579 ± 0.055	1.307ValMet: 1.307 ± 0.025	2.857ValAsn: 2.857 ± 0.037	3.596ValPro: 3.596 ± 0.068	2.718ValGln: 2.718 ± 0.039	3.389ValArg: 3.389 ± 0.04	5.785ValSer: 5.785 ± 0.07	3.56ValThr: 3.56 ± 0.073	4.373ValVal: 4.373 ± 0.065	0.765ValTrp: 0.765 ± 0.023	2.334ValTyr: 2.334 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.674TrpAla: 0.674 ± 0.019	0.212TrpCys: 0.212 ± 0.01	0.69TrpAsp: 0.69 ± 0.022	0.572TrpGlu: 0.572 ± 0.015	0.466TrpPhe: 0.466 ± 0.016	0.529TrpGly: 0.529 ± 0.017	0.264TrpHis: 0.264 ± 0.012	0.665TrpIle: 0.665 ± 0.021	0.81TrpLys: 0.81 ± 0.018	1.129TrpLeu: 1.129 ± 0.025	0.303TrpMet: 0.303 ± 0.013	0.659TrpAsn: 0.659 ± 0.02	0.383TrpPro: 0.383 ± 0.013	0.417TrpGln: 0.417 ± 0.014	0.674TrpArg: 0.674 ± 0.021	0.984TrpSer: 0.984 ± 0.031	0.715TrpThr: 0.715 ± 0.022	0.641TrpVal: 0.641 ± 0.018	0.148TrpTrp: 0.148 ± 0.009	0.374TrpTyr: 0.374 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.278TyrAla: 2.278 ± 0.034	0.55TyrCys: 0.55 ± 0.015	1.836TyrAsp: 1.836 ± 0.032	2.069TyrGlu: 2.069 ± 0.03	1.418TyrPhe: 1.418 ± 0.028	1.937TyrGly: 1.937 ± 0.036	0.759TyrHis: 0.759 ± 0.018	1.663TyrIle: 1.663 ± 0.027	1.638TyrLys: 1.638 ± 0.03	3.123TyrLeu: 3.123 ± 0.04	0.75TyrMet: 0.75 ± 0.017	1.391TyrAsn: 1.391 ± 0.026	1.389TyrPro: 1.389 ± 0.029	1.159TyrGln: 1.159 ± 0.023	1.717TyrArg: 1.717 ± 0.031	2.513TyrSer: 2.513 ± 0.036	1.853TyrThr: 1.853 ± 0.042	2.165TyrVal: 2.165 ± 0.034	0.392TyrTrp: 0.392 ± 0.013	1.18TyrTyr: 1.18 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4852 proteins (2271437 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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