Amino acid dipepetide frequency for Liberibacter asiaticus (strain psy62)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.97AlaAla: 3.97 ± 0.128
0.969AlaCys: 0.969 ± 0.055
3.282AlaAsp: 3.282 ± 0.099
3.355AlaGlu: 3.355 ± 0.116
2.544AlaPhe: 2.544 ± 0.091
4.058AlaGly: 4.058 ± 0.136
1.606AlaHis: 1.606 ± 0.082
6.135AlaIle: 6.135 ± 0.148
3.878AlaLys: 3.878 ± 0.112
6.804AlaLeu: 6.804 ± 0.153
1.966AlaMet: 1.966 ± 0.081
2.654AlaAsn: 2.654 ± 0.104
1.707AlaPro: 1.707 ± 0.084
2.351AlaGln: 2.351 ± 0.096
3.61AlaArg: 3.61 ± 0.113
4.541AlaSer: 4.541 ± 0.129
3.093AlaThr: 3.093 ± 0.114
4.506AlaVal: 4.506 ± 0.122
0.647AlaTrp: 0.647 ± 0.05
1.868AlaTyr: 1.868 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
1.007CysAla: 1.007 ± 0.059
0.246CysCys: 0.246 ± 0.027
0.843CysAsp: 0.843 ± 0.045
0.729CysGlu: 0.729 ± 0.053
0.811CysPhe: 0.811 ± 0.049
1.057CysGly: 1.057 ± 0.055
0.429CysHis: 0.429 ± 0.04
1.054CysIle: 1.054 ± 0.062
0.672CysLys: 0.672 ± 0.043
1.278CysLeu: 1.278 ± 0.06
0.36CysMet: 0.36 ± 0.034
0.584CysAsn: 0.584 ± 0.041
0.53CysPro: 0.53 ± 0.042
0.407CysGln: 0.407 ± 0.038
0.745CysArg: 0.745 ± 0.051
1.092CysSer: 1.092 ± 0.063
0.631CysThr: 0.631 ± 0.048
0.934CysVal: 0.934 ± 0.061
0.139CysTrp: 0.139 ± 0.022
0.369CysTyr: 0.369 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
2.951AspAla: 2.951 ± 0.103
0.887AspCys: 0.887 ± 0.049
2.521AspAsp: 2.521 ± 0.101
2.929AspGlu: 2.929 ± 0.114
2.837AspPhe: 2.837 ± 0.109
3.159AspGly: 3.159 ± 0.111
1.205AspHis: 1.205 ± 0.069
5.109AspIle: 5.109 ± 0.138
3.089AspLys: 3.089 ± 0.11
5.693AspLeu: 5.693 ± 0.198
1.332AspMet: 1.332 ± 0.067
2.364AspAsn: 2.364 ± 0.09
2.247AspPro: 2.247 ± 0.094
1.761AspGln: 1.761 ± 0.071
2.682AspArg: 2.682 ± 0.103
4.377AspSer: 4.377 ± 0.132
2.354AspThr: 2.354 ± 0.077
3.762AspVal: 3.762 ± 0.133
0.634AspTrp: 0.634 ± 0.046
1.673AspTyr: 1.673 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
3.478GluAla: 3.478 ± 0.107
0.615GluCys: 0.615 ± 0.047
3.001GluAsp: 3.001 ± 0.103
4.134GluGlu: 4.134 ± 0.143
1.998GluPhe: 1.998 ± 0.082
3.386GluGly: 3.386 ± 0.116
1.177GluHis: 1.177 ± 0.065
5.576GluIle: 5.576 ± 0.135
5.655GluLys: 5.655 ± 0.125
4.399GluLeu: 4.399 ± 0.128
1.698GluMet: 1.698 ± 0.071
3.512GluAsn: 3.512 ± 0.117
1.347GluPro: 1.347 ± 0.058
2.174GluGln: 2.174 ± 0.118
3.383GluArg: 3.383 ± 0.117
3.863GluSer: 3.863 ± 0.106
2.676GluThr: 2.676 ± 0.086
3.629GluVal: 3.629 ± 0.125
0.53GluTrp: 0.53 ± 0.046
1.856GluTyr: 1.856 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.638PheAla: 2.638 ± 0.101
0.849PheCys: 0.849 ± 0.05
2.585PheAsp: 2.585 ± 0.099
2.36PheGlu: 2.36 ± 0.088
2.85PhePhe: 2.85 ± 0.136
2.771PheGly: 2.771 ± 0.095
1.029PheHis: 1.029 ± 0.055
3.616PheIle: 3.616 ± 0.111
2.095PheLys: 2.095 ± 0.084
5.09PheLeu: 5.09 ± 0.142
1.265PheMet: 1.265 ± 0.068
1.818PheAsn: 1.818 ± 0.091
1.963PhePro: 1.963 ± 0.08
1.404PheGln: 1.404 ± 0.06
1.808PheArg: 1.808 ± 0.076
4.506PheSer: 4.506 ± 0.142
1.919PheThr: 1.919 ± 0.082
2.815PheVal: 2.815 ± 0.105
0.536PheTrp: 0.536 ± 0.047
1.562PheTyr: 1.562 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
3.781GlyAla: 3.781 ± 0.124
1.06GlyCys: 1.06 ± 0.067
3.257GlyAsp: 3.257 ± 0.111
3.452GlyGlu: 3.452 ± 0.116
3.178GlyPhe: 3.178 ± 0.117
4.175GlyGly: 4.175 ± 0.146
1.325GlyHis: 1.325 ± 0.065
6.466GlyIle: 6.466 ± 0.161
4.519GlyLys: 4.519 ± 0.119
5.488GlyLeu: 5.488 ± 0.144
1.941GlyMet: 1.941 ± 0.085
2.414GlyAsn: 2.414 ± 0.079
1.486GlyPro: 1.486 ± 0.06
1.994GlyGln: 1.994 ± 0.089
3.266GlyArg: 3.266 ± 0.124
4.427GlySer: 4.427 ± 0.131
2.913GlyThr: 2.913 ± 0.1
3.951GlyVal: 3.951 ± 0.124
0.685GlyTrp: 0.685 ± 0.05
2.133GlyTyr: 2.133 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.578HisAla: 1.578 ± 0.06
0.429HisCys: 0.429 ± 0.036
1.095HisAsp: 1.095 ± 0.06
1.048HisGlu: 1.048 ± 0.057
1.212HisPhe: 1.212 ± 0.056
1.49HisGly: 1.49 ± 0.067
0.615HisHis: 0.615 ± 0.043
1.878HisIle: 1.878 ± 0.076
1.31HisLys: 1.31 ± 0.067
2.307HisLeu: 2.307 ± 0.093
0.6HisMet: 0.6 ± 0.047
1.13HisAsn: 1.13 ± 0.058
1.193HisPro: 1.193 ± 0.061
0.877HisGln: 0.877 ± 0.053
1.24HisArg: 1.24 ± 0.063
1.808HisSer: 1.808 ± 0.086
1.07HisThr: 1.07 ± 0.062
1.452HisVal: 1.452 ± 0.059
0.252HisTrp: 0.252 ± 0.029
0.906HisTyr: 0.906 ± 0.058
0.0HisXaa: 0.0 ± 0.0
Ile
7.116IleAla: 7.116 ± 0.151
1.202IleCys: 1.202 ± 0.057
5.248IleAsp: 5.248 ± 0.178
5.267IleGlu: 5.267 ± 0.138
3.626IlePhe: 3.626 ± 0.148
5.819IleGly: 5.819 ± 0.158
1.9IleHis: 1.9 ± 0.075
6.75IleIle: 6.75 ± 0.211
4.756IleLys: 4.756 ± 0.126
8.382IleLeu: 8.382 ± 0.189
2.07IleMet: 2.07 ± 0.09
3.825IleAsn: 3.825 ± 0.128
4.115IlePro: 4.115 ± 0.123
2.935IleGln: 2.935 ± 0.083
4.254IleArg: 4.254 ± 0.113
8.031IleSer: 8.031 ± 0.154
4.481IleThr: 4.481 ± 0.122
6.125IleVal: 6.125 ± 0.154
0.716IleTrp: 0.716 ± 0.049
2.108IleTyr: 2.108 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
3.664LysAla: 3.664 ± 0.112
0.565LysCys: 0.565 ± 0.04
3.525LysAsp: 3.525 ± 0.114
4.544LysGlu: 4.544 ± 0.133
1.994LysPhe: 1.994 ± 0.073
3.869LysGly: 3.869 ± 0.113
1.19LysHis: 1.19 ± 0.064
6.375LysIle: 6.375 ± 0.167
6.176LysLys: 6.176 ± 0.17
4.904LysLeu: 4.904 ± 0.166
1.944LysMet: 1.944 ± 0.085
4.308LysAsn: 4.308 ± 0.151
1.916LysPro: 1.916 ± 0.074
1.909LysGln: 1.909 ± 0.076
3.623LysArg: 3.623 ± 0.121
4.743LysSer: 4.743 ± 0.109
2.963LysThr: 2.963 ± 0.093
3.695LysVal: 3.695 ± 0.117
0.606LysTrp: 0.606 ± 0.046
1.966LysTyr: 1.966 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
6.308LeuAla: 6.308 ± 0.162
1.376LeuCys: 1.376 ± 0.076
5.087LeuAsp: 5.087 ± 0.124
6.062LeuGlu: 6.062 ± 0.165
4.14LeuPhe: 4.14 ± 0.1
5.848LeuGly: 5.848 ± 0.142
2.102LeuHis: 2.102 ± 0.082
7.018LeuIle: 7.018 ± 0.166
6.053LeuLys: 6.053 ± 0.143
9.253LeuLeu: 9.253 ± 0.197
2.484LeuMet: 2.484 ± 0.085
3.828LeuAsn: 3.828 ± 0.106
3.907LeuPro: 3.907 ± 0.117
3.79LeuGln: 3.79 ± 0.116
5.289LeuArg: 5.289 ± 0.132
9.391LeuSer: 9.391 ± 0.194
4.295LeuThr: 4.295 ± 0.126
5.677LeuVal: 5.677 ± 0.147
0.918LeuTrp: 0.918 ± 0.068
2.932LeuTyr: 2.932 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.802MetAla: 1.802 ± 0.097
0.29MetCys: 0.29 ± 0.03
1.436MetAsp: 1.436 ± 0.07
1.347MetGlu: 1.347 ± 0.072
0.906MetPhe: 0.906 ± 0.054
1.758MetGly: 1.758 ± 0.084
0.666MetHis: 0.666 ± 0.049
2.348MetIle: 2.348 ± 0.095
1.736MetLys: 1.736 ± 0.076
2.471MetLeu: 2.471 ± 0.088
0.846MetMet: 0.846 ± 0.054
1.404MetAsn: 1.404 ± 0.071
1.095MetPro: 1.095 ± 0.056
1.155MetGln: 1.155 ± 0.065
1.758MetArg: 1.758 ± 0.073
2.146MetSer: 2.146 ± 0.092
1.338MetThr: 1.338 ± 0.062
1.72MetVal: 1.72 ± 0.078
0.205MetTrp: 0.205 ± 0.027
0.609MetTyr: 0.609 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.093AsnAla: 3.093 ± 0.116
0.552AsnCys: 0.552 ± 0.041
1.998AsnAsp: 1.998 ± 0.077
2.045AsnGlu: 2.045 ± 0.079
2.215AsnPhe: 2.215 ± 0.08
2.332AsnGly: 2.332 ± 0.094
1.243AsnHis: 1.243 ± 0.07
4.898AsnIle: 4.898 ± 0.137
2.73AsnLys: 2.73 ± 0.102
4.484AsnLeu: 4.484 ± 0.127
1.158AsnMet: 1.158 ± 0.064
2.48AsnAsn: 2.48 ± 0.108
2.468AsnPro: 2.468 ± 0.086
1.751AsnGln: 1.751 ± 0.076
2.436AsnArg: 2.436 ± 0.094
3.421AsnSer: 3.421 ± 0.114
2.313AsnThr: 2.313 ± 0.088
2.632AsnVal: 2.632 ± 0.091
0.458AsnTrp: 0.458 ± 0.036
1.351AsnTyr: 1.351 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
1.922ProAla: 1.922 ± 0.076
0.445ProCys: 0.445 ± 0.038
2.14ProAsp: 2.14 ± 0.085
2.452ProGlu: 2.452 ± 0.088
1.78ProPhe: 1.78 ± 0.077
2.042ProGly: 2.042 ± 0.08
1.098ProHis: 1.098 ± 0.067
3.339ProIle: 3.339 ± 0.123
1.966ProLys: 1.966 ± 0.078
3.841ProLeu: 3.841 ± 0.124
0.89ProMet: 0.89 ± 0.049
1.72ProAsn: 1.72 ± 0.077
1.426ProPro: 1.426 ± 0.058
1.471ProGln: 1.471 ± 0.054
1.723ProArg: 1.723 ± 0.076
3.156ProSer: 3.156 ± 0.125
1.786ProThr: 1.786 ± 0.073
2.405ProVal: 2.405 ± 0.088
0.385ProTrp: 0.385 ± 0.032
1.205ProTyr: 1.205 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
2.2GlnAla: 2.2 ± 0.092
0.382GlnCys: 0.382 ± 0.032
1.944GlnAsp: 1.944 ± 0.075
2.581GlnGlu: 2.581 ± 0.099
1.272GlnPhe: 1.272 ± 0.059
2.08GlnGly: 2.08 ± 0.094
0.852GlnHis: 0.852 ± 0.052
2.951GlnIle: 2.951 ± 0.13
3.317GlnLys: 3.317 ± 0.115
2.966GlnLeu: 2.966 ± 0.104
1.038GlnMet: 1.038 ± 0.059
1.871GlnAsn: 1.871 ± 0.086
0.918GlnPro: 0.918 ± 0.045
1.329GlnGln: 1.329 ± 0.064
2.001GlnArg: 2.001 ± 0.093
2.742GlnSer: 2.742 ± 0.09
1.455GlnThr: 1.455 ± 0.074
2.017GlnVal: 2.017 ± 0.088
0.413GlnTrp: 0.413 ± 0.043
1.231GlnTyr: 1.231 ± 0.06
0.0GlnXaa: 0.0 ± 0.0
Arg
3.089ArgAla: 3.089 ± 0.102
0.609ArgCys: 0.609 ± 0.048
2.897ArgAsp: 2.897 ± 0.096
3.077ArgGlu: 3.077 ± 0.125
2.597ArgPhe: 2.597 ± 0.088
3.011ArgGly: 3.011 ± 0.116
1.187ArgHis: 1.187 ± 0.069
4.977ArgIle: 4.977 ± 0.129
3.588ArgLys: 3.588 ± 0.123
5.21ArgLeu: 5.21 ± 0.131
1.442ArgMet: 1.442 ± 0.07
2.433ArgAsn: 2.433 ± 0.088
1.515ArgPro: 1.515 ± 0.068
1.783ArgGln: 1.783 ± 0.081
3.029ArgArg: 3.029 ± 0.115
4.042ArgSer: 4.042 ± 0.108
2.247ArgThr: 2.247 ± 0.079
3.405ArgVal: 3.405 ± 0.111
0.543ArgTrp: 0.543 ± 0.045
1.922ArgTyr: 1.922 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
4.715SerAla: 4.715 ± 0.121
1.224SerCys: 1.224 ± 0.062
4.049SerAsp: 4.049 ± 0.125
4.273SerGlu: 4.273 ± 0.127
4.469SerPhe: 4.469 ± 0.129
4.97SerGly: 4.97 ± 0.148
2.181SerHis: 2.181 ± 0.099
7.268SerIle: 7.268 ± 0.147
4.551SerLys: 4.551 ± 0.138
8.467SerLeu: 8.467 ± 0.166
2.089SerMet: 2.089 ± 0.082
3.326SerAsn: 3.326 ± 0.118
3.314SerPro: 3.314 ± 0.105
2.973SerGln: 2.973 ± 0.099
4.074SerArg: 4.074 ± 0.105
7.132SerSer: 7.132 ± 0.156
3.79SerThr: 3.79 ± 0.12
5.119SerVal: 5.119 ± 0.141
0.827SerTrp: 0.827 ± 0.049
2.395SerTyr: 2.395 ± 0.091
0.0SerXaa: 0.0 ± 0.0
Thr
3.184ThrAla: 3.184 ± 0.102
0.628ThrCys: 0.628 ± 0.046
2.291ThrAsp: 2.291 ± 0.082
2.518ThrGlu: 2.518 ± 0.088
1.868ThrPhe: 1.868 ± 0.079
3.424ThrGly: 3.424 ± 0.107
1.228ThrHis: 1.228 ± 0.06
4.437ThrIle: 4.437 ± 0.154
2.518ThrLys: 2.518 ± 0.098
4.51ThrLeu: 4.51 ± 0.115
1.149ThrMet: 1.149 ± 0.054
1.843ThrAsn: 1.843 ± 0.072
1.998ThrPro: 1.998 ± 0.082
1.811ThrGln: 1.811 ± 0.114
2.095ThrArg: 2.095 ± 0.078
3.459ThrSer: 3.459 ± 0.109
2.588ThrThr: 2.588 ± 0.092
3.414ThrVal: 3.414 ± 0.106
0.413ThrTrp: 0.413 ± 0.037
1.231ThrTyr: 1.231 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
4.478ValAla: 4.478 ± 0.134
0.925ValCys: 0.925 ± 0.049
3.919ValAsp: 3.919 ± 0.126
3.932ValGlu: 3.932 ± 0.127
3.168ValPhe: 3.168 ± 0.114
3.932ValGly: 3.932 ± 0.137
1.376ValHis: 1.376 ± 0.067
5.286ValIle: 5.286 ± 0.138
3.462ValLys: 3.462 ± 0.099
6.22ValLeu: 6.22 ± 0.156
1.742ValMet: 1.742 ± 0.091
2.575ValAsn: 2.575 ± 0.106
2.36ValPro: 2.36 ± 0.1
2.124ValGln: 2.124 ± 0.093
3.298ValArg: 3.298 ± 0.124
5.333ValSer: 5.333 ± 0.135
2.922ValThr: 2.922 ± 0.11
4.879ValVal: 4.879 ± 0.155
0.596ValTrp: 0.596 ± 0.042
1.802ValTyr: 1.802 ± 0.083
0.0ValXaa: 0.0 ± 0.0
Trp
0.524TrpAla: 0.524 ± 0.039
0.158TrpCys: 0.158 ± 0.021
0.521TrpAsp: 0.521 ± 0.038
0.486TrpGlu: 0.486 ± 0.038
0.483TrpPhe: 0.483 ± 0.042
0.59TrpGly: 0.59 ± 0.046
0.29TrpHis: 0.29 ± 0.029
0.972TrpIle: 0.972 ± 0.051
0.789TrpLys: 0.789 ± 0.06
1.026TrpLeu: 1.026 ± 0.061
0.303TrpMet: 0.303 ± 0.027
0.587TrpAsn: 0.587 ± 0.043
0.293TrpPro: 0.293 ± 0.032
0.398TrpGln: 0.398 ± 0.037
0.577TrpArg: 0.577 ± 0.045
0.701TrpSer: 0.701 ± 0.048
0.429TrpThr: 0.429 ± 0.036
0.439TrpVal: 0.439 ± 0.034
0.148TrpTrp: 0.148 ± 0.021
0.306TrpTyr: 0.306 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.048TyrAla: 2.048 ± 0.086
0.508TyrCys: 0.508 ± 0.043
1.928TyrAsp: 1.928 ± 0.076
1.496TyrGlu: 1.496 ± 0.061
1.534TyrPhe: 1.534 ± 0.077
2.143TyrGly: 2.143 ± 0.077
0.789TyrHis: 0.789 ± 0.057
2.275TyrIle: 2.275 ± 0.088
1.619TyrLys: 1.619 ± 0.084
2.966TyrLeu: 2.966 ± 0.101
0.716TyrMet: 0.716 ± 0.05
1.382TyrAsn: 1.382 ± 0.073
1.392TyrPro: 1.392 ± 0.06
1.161TyrGln: 1.161 ± 0.058
1.71TyrArg: 1.71 ± 0.081
2.291TyrSer: 2.291 ± 0.087
1.344TyrThr: 1.344 ± 0.066
1.755TyrVal: 1.755 ± 0.078
0.366TyrTrp: 0.366 ± 0.038
1.016TyrTyr: 1.016 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1102 proteins (316885 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski