Amino acid dipepetide frequency for Pseudomonas virus PMG1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.391AlaAla: 13.391 ± 1.324
1.973AlaCys: 1.973 ± 0.35
5.858AlaAsp: 5.858 ± 0.617
7.174AlaGlu: 7.174 ± 1.028
3.527AlaPhe: 3.527 ± 0.539
7.951AlaGly: 7.951 ± 0.787
1.614AlaHis: 1.614 ± 0.313
5.261AlaIle: 5.261 ± 0.598
5.44AlaLys: 5.44 ± 0.673
10.282AlaLeu: 10.282 ± 0.77
4.125AlaMet: 4.125 ± 0.537
3.527AlaAsn: 3.527 ± 0.47
4.603AlaPro: 4.603 ± 0.652
4.962AlaGln: 4.962 ± 0.763
7.054AlaArg: 7.054 ± 0.684
7.114AlaSer: 7.114 ± 0.711
4.484AlaThr: 4.484 ± 0.703
6.277AlaVal: 6.277 ± 0.714
2.63AlaTrp: 2.63 ± 0.421
2.511AlaTyr: 2.511 ± 0.347
0.0AlaXaa: 0.0 ± 0.0
Cys
1.255CysAla: 1.255 ± 0.264
0.179CysCys: 0.179 ± 0.099
1.196CysAsp: 1.196 ± 0.309
0.956CysGlu: 0.956 ± 0.218
0.299CysPhe: 0.299 ± 0.156
2.152CysGly: 2.152 ± 0.42
0.598CysHis: 0.598 ± 0.162
0.598CysIle: 0.598 ± 0.212
0.598CysLys: 0.598 ± 0.22
1.016CysLeu: 1.016 ± 0.247
0.478CysMet: 0.478 ± 0.16
0.538CysAsn: 0.538 ± 0.19
1.136CysPro: 1.136 ± 0.326
1.016CysGln: 1.016 ± 0.28
1.614CysArg: 1.614 ± 0.348
1.016CysSer: 1.016 ± 0.255
0.837CysThr: 0.837 ± 0.252
1.315CysVal: 1.315 ± 0.26
0.359CysTrp: 0.359 ± 0.154
0.239CysTyr: 0.239 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
5.5AspAla: 5.5 ± 0.488
0.837AspCys: 0.837 ± 0.242
2.869AspAsp: 2.869 ± 0.45
3.228AspGlu: 3.228 ± 0.404
2.391AspPhe: 2.391 ± 0.394
5.679AspGly: 5.679 ± 0.599
1.076AspHis: 1.076 ± 0.241
2.989AspIle: 2.989 ± 0.395
2.212AspLys: 2.212 ± 0.372
5.022AspLeu: 5.022 ± 0.44
1.614AspMet: 1.614 ± 0.27
1.614AspAsn: 1.614 ± 0.316
2.033AspPro: 2.033 ± 0.387
1.674AspGln: 1.674 ± 0.347
4.125AspArg: 4.125 ± 0.485
2.391AspSer: 2.391 ± 0.322
1.913AspThr: 1.913 ± 0.38
4.244AspVal: 4.244 ± 0.539
1.375AspTrp: 1.375 ± 0.277
1.913AspTyr: 1.913 ± 0.372
0.0AspXaa: 0.0 ± 0.0
Glu
6.098GluAla: 6.098 ± 0.681
1.136GluCys: 1.136 ± 0.346
2.63GluAsp: 2.63 ± 0.434
3.945GluGlu: 3.945 ± 0.511
2.869GluPhe: 2.869 ± 0.352
3.587GluGly: 3.587 ± 0.436
1.196GluHis: 1.196 ± 0.247
4.005GluIle: 4.005 ± 0.512
2.75GluLys: 2.75 ± 0.372
5.56GluLeu: 5.56 ± 0.626
1.614GluMet: 1.614 ± 0.297
2.272GluAsn: 2.272 ± 0.482
2.75GluPro: 2.75 ± 0.469
3.945GluGln: 3.945 ± 0.581
6.396GluArg: 6.396 ± 0.712
4.603GluSer: 4.603 ± 0.548
3.467GluThr: 3.467 ± 0.497
4.005GluVal: 4.005 ± 0.451
1.554GluTrp: 1.554 ± 0.354
2.331GluTyr: 2.331 ± 0.355
0.0GluXaa: 0.0 ± 0.0
Phe
3.348PheAla: 3.348 ± 0.444
0.717PheCys: 0.717 ± 0.244
1.674PheAsp: 1.674 ± 0.254
2.511PheGlu: 2.511 ± 0.402
0.897PhePhe: 0.897 ± 0.276
2.63PheGly: 2.63 ± 0.416
0.598PheHis: 0.598 ± 0.238
1.734PheIle: 1.734 ± 0.325
1.674PheLys: 1.674 ± 0.245
2.929PheLeu: 2.929 ± 0.481
0.658PheMet: 0.658 ± 0.186
0.956PheAsn: 0.956 ± 0.272
1.315PhePro: 1.315 ± 0.268
0.837PheGln: 0.837 ± 0.237
1.913PheArg: 1.913 ± 0.307
2.391PheSer: 2.391 ± 0.457
1.913PheThr: 1.913 ± 0.355
2.929PheVal: 2.929 ± 0.45
0.478PheTrp: 0.478 ± 0.168
0.837PheTyr: 0.837 ± 0.241
0.0PheXaa: 0.0 ± 0.0
Gly
6.157GlyAla: 6.157 ± 0.622
1.375GlyCys: 1.375 ± 0.33
4.902GlyAsp: 4.902 ± 0.674
4.663GlyGlu: 4.663 ± 0.529
2.929GlyPhe: 2.929 ± 0.404
6.217GlyGly: 6.217 ± 0.75
1.554GlyHis: 1.554 ± 0.322
4.125GlyIle: 4.125 ± 0.475
3.886GlyLys: 3.886 ± 0.411
6.396GlyLeu: 6.396 ± 0.684
2.212GlyMet: 2.212 ± 0.294
2.69GlyAsn: 2.69 ± 0.446
2.272GlyPro: 2.272 ± 0.402
2.989GlyGln: 2.989 ± 0.369
5.5GlyArg: 5.5 ± 0.627
4.185GlySer: 4.185 ± 0.507
3.467GlyThr: 3.467 ± 0.472
6.098GlyVal: 6.098 ± 0.652
1.734GlyTrp: 1.734 ± 0.33
2.69GlyTyr: 2.69 ± 0.462
0.0GlyXaa: 0.0 ± 0.0
His
2.212HisAla: 2.212 ± 0.348
0.418HisCys: 0.418 ± 0.208
1.016HisAsp: 1.016 ± 0.16
1.136HisGlu: 1.136 ± 0.224
0.658HisPhe: 0.658 ± 0.201
1.853HisGly: 1.853 ± 0.383
0.179HisHis: 0.179 ± 0.105
1.016HisIle: 1.016 ± 0.23
0.897HisLys: 0.897 ± 0.213
1.793HisLeu: 1.793 ± 0.356
0.538HisMet: 0.538 ± 0.156
0.478HisAsn: 0.478 ± 0.152
1.315HisPro: 1.315 ± 0.348
0.598HisGln: 0.598 ± 0.229
1.076HisArg: 1.076 ± 0.288
1.435HisSer: 1.435 ± 0.352
0.598HisThr: 0.598 ± 0.217
0.837HisVal: 0.837 ± 0.236
0.658HisTrp: 0.658 ± 0.186
0.837HisTyr: 0.837 ± 0.248
0.0HisXaa: 0.0 ± 0.0
Ile
7.532IleAla: 7.532 ± 0.719
0.897IleCys: 0.897 ± 0.257
4.304IleAsp: 4.304 ± 0.472
3.168IleGlu: 3.168 ± 0.462
1.614IlePhe: 1.614 ± 0.406
4.125IleGly: 4.125 ± 0.519
1.016IleHis: 1.016 ± 0.234
2.152IleIle: 2.152 ± 0.338
2.451IleLys: 2.451 ± 0.465
3.886IleLeu: 3.886 ± 0.693
0.658IleMet: 0.658 ± 0.175
2.092IleAsn: 2.092 ± 0.36
2.81IlePro: 2.81 ± 0.373
1.315IleGln: 1.315 ± 0.266
3.109IleArg: 3.109 ± 0.328
4.185IleSer: 4.185 ± 0.561
2.63IleThr: 2.63 ± 0.357
3.109IleVal: 3.109 ± 0.407
0.418IleTrp: 0.418 ± 0.157
2.272IleTyr: 2.272 ± 0.374
0.0IleXaa: 0.0 ± 0.0
Lys
4.782LysAla: 4.782 ± 0.625
0.837LysCys: 0.837 ± 0.281
1.973LysAsp: 1.973 ± 0.375
3.587LysGlu: 3.587 ± 0.438
1.255LysPhe: 1.255 ± 0.329
2.571LysGly: 2.571 ± 0.42
1.016LysHis: 1.016 ± 0.202
1.435LysIle: 1.435 ± 0.228
2.63LysLys: 2.63 ± 0.475
3.587LysLeu: 3.587 ± 0.592
0.239LysMet: 0.239 ± 0.115
1.853LysAsn: 1.853 ± 0.319
2.272LysPro: 2.272 ± 0.455
2.212LysGln: 2.212 ± 0.363
4.304LysArg: 4.304 ± 0.597
2.989LysSer: 2.989 ± 0.506
2.331LysThr: 2.331 ± 0.303
3.348LysVal: 3.348 ± 0.423
0.598LysTrp: 0.598 ± 0.221
1.255LysTyr: 1.255 ± 0.271
0.0LysXaa: 0.0 ± 0.0
Leu
10.402LeuAla: 10.402 ± 0.871
1.495LeuCys: 1.495 ± 0.368
4.663LeuAsp: 4.663 ± 0.653
5.739LeuGlu: 5.739 ± 0.524
2.75LeuPhe: 2.75 ± 0.497
5.32LeuGly: 5.32 ± 0.527
1.554LeuHis: 1.554 ± 0.358
4.543LeuIle: 4.543 ± 0.615
3.945LeuLys: 3.945 ± 0.582
7.293LeuLeu: 7.293 ± 0.938
2.092LeuMet: 2.092 ± 0.352
2.869LeuAsn: 2.869 ± 0.42
4.304LeuPro: 4.304 ± 0.586
2.63LeuGln: 2.63 ± 0.354
6.157LeuArg: 6.157 ± 0.651
5.858LeuSer: 5.858 ± 0.664
5.141LeuThr: 5.141 ± 0.649
5.38LeuVal: 5.38 ± 0.604
1.196LeuTrp: 1.196 ± 0.292
2.511LeuTyr: 2.511 ± 0.4
0.0LeuXaa: 0.0 ± 0.0
Met
2.69MetAla: 2.69 ± 0.372
0.418MetCys: 0.418 ± 0.181
1.315MetAsp: 1.315 ± 0.241
1.554MetGlu: 1.554 ± 0.368
0.359MetPhe: 0.359 ± 0.149
1.196MetGly: 1.196 ± 0.307
0.538MetHis: 0.538 ± 0.2
1.435MetIle: 1.435 ± 0.28
1.315MetLys: 1.315 ± 0.333
2.451MetLeu: 2.451 ± 0.385
0.478MetMet: 0.478 ± 0.185
1.554MetAsn: 1.554 ± 0.284
1.674MetPro: 1.674 ± 0.27
0.837MetGln: 0.837 ± 0.214
1.674MetArg: 1.674 ± 0.34
1.674MetSer: 1.674 ± 0.349
2.391MetThr: 2.391 ± 0.43
1.315MetVal: 1.315 ± 0.298
0.179MetTrp: 0.179 ± 0.104
0.478MetTyr: 0.478 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
3.527AsnAla: 3.527 ± 0.584
1.136AsnCys: 1.136 ± 0.259
2.272AsnAsp: 2.272 ± 0.315
1.853AsnGlu: 1.853 ± 0.368
0.598AsnPhe: 0.598 ± 0.171
3.049AsnGly: 3.049 ± 0.395
0.777AsnHis: 0.777 ± 0.234
1.973AsnIle: 1.973 ± 0.338
0.897AsnLys: 0.897 ± 0.266
2.391AsnLeu: 2.391 ± 0.328
0.956AsnMet: 0.956 ± 0.278
0.717AsnAsn: 0.717 ± 0.23
2.391AsnPro: 2.391 ± 0.433
1.196AsnGln: 1.196 ± 0.29
2.571AsnArg: 2.571 ± 0.408
2.451AsnSer: 2.451 ± 0.431
1.554AsnThr: 1.554 ± 0.347
1.255AsnVal: 1.255 ± 0.281
0.777AsnTrp: 0.777 ± 0.192
0.598AsnTyr: 0.598 ± 0.19
0.0AsnXaa: 0.0 ± 0.0
Pro
4.902ProAla: 4.902 ± 0.55
0.956ProCys: 0.956 ± 0.279
3.168ProAsp: 3.168 ± 0.378
3.647ProGlu: 3.647 ± 0.705
1.554ProPhe: 1.554 ± 0.312
4.065ProGly: 4.065 ± 0.579
0.717ProHis: 0.717 ± 0.222
2.451ProIle: 2.451 ± 0.335
1.375ProLys: 1.375 ± 0.271
3.647ProLeu: 3.647 ± 0.389
1.375ProMet: 1.375 ± 0.289
1.375ProAsn: 1.375 ± 0.24
1.614ProPro: 1.614 ± 0.332
1.973ProGln: 1.973 ± 0.373
2.331ProArg: 2.331 ± 0.389
2.81ProSer: 2.81 ± 0.422
1.853ProThr: 1.853 ± 0.336
3.647ProVal: 3.647 ± 0.382
0.837ProTrp: 0.837 ± 0.238
1.315ProTyr: 1.315 ± 0.285
0.0ProXaa: 0.0 ± 0.0
Gln
5.5GlnAla: 5.5 ± 0.912
1.076GlnCys: 1.076 ± 0.233
1.614GlnAsp: 1.614 ± 0.314
1.793GlnGlu: 1.793 ± 0.428
1.076GlnPhe: 1.076 ± 0.249
3.228GlnGly: 3.228 ± 0.379
0.897GlnHis: 0.897 ± 0.221
2.272GlnIle: 2.272 ± 0.409
1.734GlnLys: 1.734 ± 0.316
3.647GlnLeu: 3.647 ± 0.467
1.435GlnMet: 1.435 ± 0.292
1.196GlnAsn: 1.196 ± 0.253
1.016GlnPro: 1.016 ± 0.258
1.793GlnGln: 1.793 ± 0.274
2.929GlnArg: 2.929 ± 0.407
1.554GlnSer: 1.554 ± 0.367
1.495GlnThr: 1.495 ± 0.248
2.152GlnVal: 2.152 ± 0.374
0.478GlnTrp: 0.478 ± 0.202
1.016GlnTyr: 1.016 ± 0.272
0.0GlnXaa: 0.0 ± 0.0
Arg
5.978ArgAla: 5.978 ± 0.579
0.777ArgCys: 0.777 ± 0.212
3.109ArgAsp: 3.109 ± 0.389
6.337ArgGlu: 6.337 ± 0.679
2.092ArgPhe: 2.092 ± 0.37
4.603ArgGly: 4.603 ± 0.65
1.853ArgHis: 1.853 ± 0.398
4.842ArgIle: 4.842 ± 0.582
3.945ArgLys: 3.945 ± 0.519
6.576ArgLeu: 6.576 ± 0.571
1.734ArgMet: 1.734 ± 0.377
1.913ArgAsn: 1.913 ± 0.354
3.407ArgPro: 3.407 ± 0.493
2.63ArgGln: 2.63 ± 0.345
5.739ArgArg: 5.739 ± 0.686
4.244ArgSer: 4.244 ± 0.584
3.348ArgThr: 3.348 ± 0.44
4.185ArgVal: 4.185 ± 0.487
1.315ArgTrp: 1.315 ± 0.327
2.152ArgTyr: 2.152 ± 0.336
0.0ArgXaa: 0.0 ± 0.0
Ser
8.011SerAla: 8.011 ± 0.662
0.598SerCys: 0.598 ± 0.176
3.647SerAsp: 3.647 ± 0.407
4.962SerGlu: 4.962 ± 0.534
1.913SerPhe: 1.913 ± 0.369
5.978SerGly: 5.978 ± 0.656
1.315SerHis: 1.315 ± 0.337
4.065SerIle: 4.065 ± 0.44
2.69SerLys: 2.69 ± 0.416
5.32SerLeu: 5.32 ± 0.665
1.853SerMet: 1.853 ± 0.316
2.69SerAsn: 2.69 ± 0.321
3.168SerPro: 3.168 ± 0.464
1.973SerGln: 1.973 ± 0.44
3.467SerArg: 3.467 ± 0.476
4.364SerSer: 4.364 ± 0.679
2.929SerThr: 2.929 ± 0.428
3.826SerVal: 3.826 ± 0.681
0.837SerTrp: 0.837 ± 0.233
1.435SerTyr: 1.435 ± 0.258
0.0SerXaa: 0.0 ± 0.0
Thr
5.5ThrAla: 5.5 ± 0.59
0.717ThrCys: 0.717 ± 0.203
2.152ThrAsp: 2.152 ± 0.361
2.391ThrGlu: 2.391 ± 0.348
2.033ThrPhe: 2.033 ± 0.324
4.484ThrGly: 4.484 ± 0.5
1.076ThrHis: 1.076 ± 0.228
2.929ThrIle: 2.929 ± 0.439
1.973ThrLys: 1.973 ± 0.389
3.168ThrLeu: 3.168 ± 0.515
1.196ThrMet: 1.196 ± 0.278
1.435ThrAsn: 1.435 ± 0.387
3.168ThrPro: 3.168 ± 0.429
1.853ThrGln: 1.853 ± 0.362
1.973ThrArg: 1.973 ± 0.318
3.647ThrSer: 3.647 ± 0.598
2.929ThrThr: 2.929 ± 0.535
3.706ThrVal: 3.706 ± 0.504
1.076ThrTrp: 1.076 ± 0.263
0.956ThrTyr: 0.956 ± 0.265
0.0ThrXaa: 0.0 ± 0.0
Val
7.233ValAla: 7.233 ± 0.828
1.136ValCys: 1.136 ± 0.27
4.364ValAsp: 4.364 ± 0.572
5.679ValGlu: 5.679 ± 0.496
2.511ValPhe: 2.511 ± 0.363
4.484ValGly: 4.484 ± 0.647
1.016ValHis: 1.016 ± 0.318
3.647ValIle: 3.647 ± 0.494
2.69ValLys: 2.69 ± 0.312
5.978ValLeu: 5.978 ± 0.645
1.435ValMet: 1.435 ± 0.258
2.152ValAsn: 2.152 ± 0.383
2.511ValPro: 2.511 ± 0.438
1.435ValGln: 1.435 ± 0.245
3.826ValArg: 3.826 ± 0.652
5.081ValSer: 5.081 ± 0.702
3.109ValThr: 3.109 ± 0.486
4.244ValVal: 4.244 ± 0.478
0.598ValTrp: 0.598 ± 0.156
2.033ValTyr: 2.033 ± 0.509
0.0ValXaa: 0.0 ± 0.0
Trp
2.092TrpAla: 2.092 ± 0.384
0.239TrpCys: 0.239 ± 0.122
0.717TrpAsp: 0.717 ± 0.173
0.956TrpGlu: 0.956 ± 0.26
0.538TrpPhe: 0.538 ± 0.196
0.837TrpGly: 0.837 ± 0.253
0.478TrpHis: 0.478 ± 0.152
0.956TrpIle: 0.956 ± 0.28
1.016TrpLys: 1.016 ± 0.249
2.033TrpLeu: 2.033 ± 0.387
0.478TrpMet: 0.478 ± 0.24
0.418TrpAsn: 0.418 ± 0.164
0.717TrpPro: 0.717 ± 0.193
0.717TrpGln: 0.717 ± 0.3
1.973TrpArg: 1.973 ± 0.307
1.076TrpSer: 1.076 ± 0.271
0.658TrpThr: 0.658 ± 0.209
1.076TrpVal: 1.076 ± 0.323
0.478TrpTrp: 0.478 ± 0.16
0.598TrpTyr: 0.598 ± 0.145
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.647TyrAla: 3.647 ± 0.457
0.478TyrCys: 0.478 ± 0.166
1.255TyrAsp: 1.255 ± 0.277
1.435TyrGlu: 1.435 ± 0.289
1.076TyrPhe: 1.076 ± 0.279
2.033TyrGly: 2.033 ± 0.535
0.478TyrHis: 0.478 ± 0.147
1.315TyrIle: 1.315 ± 0.347
0.956TyrLys: 0.956 ± 0.214
2.869TyrLeu: 2.869 ± 0.421
0.299TyrMet: 0.299 ± 0.136
0.598TyrAsn: 0.598 ± 0.16
1.136TyrPro: 1.136 ± 0.354
1.315TyrGln: 1.315 ± 0.273
3.109TyrArg: 3.109 ± 0.471
1.973TyrSer: 1.973 ± 0.407
1.315TyrThr: 1.315 ± 0.271
2.212TyrVal: 2.212 ± 0.354
0.478TyrTrp: 0.478 ± 0.169
0.897TyrTyr: 0.897 ± 0.172
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 96 proteins (16729 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski