Amino acid dipepetide frequency for Actinobaculum suis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.151AlaAla: 18.151 ± 0.323	0.906AlaCys: 0.906 ± 0.042	6.694AlaAsp: 6.694 ± 0.121	8.806AlaGlu: 8.806 ± 0.167	3.381AlaPhe: 3.381 ± 0.072	12.6AlaGly: 12.6 ± 0.157	2.254AlaHis: 2.254 ± 0.063	5.489AlaIle: 5.489 ± 0.112	4.068AlaLys: 4.068 ± 0.117	10.939AlaLeu: 10.939 ± 0.178	2.434AlaMet: 2.434 ± 0.065	3.368AlaAsn: 3.368 ± 0.074	6.522AlaPro: 6.522 ± 0.149	5.623AlaGln: 5.623 ± 0.126	8.4AlaArg: 8.4 ± 0.186	7.183AlaSer: 7.183 ± 0.132	7.373AlaThr: 7.373 ± 0.146	8.734AlaVal: 8.734 ± 0.132	1.501AlaTrp: 1.501 ± 0.047	2.63AlaTyr: 2.63 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.928CysAla: 0.928 ± 0.041	0.077CysCys: 0.077 ± 0.013	0.344CysAsp: 0.344 ± 0.023	0.395CysGlu: 0.395 ± 0.023	0.223CysPhe: 0.223 ± 0.017	0.817CysGly: 0.817 ± 0.04	0.153CysHis: 0.153 ± 0.015	0.295CysIle: 0.295 ± 0.022	0.154CysLys: 0.154 ± 0.015	0.727CysLeu: 0.727 ± 0.037	0.157CysMet: 0.157 ± 0.013	0.164CysAsn: 0.164 ± 0.015	0.344CysPro: 0.344 ± 0.029	0.206CysGln: 0.206 ± 0.018	0.355CysArg: 0.355 ± 0.024	0.352CysSer: 0.352 ± 0.022	0.438CysThr: 0.438 ± 0.029	0.507CysVal: 0.507 ± 0.031	0.109CysTrp: 0.109 ± 0.014	0.151CysTyr: 0.151 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.462AspAla: 6.462 ± 0.119	0.316AspCys: 0.316 ± 0.022	2.506AspAsp: 2.506 ± 0.11	3.169AspGlu: 3.169 ± 0.083	1.935AspPhe: 1.935 ± 0.065	4.264AspGly: 4.264 ± 0.108	0.896AspHis: 0.896 ± 0.046	2.782AspIle: 2.782 ± 0.072	1.456AspLys: 1.456 ± 0.049	4.993AspLeu: 4.993 ± 0.102	1.003AspMet: 1.003 ± 0.036	1.345AspAsn: 1.345 ± 0.054	3.614AspPro: 3.614 ± 0.088	1.355AspGln: 1.355 ± 0.046	2.932AspArg: 2.932 ± 0.079	3.193AspSer: 3.193 ± 0.075	2.938AspThr: 2.938 ± 0.085	4.171AspVal: 4.171 ± 0.08	0.771AspTrp: 0.771 ± 0.044	1.437AspTyr: 1.437 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.65GluAla: 7.65 ± 0.133	0.334GluCys: 0.334 ± 0.025	3.213GluAsp: 3.213 ± 0.088	4.773GluGlu: 4.773 ± 0.132	1.877GluPhe: 1.877 ± 0.067	4.374GluGly: 4.374 ± 0.089	1.204GluHis: 1.204 ± 0.045	3.983GluIle: 3.983 ± 0.08	3.209GluLys: 3.209 ± 0.079	6.623GluLeu: 6.623 ± 0.127	1.357GluMet: 1.357 ± 0.048	2.752GluAsn: 2.752 ± 0.063	3.214GluPro: 3.214 ± 0.08	2.304GluGln: 2.304 ± 0.068	4.149GluArg: 4.149 ± 0.1	3.447GluSer: 3.447 ± 0.084	4.433GluThr: 4.433 ± 0.111	4.821GluVal: 4.821 ± 0.088	0.729GluTrp: 0.729 ± 0.035	1.647GluTyr: 1.647 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.99PheAla: 3.99 ± 0.089	0.223PheCys: 0.223 ± 0.02	1.87PheAsp: 1.87 ± 0.056	1.72PheGlu: 1.72 ± 0.054	1.186PhePhe: 1.186 ± 0.051	3.147PheGly: 3.147 ± 0.072	0.573PheHis: 0.573 ± 0.031	1.435PheIle: 1.435 ± 0.055	0.745PheLys: 0.745 ± 0.035	2.914PheLeu: 2.914 ± 0.077	0.58PheMet: 0.58 ± 0.033	0.828PheAsn: 0.828 ± 0.038	1.471PhePro: 1.471 ± 0.05	0.904PheGln: 0.904 ± 0.038	1.623PheArg: 1.623 ± 0.054	2.177PheSer: 2.177 ± 0.061	2.158PheThr: 2.158 ± 0.064	2.445PheVal: 2.445 ± 0.065	0.499PheTrp: 0.499 ± 0.029	0.857PheTyr: 0.857 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	9.643GlyAla: 9.643 ± 0.15	0.599GlyCys: 0.599 ± 0.033	3.964GlyAsp: 3.964 ± 0.107	5.674GlyGlu: 5.674 ± 0.098	2.919GlyPhe: 2.919 ± 0.067	6.965GlyGly: 6.965 ± 0.153	1.655GlyHis: 1.655 ± 0.057	4.884GlyIle: 4.884 ± 0.099	3.786GlyLys: 3.786 ± 0.09	7.434GlyLeu: 7.434 ± 0.126	2.036GlyMet: 2.036 ± 0.057	2.771GlyAsn: 2.771 ± 0.091	3.725GlyPro: 3.725 ± 0.083	3.38GlyGln: 3.38 ± 0.101	5.165GlyArg: 5.165 ± 0.099	5.175GlySer: 5.175 ± 0.099	6.159GlyThr: 6.159 ± 0.122	6.745GlyVal: 6.745 ± 0.123	1.284GlyTrp: 1.284 ± 0.048	2.445GlyTyr: 2.445 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	2.065HisAla: 2.065 ± 0.055	0.138HisCys: 0.138 ± 0.016	1.039HisAsp: 1.039 ± 0.043	1.182HisGlu: 1.182 ± 0.046	0.58HisPhe: 0.58 ± 0.034	1.816HisGly: 1.816 ± 0.046	0.443HisHis: 0.443 ± 0.033	0.912HisIle: 0.912 ± 0.037	0.522HisLys: 0.522 ± 0.028	1.691HisLeu: 1.691 ± 0.058	0.427HisMet: 0.427 ± 0.023	0.549HisAsn: 0.549 ± 0.027	1.323HisPro: 1.323 ± 0.05	0.554HisGln: 0.554 ± 0.028	1.307HisArg: 1.307 ± 0.048	1.01HisSer: 1.01 ± 0.04	1.183HisThr: 1.183 ± 0.045	1.41HisVal: 1.41 ± 0.047	0.273HisTrp: 0.273 ± 0.021	0.466HisTyr: 0.466 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.507IleAla: 6.507 ± 0.106	0.493IleCys: 0.493 ± 0.034	3.06IleAsp: 3.06 ± 0.076	2.813IleGlu: 2.813 ± 0.072	1.739IlePhe: 1.739 ± 0.059	4.444IleGly: 4.444 ± 0.097	0.88IleHis: 0.88 ± 0.036	2.64IleIle: 2.64 ± 0.073	1.252IleLys: 1.252 ± 0.052	4.216IleLeu: 4.216 ± 0.097	1.023IleMet: 1.023 ± 0.045	1.363IleAsn: 1.363 ± 0.053	2.864IlePro: 2.864 ± 0.069	1.313IleGln: 1.313 ± 0.048	2.917IleArg: 2.917 ± 0.072	3.587IleSer: 3.587 ± 0.078	3.28IleThr: 3.28 ± 0.078	3.961IleVal: 3.961 ± 0.087	0.533IleTrp: 0.533 ± 0.032	1.222IleTyr: 1.222 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	3.436LysAla: 3.436 ± 0.088	0.162LysCys: 0.162 ± 0.017	1.716LysAsp: 1.716 ± 0.06	1.994LysGlu: 1.994 ± 0.074	0.872LysPhe: 0.872 ± 0.04	1.862LysGly: 1.862 ± 0.068	0.687LysHis: 0.687 ± 0.035	1.976LysIle: 1.976 ± 0.051	1.427LysLys: 1.427 ± 0.061	3.017LysLeu: 3.017 ± 0.066	0.825LysMet: 0.825 ± 0.039	1.238LysAsn: 1.238 ± 0.053	1.933LysPro: 1.933 ± 0.069	1.207LysGln: 1.207 ± 0.044	2.047LysArg: 2.047 ± 0.065	1.72LysSer: 1.72 ± 0.059	2.164LysThr: 2.164 ± 0.077	2.501LysVal: 2.501 ± 0.09	0.374LysTrp: 0.374 ± 0.023	0.95LysTyr: 0.95 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	12.523LeuAla: 12.523 ± 0.201	0.719LeuCys: 0.719 ± 0.033	5.07LeuAsp: 5.07 ± 0.099	5.517LeuGlu: 5.517 ± 0.104	2.667LeuPhe: 2.667 ± 0.078	7.806LeuGly: 7.806 ± 0.125	1.623LeuHis: 1.623 ± 0.049	4.202LeuIle: 4.202 ± 0.106	2.034LeuLys: 2.034 ± 0.063	8.472LeuLeu: 8.472 ± 0.183	1.687LeuMet: 1.687 ± 0.061	2.164LeuAsn: 2.164 ± 0.065	5.127LeuPro: 5.127 ± 0.099	2.901LeuGln: 2.901 ± 0.073	6.522LeuArg: 6.522 ± 0.124	5.372LeuSer: 5.372 ± 0.102	5.608LeuThr: 5.608 ± 0.108	7.22LeuVal: 7.22 ± 0.134	1.04LeuTrp: 1.04 ± 0.048	1.874LeuTyr: 1.874 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.489MetAla: 2.489 ± 0.068	0.153MetCys: 0.153 ± 0.017	0.979MetAsp: 0.979 ± 0.047	1.09MetGlu: 1.09 ± 0.042	0.679MetPhe: 0.679 ± 0.037	1.556MetGly: 1.556 ± 0.049	0.448MetHis: 0.448 ± 0.024	1.013MetIle: 1.013 ± 0.042	0.74MetLys: 0.74 ± 0.032	1.949MetLeu: 1.949 ± 0.056	0.361MetMet: 0.361 ± 0.026	0.647MetAsn: 0.647 ± 0.03	1.18MetPro: 1.18 ± 0.04	0.727MetGln: 0.727 ± 0.031	1.556MetArg: 1.556 ± 0.042	1.294MetSer: 1.294 ± 0.047	1.203MetThr: 1.203 ± 0.049	1.484MetVal: 1.484 ± 0.049	0.244MetTrp: 0.244 ± 0.019	0.36MetTyr: 0.36 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.232AsnAla: 3.232 ± 0.087	0.193AsnCys: 0.193 ± 0.019	1.321AsnAsp: 1.321 ± 0.051	1.495AsnGlu: 1.495 ± 0.052	0.934AsnPhe: 0.934 ± 0.04	2.367AsnGly: 2.367 ± 0.079	0.498AsnHis: 0.498 ± 0.033	1.52AsnIle: 1.52 ± 0.051	0.888AsnLys: 0.888 ± 0.04	2.786AsnLeu: 2.786 ± 0.073	0.687AsnMet: 0.687 ± 0.035	0.949AsnAsn: 0.949 ± 0.047	2.347AsnPro: 2.347 ± 0.087	1.023AsnGln: 1.023 ± 0.042	1.736AsnArg: 1.736 ± 0.053	1.883AsnSer: 1.883 ± 0.057	1.917AsnThr: 1.917 ± 0.071	2.007AsnVal: 2.007 ± 0.054	0.462AsnTrp: 0.462 ± 0.027	0.867AsnTyr: 0.867 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	8.272ProAla: 8.272 ± 0.167	0.27ProCys: 0.27 ± 0.019	3.001ProAsp: 3.001 ± 0.086	5.033ProGlu: 5.033 ± 0.109	1.504ProPhe: 1.504 ± 0.043	5.399ProGly: 5.399 ± 0.126	1.215ProHis: 1.215 ± 0.04	2.22ProIle: 2.22 ± 0.057	1.406ProLys: 1.406 ± 0.054	4.218ProLeu: 4.218 ± 0.074	0.785ProMet: 0.785 ± 0.03	1.517ProAsn: 1.517 ± 0.066	1.811ProPro: 1.811 ± 0.068	2.349ProGln: 2.349 ± 0.064	3.078ProArg: 3.078 ± 0.077	2.843ProSer: 2.843 ± 0.091	2.904ProThr: 2.904 ± 0.077	4.304ProVal: 4.304 ± 0.085	0.724ProTrp: 0.724 ± 0.037	1.267ProTyr: 1.267 ± 0.058	0.0ProXaa: 0.0 ± 0.0
Gln	5.072GlnAla: 5.072 ± 0.128	0.157GlnCys: 0.157 ± 0.015	1.522GlnAsp: 1.522 ± 0.05	2.493GlnGlu: 2.493 ± 0.072	0.975GlnPhe: 0.975 ± 0.044	2.447GlnGly: 2.447 ± 0.077	0.644GlnHis: 0.644 ± 0.032	2.135GlnIle: 2.135 ± 0.052	1.333GlnLys: 1.333 ± 0.044	3.351GlnLeu: 3.351 ± 0.084	0.824GlnMet: 0.824 ± 0.038	1.145GlnAsn: 1.145 ± 0.047	2.068GlnPro: 2.068 ± 0.076	1.464GlnGln: 1.464 ± 0.063	2.542GlnArg: 2.542 ± 0.074	1.668GlnSer: 1.668 ± 0.056	2.057GlnThr: 2.057 ± 0.07	3.059GlnVal: 3.059 ± 0.079	0.499GlnTrp: 0.499 ± 0.03	0.862GlnTyr: 0.862 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	7.625ArgAla: 7.625 ± 0.145	0.419ArgCys: 0.419 ± 0.028	3.129ArgAsp: 3.129 ± 0.079	5.154ArgGlu: 5.154 ± 0.111	1.975ArgPhe: 1.975 ± 0.064	5.311ArgGly: 5.311 ± 0.093	1.262ArgHis: 1.262 ± 0.048	3.287ArgIle: 3.287 ± 0.076	2.317ArgLys: 2.317 ± 0.06	5.485ArgLeu: 5.485 ± 0.122	1.466ArgMet: 1.466 ± 0.051	1.768ArgAsn: 1.768 ± 0.051	3.067ArgPro: 3.067 ± 0.078	2.673ArgGln: 2.673 ± 0.076	5.406ArgArg: 5.406 ± 0.135	3.211ArgSer: 3.211 ± 0.069	3.726ArgThr: 3.726 ± 0.082	4.704ArgVal: 4.704 ± 0.1	0.968ArgTrp: 0.968 ± 0.045	1.758ArgTyr: 1.758 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	7.684SerAla: 7.684 ± 0.162	0.321SerCys: 0.321 ± 0.023	2.59SerAsp: 2.59 ± 0.065	3.508SerGlu: 3.508 ± 0.09	2.037SerPhe: 2.037 ± 0.059	6.042SerGly: 6.042 ± 0.112	1.09SerHis: 1.09 ± 0.042	2.569SerIle: 2.569 ± 0.07	1.57SerLys: 1.57 ± 0.05	5.098SerLeu: 5.098 ± 0.107	1.233SerMet: 1.233 ± 0.048	1.537SerAsn: 1.537 ± 0.059	3.118SerPro: 3.118 ± 0.081	2.192SerGln: 2.192 ± 0.076	3.693SerArg: 3.693 ± 0.088	3.505SerSer: 3.505 ± 0.087	3.722SerThr: 3.722 ± 0.097	4.078SerVal: 4.078 ± 0.074	0.891SerTrp: 0.891 ± 0.04	1.543SerTyr: 1.543 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	7.862ThrAla: 7.862 ± 0.158	0.437ThrCys: 0.437 ± 0.03	3.19ThrAsp: 3.19 ± 0.08	3.82ThrGlu: 3.82 ± 0.088	1.904ThrPhe: 1.904 ± 0.059	6.22ThrGly: 6.22 ± 0.122	1.227ThrHis: 1.227 ± 0.048	2.959ThrIle: 2.959 ± 0.065	1.824ThrLys: 1.824 ± 0.075	5.062ThrLeu: 5.062 ± 0.097	1.042ThrMet: 1.042 ± 0.045	1.729ThrAsn: 1.729 ± 0.05	4.158ThrPro: 4.158 ± 0.097	2.201ThrGln: 2.201 ± 0.062	3.545ThrArg: 3.545 ± 0.087	3.662ThrSer: 3.662 ± 0.083	3.641ThrThr: 3.641 ± 0.096	5.125ThrVal: 5.125 ± 0.129	0.883ThrTrp: 0.883 ± 0.039	1.551ThrTyr: 1.551 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	9.409ValAla: 9.409 ± 0.134	0.657ValCys: 0.657 ± 0.035	4.231ValAsp: 4.231 ± 0.092	5.017ValGlu: 5.017 ± 0.106	2.604ValPhe: 2.604 ± 0.078	5.619ValGly: 5.619 ± 0.118	1.381ValHis: 1.381 ± 0.042	4.067ValIle: 4.067 ± 0.1	2.286ValLys: 2.286 ± 0.091	7.357ValLeu: 7.357 ± 0.121	1.488ValMet: 1.488 ± 0.053	2.052ValAsn: 2.052 ± 0.065	4.316ValPro: 4.316 ± 0.09	2.394ValGln: 2.394 ± 0.071	4.952ValArg: 4.952 ± 0.095	4.781ValSer: 4.781 ± 0.106	4.958ValThr: 4.958 ± 0.137	6.706ValVal: 6.706 ± 0.125	0.896ValTrp: 0.896 ± 0.038	1.74ValTyr: 1.74 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.326TrpAla: 1.326 ± 0.041	0.167TrpCys: 0.167 ± 0.016	0.764TrpAsp: 0.764 ± 0.038	0.845TrpGlu: 0.845 ± 0.042	0.474TrpPhe: 0.474 ± 0.029	0.934TrpGly: 0.934 ± 0.041	0.342TrpHis: 0.342 ± 0.023	0.681TrpIle: 0.681 ± 0.035	0.47TrpLys: 0.47 ± 0.027	1.427TrpLeu: 1.427 ± 0.053	0.279TrpMet: 0.279 ± 0.023	0.539TrpAsn: 0.539 ± 0.03	0.572TrpPro: 0.572 ± 0.035	0.661TrpGln: 0.661 ± 0.028	1.005TrpArg: 1.005 ± 0.05	0.564TrpSer: 0.564 ± 0.029	0.702TrpThr: 0.702 ± 0.034	0.959TrpVal: 0.959 ± 0.046	0.329TrpTrp: 0.329 ± 0.028	0.342TrpTyr: 0.342 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.731TyrAla: 2.731 ± 0.062	0.156TyrCys: 0.156 ± 0.017	1.337TyrAsp: 1.337 ± 0.05	1.596TyrGlu: 1.596 ± 0.051	0.881TyrPhe: 0.881 ± 0.038	2.416TyrGly: 2.416 ± 0.079	0.413TyrHis: 0.413 ± 0.027	1.056TyrIle: 1.056 ± 0.042	0.623TyrLys: 0.623 ± 0.033	2.392TyrLeu: 2.392 ± 0.064	0.454TyrMet: 0.454 ± 0.031	0.686TyrAsn: 0.686 ± 0.034	1.35TyrPro: 1.35 ± 0.055	0.885TyrGln: 0.885 ± 0.041	1.782TyrArg: 1.782 ± 0.054	1.392TyrSer: 1.392 ± 0.041	1.479TyrThr: 1.479 ± 0.054	1.968TyrVal: 1.968 ± 0.061	0.371TyrTrp: 0.371 ± 0.024	0.666TyrTyr: 0.666 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1723 proteins (622842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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