Amino acid dipepetide frequency for Syntrophus gentianae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.526AlaAla: 8.526 ± 0.111	1.1AlaCys: 1.1 ± 0.038	4.506AlaAsp: 4.506 ± 0.069	5.922AlaGlu: 5.922 ± 0.094	3.57AlaPhe: 3.57 ± 0.061	7.189AlaGly: 7.189 ± 0.111	1.482AlaHis: 1.482 ± 0.036	5.305AlaIle: 5.305 ± 0.072	3.935AlaLys: 3.935 ± 0.076	9.122AlaLeu: 9.122 ± 0.121	2.357AlaMet: 2.357 ± 0.046	2.482AlaAsn: 2.482 ± 0.053	2.91AlaPro: 2.91 ± 0.059	2.529AlaGln: 2.529 ± 0.051	4.854AlaArg: 4.854 ± 0.074	4.654AlaSer: 4.654 ± 0.071	3.952AlaThr: 3.952 ± 0.067	6.513AlaVal: 6.513 ± 0.088	0.903AlaTrp: 0.903 ± 0.028	2.424AlaTyr: 2.424 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.917CysAla: 0.917 ± 0.031	0.209CysCys: 0.209 ± 0.016	0.596CysAsp: 0.596 ± 0.025	0.576CysGlu: 0.576 ± 0.023	0.501CysPhe: 0.501 ± 0.02	1.181CysGly: 1.181 ± 0.04	0.356CysHis: 0.356 ± 0.03	0.709CysIle: 0.709 ± 0.027	0.458CysLys: 0.458 ± 0.021	1.257CysLeu: 1.257 ± 0.037	0.255CysMet: 0.255 ± 0.015	0.403CysAsn: 0.403 ± 0.018	0.801CysPro: 0.801 ± 0.034	0.398CysGln: 0.398 ± 0.023	0.964CysArg: 0.964 ± 0.03	0.81CysSer: 0.81 ± 0.027	0.587CysThr: 0.587 ± 0.027	0.718CysVal: 0.718 ± 0.024	0.119CysTrp: 0.119 ± 0.011	0.343CysTyr: 0.343 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.289AspAla: 4.289 ± 0.07	0.641AspCys: 0.641 ± 0.026	2.471AspAsp: 2.471 ± 0.051	3.515AspGlu: 3.515 ± 0.063	2.555AspPhe: 2.555 ± 0.054	3.816AspGly: 3.816 ± 0.07	0.996AspHis: 0.996 ± 0.029	3.828AspIle: 3.828 ± 0.063	2.435AspLys: 2.435 ± 0.056	6.05AspLeu: 6.05 ± 0.08	1.266AspMet: 1.266 ± 0.029	1.591AspAsn: 1.591 ± 0.039	2.687AspPro: 2.687 ± 0.052	1.596AspGln: 1.596 ± 0.041	3.597AspArg: 3.597 ± 0.065	3.062AspSer: 3.062 ± 0.059	2.457AspThr: 2.457 ± 0.064	3.631AspVal: 3.631 ± 0.06	0.693AspTrp: 0.693 ± 0.026	2.025AspTyr: 2.025 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.301GluAla: 6.301 ± 0.102	0.566GluCys: 0.566 ± 0.024	3.368GluAsp: 3.368 ± 0.061	5.887GluGlu: 5.887 ± 0.107	2.188GluPhe: 2.188 ± 0.038	4.97GluGly: 4.97 ± 0.072	1.128GluHis: 1.128 ± 0.035	5.317GluIle: 5.317 ± 0.074	5.46GluLys: 5.46 ± 0.086	6.117GluLeu: 6.117 ± 0.077	2.009GluMet: 2.009 ± 0.044	2.748GluAsn: 2.748 ± 0.048	2.271GluPro: 2.271 ± 0.049	2.434GluGln: 2.434 ± 0.055	4.36GluArg: 4.36 ± 0.075	3.636GluSer: 3.636 ± 0.054	3.604GluThr: 3.604 ± 0.062	4.376GluVal: 4.376 ± 0.068	0.59GluTrp: 0.59 ± 0.028	1.728GluTyr: 1.728 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.095PheAla: 3.095 ± 0.056	0.669PheCys: 0.669 ± 0.024	2.298PheAsp: 2.298 ± 0.045	2.427PheGlu: 2.427 ± 0.047	2.175PhePhe: 2.175 ± 0.055	3.175PheGly: 3.175 ± 0.059	0.915PheHis: 0.915 ± 0.031	2.248PheIle: 2.248 ± 0.054	1.801PheLys: 1.801 ± 0.035	4.848PheLeu: 4.848 ± 0.078	0.919PheMet: 0.919 ± 0.029	1.444PheAsn: 1.444 ± 0.038	1.962PhePro: 1.962 ± 0.041	1.367PheGln: 1.367 ± 0.03	2.426PheArg: 2.426 ± 0.045	3.466PheSer: 3.466 ± 0.061	1.97PheThr: 1.97 ± 0.045	2.743PheVal: 2.743 ± 0.051	0.498PheTrp: 0.498 ± 0.023	1.438PheTyr: 1.438 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.78GlyAla: 5.78 ± 0.079	1.094GlyCys: 1.094 ± 0.036	3.785GlyAsp: 3.785 ± 0.072	4.778GlyGlu: 4.778 ± 0.061	3.335GlyPhe: 3.335 ± 0.059	6.036GlyGly: 6.036 ± 0.112	1.508GlyHis: 1.508 ± 0.036	6.011GlyIle: 6.011 ± 0.08	5.129GlyLys: 5.129 ± 0.072	7.285GlyLeu: 7.285 ± 0.091	2.308GlyMet: 2.308 ± 0.048	3.048GlyAsn: 3.048 ± 0.1	2.365GlyPro: 2.365 ± 0.05	2.458GlyGln: 2.458 ± 0.046	4.725GlyArg: 4.725 ± 0.067	4.584GlySer: 4.584 ± 0.072	4.36GlyThr: 4.36 ± 0.088	4.823GlyVal: 4.823 ± 0.077	0.964GlyTrp: 0.964 ± 0.036	2.76GlyTyr: 2.76 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.426HisAla: 1.426 ± 0.039	0.275HisCys: 0.275 ± 0.015	0.956HisAsp: 0.956 ± 0.029	1.12HisGlu: 1.12 ± 0.032	0.85HisPhe: 0.85 ± 0.03	1.436HisGly: 1.436 ± 0.037	0.476HisHis: 0.476 ± 0.024	1.125HisIle: 1.125 ± 0.028	0.754HisLys: 0.754 ± 0.024	2.093HisLeu: 2.093 ± 0.049	0.373HisMet: 0.373 ± 0.018	0.616HisAsn: 0.616 ± 0.026	1.265HisPro: 1.265 ± 0.039	0.583HisGln: 0.583 ± 0.024	1.252HisArg: 1.252 ± 0.035	1.093HisSer: 1.093 ± 0.035	0.821HisThr: 0.821 ± 0.027	1.21HisVal: 1.21 ± 0.035	0.229HisTrp: 0.229 ± 0.016	0.661HisTyr: 0.661 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.768IleAla: 5.768 ± 0.079	0.843IleCys: 0.843 ± 0.033	3.692IleAsp: 3.692 ± 0.06	4.304IleGlu: 4.304 ± 0.069	2.736IlePhe: 2.736 ± 0.056	4.851IleGly: 4.851 ± 0.07	1.25IleHis: 1.25 ± 0.035	3.488IleIle: 3.488 ± 0.072	3.069IleLys: 3.069 ± 0.066	7.443IleLeu: 7.443 ± 0.098	1.374IleMet: 1.374 ± 0.036	2.29IleAsn: 2.29 ± 0.049	3.548IlePro: 3.548 ± 0.066	2.114IleGln: 2.114 ± 0.045	4.442IleArg: 4.442 ± 0.064	4.745IleSer: 4.745 ± 0.067	3.21IleThr: 3.21 ± 0.059	4.412IleVal: 4.412 ± 0.072	0.534IleTrp: 0.534 ± 0.024	1.822IleTyr: 1.822 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.773LysAla: 4.773 ± 0.066	0.463LysCys: 0.463 ± 0.025	2.993LysAsp: 2.993 ± 0.058	4.454LysGlu: 4.454 ± 0.07	1.494LysPhe: 1.494 ± 0.038	4.221LysGly: 4.221 ± 0.064	0.746LysHis: 0.746 ± 0.03	4.126LysIle: 4.126 ± 0.064	4.193LysLys: 4.193 ± 0.08	4.341LysLeu: 4.341 ± 0.07	1.652LysMet: 1.652 ± 0.041	2.328LysAsn: 2.328 ± 0.052	2.282LysPro: 2.282 ± 0.049	1.547LysGln: 1.547 ± 0.045	3.18LysArg: 3.18 ± 0.055	3.067LysSer: 3.067 ± 0.06	3.188LysThr: 3.188 ± 0.067	3.516LysVal: 3.516 ± 0.058	0.487LysTrp: 0.487 ± 0.02	1.513LysTyr: 1.513 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	9.138LeuAla: 9.138 ± 0.111	1.321LeuCys: 1.321 ± 0.04	5.461LeuAsp: 5.461 ± 0.077	6.655LeuGlu: 6.655 ± 0.095	4.562LeuPhe: 4.562 ± 0.09	7.141LeuGly: 7.141 ± 0.098	1.863LeuHis: 1.863 ± 0.04	6.2LeuIle: 6.2 ± 0.091	6.145LeuLys: 6.145 ± 0.078	10.677LeuLeu: 10.677 ± 0.14	2.429LeuMet: 2.429 ± 0.054	3.835LeuAsn: 3.835 ± 0.069	4.973LeuPro: 4.973 ± 0.072	3.44LeuGln: 3.44 ± 0.061	6.001LeuArg: 6.001 ± 0.09	7.496LeuSer: 7.496 ± 0.099	5.414LeuThr: 5.414 ± 0.069	6.295LeuVal: 6.295 ± 0.077	1.067LeuTrp: 1.067 ± 0.037	3.042LeuTyr: 3.042 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	2.507MetAla: 2.507 ± 0.051	0.167MetCys: 0.167 ± 0.013	1.499MetAsp: 1.499 ± 0.033	1.921MetGlu: 1.921 ± 0.042	0.727MetPhe: 0.727 ± 0.026	1.902MetGly: 1.902 ± 0.049	0.39MetHis: 0.39 ± 0.023	1.793MetIle: 1.793 ± 0.044	1.915MetLys: 1.915 ± 0.04	2.233MetLeu: 2.233 ± 0.048	0.722MetMet: 0.722 ± 0.028	1.124MetAsn: 1.124 ± 0.03	1.186MetPro: 1.186 ± 0.036	0.686MetGln: 0.686 ± 0.024	1.284MetArg: 1.284 ± 0.037	1.439MetSer: 1.439 ± 0.037	1.615MetThr: 1.615 ± 0.043	1.594MetVal: 1.594 ± 0.039	0.162MetTrp: 0.162 ± 0.011	0.435MetTyr: 0.435 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.963AsnAla: 2.963 ± 0.05	0.435AsnCys: 0.435 ± 0.022	1.702AsnAsp: 1.702 ± 0.067	1.935AsnGlu: 1.935 ± 0.04	1.433AsnPhe: 1.433 ± 0.038	2.575AsnGly: 2.575 ± 0.061	0.648AsnHis: 0.648 ± 0.022	2.456AsnIle: 2.456 ± 0.053	1.594AsnLys: 1.594 ± 0.04	4.061AsnLeu: 4.061 ± 0.064	0.795AsnMet: 0.795 ± 0.025	1.197AsnAsn: 1.197 ± 0.037	2.369AsnPro: 2.369 ± 0.047	1.049AsnGln: 1.049 ± 0.032	2.464AsnArg: 2.464 ± 0.046	2.2AsnSer: 2.2 ± 0.05	1.627AsnThr: 1.627 ± 0.044	2.309AsnVal: 2.309 ± 0.046	0.473AsnTrp: 0.473 ± 0.021	1.13AsnTyr: 1.13 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.81ProAla: 3.81 ± 0.06	0.475ProCys: 0.475 ± 0.024	3.058ProAsp: 3.058 ± 0.062	4.094ProGlu: 4.094 ± 0.062	2.057ProPhe: 2.057 ± 0.041	3.809ProGly: 3.809 ± 0.07	0.788ProHis: 0.788 ± 0.026	2.346ProIle: 2.346 ± 0.049	1.776ProLys: 1.776 ± 0.046	4.436ProLeu: 4.436 ± 0.062	1.011ProMet: 1.011 ± 0.029	1.238ProAsn: 1.238 ± 0.034	2.108ProPro: 2.108 ± 0.061	1.461ProGln: 1.461 ± 0.038	2.142ProArg: 2.142 ± 0.05	2.726ProSer: 2.726 ± 0.056	1.937ProThr: 1.937 ± 0.042	3.694ProVal: 3.694 ± 0.062	0.55ProTrp: 0.55 ± 0.026	1.393ProTyr: 1.393 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.017GlnAla: 3.017 ± 0.057	0.321GlnCys: 0.321 ± 0.018	1.65GlnAsp: 1.65 ± 0.038	2.585GlnGlu: 2.585 ± 0.052	1.033GlnPhe: 1.033 ± 0.034	2.522GlnGly: 2.522 ± 0.042	0.564GlnHis: 0.564 ± 0.024	2.174GlnIle: 2.174 ± 0.049	2.151GlnLys: 2.151 ± 0.051	2.755GlnLeu: 2.755 ± 0.06	0.839GlnMet: 0.839 ± 0.027	1.161GlnAsn: 1.161 ± 0.032	1.284GlnPro: 1.284 ± 0.038	1.23GlnGln: 1.23 ± 0.046	2.051GlnArg: 2.051 ± 0.047	1.762GlnSer: 1.762 ± 0.042	1.556GlnThr: 1.556 ± 0.036	2.209GlnVal: 2.209 ± 0.039	0.356GlnTrp: 0.356 ± 0.02	0.925GlnTyr: 0.925 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.875ArgAla: 3.875 ± 0.058	0.727ArgCys: 0.727 ± 0.026	3.303ArgAsp: 3.303 ± 0.059	4.974ArgGlu: 4.974 ± 0.076	2.782ArgPhe: 2.782 ± 0.058	3.767ArgGly: 3.767 ± 0.062	1.305ArgHis: 1.305 ± 0.036	4.835ArgIle: 4.835 ± 0.07	4.019ArgLys: 4.019 ± 0.063	6.215ArgLeu: 6.215 ± 0.096	1.815ArgMet: 1.815 ± 0.037	2.442ArgAsn: 2.442 ± 0.048	2.27ArgPro: 2.27 ± 0.051	2.421ArgGln: 2.421 ± 0.055	3.986ArgArg: 3.986 ± 0.069	3.325ArgSer: 3.325 ± 0.056	2.933ArgThr: 2.933 ± 0.048	3.662ArgVal: 3.662 ± 0.062	0.646ArgTrp: 0.646 ± 0.029	2.053ArgTyr: 2.053 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.998SerAla: 4.998 ± 0.083	0.836SerCys: 0.836 ± 0.033	3.094SerAsp: 3.094 ± 0.055	3.798SerGlu: 3.798 ± 0.06	2.895SerPhe: 2.895 ± 0.057	5.816SerGly: 5.816 ± 0.096	1.155SerHis: 1.155 ± 0.035	3.847SerIle: 3.847 ± 0.065	2.405SerLys: 2.405 ± 0.047	6.952SerLeu: 6.952 ± 0.091	1.513SerMet: 1.513 ± 0.036	1.905SerAsn: 1.905 ± 0.04	3.091SerPro: 3.091 ± 0.056	1.887SerGln: 1.887 ± 0.041	4.126SerArg: 4.126 ± 0.075	4.274SerSer: 4.274 ± 0.07	2.944SerThr: 2.944 ± 0.056	4.093SerVal: 4.093 ± 0.064	0.82SerTrp: 0.82 ± 0.028	1.853SerTyr: 1.853 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.443ThrAla: 4.443 ± 0.064	0.538ThrCys: 0.538 ± 0.022	2.772ThrAsp: 2.772 ± 0.055	3.081ThrGlu: 3.081 ± 0.056	2.175ThrPhe: 2.175 ± 0.048	4.752ThrGly: 4.752 ± 0.073	0.896ThrHis: 0.896 ± 0.027	3.282ThrIle: 3.282 ± 0.061	2.017ThrLys: 2.017 ± 0.043	5.679ThrLeu: 5.679 ± 0.098	1.152ThrMet: 1.152 ± 0.036	1.635ThrAsn: 1.635 ± 0.052	2.476ThrPro: 2.476 ± 0.049	1.362ThrGln: 1.362 ± 0.038	2.682ThrArg: 2.682 ± 0.045	2.867ThrSer: 2.867 ± 0.06	2.579ThrThr: 2.579 ± 0.056	3.989ThrVal: 3.989 ± 0.062	0.548ThrTrp: 0.548 ± 0.019	1.428ThrTyr: 1.428 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	5.489ValAla: 5.489 ± 0.079	0.914ValCys: 0.914 ± 0.035	3.659ValAsp: 3.659 ± 0.061	4.421ValGlu: 4.421 ± 0.08	2.854ValPhe: 2.854 ± 0.045	4.546ValGly: 4.546 ± 0.071	1.249ValHis: 1.249 ± 0.035	4.597ValIle: 4.597 ± 0.066	3.485ValLys: 3.485 ± 0.061	7.164ValLeu: 7.164 ± 0.078	1.707ValMet: 1.707 ± 0.042	2.411ValAsn: 2.411 ± 0.051	3.075ValPro: 3.075 ± 0.054	2.065ValGln: 2.065 ± 0.044	3.942ValArg: 3.942 ± 0.069	4.489ValSer: 4.489 ± 0.066	3.642ValThr: 3.642 ± 0.063	5.078ValVal: 5.078 ± 0.088	0.65ValTrp: 0.65 ± 0.026	1.854ValTyr: 1.854 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.746TrpAla: 0.746 ± 0.03	0.141TrpCys: 0.141 ± 0.012	0.599TrpAsp: 0.599 ± 0.024	0.697TrpGlu: 0.697 ± 0.026	0.488TrpPhe: 0.488 ± 0.025	0.785TrpGly: 0.785 ± 0.03	0.253TrpHis: 0.253 ± 0.016	0.751TrpIle: 0.751 ± 0.025	0.606TrpLys: 0.606 ± 0.026	1.092TrpLeu: 1.092 ± 0.033	0.296TrpMet: 0.296 ± 0.019	0.459TrpAsn: 0.459 ± 0.023	0.423TrpPro: 0.423 ± 0.02	0.512TrpGln: 0.512 ± 0.022	0.689TrpArg: 0.689 ± 0.026	0.627TrpSer: 0.627 ± 0.024	0.547TrpThr: 0.547 ± 0.024	0.626TrpVal: 0.626 ± 0.026	0.155TrpTrp: 0.155 ± 0.013	0.325TrpTyr: 0.325 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.376TyrAla: 2.376 ± 0.055	0.425TyrCys: 0.425 ± 0.022	1.741TyrAsp: 1.741 ± 0.046	1.911TyrGlu: 1.911 ± 0.042	1.474TyrPhe: 1.474 ± 0.035	2.646TyrGly: 2.646 ± 0.065	0.644TyrHis: 0.644 ± 0.023	1.495TyrIle: 1.495 ± 0.041	1.217TyrLys: 1.217 ± 0.038	3.335TyrLeu: 3.335 ± 0.067	0.509TyrMet: 0.509 ± 0.023	1.058TyrAsn: 1.058 ± 0.037	1.564TyrPro: 1.564 ± 0.043	1.009TyrGln: 1.009 ± 0.029	2.187TyrArg: 2.187 ± 0.045	1.978TyrSer: 1.978 ± 0.045	1.41TyrThr: 1.41 ± 0.044	1.799TyrVal: 1.799 ± 0.041	0.373TyrTrp: 0.373 ± 0.021	1.022TyrTyr: 1.022 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3382 proteins (1080969 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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