Amino acid dipepetide frequency for Pseudoclavibacter endophyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.815AlaAla: 19.815 ± 0.249	0.814AlaCys: 0.814 ± 0.031	8.313AlaAsp: 8.313 ± 0.116	8.253AlaGlu: 8.253 ± 0.109	3.888AlaPhe: 3.888 ± 0.067	12.714AlaGly: 12.714 ± 0.134	2.553AlaHis: 2.553 ± 0.059	6.265AlaIle: 6.265 ± 0.102	2.441AlaLys: 2.441 ± 0.062	12.917AlaLeu: 12.917 ± 0.164	2.913AlaMet: 2.913 ± 0.057	2.456AlaAsn: 2.456 ± 0.047	7.089AlaPro: 7.089 ± 0.106	3.46AlaGln: 3.46 ± 0.065	9.795AlaArg: 9.795 ± 0.128	7.949AlaSer: 7.949 ± 0.102	8.018AlaThr: 8.018 ± 0.098	10.991AlaVal: 10.991 ± 0.136	1.852AlaTrp: 1.852 ± 0.05	2.268AlaTyr: 2.268 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.726CysAla: 0.726 ± 0.03	0.049CysCys: 0.049 ± 0.007	0.343CysAsp: 0.343 ± 0.021	0.277CysGlu: 0.277 ± 0.017	0.183CysPhe: 0.183 ± 0.015	0.628CysGly: 0.628 ± 0.027	0.116CysHis: 0.116 ± 0.012	0.222CysIle: 0.222 ± 0.016	0.059CysLys: 0.059 ± 0.007	0.461CysLeu: 0.461 ± 0.024	0.089CysMet: 0.089 ± 0.01	0.115CysAsn: 0.115 ± 0.011	0.305CysPro: 0.305 ± 0.021	0.117CysGln: 0.117 ± 0.012	0.394CysArg: 0.394 ± 0.023	0.365CysSer: 0.365 ± 0.019	0.338CysThr: 0.338 ± 0.017	0.433CysVal: 0.433 ± 0.021	0.084CysTrp: 0.084 ± 0.009	0.106CysTyr: 0.106 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	9.734AspAla: 9.734 ± 0.111	0.238AspCys: 0.238 ± 0.015	5.218AspAsp: 5.218 ± 0.081	5.263AspGlu: 5.263 ± 0.079	1.654AspPhe: 1.654 ± 0.045	6.423AspGly: 6.423 ± 0.094	1.258AspHis: 1.258 ± 0.04	2.178AspIle: 2.178 ± 0.049	0.752AspLys: 0.752 ± 0.031	6.047AspLeu: 6.047 ± 0.088	0.848AspMet: 0.848 ± 0.032	0.949AspAsn: 0.949 ± 0.037	3.989AspPro: 3.989 ± 0.077	1.364AspGln: 1.364 ± 0.042	4.938AspArg: 4.938 ± 0.076	2.41AspSer: 2.41 ± 0.053	2.836AspThr: 2.836 ± 0.061	5.535AspVal: 5.535 ± 0.079	0.885AspTrp: 0.885 ± 0.034	1.227AspTyr: 1.227 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.878GluAla: 7.878 ± 0.103	0.256GluCys: 0.256 ± 0.018	2.37GluAsp: 2.37 ± 0.051	2.568GluGlu: 2.568 ± 0.064	1.839GluPhe: 1.839 ± 0.042	4.387GluGly: 4.387 ± 0.074	1.817GluHis: 1.817 ± 0.05	2.703GluIle: 2.703 ± 0.057	1.025GluLys: 1.025 ± 0.041	7.239GluLeu: 7.239 ± 0.112	0.936GluMet: 0.936 ± 0.031	1.106GluAsn: 1.106 ± 0.035	3.586GluPro: 3.586 ± 0.069	2.418GluGln: 2.418 ± 0.049	6.392GluArg: 6.392 ± 0.109	3.139GluSer: 3.139 ± 0.06	3.411GluThr: 3.411 ± 0.067	4.805GluVal: 4.805 ± 0.083	0.871GluTrp: 0.871 ± 0.031	1.164GluTyr: 1.164 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.183PheAla: 4.183 ± 0.076	0.191PheCys: 0.191 ± 0.015	2.388PheAsp: 2.388 ± 0.054	1.979PheGlu: 1.979 ± 0.047	0.965PhePhe: 0.965 ± 0.04	3.534PheGly: 3.534 ± 0.066	0.553PheHis: 0.553 ± 0.023	1.259PheIle: 1.259 ± 0.043	0.417PheLys: 0.417 ± 0.021	2.482PheLeu: 2.482 ± 0.056	0.48PheMet: 0.48 ± 0.025	0.642PheAsn: 0.642 ± 0.027	1.362PhePro: 1.362 ± 0.041	0.723PheGln: 0.723 ± 0.03	1.783PheArg: 1.783 ± 0.035	1.593PheSer: 1.593 ± 0.042	2.049PheThr: 2.049 ± 0.046	2.808PheVal: 2.808 ± 0.049	0.375PheTrp: 0.375 ± 0.021	0.531PheTyr: 0.531 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.837GlyAla: 11.837 ± 0.128	0.596GlyCys: 0.596 ± 0.028	6.052GlyAsp: 6.052 ± 0.1	5.652GlyGlu: 5.652 ± 0.089	3.055GlyPhe: 3.055 ± 0.07	8.663GlyGly: 8.663 ± 0.131	1.89GlyHis: 1.89 ± 0.048	4.478GlyIle: 4.478 ± 0.068	1.817GlyLys: 1.817 ± 0.054	8.583GlyLeu: 8.583 ± 0.122	2.096GlyMet: 2.096 ± 0.05	1.869GlyAsn: 1.869 ± 0.044	4.434GlyPro: 4.434 ± 0.082	2.627GlyGln: 2.627 ± 0.072	7.135GlyArg: 7.135 ± 0.103	5.234GlySer: 5.234 ± 0.073	5.67GlyThr: 5.67 ± 0.086	8.074GlyVal: 8.074 ± 0.102	1.428GlyTrp: 1.428 ± 0.039	2.124GlyTyr: 2.124 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.613HisAla: 2.613 ± 0.063	0.139HisCys: 0.139 ± 0.012	1.547HisAsp: 1.547 ± 0.036	1.375HisGlu: 1.375 ± 0.041	0.573HisPhe: 0.573 ± 0.025	2.132HisGly: 2.132 ± 0.049	0.549HisHis: 0.549 ± 0.027	0.668HisIle: 0.668 ± 0.025	0.221HisLys: 0.221 ± 0.014	2.09HisLeu: 2.09 ± 0.054	0.311HisMet: 0.311 ± 0.019	0.382HisAsn: 0.382 ± 0.019	1.552HisPro: 1.552 ± 0.04	0.473HisGln: 0.473 ± 0.021	1.716HisArg: 1.716 ± 0.046	0.939HisSer: 0.939 ± 0.03	0.936HisThr: 0.936 ± 0.03	1.863HisVal: 1.863 ± 0.041	0.254HisTrp: 0.254 ± 0.015	0.41HisTyr: 0.41 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.065IleAla: 7.065 ± 0.109	0.257IleCys: 0.257 ± 0.016	3.648IleAsp: 3.648 ± 0.069	3.165IleGlu: 3.165 ± 0.059	1.058IlePhe: 1.058 ± 0.039	4.808IleGly: 4.808 ± 0.081	0.613IleHis: 0.613 ± 0.024	1.759IleIle: 1.759 ± 0.051	0.595IleLys: 0.595 ± 0.027	3.069IleLeu: 3.069 ± 0.064	0.759IleMet: 0.759 ± 0.029	0.93IleAsn: 0.93 ± 0.031	2.114IlePro: 2.114 ± 0.047	0.824IleGln: 0.824 ± 0.031	2.679IleArg: 2.679 ± 0.053	2.21IleSer: 2.21 ± 0.05	2.655IleThr: 2.655 ± 0.053	4.765IleVal: 4.765 ± 0.079	0.465IleTrp: 0.465 ± 0.023	0.659IleTyr: 0.659 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	1.871LysAla: 1.871 ± 0.051	0.06LysCys: 0.06 ± 0.009	0.786LysAsp: 0.786 ± 0.031	0.722LysGlu: 0.722 ± 0.032	0.432LysPhe: 0.432 ± 0.024	1.34LysGly: 1.34 ± 0.047	0.449LysHis: 0.449 ± 0.022	0.769LysIle: 0.769 ± 0.028	0.501LysLys: 0.501 ± 0.03	1.7LysLeu: 1.7 ± 0.045	0.295LysMet: 0.295 ± 0.017	0.397LysAsn: 0.397 ± 0.026	1.059LysPro: 1.059 ± 0.038	0.614LysGln: 0.614 ± 0.025	1.676LysArg: 1.676 ± 0.049	0.942LysSer: 0.942 ± 0.035	1.022LysThr: 1.022 ± 0.041	1.305LysVal: 1.305 ± 0.041	0.214LysTrp: 0.214 ± 0.015	0.369LysTyr: 0.369 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.114LeuAla: 14.114 ± 0.159	0.51LeuCys: 0.51 ± 0.024	6.71LeuAsp: 6.71 ± 0.093	5.798LeuGlu: 5.798 ± 0.084	2.755LeuPhe: 2.755 ± 0.056	9.191LeuGly: 9.191 ± 0.108	1.888LeuHis: 1.888 ± 0.039	4.005LeuIle: 4.005 ± 0.089	1.391LeuLys: 1.391 ± 0.04	9.282LeuLeu: 9.282 ± 0.137	1.58LeuMet: 1.58 ± 0.042	1.631LeuAsn: 1.631 ± 0.042	5.228LeuPro: 5.228 ± 0.076	2.445LeuGln: 2.445 ± 0.05	7.678LeuArg: 7.678 ± 0.12	4.99LeuSer: 4.99 ± 0.077	5.669LeuThr: 5.669 ± 0.094	9.016LeuVal: 9.016 ± 0.119	1.086LeuTrp: 1.086 ± 0.036	1.446LeuTyr: 1.446 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.099MetAla: 2.099 ± 0.045	0.105MetCys: 0.105 ± 0.011	0.732MetAsp: 0.732 ± 0.028	0.57MetGlu: 0.57 ± 0.027	0.601MetPhe: 0.601 ± 0.024	1.348MetGly: 1.348 ± 0.038	0.44MetHis: 0.44 ± 0.021	0.803MetIle: 0.803 ± 0.034	0.37MetLys: 0.37 ± 0.02	2.208MetLeu: 2.208 ± 0.047	0.312MetMet: 0.312 ± 0.019	0.48MetAsn: 0.48 ± 0.02	1.226MetPro: 1.226 ± 0.034	0.587MetGln: 0.587 ± 0.026	1.636MetArg: 1.636 ± 0.043	1.54MetSer: 1.54 ± 0.042	1.75MetThr: 1.75 ± 0.042	1.285MetVal: 1.285 ± 0.042	0.204MetTrp: 0.204 ± 0.015	0.322MetTyr: 0.322 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.719AsnAla: 2.719 ± 0.055	0.12AsnCys: 0.12 ± 0.01	1.284AsnAsp: 1.284 ± 0.04	1.199AsnGlu: 1.199 ± 0.04	0.61AsnPhe: 0.61 ± 0.028	1.955AsnGly: 1.955 ± 0.048	0.366AsnHis: 0.366 ± 0.019	0.799AsnIle: 0.799 ± 0.029	0.268AsnLys: 0.268 ± 0.016	1.788AsnLeu: 1.788 ± 0.044	0.343AsnMet: 0.343 ± 0.022	0.415AsnAsn: 0.415 ± 0.023	1.496AsnPro: 1.496 ± 0.04	0.519AsnGln: 0.519 ± 0.028	1.309AsnArg: 1.309 ± 0.037	0.924AsnSer: 0.924 ± 0.033	1.117AsnThr: 1.117 ± 0.041	1.716AsnVal: 1.716 ± 0.046	0.31AsnTrp: 0.31 ± 0.019	0.427AsnTyr: 0.427 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.349ProAla: 7.349 ± 0.105	0.241ProCys: 0.241 ± 0.016	4.165ProAsp: 4.165 ± 0.074	3.915ProGlu: 3.915 ± 0.084	1.741ProPhe: 1.741 ± 0.04	5.69ProGly: 5.69 ± 0.095	1.177ProHis: 1.177 ± 0.036	2.334ProIle: 2.334 ± 0.048	0.957ProLys: 0.957 ± 0.032	4.642ProLeu: 4.642 ± 0.069	0.964ProMet: 0.964 ± 0.035	1.148ProAsn: 1.148 ± 0.037	2.883ProPro: 2.883 ± 0.078	1.529ProGln: 1.529 ± 0.042	3.821ProArg: 3.821 ± 0.078	3.466ProSer: 3.466 ± 0.064	3.415ProThr: 3.415 ± 0.07	4.779ProVal: 4.779 ± 0.077	0.858ProTrp: 0.858 ± 0.028	1.148ProTyr: 1.148 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	3.372GlnAla: 3.372 ± 0.07	0.123GlnCys: 0.123 ± 0.01	1.03GlnAsp: 1.03 ± 0.04	1.227GlnGlu: 1.227 ± 0.039	0.892GlnPhe: 0.892 ± 0.035	2.062GlnGly: 2.062 ± 0.051	0.76GlnHis: 0.76 ± 0.028	1.183GlnIle: 1.183 ± 0.033	0.44GlnLys: 0.44 ± 0.022	3.168GlnLeu: 3.168 ± 0.063	0.439GlnMet: 0.439 ± 0.023	0.552GlnAsn: 0.552 ± 0.022	1.733GlnPro: 1.733 ± 0.06	1.249GlnGln: 1.249 ± 0.052	2.664GlnArg: 2.664 ± 0.058	1.501GlnSer: 1.501 ± 0.038	1.413GlnThr: 1.413 ± 0.037	2.265GlnVal: 2.265 ± 0.053	0.425GlnTrp: 0.425 ± 0.024	0.585GlnTyr: 0.585 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.92ArgAla: 9.92 ± 0.137	0.382ArgCys: 0.382 ± 0.022	5.127ArgAsp: 5.127 ± 0.079	4.95ArgGlu: 4.95 ± 0.085	2.461ArgPhe: 2.461 ± 0.05	6.327ArgGly: 6.327 ± 0.089	1.681ArgHis: 1.681 ± 0.044	3.709ArgIle: 3.709 ± 0.057	1.299ArgLys: 1.299 ± 0.037	7.637ArgLeu: 7.637 ± 0.11	1.77ArgMet: 1.77 ± 0.047	1.435ArgAsn: 1.435 ± 0.038	4.059ArgPro: 4.059 ± 0.086	2.087ArgGln: 2.087 ± 0.051	7.538ArgArg: 7.538 ± 0.111	4.334ArgSer: 4.334 ± 0.079	4.29ArgThr: 4.29 ± 0.073	6.601ArgVal: 6.601 ± 0.085	1.05ArgTrp: 1.05 ± 0.038	1.56ArgTyr: 1.56 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.77SerAla: 6.77 ± 0.086	0.279SerCys: 0.279 ± 0.017	3.007SerAsp: 3.007 ± 0.048	2.785SerGlu: 2.785 ± 0.069	1.79SerPhe: 1.79 ± 0.045	5.815SerGly: 5.815 ± 0.085	1.071SerHis: 1.071 ± 0.034	2.826SerIle: 2.826 ± 0.056	1.025SerLys: 1.025 ± 0.038	5.12SerLeu: 5.12 ± 0.077	1.283SerMet: 1.283 ± 0.041	1.163SerAsn: 1.163 ± 0.038	3.444SerPro: 3.444 ± 0.06	1.44SerGln: 1.44 ± 0.041	3.929SerArg: 3.929 ± 0.072	3.634SerSer: 3.634 ± 0.072	3.748SerThr: 3.748 ± 0.07	4.362SerVal: 4.362 ± 0.074	0.845SerTrp: 0.845 ± 0.031	1.062SerTyr: 1.062 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	7.48ThrAla: 7.48 ± 0.104	0.305ThrCys: 0.305 ± 0.021	3.402ThrAsp: 3.402 ± 0.056	3.279ThrGlu: 3.279 ± 0.059	1.929ThrPhe: 1.929 ± 0.037	6.024ThrGly: 6.024 ± 0.08	1.133ThrHis: 1.133 ± 0.033	2.818ThrIle: 2.818 ± 0.063	1.082ThrLys: 1.082 ± 0.031	5.594ThrLeu: 5.594 ± 0.074	1.081ThrMet: 1.081 ± 0.036	1.317ThrAsn: 1.317 ± 0.042	4.119ThrPro: 4.119 ± 0.067	1.408ThrGln: 1.408 ± 0.038	3.857ThrArg: 3.857 ± 0.065	3.624ThrSer: 3.624 ± 0.055	3.934ThrThr: 3.934 ± 0.073	5.487ThrVal: 5.487 ± 0.084	0.831ThrTrp: 0.831 ± 0.031	1.167ThrTyr: 1.167 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	11.486ValAla: 11.486 ± 0.133	0.53ValCys: 0.53 ± 0.025	5.711ValAsp: 5.711 ± 0.083	5.119ValGlu: 5.119 ± 0.071	2.648ValPhe: 2.648 ± 0.056	7.225ValGly: 7.225 ± 0.119	1.745ValHis: 1.745 ± 0.043	4.119ValIle: 4.119 ± 0.069	1.364ValLys: 1.364 ± 0.04	8.797ValLeu: 8.797 ± 0.111	1.528ValMet: 1.528 ± 0.038	1.843ValAsn: 1.843 ± 0.046	4.861ValPro: 4.861 ± 0.086	2.186ValGln: 2.186 ± 0.052	6.318ValArg: 6.318 ± 0.09	4.778ValSer: 4.778 ± 0.069	5.867ValThr: 5.867 ± 0.093	8.496ValVal: 8.496 ± 0.109	1.094ValTrp: 1.094 ± 0.037	1.494ValTyr: 1.494 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.434TrpAla: 1.434 ± 0.035	0.101TrpCys: 0.101 ± 0.01	0.662TrpAsp: 0.662 ± 0.024	0.591TrpGlu: 0.591 ± 0.027	0.558TrpPhe: 0.558 ± 0.027	1.007TrpGly: 1.007 ± 0.041	0.381TrpHis: 0.381 ± 0.02	0.614TrpIle: 0.614 ± 0.028	0.225TrpLys: 0.225 ± 0.016	1.65TrpLeu: 1.65 ± 0.043	0.34TrpMet: 0.34 ± 0.02	0.442TrpAsn: 0.442 ± 0.023	0.741TrpPro: 0.741 ± 0.028	0.489TrpGln: 0.489 ± 0.02	1.313TrpArg: 1.313 ± 0.039	0.843TrpSer: 0.843 ± 0.029	0.746TrpThr: 0.746 ± 0.027	0.998TrpVal: 0.998 ± 0.034	0.316TrpTrp: 0.316 ± 0.022	0.271TrpTyr: 0.271 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.299TyrAla: 2.299 ± 0.05	0.111TyrCys: 0.111 ± 0.011	1.251TyrAsp: 1.251 ± 0.042	1.222TyrGlu: 1.222 ± 0.042	0.666TyrPhe: 0.666 ± 0.025	2.041TyrGly: 2.041 ± 0.057	0.305TyrHis: 0.305 ± 0.018	0.587TyrIle: 0.587 ± 0.026	0.274TyrLys: 0.274 ± 0.018	1.939TyrLeu: 1.939 ± 0.043	0.252TyrMet: 0.252 ± 0.014	0.409TyrAsn: 0.409 ± 0.02	0.938TyrPro: 0.938 ± 0.033	0.524TyrGln: 0.524 ± 0.024	1.645TyrArg: 1.645 ± 0.043	0.985TyrSer: 0.985 ± 0.028	0.989TyrThr: 0.989 ± 0.037	1.628TyrVal: 1.628 ± 0.042	0.277TyrTrp: 0.277 ± 0.016	0.413TyrTyr: 0.413 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2822 proteins (967923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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