Amino acid dipepetide frequency for Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.03AlaAla: 8.03 ± 0.056	1.012AlaCys: 1.012 ± 0.014	3.902AlaAsp: 3.902 ± 0.029	4.785AlaGlu: 4.785 ± 0.034	3.012AlaPhe: 3.012 ± 0.026	5.142AlaGly: 5.142 ± 0.041	1.677AlaHis: 1.677 ± 0.016	4.543AlaIle: 4.543 ± 0.028	3.877AlaLys: 3.877 ± 0.029	7.445AlaLeu: 7.445 ± 0.043	1.816AlaMet: 1.816 ± 0.018	3.023AlaAsn: 3.023 ± 0.025	3.92AlaPro: 3.92 ± 0.032	3.247AlaGln: 3.247 ± 0.03	4.484AlaArg: 4.484 ± 0.03	6.778AlaSer: 6.778 ± 0.038	5.115AlaThr: 5.115 ± 0.033	5.076AlaVal: 5.076 ± 0.038	1.084AlaTrp: 1.084 ± 0.015	2.228AlaTyr: 2.228 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.871CysAla: 0.871 ± 0.013	0.216CysCys: 0.216 ± 0.007	0.631CysAsp: 0.631 ± 0.011	0.61CysGlu: 0.61 ± 0.01	0.557CysPhe: 0.557 ± 0.011	0.86CysGly: 0.86 ± 0.015	0.345CysHis: 0.345 ± 0.009	0.734CysIle: 0.734 ± 0.012	0.52CysLys: 0.52 ± 0.01	1.3CysLeu: 1.3 ± 0.014	0.281CysMet: 0.281 ± 0.007	0.435CysAsn: 0.435 ± 0.009	0.625CysPro: 0.625 ± 0.011	0.498CysGln: 0.498 ± 0.011	0.728CysArg: 0.728 ± 0.012	0.871CysSer: 0.871 ± 0.013	0.69CysThr: 0.69 ± 0.011	0.753CysVal: 0.753 ± 0.011	0.194CysTrp: 0.194 ± 0.005	0.361CysTyr: 0.361 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.177AspAla: 4.177 ± 0.028	0.603AspCys: 0.603 ± 0.011	4.013AspAsp: 4.013 ± 0.038	4.272AspGlu: 4.272 ± 0.033	2.186AspPhe: 2.186 ± 0.018	3.672AspGly: 3.672 ± 0.025	1.257AspHis: 1.257 ± 0.016	3.521AspIle: 3.521 ± 0.022	2.461AspLys: 2.461 ± 0.021	5.165AspLeu: 5.165 ± 0.032	1.249AspMet: 1.249 ± 0.013	2.162AspAsn: 2.162 ± 0.018	3.07AspPro: 3.07 ± 0.023	1.911AspGln: 1.911 ± 0.021	3.034AspArg: 3.034 ± 0.031	4.151AspSer: 4.151 ± 0.029	3.049AspThr: 3.049 ± 0.024	3.52AspVal: 3.52 ± 0.028	0.888AspTrp: 0.888 ± 0.012	1.701AspTyr: 1.701 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.083GluAla: 5.083 ± 0.038	0.617GluCys: 0.617 ± 0.01	4.088GluAsp: 4.088 ± 0.031	5.407GluGlu: 5.407 ± 0.054	1.989GluPhe: 1.989 ± 0.019	3.444GluGly: 3.444 ± 0.027	1.421GluHis: 1.421 ± 0.016	3.558GluIle: 3.558 ± 0.027	3.921GluLys: 3.921 ± 0.033	5.164GluLeu: 5.164 ± 0.032	1.418GluMet: 1.418 ± 0.016	2.624GluAsn: 2.624 ± 0.021	2.53GluPro: 2.53 ± 0.038	2.624GluGln: 2.624 ± 0.024	3.829GluArg: 3.829 ± 0.027	4.439GluSer: 4.439 ± 0.027	3.591GluThr: 3.591 ± 0.026	3.491GluVal: 3.491 ± 0.024	0.938GluTrp: 0.938 ± 0.013	1.815GluTyr: 1.815 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	2.964PheAla: 2.964 ± 0.024	0.55PheCys: 0.55 ± 0.011	2.361PheAsp: 2.361 ± 0.019	2.149PheGlu: 2.149 ± 0.021	1.64PhePhe: 1.64 ± 0.019	2.662PheGly: 2.662 ± 0.025	0.926PheHis: 0.926 ± 0.011	2.032PheIle: 2.032 ± 0.02	1.532PheLys: 1.532 ± 0.016	3.64PheLeu: 3.64 ± 0.03	0.831PheMet: 0.831 ± 0.012	1.549PheAsn: 1.549 ± 0.018	1.892PhePro: 1.892 ± 0.019	1.461PheGln: 1.461 ± 0.015	1.961PheArg: 1.961 ± 0.018	3.069PheSer: 3.069 ± 0.026	2.188PheThr: 2.188 ± 0.02	2.372PheVal: 2.372 ± 0.023	0.631PheTrp: 0.631 ± 0.011	1.144PheTyr: 1.144 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.672GlyAla: 4.672 ± 0.039	0.802GlyCys: 0.802 ± 0.014	3.261GlyAsp: 3.261 ± 0.026	3.257GlyGlu: 3.257 ± 0.023	2.769GlyPhe: 2.769 ± 0.022	4.99GlyGly: 4.99 ± 0.042	1.727GlyHis: 1.727 ± 0.02	3.742GlyIle: 3.742 ± 0.03	3.308GlyLys: 3.308 ± 0.026	5.844GlyLeu: 5.844 ± 0.032	1.396GlyMet: 1.396 ± 0.017	2.597GlyAsn: 2.597 ± 0.024	2.969GlyPro: 2.969 ± 0.028	2.454GlyGln: 2.454 ± 0.022	3.813GlyArg: 3.813 ± 0.029	5.366GlySer: 5.366 ± 0.043	3.797GlyThr: 3.797 ± 0.032	4.028GlyVal: 4.028 ± 0.026	1.142GlyTrp: 1.142 ± 0.016	2.178GlyTyr: 2.178 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.694HisAla: 1.694 ± 0.017	0.33HisCys: 0.33 ± 0.007	1.323HisAsp: 1.323 ± 0.018	1.393HisGlu: 1.393 ± 0.017	0.992HisPhe: 0.992 ± 0.013	1.644HisGly: 1.644 ± 0.017	0.868HisHis: 0.868 ± 0.016	1.403HisIle: 1.403 ± 0.016	0.983HisLys: 0.983 ± 0.013	2.312HisLeu: 2.312 ± 0.02	0.475HisMet: 0.475 ± 0.009	0.947HisAsn: 0.947 ± 0.013	1.567HisPro: 1.567 ± 0.016	1.017HisGln: 1.017 ± 0.015	1.546HisArg: 1.546 ± 0.017	1.889HisSer: 1.889 ± 0.02	1.35HisThr: 1.35 ± 0.014	1.45HisVal: 1.45 ± 0.014	0.361HisTrp: 0.361 ± 0.008	0.736HisTyr: 0.736 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.392IleAla: 4.392 ± 0.032	0.857IleCys: 0.857 ± 0.013	3.275IleAsp: 3.275 ± 0.024	3.319IleGlu: 3.319 ± 0.024	2.239IlePhe: 2.239 ± 0.018	3.378IleGly: 3.378 ± 0.03	1.367IleHis: 1.367 ± 0.014	3.05IleIle: 3.05 ± 0.028	2.505IleLys: 2.505 ± 0.021	5.251IleLeu: 5.251 ± 0.034	1.108IleMet: 1.108 ± 0.014	2.214IleAsn: 2.214 ± 0.02	3.324IlePro: 3.324 ± 0.026	2.275IleGln: 2.275 ± 0.021	3.204IleArg: 3.204 ± 0.027	4.553IleSer: 4.553 ± 0.027	3.239IleThr: 3.239 ± 0.029	3.359IleVal: 3.359 ± 0.026	0.795IleTrp: 0.795 ± 0.014	1.697IleTyr: 1.697 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.064LysAla: 4.064 ± 0.029	0.546LysCys: 0.546 ± 0.009	2.876LysAsp: 2.876 ± 0.025	3.616LysGlu: 3.616 ± 0.034	1.541LysPhe: 1.541 ± 0.018	2.853LysGly: 2.853 ± 0.023	1.142LysHis: 1.142 ± 0.014	2.665LysIle: 2.665 ± 0.022	3.378LysLys: 3.378 ± 0.035	4.268LysLeu: 4.268 ± 0.029	1.018LysMet: 1.018 ± 0.011	1.979LysAsn: 1.979 ± 0.019	2.582LysPro: 2.582 ± 0.024	1.99LysGln: 1.99 ± 0.022	3.577LysArg: 3.577 ± 0.031	3.695LysSer: 3.695 ± 0.028	2.915LysThr: 2.915 ± 0.022	2.786LysVal: 2.786 ± 0.026	0.719LysTrp: 0.719 ± 0.01	1.517LysTyr: 1.517 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.431LeuAla: 7.431 ± 0.037	1.205LeuCys: 1.205 ± 0.017	5.26LeuAsp: 5.26 ± 0.031	5.615LeuGlu: 5.615 ± 0.033	3.418LeuPhe: 3.418 ± 0.029	5.645LeuGly: 5.645 ± 0.035	2.316LeuHis: 2.316 ± 0.021	4.535LeuIle: 4.535 ± 0.04	4.397LeuLys: 4.397 ± 0.03	8.674LeuLeu: 8.674 ± 0.056	1.792LeuMet: 1.792 ± 0.018	3.503LeuAsn: 3.503 ± 0.026	5.297LeuPro: 5.297 ± 0.038	4.207LeuGln: 4.207 ± 0.034	5.807LeuArg: 5.807 ± 0.039	7.621LeuSer: 7.621 ± 0.043	5.009LeuThr: 5.009 ± 0.031	5.407LeuVal: 5.407 ± 0.039	1.235LeuTrp: 1.235 ± 0.015	2.543LeuTyr: 2.543 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.093MetAla: 2.093 ± 0.019	0.23MetCys: 0.23 ± 0.006	1.225MetAsp: 1.225 ± 0.015	1.293MetGlu: 1.293 ± 0.014	0.706MetPhe: 0.706 ± 0.009	1.362MetGly: 1.362 ± 0.017	0.475MetHis: 0.475 ± 0.009	1.119MetIle: 1.119 ± 0.016	1.019MetLys: 1.019 ± 0.012	1.825MetLeu: 1.825 ± 0.019	0.532MetMet: 0.532 ± 0.01	0.836MetAsn: 0.836 ± 0.014	1.142MetPro: 1.142 ± 0.016	0.816MetGln: 0.816 ± 0.014	1.175MetArg: 1.175 ± 0.013	1.794MetSer: 1.794 ± 0.017	1.37MetThr: 1.37 ± 0.014	1.228MetVal: 1.228 ± 0.013	0.257MetTrp: 0.257 ± 0.007	0.518MetTyr: 0.518 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.204AsnAla: 3.204 ± 0.027	0.493AsnCys: 0.493 ± 0.01	2.186AsnAsp: 2.186 ± 0.021	2.349AsnGlu: 2.349 ± 0.022	1.464AsnPhe: 1.464 ± 0.016	3.049AsnGly: 3.049 ± 0.026	0.979AsnHis: 0.979 ± 0.014	2.459AsnIle: 2.459 ± 0.022	1.812AsnLys: 1.812 ± 0.018	3.515AsnLeu: 3.515 ± 0.025	0.891AsnMet: 0.891 ± 0.011	1.905AsnAsn: 1.905 ± 0.022	2.512AsnPro: 2.512 ± 0.022	1.56AsnGln: 1.56 ± 0.018	2.175AsnArg: 2.175 ± 0.02	3.047AsnSer: 3.047 ± 0.023	2.498AsnThr: 2.498 ± 0.021	2.427AsnVal: 2.427 ± 0.022	0.612AsnTrp: 0.612 ± 0.009	1.187AsnTyr: 1.187 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.301ProAla: 4.301 ± 0.04	0.491ProCys: 0.491 ± 0.009	3.04ProAsp: 3.04 ± 0.025	3.746ProGlu: 3.746 ± 0.036	2.005ProPhe: 2.005 ± 0.019	3.49ProGly: 3.49 ± 0.027	1.236ProHis: 1.236 ± 0.015	2.691ProIle: 2.691 ± 0.024	2.534ProLys: 2.534 ± 0.024	4.665ProLeu: 4.665 ± 0.032	0.957ProMet: 0.957 ± 0.012	2.181ProAsn: 2.181 ± 0.019	4.369ProPro: 4.369 ± 0.053	2.304ProGln: 2.304 ± 0.026	3.17ProArg: 3.17 ± 0.027	5.567ProSer: 5.567 ± 0.043	3.741ProThr: 3.741 ± 0.032	3.327ProVal: 3.327 ± 0.028	0.718ProTrp: 0.718 ± 0.012	1.523ProTyr: 1.523 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.413GlnAla: 3.413 ± 0.028	0.46GlnCys: 0.46 ± 0.01	2.042GlnAsp: 2.042 ± 0.02	2.56GlnGlu: 2.56 ± 0.021	1.384GlnPhe: 1.384 ± 0.014	2.406GlnGly: 2.406 ± 0.025	1.087GlnHis: 1.087 ± 0.013	2.247GlnIle: 2.247 ± 0.022	2.209GlnLys: 2.209 ± 0.023	3.656GlnLeu: 3.656 ± 0.028	0.876GlnMet: 0.876 ± 0.013	1.764GlnAsn: 1.764 ± 0.018	2.41GlnPro: 2.41 ± 0.026	2.557GlnGln: 2.557 ± 0.037	2.721GlnArg: 2.721 ± 0.022	3.278GlnSer: 3.278 ± 0.027	2.452GlnThr: 2.452 ± 0.022	2.143GlnVal: 2.143 ± 0.02	0.6GlnTrp: 0.6 ± 0.01	1.326GlnTyr: 1.326 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.427ArgAla: 4.427 ± 0.028	0.7ArgCys: 0.7 ± 0.012	3.278ArgAsp: 3.278 ± 0.029	3.815ArgGlu: 3.815 ± 0.023	2.145ArgPhe: 2.145 ± 0.02	3.429ArgGly: 3.429 ± 0.029	1.586ArgHis: 1.586 ± 0.017	3.232ArgIle: 3.232 ± 0.025	3.543ArgLys: 3.543 ± 0.03	5.685ArgLeu: 5.685 ± 0.033	1.222ArgMet: 1.222 ± 0.016	2.433ArgAsn: 2.433 ± 0.021	3.148ArgPro: 3.148 ± 0.028	2.72ArgGln: 2.72 ± 0.023	4.972ArgArg: 4.972 ± 0.04	4.644ArgSer: 4.644 ± 0.035	3.327ArgThr: 3.327 ± 0.027	3.302ArgVal: 3.302 ± 0.022	0.938ArgTrp: 0.938 ± 0.014	1.782ArgTyr: 1.782 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.149SerAla: 6.149 ± 0.043	0.852SerCys: 0.852 ± 0.013	4.261SerAsp: 4.261 ± 0.028	4.237SerGlu: 4.237 ± 0.032	3.096SerPhe: 3.096 ± 0.026	5.274SerGly: 5.274 ± 0.034	2.008SerHis: 2.008 ± 0.02	4.436SerIle: 4.436 ± 0.027	3.896SerLys: 3.896 ± 0.027	7.391SerLeu: 7.391 ± 0.04	1.701SerMet: 1.701 ± 0.017	3.326SerAsn: 3.326 ± 0.024	5.103SerPro: 5.103 ± 0.049	3.495SerGln: 3.495 ± 0.031	5.025SerArg: 5.025 ± 0.034	8.957SerSer: 8.957 ± 0.07	5.922SerThr: 5.922 ± 0.039	4.615SerVal: 4.615 ± 0.03	1.107SerTrp: 1.107 ± 0.015	2.259SerTyr: 2.259 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.143ThrAla: 5.143 ± 0.033	0.736ThrCys: 0.736 ± 0.012	2.914ThrAsp: 2.914 ± 0.023	3.359ThrGlu: 3.359 ± 0.031	2.242ThrPhe: 2.242 ± 0.02	4.178ThrGly: 4.178 ± 0.032	1.292ThrHis: 1.292 ± 0.014	3.469ThrIle: 3.469 ± 0.028	2.787ThrLys: 2.787 ± 0.028	5.359ThrLeu: 5.359 ± 0.034	1.193ThrMet: 1.193 ± 0.014	2.4ThrAsn: 2.4 ± 0.021	4.065ThrPro: 4.065 ± 0.034	2.222ThrGln: 2.222 ± 0.019	3.117ThrArg: 3.117 ± 0.023	5.535ThrSer: 5.535 ± 0.037	4.79ThrThr: 4.79 ± 0.046	3.873ThrVal: 3.873 ± 0.029	0.883ThrTrp: 0.883 ± 0.012	1.713ThrTyr: 1.713 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.809ValAla: 4.809 ± 0.033	0.774ValCys: 0.774 ± 0.012	3.562ValAsp: 3.562 ± 0.027	3.692ValGlu: 3.692 ± 0.026	2.39ValPhe: 2.39 ± 0.021	3.67ValGly: 3.67 ± 0.028	1.396ValHis: 1.396 ± 0.017	3.373ValIle: 3.373 ± 0.028	2.916ValLys: 2.916 ± 0.025	5.544ValLeu: 5.544 ± 0.033	1.258ValMet: 1.258 ± 0.015	2.442ValAsn: 2.442 ± 0.023	3.379ValPro: 3.379 ± 0.024	2.432ValGln: 2.432 ± 0.022	3.318ValArg: 3.318 ± 0.024	4.634ValSer: 4.634 ± 0.033	3.602ValThr: 3.602 ± 0.028	4.099ValVal: 4.099 ± 0.033	0.802ValTrp: 0.802 ± 0.012	1.757ValTyr: 1.757 ± 0.018	0.001ValXaa: 0.001 ± 0.0
Trp	1.095TrpAla: 1.095 ± 0.014	0.18TrpCys: 0.18 ± 0.005	0.872TrpAsp: 0.872 ± 0.013	0.827TrpGlu: 0.827 ± 0.012	0.549TrpPhe: 0.549 ± 0.01	0.828TrpGly: 0.828 ± 0.012	0.359TrpHis: 0.359 ± 0.008	0.897TrpIle: 0.897 ± 0.015	0.857TrpLys: 0.857 ± 0.011	1.385TrpLeu: 1.385 ± 0.016	0.355TrpMet: 0.355 ± 0.007	0.687TrpAsn: 0.687 ± 0.011	0.607TrpPro: 0.607 ± 0.01	0.593TrpGln: 0.593 ± 0.01	0.955TrpArg: 0.955 ± 0.014	1.054TrpSer: 1.054 ± 0.015	0.891TrpThr: 0.891 ± 0.013	0.919TrpVal: 0.919 ± 0.013	0.271TrpTrp: 0.271 ± 0.007	0.455TrpTyr: 0.455 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.185TyrAla: 2.185 ± 0.017	0.425TyrCys: 0.425 ± 0.007	1.691TyrAsp: 1.691 ± 0.018	1.688TyrGlu: 1.688 ± 0.019	1.23TyrPhe: 1.23 ± 0.016	2.139TyrGly: 2.139 ± 0.024	0.815TyrHis: 0.815 ± 0.01	1.694TyrIle: 1.694 ± 0.016	1.275TyrLys: 1.275 ± 0.015	2.829TyrLeu: 2.829 ± 0.024	0.649TyrMet: 0.649 ± 0.01	1.318TyrAsn: 1.318 ± 0.018	1.545TyrPro: 1.545 ± 0.017	1.208TyrGln: 1.208 ± 0.015	1.715TyrArg: 1.715 ± 0.016	2.167TyrSer: 2.167 ± 0.017	1.734TyrThr: 1.734 ± 0.017	1.676TyrVal: 1.676 ± 0.019	0.457TyrTrp: 0.457 ± 0.01	1.054TyrTyr: 1.054 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.001

Statistics based on 13021 proteins (6264805 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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