Amino acid dipepetide frequency for Hirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.983AlaAla: 10.983 ± 0.143	1.122AlaCys: 1.122 ± 0.035	5.802AlaAsp: 5.802 ± 0.081	6.408AlaGlu: 6.408 ± 0.102	4.2AlaPhe: 4.2 ± 0.061	7.798AlaGly: 7.798 ± 0.113	1.853AlaHis: 1.853 ± 0.041	6.396AlaIle: 6.396 ± 0.088	5.023AlaLys: 5.023 ± 0.087	10.267AlaLeu: 10.267 ± 0.114	2.862AlaMet: 2.862 ± 0.054	3.792AlaAsn: 3.792 ± 0.063	4.371AlaPro: 4.371 ± 0.078	3.844AlaGln: 3.844 ± 0.058	5.257AlaArg: 5.257 ± 0.073	6.624AlaSer: 6.624 ± 0.084	4.874AlaThr: 4.874 ± 0.086	6.329AlaVal: 6.329 ± 0.092	1.145AlaTrp: 1.145 ± 0.036	2.513AlaTyr: 2.513 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.938CysAla: 0.938 ± 0.031	0.109CysCys: 0.109 ± 0.012	0.579CysAsp: 0.579 ± 0.026	0.532CysGlu: 0.532 ± 0.025	0.411CysPhe: 0.411 ± 0.021	0.769CysGly: 0.769 ± 0.029	0.205CysHis: 0.205 ± 0.013	0.486CysIle: 0.486 ± 0.021	0.316CysLys: 0.316 ± 0.017	0.873CysLeu: 0.873 ± 0.034	0.186CysMet: 0.186 ± 0.012	0.28CysAsn: 0.28 ± 0.018	0.402CysPro: 0.402 ± 0.022	0.271CysGln: 0.271 ± 0.017	0.43CysArg: 0.43 ± 0.022	0.596CysSer: 0.596 ± 0.023	0.42CysThr: 0.42 ± 0.022	0.719CysVal: 0.719 ± 0.024	0.098CysTrp: 0.098 ± 0.011	0.22CysTyr: 0.22 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.336AspAla: 6.336 ± 0.088	0.457AspCys: 0.457 ± 0.021	3.565AspAsp: 3.565 ± 0.068	4.255AspGlu: 4.255 ± 0.088	2.497AspPhe: 2.497 ± 0.047	4.93AspGly: 4.93 ± 0.084	1.137AspHis: 1.137 ± 0.036	4.075AspIle: 4.075 ± 0.058	2.781AspLys: 2.781 ± 0.059	5.967AspLeu: 5.967 ± 0.071	1.638AspMet: 1.638 ± 0.041	2.058AspAsn: 2.058 ± 0.046	2.723AspPro: 2.723 ± 0.054	1.969AspGln: 1.969 ± 0.041	3.052AspArg: 3.052 ± 0.057	2.906AspSer: 2.906 ± 0.055	3.145AspThr: 3.145 ± 0.057	4.534AspVal: 4.534 ± 0.086	1.019AspTrp: 1.019 ± 0.028	1.715AspTyr: 1.715 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.236GluAla: 7.236 ± 0.133	0.4GluCys: 0.4 ± 0.021	3.785GluAsp: 3.785 ± 0.068	4.511GluGlu: 4.511 ± 0.089	2.47GluPhe: 2.47 ± 0.053	4.473GluGly: 4.473 ± 0.072	1.304GluHis: 1.304 ± 0.04	4.455GluIle: 4.455 ± 0.061	3.717GluLys: 3.717 ± 0.067	5.913GluLeu: 5.913 ± 0.073	1.799GluMet: 1.799 ± 0.042	3.212GluAsn: 3.212 ± 0.06	2.296GluPro: 2.296 ± 0.05	2.273GluGln: 2.273 ± 0.049	3.833GluArg: 3.833 ± 0.075	3.067GluSer: 3.067 ± 0.054	4.315GluThr: 4.315 ± 0.07	4.075GluVal: 4.075 ± 0.067	0.857GluTrp: 0.857 ± 0.027	1.591GluTyr: 1.591 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	4.089PheAla: 4.089 ± 0.072	0.445PheCys: 0.445 ± 0.02	3.042PheAsp: 3.042 ± 0.055	2.839PheGlu: 2.839 ± 0.048	1.696PhePhe: 1.696 ± 0.055	3.62PheGly: 3.62 ± 0.072	0.724PheHis: 0.724 ± 0.027	2.394PheIle: 2.394 ± 0.057	1.81PheLys: 1.81 ± 0.04	3.607PheLeu: 3.607 ± 0.066	1.011PheMet: 1.011 ± 0.035	1.557PheAsn: 1.557 ± 0.044	1.487PhePro: 1.487 ± 0.038	1.202PheGln: 1.202 ± 0.036	1.684PheArg: 1.684 ± 0.041	3.113PheSer: 3.113 ± 0.057	2.135PheThr: 2.135 ± 0.049	2.833PheVal: 2.833 ± 0.051	0.56PheTrp: 0.56 ± 0.026	1.025PheTyr: 1.025 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.371GlyAla: 7.371 ± 0.092	0.771GlyCys: 0.771 ± 0.031	4.371GlyAsp: 4.371 ± 0.076	4.76GlyGlu: 4.76 ± 0.07	3.56GlyPhe: 3.56 ± 0.062	6.271GlyGly: 6.271 ± 0.114	1.592GlyHis: 1.592 ± 0.04	4.432GlyIle: 4.432 ± 0.073	3.753GlyLys: 3.753 ± 0.059	7.594GlyLeu: 7.594 ± 0.088	2.078GlyMet: 2.078 ± 0.049	2.557GlyAsn: 2.557 ± 0.056	2.828GlyPro: 2.828 ± 0.058	2.609GlyGln: 2.609 ± 0.047	4.174GlyArg: 4.174 ± 0.078	4.317GlySer: 4.317 ± 0.074	3.434GlyThr: 3.434 ± 0.064	6.054GlyVal: 6.054 ± 0.082	1.179GlyTrp: 1.179 ± 0.036	2.259GlyTyr: 2.259 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.85HisAla: 1.85 ± 0.039	0.23HisCys: 0.23 ± 0.015	1.112HisAsp: 1.112 ± 0.032	1.069HisGlu: 1.069 ± 0.033	0.879HisPhe: 0.879 ± 0.027	1.51HisGly: 1.51 ± 0.044	0.422HisHis: 0.422 ± 0.024	1.238HisIle: 1.238 ± 0.035	0.799HisLys: 0.799 ± 0.027	1.791HisLeu: 1.791 ± 0.048	0.546HisMet: 0.546 ± 0.021	0.68HisAsn: 0.68 ± 0.026	1.087HisPro: 1.087 ± 0.033	0.636HisGln: 0.636 ± 0.025	0.952HisArg: 0.952 ± 0.033	1.193HisSer: 1.193 ± 0.037	1.002HisThr: 1.002 ± 0.028	1.224HisVal: 1.224 ± 0.035	0.302HisTrp: 0.302 ± 0.017	0.572HisTyr: 0.572 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.103IleAla: 7.103 ± 0.076	0.652IleCys: 0.652 ± 0.023	4.215IleAsp: 4.215 ± 0.072	4.752IleGlu: 4.752 ± 0.078	2.251IlePhe: 2.251 ± 0.052	5.072IleGly: 5.072 ± 0.094	1.063IleHis: 1.063 ± 0.036	3.517IleIle: 3.517 ± 0.066	2.649IleLys: 2.649 ± 0.053	5.54IleLeu: 5.54 ± 0.08	1.385IleMet: 1.385 ± 0.034	2.234IleAsn: 2.234 ± 0.055	2.774IlePro: 2.774 ± 0.058	1.886IleGln: 1.886 ± 0.042	2.89IleArg: 2.89 ± 0.051	4.735IleSer: 4.735 ± 0.076	3.109IleThr: 3.109 ± 0.05	4.401IleVal: 4.401 ± 0.069	0.773IleTrp: 0.773 ± 0.026	1.526IleTyr: 1.526 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.018LysAla: 5.018 ± 0.081	0.31LysCys: 0.31 ± 0.02	2.861LysAsp: 2.861 ± 0.063	2.933LysGlu: 2.933 ± 0.057	1.688LysPhe: 1.688 ± 0.043	3.077LysGly: 3.077 ± 0.056	0.982LysHis: 0.982 ± 0.032	3.034LysIle: 3.034 ± 0.057	2.704LysLys: 2.704 ± 0.061	4.856LysLeu: 4.856 ± 0.072	1.306LysMet: 1.306 ± 0.038	1.971LysAsn: 1.971 ± 0.042	2.46LysPro: 2.46 ± 0.054	1.739LysGln: 1.739 ± 0.044	2.805LysArg: 2.805 ± 0.053	3.506LysSer: 3.506 ± 0.057	3.043LysThr: 3.043 ± 0.051	2.986LysVal: 2.986 ± 0.056	0.629LysTrp: 0.629 ± 0.027	1.179LysTyr: 1.179 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	9.846LeuAla: 9.846 ± 0.124	0.798LeuCys: 0.798 ± 0.029	5.733LeuAsp: 5.733 ± 0.087	6.397LeuGlu: 6.397 ± 0.09	3.598LeuPhe: 3.598 ± 0.072	7.141LeuGly: 7.141 ± 0.098	1.695LeuHis: 1.695 ± 0.043	5.867LeuIle: 5.867 ± 0.082	5.23LeuLys: 5.23 ± 0.075	7.905LeuLeu: 7.905 ± 0.119	2.325LeuMet: 2.325 ± 0.049	3.968LeuAsn: 3.968 ± 0.06	4.422LeuPro: 4.422 ± 0.067	2.939LeuGln: 2.939 ± 0.05	4.752LeuArg: 4.752 ± 0.07	7.327LeuSer: 7.327 ± 0.088	5.306LeuThr: 5.306 ± 0.074	6.04LeuVal: 6.04 ± 0.096	0.977LeuTrp: 0.977 ± 0.033	2.067LeuTyr: 2.067 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.599MetAla: 2.599 ± 0.057	0.205MetCys: 0.205 ± 0.014	1.399MetAsp: 1.399 ± 0.035	1.351MetGlu: 1.351 ± 0.035	0.867MetPhe: 0.867 ± 0.028	1.942MetGly: 1.942 ± 0.045	0.515MetHis: 0.515 ± 0.024	1.465MetIle: 1.465 ± 0.042	1.386MetLys: 1.386 ± 0.034	2.339MetLeu: 2.339 ± 0.054	0.727MetMet: 0.727 ± 0.031	1.015MetAsn: 1.015 ± 0.027	1.34MetPro: 1.34 ± 0.037	0.978MetGln: 0.978 ± 0.031	1.619MetArg: 1.619 ± 0.039	2.131MetSer: 2.131 ± 0.049	1.752MetThr: 1.752 ± 0.043	1.54MetVal: 1.54 ± 0.037	0.242MetTrp: 0.242 ± 0.013	0.376MetTyr: 0.376 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	4.087AsnAla: 4.087 ± 0.066	0.344AsnCys: 0.344 ± 0.019	2.205AsnAsp: 2.205 ± 0.046	2.173AsnGlu: 2.173 ± 0.049	1.573AsnPhe: 1.573 ± 0.046	3.126AsnGly: 3.126 ± 0.058	0.708AsnHis: 0.708 ± 0.03	2.497AsnIle: 2.497 ± 0.056	1.698AsnLys: 1.698 ± 0.042	3.628AsnLeu: 3.628 ± 0.062	0.964AsnMet: 0.964 ± 0.032	1.437AsnAsn: 1.437 ± 0.04	1.972AsnPro: 1.972 ± 0.038	1.306AsnGln: 1.306 ± 0.033	1.848AsnArg: 1.848 ± 0.04	2.489AsnSer: 2.489 ± 0.059	2.071AsnThr: 2.071 ± 0.049	2.611AsnVal: 2.611 ± 0.051	0.663AsnTrp: 0.663 ± 0.025	1.131AsnTyr: 1.131 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.966ProAla: 3.966 ± 0.069	0.288ProCys: 0.288 ± 0.015	3.265ProAsp: 3.265 ± 0.056	3.689ProGlu: 3.689 ± 0.067	1.98ProPhe: 1.98 ± 0.048	2.785ProGly: 2.785 ± 0.057	0.905ProHis: 0.905 ± 0.032	2.897ProIle: 2.897 ± 0.048	2.262ProLys: 2.262 ± 0.052	3.756ProLeu: 3.756 ± 0.063	1.038ProMet: 1.038 ± 0.033	1.915ProAsn: 1.915 ± 0.045	1.894ProPro: 1.894 ± 0.067	1.467ProGln: 1.467 ± 0.04	1.867ProArg: 1.867 ± 0.039	2.919ProSer: 2.919 ± 0.052	2.415ProThr: 2.415 ± 0.048	3.213ProVal: 3.213 ± 0.054	0.543ProTrp: 0.543 ± 0.026	1.172ProTyr: 1.172 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.71GlnAla: 3.71 ± 0.07	0.238GlnCys: 0.238 ± 0.019	1.847GlnAsp: 1.847 ± 0.05	1.999GlnGlu: 1.999 ± 0.046	1.364GlnPhe: 1.364 ± 0.036	2.12GlnGly: 2.12 ± 0.047	0.68GlnHis: 0.68 ± 0.024	2.47GlnIle: 2.47 ± 0.052	1.807GlnLys: 1.807 ± 0.046	3.115GlnLeu: 3.115 ± 0.054	0.997GlnMet: 0.997 ± 0.031	1.491GlnAsn: 1.491 ± 0.038	1.387GlnPro: 1.387 ± 0.039	1.204GlnGln: 1.204 ± 0.038	1.949GlnArg: 1.949 ± 0.048	2.53GlnSer: 2.53 ± 0.052	2.248GlnThr: 2.248 ± 0.045	2.022GlnVal: 2.022 ± 0.045	0.41GlnTrp: 0.41 ± 0.02	0.803GlnTyr: 0.803 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.092ArgAla: 5.092 ± 0.074	0.396ArgCys: 0.396 ± 0.023	2.978ArgAsp: 2.978 ± 0.056	3.391ArgGlu: 3.391 ± 0.061	2.316ArgPhe: 2.316 ± 0.05	3.283ArgGly: 3.283 ± 0.064	1.062ArgHis: 1.062 ± 0.034	3.427ArgIle: 3.427 ± 0.062	2.517ArgLys: 2.517 ± 0.056	5.468ArgLeu: 5.468 ± 0.081	1.46ArgMet: 1.46 ± 0.035	1.863ArgAsn: 1.863 ± 0.045	2.298ArgPro: 2.298 ± 0.042	1.953ArgGln: 1.953 ± 0.047	3.159ArgArg: 3.159 ± 0.071	3.085ArgSer: 3.085 ± 0.058	2.565ArgThr: 2.565 ± 0.047	3.552ArgVal: 3.552 ± 0.066	0.644ArgTrp: 0.644 ± 0.022	1.524ArgTyr: 1.524 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.314SerAla: 6.314 ± 0.083	0.537SerCys: 0.537 ± 0.022	4.153SerAsp: 4.153 ± 0.065	4.228SerGlu: 4.228 ± 0.067	2.806SerPhe: 2.806 ± 0.055	5.493SerGly: 5.493 ± 0.079	1.223SerHis: 1.223 ± 0.038	4.234SerIle: 4.234 ± 0.067	3.359SerLys: 3.359 ± 0.065	6.31SerLeu: 6.31 ± 0.079	1.687SerMet: 1.687 ± 0.043	2.637SerAsn: 2.637 ± 0.056	3.021SerPro: 3.021 ± 0.058	2.449SerGln: 2.449 ± 0.048	3.29SerArg: 3.29 ± 0.055	4.596SerSer: 4.596 ± 0.078	3.41SerThr: 3.41 ± 0.054	4.531SerVal: 4.531 ± 0.062	0.825SerTrp: 0.825 ± 0.023	1.746SerTyr: 1.746 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	5.024ThrAla: 5.024 ± 0.081	0.454ThrCys: 0.454 ± 0.024	3.139ThrAsp: 3.139 ± 0.059	3.026ThrGlu: 3.026 ± 0.056	2.119ThrPhe: 2.119 ± 0.044	4.667ThrGly: 4.667 ± 0.063	1.155ThrHis: 1.155 ± 0.036	3.437ThrIle: 3.437 ± 0.06	2.386ThrLys: 2.386 ± 0.045	5.399ThrLeu: 5.399 ± 0.08	1.121ThrMet: 1.121 ± 0.033	2.004ThrAsn: 2.004 ± 0.045	3.341ThrPro: 3.341 ± 0.071	2.118ThrGln: 2.118 ± 0.05	2.539ThrArg: 2.539 ± 0.048	3.796ThrSer: 3.796 ± 0.061	2.939ThrThr: 2.939 ± 0.062	3.299ThrVal: 3.299 ± 0.065	0.534ThrTrp: 0.534 ± 0.024	1.478ThrTyr: 1.478 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	6.306ValAla: 6.306 ± 0.09	0.696ValCys: 0.696 ± 0.023	4.275ValAsp: 4.275 ± 0.073	4.933ValGlu: 4.933 ± 0.1	3.009ValPhe: 3.009 ± 0.061	4.884ValGly: 4.884 ± 0.07	1.142ValHis: 1.142 ± 0.029	4.124ValIle: 4.124 ± 0.059	3.083ValLys: 3.083 ± 0.065	6.245ValLeu: 6.245 ± 0.076	1.736ValMet: 1.736 ± 0.041	2.395ValAsn: 2.395 ± 0.052	2.484ValPro: 2.484 ± 0.051	2.113ValGln: 2.113 ± 0.046	3.604ValArg: 3.604 ± 0.063	5.252ValSer: 5.252 ± 0.084	3.731ValThr: 3.731 ± 0.072	4.831ValVal: 4.831 ± 0.079	0.845ValTrp: 0.845 ± 0.032	1.628ValTyr: 1.628 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.088TrpAla: 1.088 ± 0.036	0.133TrpCys: 0.133 ± 0.011	0.664TrpAsp: 0.664 ± 0.027	0.663TrpGlu: 0.663 ± 0.025	0.525TrpPhe: 0.525 ± 0.025	0.897TrpGly: 0.897 ± 0.031	0.254TrpHis: 0.254 ± 0.014	0.781TrpIle: 0.781 ± 0.03	0.725TrpLys: 0.725 ± 0.03	1.326TrpLeu: 1.326 ± 0.034	0.355TrpMet: 0.355 ± 0.024	0.536TrpAsn: 0.536 ± 0.021	0.565TrpPro: 0.565 ± 0.022	0.475TrpGln: 0.475 ± 0.023	0.941TrpArg: 0.941 ± 0.033	0.904TrpSer: 0.904 ± 0.029	0.72TrpThr: 0.72 ± 0.029	0.786TrpVal: 0.786 ± 0.03	0.194TrpTrp: 0.194 ± 0.012	0.281TrpTyr: 0.281 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.508TyrAla: 2.508 ± 0.05	0.253TyrCys: 0.253 ± 0.015	1.771TyrAsp: 1.771 ± 0.045	1.676TyrGlu: 1.676 ± 0.047	1.064TyrPhe: 1.064 ± 0.035	2.105TyrGly: 2.105 ± 0.043	0.471TyrHis: 0.471 ± 0.023	1.301TyrIle: 1.301 ± 0.041	1.083TyrLys: 1.083 ± 0.029	2.435TyrLeu: 2.435 ± 0.049	0.567TyrMet: 0.567 ± 0.024	0.93TyrAsn: 0.93 ± 0.03	1.086TyrPro: 1.086 ± 0.035	0.957TyrGln: 0.957 ± 0.032	1.387TyrArg: 1.387 ± 0.036	1.762TyrSer: 1.762 ± 0.036	1.342TyrThr: 1.342 ± 0.037	1.736TyrVal: 1.736 ± 0.043	0.371TyrTrp: 0.371 ± 0.019	0.74TyrTyr: 0.74 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3187 proteins (1051554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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