Amino acid dipepetide frequency for Mycoplasma ovis str. Michigan

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.052AlaAla: 1.052 ± 0.107
0.624AlaCys: 0.624 ± 0.054
1.45AlaAsp: 1.45 ± 0.097
2.719AlaGlu: 2.719 ± 0.14
2.043AlaPhe: 2.043 ± 0.115
3.002AlaGly: 3.002 ± 0.134
0.624AlaHis: 0.624 ± 0.061
3.709AlaIle: 3.709 ± 0.158
3.988AlaLys: 3.988 ± 0.126
4.467AlaLeu: 4.467 ± 0.157
0.614AlaMet: 0.614 ± 0.06
1.893AlaAsn: 1.893 ± 0.095
1.408AlaPro: 1.408 ± 0.09
1.723AlaGln: 1.723 ± 0.087
1.677AlaArg: 1.677 ± 0.099
3.157AlaSer: 3.157 ± 0.116
2.378AlaThr: 2.378 ± 0.127
2.265AlaVal: 2.265 ± 0.126
0.557AlaTrp: 0.557 ± 0.056
1.088AlaTyr: 1.088 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.438CysAla: 0.438 ± 0.047
0.31CysCys: 0.31 ± 0.071
0.382CysAsp: 0.382 ± 0.045
0.743CysGlu: 0.743 ± 0.065
0.805CysPhe: 0.805 ± 0.065
0.671CysGly: 0.671 ± 0.064
0.113CysHis: 0.113 ± 0.024
0.686CysIle: 0.686 ± 0.061
1.46CysLys: 1.46 ± 0.105
1.202CysLeu: 1.202 ± 0.074
0.108CysMet: 0.108 ± 0.02
0.624CysAsn: 0.624 ± 0.045
0.454CysPro: 0.454 ± 0.051
0.511CysGln: 0.511 ± 0.05
0.418CysArg: 0.418 ± 0.057
1.259CysSer: 1.259 ± 0.075
0.537CysThr: 0.537 ± 0.048
0.526CysVal: 0.526 ± 0.052
0.15CysTrp: 0.15 ± 0.024
0.413CysTyr: 0.413 ± 0.045
0.0CysXaa: 0.0 ± 0.0
Asp
1.46AspAla: 1.46 ± 0.087
0.743AspCys: 0.743 ± 0.063
1.697AspAsp: 1.697 ± 0.094
3.038AspGlu: 3.038 ± 0.138
2.327AspPhe: 2.327 ± 0.105
2.285AspGly: 2.285 ± 0.131
0.707AspHis: 0.707 ± 0.064
2.966AspIle: 2.966 ± 0.12
4.916AspLys: 4.916 ± 0.166
5.556AspLeu: 5.556 ± 0.198
0.665AspMet: 0.665 ± 0.056
2.708AspAsn: 2.708 ± 0.115
1.238AspPro: 1.238 ± 0.081
1.934AspGln: 1.934 ± 0.106
1.604AspArg: 1.604 ± 0.089
4.71AspSer: 4.71 ± 0.175
1.537AspThr: 1.537 ± 0.089
2.033AspVal: 2.033 ± 0.104
1.264AspTrp: 1.264 ± 0.093
2.192AspTyr: 2.192 ± 0.093
0.0AspXaa: 0.0 ± 0.0
Glu
2.977GluAla: 2.977 ± 0.133
0.769GluCys: 0.769 ± 0.058
4.055GluAsp: 4.055 ± 0.131
7.635GluGlu: 7.635 ± 0.234
3.028GluPhe: 3.028 ± 0.122
4.199GluGly: 4.199 ± 0.149
1.001GluHis: 1.001 ± 0.068
6.753GluIle: 6.753 ± 0.22
9.219GluLys: 9.219 ± 0.261
8.801GluLeu: 8.801 ± 0.229
1.145GluMet: 1.145 ± 0.084
4.607GluAsn: 4.607 ± 0.138
1.444GluPro: 1.444 ± 0.098
3.162GluGln: 3.162 ± 0.122
3.044GluArg: 3.044 ± 0.14
5.241GluSer: 5.241 ± 0.181
3.41GluThr: 3.41 ± 0.132
4.06GluVal: 4.06 ± 0.198
1.207GluTrp: 1.207 ± 0.081
2.192GluTyr: 2.192 ± 0.118
0.0GluXaa: 0.0 ± 0.0
Phe
2.182PheAla: 2.182 ± 0.118
0.691PheCys: 0.691 ± 0.059
2.347PheAsp: 2.347 ± 0.108
3.193PheGlu: 3.193 ± 0.14
3.332PhePhe: 3.332 ± 0.16
2.904PheGly: 2.904 ± 0.139
0.707PheHis: 0.707 ± 0.06
3.085PheIle: 3.085 ± 0.14
4.834PheLys: 4.834 ± 0.177
6.65PheLeu: 6.65 ± 0.223
0.702PheMet: 0.702 ± 0.055
3.023PheAsn: 3.023 ± 0.119
2.012PhePro: 2.012 ± 0.096
1.857PheGln: 1.857 ± 0.103
1.625PheArg: 1.625 ± 0.089
5.793PheSer: 5.793 ± 0.168
2.244PheThr: 2.244 ± 0.107
2.471PheVal: 2.471 ± 0.126
0.985PheTrp: 0.985 ± 0.075
2.115PheTyr: 2.115 ± 0.105
0.0PheXaa: 0.0 ± 0.0
Gly
2.909GlyAla: 2.909 ± 0.133
0.686GlyCys: 0.686 ± 0.048
2.858GlyAsp: 2.858 ± 0.129
4.426GlyGlu: 4.426 ± 0.167
2.683GlyPhe: 2.683 ± 0.114
5.344GlyGly: 5.344 ± 0.235
0.784GlyHis: 0.784 ± 0.056
4.529GlyIle: 4.529 ± 0.133
5.257GlyLys: 5.257 ± 0.188
4.89GlyLeu: 4.89 ± 0.193
0.753GlyMet: 0.753 ± 0.06
3.018GlyAsn: 3.018 ± 0.127
1.016GlyPro: 1.016 ± 0.074
2.11GlyGln: 2.11 ± 0.106
2.203GlyArg: 2.203 ± 0.114
4.705GlySer: 4.705 ± 0.184
2.956GlyThr: 2.956 ± 0.132
3.627GlyVal: 3.627 ± 0.162
1.058GlyTrp: 1.058 ± 0.079
1.635GlyTyr: 1.635 ± 0.094
0.0GlyXaa: 0.0 ± 0.0
His
0.402HisAla: 0.402 ± 0.045
0.124HisCys: 0.124 ± 0.025
0.366HisAsp: 0.366 ± 0.047
0.681HisGlu: 0.681 ± 0.06
0.965HisPhe: 0.965 ± 0.072
0.588HisGly: 0.588 ± 0.065
0.242HisHis: 0.242 ± 0.034
1.15HisIle: 1.15 ± 0.085
1.424HisLys: 1.424 ± 0.085
1.929HisLeu: 1.929 ± 0.098
0.206HisMet: 0.206 ± 0.036
0.851HisAsn: 0.851 ± 0.063
0.397HisPro: 0.397 ± 0.04
0.531HisGln: 0.531 ± 0.049
0.511HisArg: 0.511 ± 0.052
1.444HisSer: 1.444 ± 0.075
0.583HisThr: 0.583 ± 0.053
0.464HisVal: 0.464 ± 0.053
0.268HisTrp: 0.268 ± 0.039
0.707HisTyr: 0.707 ± 0.057
0.0HisXaa: 0.0 ± 0.0
Ile
3.461IleAla: 3.461 ± 0.141
0.98IleCys: 0.98 ± 0.063
3.219IleAsp: 3.219 ± 0.132
5.107IleGlu: 5.107 ± 0.169
4.54IlePhe: 4.54 ± 0.182
3.946IleGly: 3.946 ± 0.128
1.027IleHis: 1.027 ± 0.075
4.385IleIle: 4.385 ± 0.194
6.861IleLys: 6.861 ± 0.194
6.252IleLeu: 6.252 ± 0.216
1.156IleMet: 1.156 ± 0.08
4.271IleAsn: 4.271 ± 0.159
3.023IlePro: 3.023 ± 0.139
2.667IleGln: 2.667 ± 0.123
2.507IleArg: 2.507 ± 0.116
7.547IleSer: 7.547 ± 0.204
4.055IleThr: 4.055 ± 0.13
4.106IleVal: 4.106 ± 0.167
0.841IleTrp: 0.841 ± 0.062
2.791IleTyr: 2.791 ± 0.142
0.0IleXaa: 0.0 ± 0.0
Lys
3.884LysAla: 3.884 ± 0.146
0.975LysCys: 0.975 ± 0.067
5.834LysAsp: 5.834 ± 0.184
9.982LysGlu: 9.982 ± 0.282
4.395LysPhe: 4.395 ± 0.145
5.019LysGly: 5.019 ± 0.161
1.439LysHis: 1.439 ± 0.096
7.759LysIle: 7.759 ± 0.205
10.472LysLys: 10.472 ± 0.259
10.601LysLeu: 10.601 ± 0.263
1.775LysMet: 1.775 ± 0.098
6.433LysAsn: 6.433 ± 0.201
2.213LysPro: 2.213 ± 0.121
3.59LysGln: 3.59 ± 0.127
3.668LysArg: 3.668 ± 0.14
7.346LysSer: 7.346 ± 0.183
5.169LysThr: 5.169 ± 0.17
5.35LysVal: 5.35 ± 0.169
1.749LysTrp: 1.749 ± 0.104
3.848LysTyr: 3.848 ± 0.142
0.0LysXaa: 0.0 ± 0.0
Leu
4.54LeuAla: 4.54 ± 0.156
0.929LeuCys: 0.929 ± 0.064
5.324LeuAsp: 5.324 ± 0.171
8.94LeuGlu: 8.94 ± 0.265
6.067LeuPhe: 6.067 ± 0.221
6.046LeuGly: 6.046 ± 0.189
1.352LeuHis: 1.352 ± 0.072
8.146LeuIle: 8.146 ± 0.252
11.179LeuLys: 11.179 ± 0.21
9.76LeuLeu: 9.76 ± 0.305
1.651LeuMet: 1.651 ± 0.098
6.288LeuAsn: 6.288 ± 0.211
3.663LeuPro: 3.663 ± 0.145
3.394LeuGln: 3.394 ± 0.132
3.817LeuArg: 3.817 ± 0.14
10.451LeuSer: 10.451 ± 0.244
5.52LeuThr: 5.52 ± 0.176
5.757LeuVal: 5.757 ± 0.184
1.145LeuTrp: 1.145 ± 0.091
2.688LeuTyr: 2.688 ± 0.128
0.0LeuXaa: 0.0 ± 0.0
Met
0.81MetAla: 0.81 ± 0.07
0.119MetCys: 0.119 ± 0.026
0.619MetAsp: 0.619 ± 0.052
0.985MetGlu: 0.985 ± 0.062
0.805MetPhe: 0.805 ± 0.068
1.13MetGly: 1.13 ± 0.086
0.217MetHis: 0.217 ± 0.033
1.223MetIle: 1.223 ± 0.079
1.579MetLys: 1.579 ± 0.097
1.228MetLeu: 1.228 ± 0.071
0.175MetMet: 0.175 ± 0.028
0.908MetAsn: 0.908 ± 0.082
0.593MetPro: 0.593 ± 0.063
0.526MetGln: 0.526 ± 0.051
0.552MetArg: 0.552 ± 0.056
1.548MetSer: 1.548 ± 0.082
0.789MetThr: 0.789 ± 0.058
0.769MetVal: 0.769 ± 0.066
0.191MetTrp: 0.191 ± 0.029
0.516MetTyr: 0.516 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
1.702AsnAla: 1.702 ± 0.094
0.872AsnCys: 0.872 ± 0.073
1.94AsnAsp: 1.94 ± 0.109
2.951AsnGlu: 2.951 ± 0.155
3.332AsnPhe: 3.332 ± 0.115
3.25AsnGly: 3.25 ± 0.218
0.743AsnHis: 0.743 ± 0.063
3.627AsnIle: 3.627 ± 0.141
5.468AsnLys: 5.468 ± 0.163
7.078AsnLeu: 7.078 ± 0.195
1.027AsnMet: 1.027 ± 0.064
3.523AsnAsn: 3.523 ± 0.138
2.265AsnPro: 2.265 ± 0.094
2.486AsnGln: 2.486 ± 0.118
1.836AsnArg: 1.836 ± 0.091
5.85AsnSer: 5.85 ± 0.189
2.404AsnThr: 2.404 ± 0.109
2.486AsnVal: 2.486 ± 0.11
1.367AsnTrp: 1.367 ± 0.099
2.853AsnTyr: 2.853 ± 0.128
0.0AsnXaa: 0.0 ± 0.0
Pro
1.568ProAla: 1.568 ± 0.089
0.242ProCys: 0.242 ± 0.038
1.486ProAsp: 1.486 ± 0.088
2.971ProGlu: 2.971 ± 0.132
1.475ProPhe: 1.475 ± 0.091
0.681ProGly: 0.681 ± 0.068
0.423ProHis: 0.423 ± 0.044
2.435ProIle: 2.435 ± 0.121
3.224ProLys: 3.224 ± 0.126
3.281ProLeu: 3.281 ± 0.135
0.459ProMet: 0.459 ± 0.045
1.718ProAsn: 1.718 ± 0.087
1.212ProPro: 1.212 ± 0.096
1.119ProGln: 1.119 ± 0.081
1.161ProArg: 1.161 ± 0.08
2.724ProSer: 2.724 ± 0.123
1.697ProThr: 1.697 ± 0.09
1.728ProVal: 1.728 ± 0.103
0.438ProTrp: 0.438 ± 0.044
0.975ProTyr: 0.975 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
1.589GlnAla: 1.589 ± 0.089
0.248GlnCys: 0.248 ± 0.034
1.718GlnAsp: 1.718 ± 0.095
3.709GlnGlu: 3.709 ± 0.16
1.434GlnPhe: 1.434 ± 0.079
1.826GlnGly: 1.826 ± 0.1
0.521GlnHis: 0.521 ± 0.051
3.08GlnIle: 3.08 ± 0.165
4.395GlnLys: 4.395 ± 0.172
4.679GlnLeu: 4.679 ± 0.198
0.619GlnMet: 0.619 ± 0.062
1.909GlnAsn: 1.909 ± 0.099
0.939GlnPro: 0.939 ± 0.079
1.749GlnGln: 1.749 ± 0.121
1.326GlnArg: 1.326 ± 0.073
2.569GlnSer: 2.569 ± 0.121
1.826GlnThr: 1.826 ± 0.1
2.146GlnVal: 2.146 ± 0.107
0.459GlnTrp: 0.459 ± 0.05
1.052GlnTyr: 1.052 ± 0.073
0.0GlnXaa: 0.0 ± 0.0
Arg
1.604ArgAla: 1.604 ± 0.092
0.32ArgCys: 0.32 ± 0.04
1.95ArgAsp: 1.95 ± 0.093
3.792ArgGlu: 3.792 ± 0.15
1.522ArgPhe: 1.522 ± 0.107
2.213ArgGly: 2.213 ± 0.127
0.562ArgHis: 0.562 ± 0.049
2.471ArgIle: 2.471 ± 0.124
3.642ArgLys: 3.642 ± 0.136
3.719ArgLeu: 3.719 ± 0.158
0.681ArgMet: 0.681 ± 0.057
1.986ArgAsn: 1.986 ± 0.115
0.815ArgPro: 0.815 ± 0.062
1.171ArgGln: 1.171 ± 0.084
1.429ArgArg: 1.429 ± 0.094
2.321ArgSer: 2.321 ± 0.098
1.671ArgThr: 1.671 ± 0.084
2.1ArgVal: 2.1 ± 0.103
0.64ArgTrp: 0.64 ± 0.055
1.269ArgTyr: 1.269 ± 0.083
0.0ArgXaa: 0.0 ± 0.0
Ser
3.611SerAla: 3.611 ± 0.142
1.181SerCys: 1.181 ± 0.079
3.848SerAsp: 3.848 ± 0.141
6.84SerGlu: 6.84 ± 0.205
5.277SerPhe: 5.277 ± 0.174
5.324SerGly: 5.324 ± 0.157
1.181SerHis: 1.181 ± 0.083
5.994SerIle: 5.994 ± 0.199
8.625SerLys: 8.625 ± 0.219
9.791SerLeu: 9.791 ± 0.233
1.362SerMet: 1.362 ± 0.074
4.978SerAsn: 4.978 ± 0.158
3.033SerPro: 3.033 ± 0.141
3.637SerGln: 3.637 ± 0.14
3.224SerArg: 3.224 ± 0.122
10.054SerSer: 10.054 ± 0.265
4.235SerThr: 4.235 ± 0.172
4.013SerVal: 4.013 ± 0.157
1.666SerTrp: 1.666 ± 0.096
2.879SerTyr: 2.879 ± 0.132
0.0SerXaa: 0.0 ± 0.0
Thr
1.775ThrAla: 1.775 ± 0.102
0.537ThrCys: 0.537 ± 0.052
1.934ThrAsp: 1.934 ± 0.09
3.431ThrGlu: 3.431 ± 0.129
2.254ThrPhe: 2.254 ± 0.124
2.997ThrGly: 2.997 ± 0.149
0.815ThrHis: 0.815 ± 0.064
3.74ThrIle: 3.74 ± 0.138
5.03ThrLys: 5.03 ± 0.155
4.978ThrLeu: 4.978 ± 0.153
0.733ThrMet: 0.733 ± 0.063
2.977ThrAsn: 2.977 ± 0.123
2.089ThrPro: 2.089 ± 0.113
2.131ThrGln: 2.131 ± 0.098
1.589ThrArg: 1.589 ± 0.093
4.509ThrSer: 4.509 ± 0.178
2.961ThrThr: 2.961 ± 0.143
2.543ThrVal: 2.543 ± 0.122
0.671ThrTrp: 0.671 ± 0.063
1.429ThrTyr: 1.429 ± 0.088
0.0ThrXaa: 0.0 ± 0.0
Val
2.822ValAla: 2.822 ± 0.13
0.779ValCys: 0.779 ± 0.059
2.461ValAsp: 2.461 ± 0.128
3.606ValGlu: 3.606 ± 0.146
2.899ValPhe: 2.899 ± 0.114
3.492ValGly: 3.492 ± 0.16
0.65ValHis: 0.65 ± 0.05
3.761ValIle: 3.761 ± 0.143
4.653ValLys: 4.653 ± 0.156
4.988ValLeu: 4.988 ± 0.147
0.702ValMet: 0.702 ± 0.063
2.966ValAsn: 2.966 ± 0.118
1.883ValPro: 1.883 ± 0.093
1.713ValGln: 1.713 ± 0.097
1.522ValArg: 1.522 ± 0.1
4.854ValSer: 4.854 ± 0.171
2.837ValThr: 2.837 ± 0.125
3.425ValVal: 3.425 ± 0.148
0.665ValTrp: 0.665 ± 0.065
1.331ValTyr: 1.331 ± 0.076
0.0ValXaa: 0.0 ± 0.0
Trp
0.588TrpAla: 0.588 ± 0.055
0.124TrpCys: 0.124 ± 0.024
0.841TrpAsp: 0.841 ± 0.064
1.259TrpGlu: 1.259 ± 0.075
1.063TrpPhe: 1.063 ± 0.082
1.037TrpGly: 1.037 ± 0.072
0.181TrpHis: 0.181 ± 0.028
1.321TrpIle: 1.321 ± 0.087
1.852TrpLys: 1.852 ± 0.114
1.568TrpLeu: 1.568 ± 0.097
0.335TrpMet: 0.335 ± 0.041
1.104TrpAsn: 1.104 ± 0.082
0.31TrpPro: 0.31 ± 0.039
0.418TrpGln: 0.418 ± 0.046
0.671TrpArg: 0.671 ± 0.06
1.104TrpSer: 1.104 ± 0.075
1.027TrpThr: 1.027 ± 0.081
0.784TrpVal: 0.784 ± 0.07
0.346TrpTrp: 0.346 ± 0.045
0.433TrpTyr: 0.433 ± 0.051
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.063TyrAla: 1.063 ± 0.078
0.557TyrCys: 0.557 ± 0.048
1.254TyrAsp: 1.254 ± 0.087
1.94TyrGlu: 1.94 ± 0.108
2.507TyrPhe: 2.507 ± 0.118
1.491TyrGly: 1.491 ± 0.088
0.547TyrHis: 0.547 ± 0.06
1.929TyrIle: 1.929 ± 0.104
3.425TyrLys: 3.425 ± 0.117
5.236TyrLeu: 5.236 ± 0.176
0.408TyrMet: 0.408 ± 0.042
1.274TyrAsn: 1.274 ± 0.079
1.011TyrPro: 1.011 ± 0.064
1.362TyrGln: 1.362 ± 0.088
1.496TyrArg: 1.496 ± 0.081
3.57TyrSer: 3.57 ± 0.129
1.285TyrThr: 1.285 ± 0.076
1.357TyrVal: 1.357 ± 0.086
0.696TyrTrp: 0.696 ± 0.067
1.604TyrTyr: 1.604 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 834 proteins (193850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski