Amino acid dipepetide frequency for Marinobacterium lutimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.932AlaAla: 10.932 ± 0.119	1.092AlaCys: 1.092 ± 0.032	5.827AlaAsp: 5.827 ± 0.081	7.238AlaGlu: 7.238 ± 0.089	3.567AlaPhe: 3.567 ± 0.056	8.241AlaGly: 8.241 ± 0.09	1.752AlaHis: 1.752 ± 0.031	5.42AlaIle: 5.42 ± 0.062	3.443AlaLys: 3.443 ± 0.058	12.071AlaLeu: 12.071 ± 0.121	2.854AlaMet: 2.854 ± 0.043	2.931AlaAsn: 2.931 ± 0.047	3.817AlaPro: 3.817 ± 0.056	4.183AlaGln: 4.183 ± 0.057	5.875AlaArg: 5.875 ± 0.065	5.991AlaSer: 5.991 ± 0.071	4.612AlaThr: 4.612 ± 0.077	6.972AlaVal: 6.972 ± 0.07	1.281AlaTrp: 1.281 ± 0.029	2.376AlaTyr: 2.376 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.976CysAla: 0.976 ± 0.031	0.169CysCys: 0.169 ± 0.01	0.615CysAsp: 0.615 ± 0.018	0.65CysGlu: 0.65 ± 0.02	0.384CysPhe: 0.384 ± 0.015	0.999CysGly: 0.999 ± 0.03	0.29CysHis: 0.29 ± 0.016	0.527CysIle: 0.527 ± 0.019	0.29CysLys: 0.29 ± 0.015	0.964CysLeu: 0.964 ± 0.026	0.217CysMet: 0.217 ± 0.011	0.316CysAsn: 0.316 ± 0.015	0.49CysPro: 0.49 ± 0.018	0.348CysGln: 0.348 ± 0.015	0.61CysArg: 0.61 ± 0.024	0.685CysSer: 0.685 ± 0.022	0.469CysThr: 0.469 ± 0.019	0.692CysVal: 0.692 ± 0.024	0.143CysTrp: 0.143 ± 0.009	0.288CysTyr: 0.288 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.482AspAla: 5.482 ± 0.089	0.522AspCys: 0.522 ± 0.02	3.144AspAsp: 3.144 ± 0.073	4.102AspGlu: 4.102 ± 0.06	2.057AspPhe: 2.057 ± 0.033	4.268AspGly: 4.268 ± 0.09	1.199AspHis: 1.199 ± 0.028	3.18AspIle: 3.18 ± 0.048	2.182AspLys: 2.182 ± 0.041	6.136AspLeu: 6.136 ± 0.06	1.4AspMet: 1.4 ± 0.027	1.878AspAsn: 1.878 ± 0.039	2.818AspPro: 2.818 ± 0.046	2.456AspGln: 2.456 ± 0.045	3.376AspArg: 3.376 ± 0.047	3.497AspSer: 3.497 ± 0.059	2.826AspThr: 2.826 ± 0.064	3.419AspVal: 3.419 ± 0.059	0.95AspTrp: 0.95 ± 0.028	1.866AspTyr: 1.866 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.754GluAla: 6.754 ± 0.075	0.502GluCys: 0.502 ± 0.018	2.938GluAsp: 2.938 ± 0.052	4.318GluGlu: 4.318 ± 0.072	2.113GluPhe: 2.113 ± 0.033	4.483GluGly: 4.483 ± 0.055	1.588GluHis: 1.588 ± 0.035	3.649GluIle: 3.649 ± 0.046	2.804GluLys: 2.804 ± 0.048	7.742GluLeu: 7.742 ± 0.084	1.708GluMet: 1.708 ± 0.039	2.048GluAsn: 2.048 ± 0.034	2.778GluPro: 2.778 ± 0.047	4.097GluGln: 4.097 ± 0.065	4.63GluArg: 4.63 ± 0.065	3.664GluSer: 3.664 ± 0.047	3.325GluThr: 3.325 ± 0.041	4.606GluVal: 4.606 ± 0.053	0.798GluTrp: 0.798 ± 0.023	1.616GluTyr: 1.616 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.609PheAla: 3.609 ± 0.043	0.461PheCys: 0.461 ± 0.02	2.711PheAsp: 2.711 ± 0.038	2.276PheGlu: 2.276 ± 0.034	1.455PhePhe: 1.455 ± 0.035	3.26PheGly: 3.26 ± 0.051	0.745PheHis: 0.745 ± 0.022	2.069PheIle: 2.069 ± 0.04	1.291PheLys: 1.291 ± 0.029	3.197PheLeu: 3.197 ± 0.052	0.926PheMet: 0.926 ± 0.024	1.46PheAsn: 1.46 ± 0.029	1.462PhePro: 1.462 ± 0.031	1.131PheGln: 1.131 ± 0.026	1.92PheArg: 1.92 ± 0.037	2.759PheSer: 2.759 ± 0.046	1.967PheThr: 1.967 ± 0.031	2.499PheVal: 2.499 ± 0.048	0.531PheTrp: 0.531 ± 0.018	1.127PheTyr: 1.127 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	6.963GlyAla: 6.963 ± 0.085	0.952GlyCys: 0.952 ± 0.028	4.175GlyAsp: 4.175 ± 0.097	5.151GlyGlu: 5.151 ± 0.067	3.461GlyPhe: 3.461 ± 0.044	5.937GlyGly: 5.937 ± 0.114	1.612GlyHis: 1.612 ± 0.03	4.737GlyIle: 4.737 ± 0.057	3.221GlyLys: 3.221 ± 0.05	8.437GlyLeu: 8.437 ± 0.084	2.321GlyMet: 2.321 ± 0.036	2.408GlyAsn: 2.408 ± 0.059	2.347GlyPro: 2.347 ± 0.034	3.093GlyGln: 3.093 ± 0.046	4.5GlyArg: 4.5 ± 0.058	4.865GlySer: 4.865 ± 0.087	3.77GlyThr: 3.77 ± 0.077	5.98GlyVal: 5.98 ± 0.072	1.237GlyTrp: 1.237 ± 0.032	2.544GlyTyr: 2.544 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.762HisAla: 1.762 ± 0.033	0.324HisCys: 0.324 ± 0.015	1.078HisAsp: 1.078 ± 0.027	1.204HisGlu: 1.204 ± 0.029	0.932HisPhe: 0.932 ± 0.026	1.594HisGly: 1.594 ± 0.035	0.577HisHis: 0.577 ± 0.02	1.077HisIle: 1.077 ± 0.027	0.684HisLys: 0.684 ± 0.022	2.352HisLeu: 2.352 ± 0.04	0.508HisMet: 0.508 ± 0.018	0.648HisAsn: 0.648 ± 0.021	1.252HisPro: 1.252 ± 0.025	0.99HisGln: 0.99 ± 0.025	1.373HisArg: 1.373 ± 0.033	1.26HisSer: 1.26 ± 0.024	0.953HisThr: 0.953 ± 0.022	1.129HisVal: 1.129 ± 0.031	0.422HisTrp: 0.422 ± 0.015	0.735HisTyr: 0.735 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.903IleAla: 5.903 ± 0.072	0.654IleCys: 0.654 ± 0.021	3.953IleAsp: 3.953 ± 0.058	4.106IleGlu: 4.106 ± 0.056	1.696IlePhe: 1.696 ± 0.035	4.684IleGly: 4.684 ± 0.066	1.125IleHis: 1.125 ± 0.027	2.574IleIle: 2.574 ± 0.043	2.005IleLys: 2.005 ± 0.037	4.809IleLeu: 4.809 ± 0.068	1.003IleMet: 1.003 ± 0.028	2.186IleAsn: 2.186 ± 0.038	2.563IlePro: 2.563 ± 0.048	1.801IleGln: 1.801 ± 0.036	3.223IleArg: 3.223 ± 0.047	3.729IleSer: 3.729 ± 0.055	3.002IleThr: 3.002 ± 0.047	3.377IleVal: 3.377 ± 0.052	0.616IleTrp: 0.616 ± 0.019	1.511IleTyr: 1.511 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.996LysAla: 3.996 ± 0.059	0.209LysCys: 0.209 ± 0.012	1.797LysAsp: 1.797 ± 0.037	2.309LysGlu: 2.309 ± 0.045	0.921LysPhe: 0.921 ± 0.026	2.67LysGly: 2.67 ± 0.044	0.773LysHis: 0.773 ± 0.025	1.843LysIle: 1.843 ± 0.037	1.587LysLys: 1.587 ± 0.039	4.005LysLeu: 4.005 ± 0.054	0.877LysMet: 0.877 ± 0.024	1.119LysAsn: 1.119 ± 0.032	2.131LysPro: 2.131 ± 0.037	1.833LysGln: 1.833 ± 0.036	2.533LysArg: 2.533 ± 0.049	2.119LysSer: 2.119 ± 0.035	1.924LysThr: 1.924 ± 0.038	2.673LysVal: 2.673 ± 0.042	0.351LysTrp: 0.351 ± 0.015	0.858LysTyr: 0.858 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	11.909LeuAla: 11.909 ± 0.121	1.175LeuCys: 1.175 ± 0.027	6.349LeuAsp: 6.349 ± 0.07	7.097LeuGlu: 7.097 ± 0.08	4.194LeuPhe: 4.194 ± 0.074	8.29LeuGly: 8.29 ± 0.086	2.1LeuHis: 2.1 ± 0.038	6.286LeuIle: 6.286 ± 0.08	4.531LeuLys: 4.531 ± 0.061	12.404LeuLeu: 12.404 ± 0.145	2.894LeuMet: 2.894 ± 0.046	3.937LeuAsn: 3.937 ± 0.05	5.482LeuPro: 5.482 ± 0.067	4.012LeuGln: 4.012 ± 0.05	5.922LeuArg: 5.922 ± 0.062	7.926LeuSer: 7.926 ± 0.077	5.917LeuThr: 5.917 ± 0.072	7.65LeuVal: 7.65 ± 0.078	1.212LeuTrp: 1.212 ± 0.028	2.508LeuTyr: 2.508 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.65MetAla: 2.65 ± 0.041	0.152MetCys: 0.152 ± 0.01	1.302MetAsp: 1.302 ± 0.029	1.39MetGlu: 1.39 ± 0.032	0.786MetPhe: 0.786 ± 0.023	1.781MetGly: 1.781 ± 0.039	0.483MetHis: 0.483 ± 0.021	1.412MetIle: 1.412 ± 0.031	1.167MetLys: 1.167 ± 0.03	2.985MetLeu: 2.985 ± 0.05	0.688MetMet: 0.688 ± 0.024	0.976MetAsn: 0.976 ± 0.024	1.365MetPro: 1.365 ± 0.033	1.11MetGln: 1.11 ± 0.027	1.461MetArg: 1.461 ± 0.031	1.872MetSer: 1.872 ± 0.03	1.517MetThr: 1.517 ± 0.03	1.691MetVal: 1.691 ± 0.038	0.157MetTrp: 0.157 ± 0.009	0.379MetTyr: 0.379 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.232AsnAla: 3.232 ± 0.05	0.33AsnCys: 0.33 ± 0.015	1.799AsnAsp: 1.799 ± 0.048	1.894AsnGlu: 1.894 ± 0.035	1.146AsnPhe: 1.146 ± 0.031	2.715AsnGly: 2.715 ± 0.057	0.679AsnHis: 0.679 ± 0.019	1.828AsnIle: 1.828 ± 0.035	1.077AsnLys: 1.077 ± 0.027	3.567AsnLeu: 3.567 ± 0.048	0.715AsnMet: 0.715 ± 0.02	1.126AsnAsn: 1.126 ± 0.031	1.984AsnPro: 1.984 ± 0.034	1.358AsnGln: 1.358 ± 0.033	2.203AsnArg: 2.203 ± 0.036	1.961AsnSer: 1.961 ± 0.042	1.657AsnThr: 1.657 ± 0.038	1.96AsnVal: 1.96 ± 0.046	0.488AsnTrp: 0.488 ± 0.018	0.94AsnTyr: 0.94 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.619ProAla: 4.619 ± 0.062	0.345ProCys: 0.345 ± 0.014	2.978ProAsp: 2.978 ± 0.05	3.953ProGlu: 3.953 ± 0.053	1.785ProPhe: 1.785 ± 0.039	3.687ProGly: 3.687 ± 0.046	0.857ProHis: 0.857 ± 0.024	2.112ProIle: 2.112 ± 0.037	1.522ProLys: 1.522 ± 0.035	4.866ProLeu: 4.866 ± 0.064	1.168ProMet: 1.168 ± 0.027	1.324ProAsn: 1.324 ± 0.033	1.646ProPro: 1.646 ± 0.038	1.84ProGln: 1.84 ± 0.035	2.07ProArg: 2.07 ± 0.034	2.539ProSer: 2.539 ± 0.045	2.117ProThr: 2.117 ± 0.038	3.806ProVal: 3.806 ± 0.044	0.65ProTrp: 0.65 ± 0.022	1.174ProTyr: 1.174 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.611GlnAla: 4.611 ± 0.066	0.332GlnCys: 0.332 ± 0.016	1.677GlnAsp: 1.677 ± 0.036	2.32GlnGlu: 2.32 ± 0.044	1.313GlnPhe: 1.313 ± 0.03	3.093GlnGly: 3.093 ± 0.044	0.94GlnHis: 0.94 ± 0.024	2.288GlnIle: 2.288 ± 0.04	1.44GlnLys: 1.44 ± 0.027	5.162GlnLeu: 5.162 ± 0.064	1.111GlnMet: 1.111 ± 0.025	1.206GlnAsn: 1.206 ± 0.03	2.033GlnPro: 2.033 ± 0.038	2.726GlnGln: 2.726 ± 0.061	3.033GlnArg: 3.033 ± 0.053	2.517GlnSer: 2.517 ± 0.046	1.955GlnThr: 1.955 ± 0.035	3.152GlnVal: 3.152 ± 0.041	0.552GlnTrp: 0.552 ± 0.019	1.006GlnTyr: 1.006 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.29ArgAla: 5.29 ± 0.067	0.581ArgCys: 0.581 ± 0.021	3.267ArgAsp: 3.267 ± 0.042	4.242ArgGlu: 4.242 ± 0.064	2.665ArgPhe: 2.665 ± 0.044	3.678ArgGly: 3.678 ± 0.052	1.446ArgHis: 1.446 ± 0.033	3.613ArgIle: 3.613 ± 0.049	2.247ArgLys: 2.247 ± 0.042	7.121ArgLeu: 7.121 ± 0.083	1.612ArgMet: 1.612 ± 0.035	1.963ArgAsn: 1.963 ± 0.038	2.365ArgPro: 2.365 ± 0.039	2.832ArgGln: 2.832 ± 0.051	3.941ArgArg: 3.941 ± 0.057	3.538ArgSer: 3.538 ± 0.039	2.587ArgThr: 2.587 ± 0.041	4.212ArgVal: 4.212 ± 0.053	0.932ArgTrp: 0.932 ± 0.027	2.022ArgTyr: 2.022 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.385SerAla: 6.385 ± 0.08	0.627SerCys: 0.627 ± 0.023	3.653SerAsp: 3.653 ± 0.06	3.904SerGlu: 3.904 ± 0.049	2.466SerPhe: 2.466 ± 0.036	5.878SerGly: 5.878 ± 0.091	1.329SerHis: 1.329 ± 0.028	3.413SerIle: 3.413 ± 0.051	1.972SerLys: 1.972 ± 0.039	7.132SerLeu: 7.132 ± 0.075	1.625SerMet: 1.625 ± 0.038	1.953SerAsn: 1.953 ± 0.037	2.656SerPro: 2.656 ± 0.045	2.389SerGln: 2.389 ± 0.047	3.82SerArg: 3.82 ± 0.051	4.069SerSer: 4.069 ± 0.062	2.956SerThr: 2.956 ± 0.044	4.567SerVal: 4.567 ± 0.073	0.869SerTrp: 0.869 ± 0.024	1.667SerTyr: 1.667 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.977ThrAla: 4.977 ± 0.078	0.457ThrCys: 0.457 ± 0.017	2.906ThrAsp: 2.906 ± 0.053	3.179ThrGlu: 3.179 ± 0.044	1.753ThrPhe: 1.753 ± 0.034	4.464ThrGly: 4.464 ± 0.068	1.061ThrHis: 1.061 ± 0.024	2.329ThrIle: 2.329 ± 0.045	1.273ThrLys: 1.273 ± 0.028	6.761ThrLeu: 6.761 ± 0.067	0.884ThrMet: 0.884 ± 0.023	1.402ThrAsn: 1.402 ± 0.037	2.956ThrPro: 2.956 ± 0.044	1.936ThrGln: 1.936 ± 0.037	2.883ThrArg: 2.883 ± 0.045	2.91ThrSer: 2.91 ± 0.056	2.54ThrThr: 2.54 ± 0.051	3.293ThrVal: 3.293 ± 0.066	0.623ThrTrp: 0.623 ± 0.018	1.255ThrTyr: 1.255 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.074ValAla: 7.074 ± 0.07	0.779ValCys: 0.779 ± 0.022	4.364ValAsp: 4.364 ± 0.068	4.692ValGlu: 4.692 ± 0.057	2.493ValPhe: 2.493 ± 0.039	4.966ValGly: 4.966 ± 0.07	1.328ValHis: 1.328 ± 0.031	4.118ValIle: 4.118 ± 0.056	2.475ValLys: 2.475 ± 0.047	7.199ValLeu: 7.199 ± 0.079	1.912ValMet: 1.912 ± 0.037	2.436ValAsn: 2.436 ± 0.043	2.978ValPro: 2.978 ± 0.04	2.362ValGln: 2.362 ± 0.042	3.935ValArg: 3.935 ± 0.05	4.836ValSer: 4.836 ± 0.073	3.771ValThr: 3.771 ± 0.067	5.234ValVal: 5.234 ± 0.069	0.766ValTrp: 0.766 ± 0.023	1.717ValTyr: 1.717 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.996TrpAla: 0.996 ± 0.027	0.162TrpCys: 0.162 ± 0.01	0.65TrpAsp: 0.65 ± 0.023	0.605TrpGlu: 0.605 ± 0.019	0.566TrpPhe: 0.566 ± 0.019	0.88TrpGly: 0.88 ± 0.022	0.367TrpHis: 0.367 ± 0.015	0.752TrpIle: 0.752 ± 0.025	0.482TrpLys: 0.482 ± 0.018	1.852TrpLeu: 1.852 ± 0.039	0.353TrpMet: 0.353 ± 0.014	0.445TrpAsn: 0.445 ± 0.018	0.595TrpPro: 0.595 ± 0.021	0.763TrpGln: 0.763 ± 0.026	0.846TrpArg: 0.846 ± 0.022	0.851TrpSer: 0.851 ± 0.021	0.558TrpThr: 0.558 ± 0.019	0.904TrpVal: 0.904 ± 0.023	0.18TrpTrp: 0.18 ± 0.011	0.354TrpTyr: 0.354 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.356TyrAla: 2.356 ± 0.035	0.3TyrCys: 0.3 ± 0.014	1.574TyrAsp: 1.574 ± 0.034	1.532TyrGlu: 1.532 ± 0.034	1.102TyrPhe: 1.102 ± 0.026	2.14TyrGly: 2.14 ± 0.04	0.602TyrHis: 0.602 ± 0.02	1.295TyrIle: 1.295 ± 0.03	0.836TyrLys: 0.836 ± 0.024	3.031TyrLeu: 3.031 ± 0.049	0.549TyrMet: 0.549 ± 0.021	0.898TyrAsn: 0.898 ± 0.026	1.34TyrPro: 1.34 ± 0.033	1.206TyrGln: 1.206 ± 0.024	2.001TyrArg: 2.001 ± 0.037	1.744TyrSer: 1.744 ± 0.035	1.419TyrThr: 1.419 ± 0.031	1.615TyrVal: 1.615 ± 0.032	0.404TyrTrp: 0.404 ± 0.019	0.839TyrTyr: 0.839 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5061 proteins (1652987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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