Amino acid dipepetide frequency for Salimicrobium jeotgali

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.027AlaAla: 6.027 ± 0.118	0.536AlaCys: 0.536 ± 0.03	3.662AlaAsp: 3.662 ± 0.073	5.374AlaGlu: 5.374 ± 0.079	3.298AlaPhe: 3.298 ± 0.06	6.415AlaGly: 6.415 ± 0.106	1.349AlaHis: 1.349 ± 0.041	4.886AlaIle: 4.886 ± 0.088	3.89AlaLys: 3.89 ± 0.08	7.14AlaLeu: 7.14 ± 0.106	2.115AlaMet: 2.115 ± 0.054	2.243AlaAsn: 2.243 ± 0.058	2.305AlaPro: 2.305 ± 0.053	2.047AlaGln: 2.047 ± 0.046	3.249AlaArg: 3.249 ± 0.073	4.441AlaSer: 4.441 ± 0.077	3.5AlaThr: 3.5 ± 0.065	6.24AlaVal: 6.24 ± 0.118	0.671AlaTrp: 0.671 ± 0.032	2.416AlaTyr: 2.416 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.37CysAla: 0.37 ± 0.021	0.07CysCys: 0.07 ± 0.011	0.351CysAsp: 0.351 ± 0.022	0.378CysGlu: 0.378 ± 0.022	0.246CysPhe: 0.246 ± 0.019	0.556CysGly: 0.556 ± 0.03	0.169CysHis: 0.169 ± 0.014	0.353CysIle: 0.353 ± 0.022	0.249CysLys: 0.249 ± 0.018	0.465CysLeu: 0.465 ± 0.026	0.144CysMet: 0.144 ± 0.015	0.23CysAsn: 0.23 ± 0.018	0.309CysPro: 0.309 ± 0.023	0.16CysGln: 0.16 ± 0.014	0.314CysArg: 0.314 ± 0.019	0.367CysSer: 0.367 ± 0.022	0.366CysThr: 0.366 ± 0.024	0.353CysVal: 0.353 ± 0.019	0.038CysTrp: 0.038 ± 0.007	0.221CysTyr: 0.221 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.359AspAla: 3.359 ± 0.073	0.323AspCys: 0.323 ± 0.024	2.595AspAsp: 2.595 ± 0.066	4.946AspGlu: 4.946 ± 0.094	2.459AspPhe: 2.459 ± 0.06	3.737AspGly: 3.737 ± 0.083	1.229AspHis: 1.229 ± 0.042	3.936AspIle: 3.936 ± 0.073	3.133AspLys: 3.133 ± 0.069	4.801AspLeu: 4.801 ± 0.086	1.636AspMet: 1.636 ± 0.048	1.838AspAsn: 1.838 ± 0.052	2.134AspPro: 2.134 ± 0.051	1.689AspGln: 1.689 ± 0.051	2.864AspArg: 2.864 ± 0.062	2.905AspSer: 2.905 ± 0.069	2.762AspThr: 2.762 ± 0.062	4.243AspVal: 4.243 ± 0.087	0.617AspTrp: 0.617 ± 0.03	2.367AspTyr: 2.367 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	6.649GluAla: 6.649 ± 0.122	0.328GluCys: 0.328 ± 0.023	5.257GluAsp: 5.257 ± 0.091	10.633GluGlu: 10.633 ± 0.166	2.66GluPhe: 2.66 ± 0.059	5.761GluGly: 5.761 ± 0.104	1.67GluHis: 1.67 ± 0.045	5.218GluIle: 5.218 ± 0.095	7.059GluLys: 7.059 ± 0.128	7.133GluLeu: 7.133 ± 0.108	2.591GluMet: 2.591 ± 0.054	3.991GluAsn: 3.991 ± 0.08	2.212GluPro: 2.212 ± 0.056	3.314GluGln: 3.314 ± 0.066	4.422GluArg: 4.422 ± 0.078	4.022GluSer: 4.022 ± 0.077	4.769GluThr: 4.769 ± 0.087	5.959GluVal: 5.959 ± 0.093	1.04GluTrp: 1.04 ± 0.035	2.404GluTyr: 2.404 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	2.929PheAla: 2.929 ± 0.071	0.269PheCys: 0.269 ± 0.015	2.319PheAsp: 2.319 ± 0.058	3.063PheGlu: 3.063 ± 0.061	2.398PhePhe: 2.398 ± 0.071	3.378PheGly: 3.378 ± 0.08	1.014PheHis: 1.014 ± 0.041	3.333PheIle: 3.333 ± 0.072	1.872PheLys: 1.872 ± 0.055	4.649PheLeu: 4.649 ± 0.107	1.115PheMet: 1.115 ± 0.039	1.542PheAsn: 1.542 ± 0.049	1.831PhePro: 1.831 ± 0.049	1.534PheGln: 1.534 ± 0.049	2.055PheArg: 2.055 ± 0.05	3.208PheSer: 3.208 ± 0.072	2.677PheThr: 2.677 ± 0.062	3.025PheVal: 3.025 ± 0.078	0.466PheTrp: 0.466 ± 0.025	1.666PheTyr: 1.666 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	5.461GlyAla: 5.461 ± 0.107	0.531GlyCys: 0.531 ± 0.026	3.687GlyAsp: 3.687 ± 0.084	5.922GlyGlu: 5.922 ± 0.093	3.441GlyPhe: 3.441 ± 0.075	5.447GlyGly: 5.447 ± 0.115	1.473GlyHis: 1.473 ± 0.045	5.333GlyIle: 5.333 ± 0.094	4.95GlyLys: 4.95 ± 0.084	6.579GlyLeu: 6.579 ± 0.106	2.482GlyMet: 2.482 ± 0.059	2.681GlyAsn: 2.681 ± 0.062	1.899GlyPro: 1.899 ± 0.047	2.003GlyGln: 2.003 ± 0.052	3.187GlyArg: 3.187 ± 0.068	4.335GlySer: 4.335 ± 0.083	4.435GlyThr: 4.435 ± 0.081	5.762GlyVal: 5.762 ± 0.089	0.817GlyTrp: 0.817 ± 0.033	2.854GlyTyr: 2.854 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.349HisAla: 1.349 ± 0.047	0.175HisCys: 0.175 ± 0.014	0.973HisAsp: 0.973 ± 0.038	1.414HisGlu: 1.414 ± 0.038	0.977HisPhe: 0.977 ± 0.034	1.458HisGly: 1.458 ± 0.038	0.611HisHis: 0.611 ± 0.033	1.41HisIle: 1.41 ± 0.039	1.085HisLys: 1.085 ± 0.04	2.121HisLeu: 2.121 ± 0.062	0.566HisMet: 0.566 ± 0.028	0.765HisAsn: 0.765 ± 0.028	1.257HisPro: 1.257 ± 0.046	0.748HisGln: 0.748 ± 0.035	1.055HisArg: 1.055 ± 0.036	1.235HisSer: 1.235 ± 0.041	1.177HisThr: 1.177 ± 0.034	1.472HisVal: 1.472 ± 0.046	0.203HisTrp: 0.203 ± 0.015	0.853HisTyr: 0.853 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.498IleAla: 5.498 ± 0.093	0.433IleCys: 0.433 ± 0.022	4.132IleAsp: 4.132 ± 0.073	5.026IleGlu: 5.026 ± 0.082	2.949IlePhe: 2.949 ± 0.083	5.419IleGly: 5.419 ± 0.1	1.52IleHis: 1.52 ± 0.043	4.798IleIle: 4.798 ± 0.102	3.231IleLys: 3.231 ± 0.07	5.968IleLeu: 5.968 ± 0.087	1.717IleMet: 1.717 ± 0.051	2.563IleAsn: 2.563 ± 0.065	2.957IlePro: 2.957 ± 0.061	2.199IleGln: 2.199 ± 0.053	3.264IleArg: 3.264 ± 0.069	4.676IleSer: 4.676 ± 0.074	4.024IleThr: 4.024 ± 0.064	4.868IleVal: 4.868 ± 0.093	0.55IleTrp: 0.55 ± 0.025	1.994IleTyr: 1.994 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.505LysAla: 4.505 ± 0.083	0.206LysCys: 0.206 ± 0.015	3.724LysAsp: 3.724 ± 0.081	7.549LysGlu: 7.549 ± 0.123	1.715LysPhe: 1.715 ± 0.048	4.143LysGly: 4.143 ± 0.07	1.207LysHis: 1.207 ± 0.044	3.49LysIle: 3.49 ± 0.074	5.301LysLys: 5.301 ± 0.096	4.788LysLeu: 4.788 ± 0.081	1.991LysMet: 1.991 ± 0.056	2.883LysAsn: 2.883 ± 0.061	1.887LysPro: 1.887 ± 0.047	2.785LysGln: 2.785 ± 0.067	3.457LysArg: 3.457 ± 0.075	3.083LysSer: 3.083 ± 0.075	3.169LysThr: 3.169 ± 0.061	4.203LysVal: 4.203 ± 0.07	0.72LysTrp: 0.72 ± 0.029	1.886LysTyr: 1.886 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.908LeuAla: 6.908 ± 0.108	0.457LeuCys: 0.457 ± 0.025	4.722LeuAsp: 4.722 ± 0.083	7.125LeuGlu: 7.125 ± 0.112	4.65LeuPhe: 4.65 ± 0.103	6.637LeuGly: 6.637 ± 0.114	1.965LeuHis: 1.965 ± 0.053	6.319LeuIle: 6.319 ± 0.108	5.705LeuLys: 5.705 ± 0.092	9.382LeuLeu: 9.382 ± 0.158	2.6LeuMet: 2.6 ± 0.064	3.563LeuAsn: 3.563 ± 0.072	4.043LeuPro: 4.043 ± 0.075	3.376LeuGln: 3.376 ± 0.071	3.983LeuArg: 3.983 ± 0.08	6.598LeuSer: 6.598 ± 0.106	5.463LeuThr: 5.463 ± 0.087	5.889LeuVal: 5.889 ± 0.106	0.796LeuTrp: 0.796 ± 0.035	2.983LeuTyr: 2.983 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.169MetAla: 2.169 ± 0.059	0.135MetCys: 0.135 ± 0.013	1.656MetAsp: 1.656 ± 0.047	2.586MetGlu: 2.586 ± 0.053	1.149MetPhe: 1.149 ± 0.044	1.797MetGly: 1.797 ± 0.042	0.46MetHis: 0.46 ± 0.023	2.061MetIle: 2.061 ± 0.056	2.661MetLys: 2.661 ± 0.062	2.465MetLeu: 2.465 ± 0.057	0.907MetMet: 0.907 ± 0.037	1.69MetAsn: 1.69 ± 0.046	1.021MetPro: 1.021 ± 0.035	1.047MetGln: 1.047 ± 0.039	1.246MetArg: 1.246 ± 0.041	1.778MetSer: 1.778 ± 0.053	1.732MetThr: 1.732 ± 0.048	1.806MetVal: 1.806 ± 0.053	0.216MetTrp: 0.216 ± 0.015	0.832MetTyr: 0.832 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.432AsnAla: 2.432 ± 0.058	0.229AsnCys: 0.229 ± 0.018	2.031AsnAsp: 2.031 ± 0.047	3.399AsnGlu: 3.399 ± 0.069	1.538AsnPhe: 1.538 ± 0.045	2.837AsnGly: 2.837 ± 0.064	0.831AsnHis: 0.831 ± 0.032	2.842AsnIle: 2.842 ± 0.065	2.465AsnLys: 2.465 ± 0.06	3.33AsnLeu: 3.33 ± 0.066	1.104AsnMet: 1.104 ± 0.032	1.724AsnAsn: 1.724 ± 0.055	1.896AsnPro: 1.896 ± 0.046	1.433AsnGln: 1.433 ± 0.042	2.152AsnArg: 2.152 ± 0.057	2.047AsnSer: 2.047 ± 0.062	2.003AsnThr: 2.003 ± 0.05	2.977AsnVal: 2.977 ± 0.066	0.422AsnTrp: 0.422 ± 0.024	1.425AsnTyr: 1.425 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.61ProAla: 2.61 ± 0.057	0.196ProCys: 0.196 ± 0.017	2.254ProAsp: 2.254 ± 0.06	4.043ProGlu: 4.043 ± 0.08	1.965ProPhe: 1.965 ± 0.058	2.883ProGly: 2.883 ± 0.061	0.827ProHis: 0.827 ± 0.037	2.072ProIle: 2.072 ± 0.051	1.868ProLys: 1.868 ± 0.053	3.599ProLeu: 3.599 ± 0.067	0.936ProMet: 0.936 ± 0.036	1.166ProAsn: 1.166 ± 0.036	1.049ProPro: 1.049 ± 0.038	0.885ProGln: 0.885 ± 0.038	1.213ProArg: 1.213 ± 0.038	2.389ProSer: 2.389 ± 0.056	1.569ProThr: 1.569 ± 0.042	3.566ProVal: 3.566 ± 0.07	0.419ProTrp: 0.419 ± 0.024	1.395ProTyr: 1.395 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.616GlnAla: 2.616 ± 0.062	0.116GlnCys: 0.116 ± 0.012	1.412GlnAsp: 1.412 ± 0.049	3.226GlnGlu: 3.226 ± 0.081	1.351GlnPhe: 1.351 ± 0.045	2.212GlnGly: 2.212 ± 0.05	0.654GlnHis: 0.654 ± 0.03	1.975GlnIle: 1.975 ± 0.053	2.493GlnLys: 2.493 ± 0.061	3.413GlnLeu: 3.413 ± 0.074	1.151GlnMet: 1.151 ± 0.043	1.374GlnAsn: 1.374 ± 0.045	1.124GlnPro: 1.124 ± 0.039	1.421GlnGln: 1.421 ± 0.048	1.539GlnArg: 1.539 ± 0.043	1.887GlnSer: 1.887 ± 0.046	1.806GlnThr: 1.806 ± 0.048	2.206GlnVal: 2.206 ± 0.053	0.427GlnTrp: 0.427 ± 0.026	1.078GlnTyr: 1.078 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.859ArgAla: 2.859 ± 0.064	0.203ArgCys: 0.203 ± 0.015	2.416ArgAsp: 2.416 ± 0.064	4.591ArgGlu: 4.591 ± 0.087	2.06ArgPhe: 2.06 ± 0.065	2.793ArgGly: 2.793 ± 0.064	1.024ArgHis: 1.024 ± 0.038	3.126ArgIle: 3.126 ± 0.067	3.795ArgLys: 3.795 ± 0.076	4.369ArgLeu: 4.369 ± 0.082	1.55ArgMet: 1.55 ± 0.043	2.117ArgAsn: 2.117 ± 0.059	1.616ArgPro: 1.616 ± 0.049	1.769ArgGln: 1.769 ± 0.051	2.388ArgArg: 2.388 ± 0.056	2.586ArgSer: 2.586 ± 0.057	2.671ArgThr: 2.671 ± 0.06	2.968ArgVal: 2.968 ± 0.062	0.446ArgTrp: 0.446 ± 0.028	1.692ArgTyr: 1.692 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.0SerAla: 4.0 ± 0.079	0.342SerCys: 0.342 ± 0.022	3.095SerAsp: 3.095 ± 0.067	4.553SerGlu: 4.553 ± 0.084	3.286SerPhe: 3.286 ± 0.071	5.197SerGly: 5.197 ± 0.101	1.218SerHis: 1.218 ± 0.037	4.353SerIle: 4.353 ± 0.075	3.129SerLys: 3.129 ± 0.071	6.161SerLeu: 6.161 ± 0.095	1.83SerMet: 1.83 ± 0.048	2.073SerAsn: 2.073 ± 0.059	2.242SerPro: 2.242 ± 0.057	1.765SerGln: 1.765 ± 0.046	2.933SerArg: 2.933 ± 0.068	4.163SerSer: 4.163 ± 0.085	3.083SerThr: 3.083 ± 0.061	4.476SerVal: 4.476 ± 0.079	0.593SerTrp: 0.593 ± 0.03	2.262SerTyr: 2.262 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.184ThrAla: 4.184 ± 0.086	0.32ThrCys: 0.32 ± 0.02	2.931ThrAsp: 2.931 ± 0.067	4.142ThrGlu: 4.142 ± 0.081	2.681ThrPhe: 2.681 ± 0.068	4.943ThrGly: 4.943 ± 0.084	1.102ThrHis: 1.102 ± 0.036	3.865ThrIle: 3.865 ± 0.069	2.865ThrLys: 2.865 ± 0.063	5.291ThrLeu: 5.291 ± 0.079	1.544ThrMet: 1.544 ± 0.044	2.028ThrAsn: 2.028 ± 0.055	2.446ThrPro: 2.446 ± 0.059	1.293ThrGln: 1.293 ± 0.046	2.163ThrArg: 2.163 ± 0.058	3.542ThrSer: 3.542 ± 0.072	2.911ThrThr: 2.911 ± 0.073	4.58ThrVal: 4.58 ± 0.075	0.523ThrTrp: 0.523 ± 0.026	2.021ThrTyr: 2.021 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	5.064ValAla: 5.064 ± 0.099	0.513ValCys: 0.513 ± 0.026	3.932ValAsp: 3.932 ± 0.068	5.558ValGlu: 5.558 ± 0.099	3.273ValPhe: 3.273 ± 0.079	4.438ValGly: 4.438 ± 0.089	1.532ValHis: 1.532 ± 0.048	5.327ValIle: 5.327 ± 0.079	4.318ValLys: 4.318 ± 0.078	7.194ValLeu: 7.194 ± 0.115	2.162ValMet: 2.162 ± 0.051	2.867ValAsn: 2.867 ± 0.065	2.996ValPro: 2.996 ± 0.065	2.416ValGln: 2.416 ± 0.06	3.208ValArg: 3.208 ± 0.07	4.831ValSer: 4.831 ± 0.076	4.801ValThr: 4.801 ± 0.079	5.2ValVal: 5.2 ± 0.102	0.667ValTrp: 0.667 ± 0.034	2.484ValTyr: 2.484 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.626TrpAla: 0.626 ± 0.032	0.056TrpCys: 0.056 ± 0.009	0.448TrpAsp: 0.448 ± 0.025	0.723TrpGlu: 0.723 ± 0.031	0.511TrpPhe: 0.511 ± 0.026	0.671TrpGly: 0.671 ± 0.033	0.212TrpHis: 0.212 ± 0.017	0.744TrpIle: 0.744 ± 0.034	0.808TrpLys: 0.808 ± 0.034	1.081TrpLeu: 1.081 ± 0.04	0.372TrpMet: 0.372 ± 0.021	0.475TrpAsn: 0.475 ± 0.025	0.265TrpPro: 0.265 ± 0.018	0.349TrpGln: 0.349 ± 0.019	0.432TrpArg: 0.432 ± 0.021	0.612TrpSer: 0.612 ± 0.034	0.566TrpThr: 0.566 ± 0.032	0.711TrpVal: 0.711 ± 0.033	0.156TrpTrp: 0.156 ± 0.014	0.334TrpTyr: 0.334 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.19TyrAla: 2.19 ± 0.059	0.272TyrCys: 0.272 ± 0.019	1.976TyrAsp: 1.976 ± 0.052	2.841TyrGlu: 2.841 ± 0.058	1.739TyrPhe: 1.739 ± 0.054	2.554TyrGly: 2.554 ± 0.054	0.838TyrHis: 0.838 ± 0.026	2.348TyrIle: 2.348 ± 0.061	1.814TyrLys: 1.814 ± 0.045	3.235TyrLeu: 3.235 ± 0.066	0.902TyrMet: 0.902 ± 0.032	1.304TyrAsn: 1.304 ± 0.043	1.414TyrPro: 1.414 ± 0.043	1.25TyrGln: 1.25 ± 0.044	1.914TyrArg: 1.914 ± 0.05	2.046TyrSer: 2.046 ± 0.05	1.892TyrThr: 1.892 ± 0.05	2.273TyrVal: 2.273 ± 0.056	0.366TyrTrp: 0.366 ± 0.023	1.461TyrTyr: 1.461 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2724 proteins (787348 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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