Amino acid dipepetide frequency for Paenibacillus xerothermodurans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.91AlaAla: 10.91 ± 0.159	0.757AlaCys: 0.757 ± 0.025	4.772AlaAsp: 4.772 ± 0.059	5.906AlaGlu: 5.906 ± 0.079	3.305AlaPhe: 3.305 ± 0.048	7.671AlaGly: 7.671 ± 0.123	1.828AlaHis: 1.828 ± 0.047	5.48AlaIle: 5.48 ± 0.078	4.494AlaLys: 4.494 ± 0.071	8.857AlaLeu: 8.857 ± 0.101	2.586AlaMet: 2.586 ± 0.054	2.916AlaAsn: 2.916 ± 0.052	3.227AlaPro: 3.227 ± 0.071	3.487AlaGln: 3.487 ± 0.063	4.214AlaArg: 4.214 ± 0.077	4.784AlaSer: 4.784 ± 0.077	3.83AlaThr: 3.83 ± 0.065	7.478AlaVal: 7.478 ± 0.106	0.977AlaTrp: 0.977 ± 0.032	2.68AlaTyr: 2.68 ± 0.041	0.002AlaXaa: 0.002 ± 0.001
Cys	0.686CysAla: 0.686 ± 0.026	0.14CysCys: 0.14 ± 0.011	0.421CysAsp: 0.421 ± 0.02	0.457CysGlu: 0.457 ± 0.022	0.34CysPhe: 0.34 ± 0.016	0.78CysGly: 0.78 ± 0.031	0.207CysHis: 0.207 ± 0.013	0.546CysIle: 0.546 ± 0.024	0.364CysLys: 0.364 ± 0.019	0.779CysLeu: 0.779 ± 0.03	0.221CysMet: 0.221 ± 0.014	0.294CysAsn: 0.294 ± 0.017	0.371CysPro: 0.371 ± 0.017	0.256CysGln: 0.256 ± 0.016	0.508CysArg: 0.508 ± 0.021	0.626CysSer: 0.626 ± 0.022	0.461CysThr: 0.461 ± 0.024	0.583CysVal: 0.583 ± 0.02	0.1CysTrp: 0.1 ± 0.008	0.274CysTyr: 0.274 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.423AspAla: 4.423 ± 0.074	0.391AspCys: 0.391 ± 0.016	2.513AspAsp: 2.513 ± 0.057	3.722AspGlu: 3.722 ± 0.061	2.03AspPhe: 2.03 ± 0.046	3.893AspGly: 3.893 ± 0.067	1.225AspHis: 1.225 ± 0.032	3.552AspIle: 3.552 ± 0.066	2.685AspLys: 2.685 ± 0.052	4.706AspLeu: 4.706 ± 0.075	1.455AspMet: 1.455 ± 0.033	1.761AspAsn: 1.761 ± 0.045	2.411AspPro: 2.411 ± 0.05	1.836AspGln: 1.836 ± 0.036	2.876AspArg: 2.876 ± 0.047	2.532AspSer: 2.532 ± 0.046	2.745AspThr: 2.745 ± 0.046	3.991AspVal: 3.991 ± 0.066	0.763AspTrp: 0.763 ± 0.026	1.966AspTyr: 1.966 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.772GluAla: 5.772 ± 0.089	0.403GluCys: 0.403 ± 0.021	2.808GluAsp: 2.808 ± 0.052	4.44GluGlu: 4.44 ± 0.071	2.127GluPhe: 2.127 ± 0.044	3.799GluGly: 3.799 ± 0.051	1.741GluHis: 1.741 ± 0.043	4.093GluIle: 4.093 ± 0.064	3.608GluLys: 3.608 ± 0.062	6.98GluLeu: 6.98 ± 0.093	1.894GluMet: 1.894 ± 0.042	2.198GluAsn: 2.198 ± 0.042	2.344GluPro: 2.344 ± 0.053	3.981GluGln: 3.981 ± 0.068	4.124GluArg: 4.124 ± 0.066	3.087GluSer: 3.087 ± 0.058	3.102GluThr: 3.102 ± 0.055	4.398GluVal: 4.398 ± 0.067	0.854GluTrp: 0.854 ± 0.028	1.817GluTyr: 1.817 ± 0.042	0.001GluXaa: 0.001 ± 0.001
Phe	3.368PheAla: 3.368 ± 0.059	0.384PheCys: 0.384 ± 0.019	2.344PheAsp: 2.344 ± 0.047	2.306PheGlu: 2.306 ± 0.043	1.819PhePhe: 1.819 ± 0.044	3.161PheGly: 3.161 ± 0.058	0.927PheHis: 0.927 ± 0.03	2.812PheIle: 2.812 ± 0.058	1.729PheLys: 1.729 ± 0.043	3.65PheLeu: 3.65 ± 0.066	1.092PheMet: 1.092 ± 0.031	1.468PheAsn: 1.468 ± 0.031	1.611PhePro: 1.611 ± 0.041	1.42PheGln: 1.42 ± 0.032	1.888PheArg: 1.888 ± 0.039	2.649PheSer: 2.649 ± 0.044	2.428PheThr: 2.428 ± 0.047	2.996PheVal: 2.996 ± 0.059	0.498PheTrp: 0.498 ± 0.022	1.369PheTyr: 1.369 ± 0.035	0.001PheXaa: 0.001 ± 0.001
Gly	6.466GlyAla: 6.466 ± 0.134	0.829GlyCys: 0.829 ± 0.028	3.465GlyAsp: 3.465 ± 0.066	4.341GlyGlu: 4.341 ± 0.067	3.19GlyPhe: 3.19 ± 0.055	5.984GlyGly: 5.984 ± 0.088	1.699GlyHis: 1.699 ± 0.041	5.32GlyIle: 5.32 ± 0.068	4.195GlyLys: 4.195 ± 0.07	7.181GlyLeu: 7.181 ± 0.082	2.407GlyMet: 2.407 ± 0.063	2.447GlyAsn: 2.447 ± 0.048	2.15GlyPro: 2.15 ± 0.046	2.692GlyGln: 2.692 ± 0.044	3.884GlyArg: 3.884 ± 0.063	4.526GlySer: 4.526 ± 0.065	4.578GlyThr: 4.578 ± 0.071	5.803GlyVal: 5.803 ± 0.069	1.061GlyTrp: 1.061 ± 0.03	2.854GlyTyr: 2.854 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.016HisAla: 2.016 ± 0.047	0.241HisCys: 0.241 ± 0.016	1.144HisAsp: 1.144 ± 0.034	1.348HisGlu: 1.348 ± 0.035	1.08HisPhe: 1.08 ± 0.03	1.82HisGly: 1.82 ± 0.043	0.688HisHis: 0.688 ± 0.03	1.546HisIle: 1.546 ± 0.039	0.983HisLys: 0.983 ± 0.029	2.203HisLeu: 2.203 ± 0.054	0.646HisMet: 0.646 ± 0.023	0.861HisAsn: 0.861 ± 0.029	1.322HisPro: 1.322 ± 0.037	0.893HisGln: 0.893 ± 0.029	1.347HisArg: 1.347 ± 0.033	1.371HisSer: 1.371 ± 0.037	1.295HisThr: 1.295 ± 0.033	1.692HisVal: 1.692 ± 0.041	0.328HisTrp: 0.328 ± 0.017	0.881HisTyr: 0.881 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.986IleAla: 5.986 ± 0.076	0.639IleCys: 0.639 ± 0.025	3.744IleAsp: 3.744 ± 0.068	4.085IleGlu: 4.085 ± 0.063	2.321IlePhe: 2.321 ± 0.05	5.341IleGly: 5.341 ± 0.076	1.51IleHis: 1.51 ± 0.036	4.204IleIle: 4.204 ± 0.072	2.869IleLys: 2.869 ± 0.059	5.562IleLeu: 5.562 ± 0.069	1.624IleMet: 1.624 ± 0.039	2.434IleAsn: 2.434 ± 0.055	3.105IlePro: 3.105 ± 0.045	2.451IleGln: 2.451 ± 0.053	3.635IleArg: 3.635 ± 0.057	4.111IleSer: 4.111 ± 0.06	3.677IleThr: 3.677 ± 0.059	5.085IleVal: 5.085 ± 0.066	0.677IleTrp: 0.677 ± 0.023	1.912IleTyr: 1.912 ± 0.04	0.001IleXaa: 0.001 ± 0.001
Lys	4.012LysAla: 4.012 ± 0.06	0.271LysCys: 0.271 ± 0.015	2.737LysAsp: 2.737 ± 0.053	3.679LysGlu: 3.679 ± 0.061	1.53LysPhe: 1.53 ± 0.041	3.33LysGly: 3.33 ± 0.059	1.283LysHis: 1.283 ± 0.032	3.061LysIle: 3.061 ± 0.058	3.091LysLys: 3.091 ± 0.056	5.063LysLeu: 5.063 ± 0.074	1.551LysMet: 1.551 ± 0.038	1.872LysAsn: 1.872 ± 0.041	2.193LysPro: 2.193 ± 0.043	2.673LysGln: 2.673 ± 0.05	2.75LysArg: 2.75 ± 0.051	2.671LysSer: 2.671 ± 0.049	2.708LysThr: 2.708 ± 0.05	3.605LysVal: 3.605 ± 0.07	0.624LysTrp: 0.624 ± 0.023	1.674LysTyr: 1.674 ± 0.041	0.002LysXaa: 0.002 ± 0.001
Leu	8.929LeuAla: 8.929 ± 0.129	0.903LeuCys: 0.903 ± 0.028	5.068LeuAsp: 5.068 ± 0.069	5.75LeuGlu: 5.75 ± 0.084	4.348LeuPhe: 4.348 ± 0.081	7.101LeuGly: 7.101 ± 0.079	2.347LeuHis: 2.347 ± 0.042	6.344LeuIle: 6.344 ± 0.086	4.807LeuLys: 4.807 ± 0.064	10.541LeuLeu: 10.541 ± 0.139	2.522LeuMet: 2.522 ± 0.041	3.598LeuAsn: 3.598 ± 0.06	4.466LeuPro: 4.466 ± 0.061	4.392LeuGln: 4.392 ± 0.069	4.979LeuArg: 4.979 ± 0.065	6.69LeuSer: 6.69 ± 0.087	5.759LeuThr: 5.759 ± 0.082	6.498LeuVal: 6.498 ± 0.082	0.995LeuTrp: 0.995 ± 0.03	2.951LeuTyr: 2.951 ± 0.054	0.003LeuXaa: 0.003 ± 0.001
Met	2.494MetAla: 2.494 ± 0.049	0.181MetCys: 0.181 ± 0.011	1.504MetAsp: 1.504 ± 0.036	1.787MetGlu: 1.787 ± 0.038	1.077MetPhe: 1.077 ± 0.029	1.897MetGly: 1.897 ± 0.045	0.572MetHis: 0.572 ± 0.021	1.892MetIle: 1.892 ± 0.044	1.807MetLys: 1.807 ± 0.039	2.979MetLeu: 2.979 ± 0.052	0.898MetMet: 0.898 ± 0.033	1.298MetAsn: 1.298 ± 0.037	1.223MetPro: 1.223 ± 0.033	1.218MetGln: 1.218 ± 0.031	1.453MetArg: 1.453 ± 0.034	1.764MetSer: 1.764 ± 0.037	1.609MetThr: 1.609 ± 0.036	1.961MetVal: 1.961 ± 0.043	0.258MetTrp: 0.258 ± 0.016	0.754MetTyr: 0.754 ± 0.025	0.002MetXaa: 0.002 ± 0.001
Asn	2.99AsnAla: 2.99 ± 0.054	0.268AsnCys: 0.268 ± 0.015	1.782AsnAsp: 1.782 ± 0.036	2.276AsnGlu: 2.276 ± 0.048	1.345AsnPhe: 1.345 ± 0.033	2.936AsnGly: 2.936 ± 0.053	0.841AsnHis: 0.841 ± 0.031	2.308AsnIle: 2.308 ± 0.045	1.922AsnLys: 1.922 ± 0.048	3.184AsnLeu: 3.184 ± 0.055	1.051AsnMet: 1.051 ± 0.028	1.468AsnAsn: 1.468 ± 0.037	2.0AsnPro: 2.0 ± 0.046	1.457AsnGln: 1.457 ± 0.039	2.0AsnArg: 2.0 ± 0.049	1.977AsnSer: 1.977 ± 0.042	1.943AsnThr: 1.943 ± 0.043	2.681AsnVal: 2.681 ± 0.049	0.449AsnTrp: 0.449 ± 0.022	1.33AsnTyr: 1.33 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	4.044ProAla: 4.044 ± 0.058	0.276ProCys: 0.276 ± 0.017	2.764ProAsp: 2.764 ± 0.051	3.235ProGlu: 3.235 ± 0.059	1.865ProPhe: 1.865 ± 0.047	3.24ProGly: 3.24 ± 0.056	1.151ProHis: 1.151 ± 0.033	2.418ProIle: 2.418 ± 0.048	1.739ProLys: 1.739 ± 0.038	4.02ProLeu: 4.02 ± 0.071	1.116ProMet: 1.116 ± 0.033	1.564ProAsn: 1.564 ± 0.038	1.524ProPro: 1.524 ± 0.045	1.55ProGln: 1.55 ± 0.037	1.674ProArg: 1.674 ± 0.043	2.389ProSer: 2.389 ± 0.046	2.2ProThr: 2.2 ± 0.051	3.42ProVal: 3.42 ± 0.055	0.494ProTrp: 0.494 ± 0.022	1.476ProTyr: 1.476 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.906GlnAla: 3.906 ± 0.068	0.293GlnCys: 0.293 ± 0.018	1.757GlnAsp: 1.757 ± 0.036	2.522GlnGlu: 2.522 ± 0.047	1.636GlnPhe: 1.636 ± 0.034	2.583GlnGly: 2.583 ± 0.047	1.098GlnHis: 1.098 ± 0.032	2.496GlnIle: 2.496 ± 0.042	1.963GlnLys: 1.963 ± 0.041	4.796GlnLeu: 4.796 ± 0.072	1.318GlnMet: 1.318 ± 0.038	1.308GlnAsn: 1.308 ± 0.03	1.993GlnPro: 1.993 ± 0.045	2.434GlnGln: 2.434 ± 0.059	2.303GlnArg: 2.303 ± 0.044	2.339GlnSer: 2.339 ± 0.052	2.125GlnThr: 2.125 ± 0.041	2.87GlnVal: 2.87 ± 0.046	0.569GlnTrp: 0.569 ± 0.023	1.306GlnTyr: 1.306 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.046ArgAla: 4.046 ± 0.064	0.422ArgCys: 0.422 ± 0.02	2.539ArgAsp: 2.539 ± 0.052	3.7ArgGlu: 3.7 ± 0.069	2.249ArgPhe: 2.249 ± 0.048	3.312ArgGly: 3.312 ± 0.058	1.319ArgHis: 1.319 ± 0.033	3.498ArgIle: 3.498 ± 0.057	2.914ArgLys: 2.914 ± 0.051	5.427ArgLeu: 5.427 ± 0.08	1.734ArgMet: 1.734 ± 0.043	1.974ArgAsn: 1.974 ± 0.043	1.951ArgPro: 1.951 ± 0.04	2.339ArgGln: 2.339 ± 0.036	3.096ArgArg: 3.096 ± 0.054	3.069ArgSer: 3.069 ± 0.057	2.701ArgThr: 2.701 ± 0.046	3.527ArgVal: 3.527 ± 0.057	0.727ArgTrp: 0.727 ± 0.027	1.887ArgTyr: 1.887 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.117SerAla: 5.117 ± 0.082	0.438SerCys: 0.438 ± 0.021	2.816SerAsp: 2.816 ± 0.051	3.47SerGlu: 3.47 ± 0.064	2.559SerPhe: 2.559 ± 0.051	4.954SerGly: 4.954 ± 0.07	1.299SerHis: 1.299 ± 0.032	3.922SerIle: 3.922 ± 0.061	2.842SerLys: 2.842 ± 0.049	5.745SerLeu: 5.745 ± 0.082	1.7SerMet: 1.7 ± 0.038	2.0SerAsn: 2.0 ± 0.037	2.393SerPro: 2.393 ± 0.048	2.03SerGln: 2.03 ± 0.048	3.031SerArg: 3.031 ± 0.046	3.766SerSer: 3.766 ± 0.076	3.224SerThr: 3.224 ± 0.056	4.457SerVal: 4.457 ± 0.06	0.739SerTrp: 0.739 ± 0.027	2.013SerTyr: 2.013 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.323ThrAla: 5.323 ± 0.081	0.418ThrCys: 0.418 ± 0.016	2.944ThrAsp: 2.944 ± 0.057	3.151ThrGlu: 3.151 ± 0.05	2.191ThrPhe: 2.191 ± 0.045	4.738ThrGly: 4.738 ± 0.073	1.136ThrHis: 1.136 ± 0.031	3.487ThrIle: 3.487 ± 0.056	2.448ThrLys: 2.448 ± 0.049	5.37ThrLeu: 5.37 ± 0.071	1.494ThrMet: 1.494 ± 0.033	1.922ThrAsn: 1.922 ± 0.041	2.676ThrPro: 2.676 ± 0.051	1.812ThrGln: 1.812 ± 0.05	2.315ThrArg: 2.315 ± 0.048	2.966ThrSer: 2.966 ± 0.055	2.918ThrThr: 2.918 ± 0.057	4.615ThrVal: 4.615 ± 0.072	0.631ThrTrp: 0.631 ± 0.024	1.712ThrTyr: 1.712 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.054ValAla: 6.054 ± 0.079	0.743ValCys: 0.743 ± 0.027	3.822ValAsp: 3.822 ± 0.061	4.696ValGlu: 4.696 ± 0.071	2.868ValPhe: 2.868 ± 0.054	5.168ValGly: 5.168 ± 0.079	1.694ValHis: 1.694 ± 0.039	5.191ValIle: 5.191 ± 0.067	3.794ValLys: 3.794 ± 0.064	7.327ValLeu: 7.327 ± 0.087	2.048ValMet: 2.048 ± 0.042	2.951ValAsn: 2.951 ± 0.057	3.342ValPro: 3.342 ± 0.055	2.899ValGln: 2.899 ± 0.055	3.775ValArg: 3.775 ± 0.06	4.621ValSer: 4.621 ± 0.063	4.623ValThr: 4.623 ± 0.072	5.6ValVal: 5.6 ± 0.076	0.867ValTrp: 0.867 ± 0.029	2.357ValTyr: 2.357 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.901TrpAla: 0.901 ± 0.028	0.104TrpCys: 0.104 ± 0.009	0.651TrpAsp: 0.651 ± 0.026	0.697TrpGlu: 0.697 ± 0.022	0.549TrpPhe: 0.549 ± 0.025	0.832TrpGly: 0.832 ± 0.031	0.302TrpHis: 0.302 ± 0.018	0.787TrpIle: 0.787 ± 0.025	0.672TrpLys: 0.672 ± 0.026	1.44TrpLeu: 1.44 ± 0.038	0.418TrpMet: 0.418 ± 0.019	0.6TrpAsn: 0.6 ± 0.021	0.345TrpPro: 0.345 ± 0.018	0.562TrpGln: 0.562 ± 0.022	0.658TrpArg: 0.658 ± 0.024	0.697TrpSer: 0.697 ± 0.028	0.61TrpThr: 0.61 ± 0.023	0.803TrpVal: 0.803 ± 0.025	0.186TrpTrp: 0.186 ± 0.012	0.387TrpTyr: 0.387 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.717TyrAla: 2.717 ± 0.058	0.314TyrCys: 0.314 ± 0.018	1.88TyrAsp: 1.88 ± 0.043	2.003TyrGlu: 2.003 ± 0.045	1.493TyrPhe: 1.493 ± 0.038	2.531TyrGly: 2.531 ± 0.051	0.839TyrHis: 0.839 ± 0.024	2.017TyrIle: 2.017 ± 0.038	1.454TyrLys: 1.454 ± 0.036	3.179TyrLeu: 3.179 ± 0.055	0.852TyrMet: 0.852 ± 0.03	1.271TyrAsn: 1.271 ± 0.039	1.51TyrPro: 1.51 ± 0.038	1.23TyrGln: 1.23 ± 0.027	1.922TyrArg: 1.922 ± 0.042	1.878TyrSer: 1.878 ± 0.043	1.728TyrThr: 1.728 ± 0.041	2.377TyrVal: 2.377 ± 0.049	0.404TyrTrp: 0.404 ± 0.018	1.257TyrTyr: 1.257 ± 0.032	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.003XaaLeu: 0.003 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.002XaaTrp: 0.002 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3922 proteins (1195824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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