Amino acid dipepetide frequency for Campylobacter phage CJIE4-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.247AlaAla: 1.247 ± 0.365
0.712AlaCys: 0.712 ± 0.314
1.959AlaAsp: 1.959 ± 0.316
3.383AlaGlu: 3.383 ± 0.812
4.363AlaPhe: 4.363 ± 0.637
2.849AlaGly: 2.849 ± 0.648
0.712AlaHis: 0.712 ± 0.276
3.918AlaIle: 3.918 ± 0.571
7.212AlaLys: 7.212 ± 0.782
8.548AlaLeu: 8.548 ± 0.806
1.425AlaMet: 1.425 ± 0.338
5.699AlaAsn: 5.699 ± 1.054
1.514AlaPro: 1.514 ± 0.31
1.959AlaGln: 1.959 ± 0.435
1.514AlaArg: 1.514 ± 0.564
4.363AlaSer: 4.363 ± 0.522
2.76AlaThr: 2.76 ± 0.624
1.603AlaVal: 1.603 ± 0.345
0.89AlaTrp: 0.89 ± 0.273
2.226AlaTyr: 2.226 ± 0.469
0.0AlaXaa: 0.0 ± 0.0
Cys
0.534CysAla: 0.534 ± 0.161
0.178CysCys: 0.178 ± 0.132
0.979CysAsp: 0.979 ± 0.295
0.89CysGlu: 0.89 ± 0.275
0.712CysPhe: 0.712 ± 0.295
0.623CysGly: 0.623 ± 0.266
0.089CysHis: 0.089 ± 0.087
0.623CysIle: 0.623 ± 0.262
1.247CysLys: 1.247 ± 0.349
1.247CysLeu: 1.247 ± 0.403
0.267CysMet: 0.267 ± 0.21
0.801CysAsn: 0.801 ± 0.273
0.356CysPro: 0.356 ± 0.176
0.089CysGln: 0.089 ± 0.083
0.0CysArg: 0.0 ± 0.0
0.979CysSer: 0.979 ± 0.312
0.267CysThr: 0.267 ± 0.171
0.534CysVal: 0.534 ± 0.25
0.0CysTrp: 0.0 ± 0.0
0.267CysTyr: 0.267 ± 0.17
0.0CysXaa: 0.0 ± 0.0
Asp
2.582AspAla: 2.582 ± 0.384
0.178AspCys: 0.178 ± 0.125
3.027AspAsp: 3.027 ± 0.718
6.055AspGlu: 6.055 ± 1.004
3.651AspPhe: 3.651 ± 0.537
2.493AspGly: 2.493 ± 0.46
0.445AspHis: 0.445 ± 0.205
3.562AspIle: 3.562 ± 0.464
6.411AspLys: 6.411 ± 0.783
5.609AspLeu: 5.609 ± 0.878
0.623AspMet: 0.623 ± 0.224
3.562AspAsn: 3.562 ± 0.688
0.89AspPro: 0.89 ± 0.321
0.623AspGln: 0.623 ± 0.191
1.068AspArg: 1.068 ± 0.34
1.514AspSer: 1.514 ± 0.334
2.582AspThr: 2.582 ± 0.473
2.315AspVal: 2.315 ± 0.458
0.356AspTrp: 0.356 ± 0.153
3.027AspTyr: 3.027 ± 0.492
0.0AspXaa: 0.0 ± 0.0
Glu
5.164GluAla: 5.164 ± 0.784
1.068GluCys: 1.068 ± 0.276
2.938GluAsp: 2.938 ± 0.586
8.103GluGlu: 8.103 ± 1.212
4.363GluPhe: 4.363 ± 0.63
1.781GluGly: 1.781 ± 0.412
0.712GluHis: 0.712 ± 0.273
8.103GluIle: 8.103 ± 0.933
11.575GluLys: 11.575 ± 0.868
11.041GluLeu: 11.041 ± 1.493
1.692GluMet: 1.692 ± 0.362
8.37GluAsn: 8.37 ± 0.801
1.068GluPro: 1.068 ± 0.366
4.363GluGln: 4.363 ± 0.635
2.938GluArg: 2.938 ± 0.669
4.63GluSer: 4.63 ± 0.791
2.404GluThr: 2.404 ± 0.511
4.274GluVal: 4.274 ± 0.578
0.534GluTrp: 0.534 ± 0.159
2.493GluTyr: 2.493 ± 0.513
0.0GluXaa: 0.0 ± 0.0
Phe
2.582PheAla: 2.582 ± 0.441
0.89PheCys: 0.89 ± 0.325
2.671PheAsp: 2.671 ± 0.463
4.452PheGlu: 4.452 ± 0.592
2.76PhePhe: 2.76 ± 0.712
2.404PheGly: 2.404 ± 0.449
0.623PheHis: 0.623 ± 0.24
4.363PheIle: 4.363 ± 0.807
7.123PheLys: 7.123 ± 0.716
6.233PheLeu: 6.233 ± 0.896
1.158PheMet: 1.158 ± 0.35
4.096PheAsn: 4.096 ± 0.572
0.534PhePro: 0.534 ± 0.196
1.336PheGln: 1.336 ± 0.247
1.336PheArg: 1.336 ± 0.382
3.383PheSer: 3.383 ± 0.659
2.493PheThr: 2.493 ± 0.46
2.315PheVal: 2.315 ± 0.594
0.178PheTrp: 0.178 ± 0.108
3.116PheTyr: 3.116 ± 0.599
0.0PheXaa: 0.0 ± 0.0
Gly
2.582GlyAla: 2.582 ± 0.714
0.623GlyCys: 0.623 ± 0.224
3.562GlyAsp: 3.562 ± 0.631
2.849GlyGlu: 2.849 ± 0.446
3.74GlyPhe: 3.74 ± 0.497
2.493GlyGly: 2.493 ± 0.679
0.267GlyHis: 0.267 ± 0.153
4.719GlyIle: 4.719 ± 0.622
4.541GlyLys: 4.541 ± 0.84
4.63GlyLeu: 4.63 ± 0.842
0.623GlyMet: 0.623 ± 0.189
3.116GlyAsn: 3.116 ± 0.493
0.0GlyPro: 0.0 ± 0.0
0.801GlyGln: 0.801 ± 0.248
0.0GlyArg: 0.0 ± 0.0
2.76GlySer: 2.76 ± 0.642
1.87GlyThr: 1.87 ± 0.613
2.938GlyVal: 2.938 ± 0.46
0.267GlyTrp: 0.267 ± 0.139
2.048GlyTyr: 2.048 ± 0.466
0.0GlyXaa: 0.0 ± 0.0
His
0.356HisAla: 0.356 ± 0.161
0.178HisCys: 0.178 ± 0.131
0.178HisAsp: 0.178 ± 0.117
1.068HisGlu: 1.068 ± 0.363
1.068HisPhe: 1.068 ± 0.364
0.534HisGly: 0.534 ± 0.247
0.445HisHis: 0.445 ± 0.215
0.534HisIle: 0.534 ± 0.193
1.247HisLys: 1.247 ± 0.325
0.979HisLeu: 0.979 ± 0.263
0.178HisMet: 0.178 ± 0.133
0.623HisAsn: 0.623 ± 0.212
0.267HisPro: 0.267 ± 0.219
0.445HisGln: 0.445 ± 0.224
0.267HisArg: 0.267 ± 0.185
0.534HisSer: 0.534 ± 0.194
0.89HisThr: 0.89 ± 0.243
0.178HisVal: 0.178 ± 0.104
0.089HisTrp: 0.089 ± 0.093
0.356HisTyr: 0.356 ± 0.148
0.0HisXaa: 0.0 ± 0.0
Ile
5.52IleAla: 5.52 ± 0.544
0.445IleCys: 0.445 ± 0.211
4.63IleAsp: 4.63 ± 0.608
6.856IleGlu: 6.856 ± 0.724
3.651IlePhe: 3.651 ± 0.571
3.829IleGly: 3.829 ± 0.693
0.979IleHis: 0.979 ± 0.327
6.411IleIle: 6.411 ± 1.079
10.596IleLys: 10.596 ± 0.834
7.479IleLeu: 7.479 ± 1.012
1.514IleMet: 1.514 ± 0.329
7.034IleAsn: 7.034 ± 0.762
1.87IlePro: 1.87 ± 0.463
2.582IleGln: 2.582 ± 0.406
2.315IleArg: 2.315 ± 0.471
5.075IleSer: 5.075 ± 0.611
4.363IleThr: 4.363 ± 0.578
2.671IleVal: 2.671 ± 0.48
0.89IleTrp: 0.89 ± 0.361
2.671IleTyr: 2.671 ± 0.503
0.0IleXaa: 0.0 ± 0.0
Lys
8.459LysAla: 8.459 ± 0.837
1.158LysCys: 1.158 ± 0.336
6.856LysAsp: 6.856 ± 0.851
12.198LysGlu: 12.198 ± 1.114
3.562LysPhe: 3.562 ± 0.625
5.877LysGly: 5.877 ± 0.881
1.158LysHis: 1.158 ± 0.407
11.041LysIle: 11.041 ± 1.367
12.109LysLys: 12.109 ± 1.317
9.616LysLeu: 9.616 ± 0.883
2.582LysMet: 2.582 ± 0.456
10.507LysAsn: 10.507 ± 0.917
3.205LysPro: 3.205 ± 0.643
5.431LysGln: 5.431 ± 0.636
3.473LysArg: 3.473 ± 0.59
5.164LysSer: 5.164 ± 0.699
6.589LysThr: 6.589 ± 0.615
4.541LysVal: 4.541 ± 0.566
0.623LysTrp: 0.623 ± 0.197
3.562LysTyr: 3.562 ± 0.57
0.0LysXaa: 0.0 ± 0.0
Leu
5.966LeuAla: 5.966 ± 0.705
1.247LeuCys: 1.247 ± 0.388
3.562LeuAsp: 3.562 ± 0.531
11.664LeuGlu: 11.664 ± 1.208
4.719LeuPhe: 4.719 ± 0.719
5.609LeuGly: 5.609 ± 1.006
0.979LeuHis: 0.979 ± 0.297
5.966LeuIle: 5.966 ± 0.714
14.157LeuLys: 14.157 ± 1.138
5.966LeuLeu: 5.966 ± 0.643
2.849LeuMet: 2.849 ± 0.495
9.082LeuAsn: 9.082 ± 0.679
1.425LeuPro: 1.425 ± 0.317
3.027LeuGln: 3.027 ± 0.684
4.452LeuArg: 4.452 ± 0.488
9.349LeuSer: 9.349 ± 0.933
3.918LeuThr: 3.918 ± 0.56
3.829LeuVal: 3.829 ± 0.532
0.979LeuTrp: 0.979 ± 0.308
2.938LeuTyr: 2.938 ± 0.546
0.0LeuXaa: 0.0 ± 0.0
Met
0.89MetAla: 0.89 ± 0.268
0.089MetCys: 0.089 ± 0.083
1.158MetAsp: 1.158 ± 0.33
0.979MetGlu: 0.979 ± 0.309
0.801MetPhe: 0.801 ± 0.274
0.623MetGly: 0.623 ± 0.202
0.178MetHis: 0.178 ± 0.137
2.315MetIle: 2.315 ± 0.486
2.137MetLys: 2.137 ± 0.44
2.582MetLeu: 2.582 ± 0.617
0.178MetMet: 0.178 ± 0.121
1.158MetAsn: 1.158 ± 0.278
0.623MetPro: 0.623 ± 0.216
2.137MetGln: 2.137 ± 0.412
1.336MetArg: 1.336 ± 0.377
2.76MetSer: 2.76 ± 0.489
0.712MetThr: 0.712 ± 0.225
0.712MetVal: 0.712 ± 0.268
0.178MetTrp: 0.178 ± 0.121
0.445MetTyr: 0.445 ± 0.184
0.0MetXaa: 0.0 ± 0.0
Asn
6.411AsnAla: 6.411 ± 0.705
0.89AsnCys: 0.89 ± 0.292
5.164AsnAsp: 5.164 ± 0.726
8.103AsnGlu: 8.103 ± 0.901
2.849AsnPhe: 2.849 ± 0.468
4.096AsnGly: 4.096 ± 0.601
1.068AsnHis: 1.068 ± 0.306
7.212AsnIle: 7.212 ± 0.779
6.945AsnLys: 6.945 ± 0.738
8.993AsnLeu: 8.993 ± 0.899
1.781AsnMet: 1.781 ± 0.372
4.986AsnAsn: 4.986 ± 0.686
1.781AsnPro: 1.781 ± 0.401
3.651AsnGln: 3.651 ± 0.843
1.158AsnArg: 1.158 ± 0.299
5.609AsnSer: 5.609 ± 0.84
2.671AsnThr: 2.671 ± 0.465
2.404AsnVal: 2.404 ± 0.447
0.445AsnTrp: 0.445 ± 0.204
2.048AsnTyr: 2.048 ± 0.414
0.089AsnXaa: 0.089 ± 0.098
Pro
0.89ProAla: 0.89 ± 0.324
0.178ProCys: 0.178 ± 0.196
0.534ProAsp: 0.534 ± 0.24
1.068ProGlu: 1.068 ± 0.284
1.603ProPhe: 1.603 ± 0.355
0.356ProGly: 0.356 ± 0.149
0.445ProHis: 0.445 ± 0.201
1.336ProIle: 1.336 ± 0.324
2.048ProLys: 2.048 ± 0.552
1.959ProLeu: 1.959 ± 0.535
0.445ProMet: 0.445 ± 0.18
1.336ProAsn: 1.336 ± 0.36
0.356ProPro: 0.356 ± 0.159
1.692ProGln: 1.692 ± 0.462
0.623ProArg: 0.623 ± 0.271
1.692ProSer: 1.692 ± 0.504
1.336ProThr: 1.336 ± 0.356
0.801ProVal: 0.801 ± 0.331
0.089ProTrp: 0.089 ± 0.083
1.514ProTyr: 1.514 ± 0.337
0.089ProXaa: 0.089 ± 0.099
Gln
2.849GlnAla: 2.849 ± 0.604
0.356GlnCys: 0.356 ± 0.166
1.87GlnAsp: 1.87 ± 0.33
3.473GlnGlu: 3.473 ± 0.645
0.801GlnPhe: 0.801 ± 0.233
1.781GlnGly: 1.781 ± 0.394
0.267GlnHis: 0.267 ± 0.144
3.74GlnIle: 3.74 ± 0.623
4.719GlnLys: 4.719 ± 0.538
2.671GlnLeu: 2.671 ± 0.644
1.247GlnMet: 1.247 ± 0.406
3.562GlnAsn: 3.562 ± 0.589
0.178GlnPro: 0.178 ± 0.129
0.801GlnGln: 0.801 ± 0.265
1.336GlnArg: 1.336 ± 0.357
3.294GlnSer: 3.294 ± 0.532
2.137GlnThr: 2.137 ± 0.416
1.514GlnVal: 1.514 ± 0.391
0.089GlnTrp: 0.089 ± 0.098
1.158GlnTyr: 1.158 ± 0.302
0.0GlnXaa: 0.0 ± 0.0
Arg
1.692ArgAla: 1.692 ± 0.374
0.267ArgCys: 0.267 ± 0.154
1.068ArgAsp: 1.068 ± 0.298
2.671ArgGlu: 2.671 ± 0.598
1.692ArgPhe: 1.692 ± 0.411
0.712ArgGly: 0.712 ± 0.282
0.089ArgHis: 0.089 ± 0.093
2.137ArgIle: 2.137 ± 0.482
3.383ArgLys: 3.383 ± 0.613
3.473ArgLeu: 3.473 ± 0.663
0.801ArgMet: 0.801 ± 0.277
1.692ArgAsn: 1.692 ± 0.373
0.623ArgPro: 0.623 ± 0.178
1.068ArgGln: 1.068 ± 0.244
0.623ArgArg: 0.623 ± 0.212
1.603ArgSer: 1.603 ± 0.467
0.89ArgThr: 0.89 ± 0.239
1.692ArgVal: 1.692 ± 0.386
0.356ArgTrp: 0.356 ± 0.216
0.801ArgTyr: 0.801 ± 0.298
0.0ArgXaa: 0.0 ± 0.0
Ser
4.096SerAla: 4.096 ± 0.561
0.356SerCys: 0.356 ± 0.171
3.74SerAsp: 3.74 ± 0.484
4.719SerGlu: 4.719 ± 0.644
5.609SerPhe: 5.609 ± 1.088
2.938SerGly: 2.938 ± 0.496
0.178SerHis: 0.178 ± 0.105
5.52SerIle: 5.52 ± 0.652
8.014SerLys: 8.014 ± 0.799
7.746SerLeu: 7.746 ± 0.716
1.692SerMet: 1.692 ± 0.306
3.918SerAsn: 3.918 ± 0.607
1.781SerPro: 1.781 ± 0.353
2.315SerGln: 2.315 ± 0.39
1.336SerArg: 1.336 ± 0.388
5.164SerSer: 5.164 ± 1.114
3.294SerThr: 3.294 ± 0.535
3.116SerVal: 3.116 ± 0.543
0.534SerTrp: 0.534 ± 0.163
1.603SerTyr: 1.603 ± 0.327
0.0SerXaa: 0.0 ± 0.0
Thr
2.315ThrAla: 2.315 ± 0.503
0.445ThrCys: 0.445 ± 0.194
1.781ThrAsp: 1.781 ± 0.394
2.76ThrGlu: 2.76 ± 0.427
2.315ThrPhe: 2.315 ± 0.405
1.959ThrGly: 1.959 ± 0.463
1.068ThrHis: 1.068 ± 0.285
3.473ThrIle: 3.473 ± 0.476
4.986ThrLys: 4.986 ± 0.545
4.007ThrLeu: 4.007 ± 0.53
1.336ThrMet: 1.336 ± 0.323
4.007ThrAsn: 4.007 ± 0.622
1.514ThrPro: 1.514 ± 0.424
2.76ThrGln: 2.76 ± 0.516
0.979ThrArg: 0.979 ± 0.253
4.096ThrSer: 4.096 ± 0.551
2.849ThrThr: 2.849 ± 0.428
0.267ThrVal: 0.267 ± 0.154
0.623ThrTrp: 0.623 ± 0.2
2.048ThrTyr: 2.048 ± 0.439
0.0ThrXaa: 0.0 ± 0.0
Val
2.226ValAla: 2.226 ± 0.386
0.89ValCys: 0.89 ± 0.338
1.781ValAsp: 1.781 ± 0.406
2.315ValGlu: 2.315 ± 0.475
3.027ValPhe: 3.027 ± 0.655
1.781ValGly: 1.781 ± 0.405
0.178ValHis: 0.178 ± 0.137
2.76ValIle: 2.76 ± 0.508
4.096ValLys: 4.096 ± 0.616
5.253ValLeu: 5.253 ± 0.833
0.801ValMet: 0.801 ± 0.239
2.137ValAsn: 2.137 ± 0.346
1.336ValPro: 1.336 ± 0.34
0.979ValGln: 0.979 ± 0.33
0.801ValArg: 0.801 ± 0.283
3.74ValSer: 3.74 ± 0.573
1.336ValThr: 1.336 ± 0.357
2.404ValVal: 2.404 ± 0.457
0.712ValTrp: 0.712 ± 0.225
1.247ValTyr: 1.247 ± 0.349
0.0ValXaa: 0.0 ± 0.0
Trp
0.356TrpAla: 0.356 ± 0.148
0.089TrpCys: 0.089 ± 0.083
0.534TrpAsp: 0.534 ± 0.193
0.534TrpGlu: 0.534 ± 0.193
0.445TrpPhe: 0.445 ± 0.275
0.445TrpGly: 0.445 ± 0.187
0.267TrpHis: 0.267 ± 0.148
0.712TrpIle: 0.712 ± 0.218
0.89TrpLys: 0.89 ± 0.289
0.979TrpLeu: 0.979 ± 0.337
0.0TrpMet: 0.0 ± 0.0
0.712TrpAsn: 0.712 ± 0.339
0.0TrpPro: 0.0 ± 0.0
0.267TrpGln: 0.267 ± 0.143
0.267TrpArg: 0.267 ± 0.167
0.356TrpSer: 0.356 ± 0.162
0.534TrpThr: 0.534 ± 0.173
0.356TrpVal: 0.356 ± 0.219
0.267TrpTrp: 0.267 ± 0.165
0.267TrpTyr: 0.267 ± 0.136
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.137TyrAla: 2.137 ± 0.5
0.445TyrCys: 0.445 ± 0.217
2.582TyrAsp: 2.582 ± 0.463
3.383TyrGlu: 3.383 ± 0.404
2.315TyrPhe: 2.315 ± 0.53
1.247TyrGly: 1.247 ± 0.371
0.267TyrHis: 0.267 ± 0.153
2.938TyrIle: 2.938 ± 0.44
4.274TyrLys: 4.274 ± 0.66
2.671TyrLeu: 2.671 ± 0.613
0.712TyrMet: 0.712 ± 0.237
1.87TyrAsn: 1.87 ± 0.513
1.068TyrPro: 1.068 ± 0.396
1.603TyrGln: 1.603 ± 0.392
1.514TyrArg: 1.514 ± 0.385
1.603TyrSer: 1.603 ± 0.346
1.692TyrThr: 1.692 ± 0.346
1.336TyrVal: 1.336 ± 0.273
0.178TyrTrp: 0.178 ± 0.144
1.336TyrTyr: 1.336 ± 0.394
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.089XaaGlu: 0.089 ± 0.098
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.089XaaAsn: 0.089 ± 0.099
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (11232 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski