Amino acid dipepetide frequency for Lettuce yellow mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.146AlaAla: 4.146 ± 1.76
1.296AlaCys: 1.296 ± 0.389
1.814AlaAsp: 1.814 ± 0.767
3.11AlaGlu: 3.11 ± 1.178
0.777AlaPhe: 0.777 ± 0.318
3.628AlaGly: 3.628 ± 1.324
1.037AlaHis: 1.037 ± 0.679
5.701AlaIle: 5.701 ± 1.375
2.591AlaLys: 2.591 ± 0.397
5.183AlaLeu: 5.183 ± 1.492
1.037AlaMet: 1.037 ± 0.809
3.887AlaAsn: 3.887 ± 1.742
1.555AlaPro: 1.555 ± 0.432
2.85AlaGln: 2.85 ± 1.247
2.073AlaArg: 2.073 ± 1.581
3.887AlaSer: 3.887 ± 1.565
2.591AlaThr: 2.591 ± 0.792
3.11AlaVal: 3.11 ± 0.891
1.037AlaTrp: 1.037 ± 0.374
2.073AlaTyr: 2.073 ± 0.901
0.0AlaXaa: 0.0 ± 0.0
Cys
1.296CysAla: 1.296 ± 0.382
0.259CysCys: 0.259 ± 0.154
1.555CysAsp: 1.555 ± 0.496
0.777CysGlu: 0.777 ± 0.593
0.518CysPhe: 0.518 ± 0.308
0.259CysGly: 0.259 ± 0.321
0.259CysHis: 0.259 ± 0.321
1.037CysIle: 1.037 ± 0.444
0.777CysLys: 0.777 ± 0.664
1.037CysLeu: 1.037 ± 1.199
0.777CysMet: 0.777 ± 0.462
1.037CysAsn: 1.037 ± 0.583
1.037CysPro: 1.037 ± 0.679
1.037CysGln: 1.037 ± 1.283
1.555CysArg: 1.555 ± 0.503
1.814CysSer: 1.814 ± 0.841
1.555CysThr: 1.555 ± 0.579
1.037CysVal: 1.037 ± 0.349
0.518CysTrp: 0.518 ± 0.308
0.777CysTyr: 0.777 ± 0.419
0.0CysXaa: 0.0 ± 0.0
Asp
3.369AspAla: 3.369 ± 1.528
1.296AspCys: 1.296 ± 0.505
3.887AspAsp: 3.887 ± 0.665
3.11AspGlu: 3.11 ± 0.822
2.073AspPhe: 2.073 ± 0.485
2.85AspGly: 2.85 ± 0.637
1.814AspHis: 1.814 ± 0.596
5.96AspIle: 5.96 ± 1.178
3.628AspLys: 3.628 ± 1.0
5.183AspLeu: 5.183 ± 0.572
2.073AspMet: 2.073 ± 0.881
2.332AspAsn: 2.332 ± 1.066
4.146AspPro: 4.146 ± 0.668
2.332AspGln: 2.332 ± 0.935
2.591AspArg: 2.591 ± 0.841
3.628AspSer: 3.628 ± 1.026
3.369AspThr: 3.369 ± 0.575
2.85AspVal: 2.85 ± 0.885
2.332AspTrp: 2.332 ± 1.135
1.555AspTyr: 1.555 ± 0.432
0.0AspXaa: 0.0 ± 0.0
Glu
3.11GluAla: 3.11 ± 2.191
1.296GluCys: 1.296 ± 0.602
4.924GluAsp: 4.924 ± 0.874
2.85GluGlu: 2.85 ± 0.732
1.814GluPhe: 1.814 ± 1.078
2.073GluGly: 2.073 ± 0.62
1.555GluHis: 1.555 ± 0.874
5.701GluIle: 5.701 ± 0.67
4.146GluLys: 4.146 ± 0.951
5.701GluLeu: 5.701 ± 1.396
0.777GluMet: 0.777 ± 0.419
2.332GluAsn: 2.332 ± 0.735
2.073GluPro: 2.073 ± 0.588
1.296GluGln: 1.296 ± 1.086
3.11GluArg: 3.11 ± 1.028
5.96GluSer: 5.96 ± 0.745
3.628GluThr: 3.628 ± 0.826
3.887GluVal: 3.887 ± 1.946
1.037GluTrp: 1.037 ± 0.484
1.037GluTyr: 1.037 ± 0.583
0.0GluXaa: 0.0 ± 0.0
Phe
1.814PheAla: 1.814 ± 0.564
0.777PheCys: 0.777 ± 0.338
2.591PheAsp: 2.591 ± 0.599
2.591PheGlu: 2.591 ± 0.792
0.777PhePhe: 0.777 ± 0.444
3.887PheGly: 3.887 ± 1.124
0.518PheHis: 0.518 ± 0.308
1.814PheIle: 1.814 ± 0.564
1.814PheLys: 1.814 ± 1.078
2.85PheLeu: 2.85 ± 0.957
1.037PheMet: 1.037 ± 0.438
1.555PheAsn: 1.555 ± 0.418
3.628PhePro: 3.628 ± 1.453
0.518PheGln: 0.518 ± 0.308
1.814PheArg: 1.814 ± 0.507
3.887PheSer: 3.887 ± 0.812
2.073PheThr: 2.073 ± 0.946
1.814PheVal: 1.814 ± 0.804
0.259PheTrp: 0.259 ± 0.154
0.777PheTyr: 0.777 ± 0.462
0.0PheXaa: 0.0 ± 0.0
Gly
2.332GlyAla: 2.332 ± 0.872
1.555GlyCys: 1.555 ± 0.866
2.332GlyAsp: 2.332 ± 0.552
3.887GlyGlu: 3.887 ± 1.426
2.591GlyPhe: 2.591 ± 0.6
3.628GlyGly: 3.628 ± 1.172
1.296GlyHis: 1.296 ± 0.542
3.628GlyIle: 3.628 ± 1.501
4.664GlyLys: 4.664 ± 1.046
6.997GlyLeu: 6.997 ± 0.893
2.85GlyMet: 2.85 ± 1.061
1.555GlyAsn: 1.555 ± 0.62
1.037GlyPro: 1.037 ± 0.662
1.555GlyGln: 1.555 ± 0.635
2.591GlyArg: 2.591 ± 1.411
4.664GlySer: 4.664 ± 1.24
3.11GlyThr: 3.11 ± 1.828
4.664GlyVal: 4.664 ± 1.171
1.037GlyTrp: 1.037 ± 0.616
2.332GlyTyr: 2.332 ± 0.564
0.0GlyXaa: 0.0 ± 0.0
His
0.777HisAla: 0.777 ± 0.318
0.777HisCys: 0.777 ± 0.801
1.296HisAsp: 1.296 ± 0.406
1.296HisGlu: 1.296 ± 0.373
0.777HisPhe: 0.777 ± 0.338
0.777HisGly: 0.777 ± 0.338
1.296HisHis: 1.296 ± 0.557
1.555HisIle: 1.555 ± 0.802
2.073HisLys: 2.073 ± 0.577
2.073HisLeu: 2.073 ± 0.987
0.259HisMet: 0.259 ± 0.154
1.037HisAsn: 1.037 ± 0.484
1.555HisPro: 1.555 ± 0.313
1.037HisGln: 1.037 ± 0.349
1.555HisArg: 1.555 ± 0.698
0.518HisSer: 0.518 ± 0.291
0.259HisThr: 0.259 ± 0.154
1.814HisVal: 1.814 ± 0.538
0.0HisTrp: 0.0 ± 0.0
1.296HisTyr: 1.296 ± 0.437
0.0HisXaa: 0.0 ± 0.0
Ile
2.85IleAla: 2.85 ± 1.335
1.037IleCys: 1.037 ± 0.583
4.146IleAsp: 4.146 ± 0.436
3.628IleGlu: 3.628 ± 0.724
2.85IlePhe: 2.85 ± 1.258
4.924IleGly: 4.924 ± 0.856
2.073IleHis: 2.073 ± 0.62
6.478IleIle: 6.478 ± 1.886
4.146IleLys: 4.146 ± 2.168
3.887IleLeu: 3.887 ± 0.856
1.555IleMet: 1.555 ± 0.666
2.073IleAsn: 2.073 ± 0.493
2.591IlePro: 2.591 ± 0.612
2.332IleGln: 2.332 ± 0.886
3.369IleArg: 3.369 ± 1.041
7.515IleSer: 7.515 ± 1.824
7.774IleThr: 7.774 ± 0.965
3.887IleVal: 3.887 ± 1.069
0.518IleTrp: 0.518 ± 0.308
1.555IleTyr: 1.555 ± 0.595
0.0IleXaa: 0.0 ± 0.0
Lys
2.85LysAla: 2.85 ± 0.893
1.037LysCys: 1.037 ± 0.583
3.369LysAsp: 3.369 ± 0.259
5.442LysGlu: 5.442 ± 0.582
2.073LysPhe: 2.073 ± 0.591
5.701LysGly: 5.701 ± 1.785
1.037LysHis: 1.037 ± 0.528
4.146LysIle: 4.146 ± 1.402
4.924LysLys: 4.924 ± 0.866
4.664LysLeu: 4.664 ± 1.195
2.85LysMet: 2.85 ± 1.214
2.591LysAsn: 2.591 ± 0.71
1.814LysPro: 1.814 ± 0.609
2.073LysGln: 2.073 ± 0.49
2.85LysArg: 2.85 ± 1.736
6.478LysSer: 6.478 ± 0.911
5.442LysThr: 5.442 ± 1.919
2.332LysVal: 2.332 ± 0.749
0.518LysTrp: 0.518 ± 0.291
2.85LysTyr: 2.85 ± 0.91
0.0LysXaa: 0.0 ± 0.0
Leu
5.183LeuAla: 5.183 ± 1.934
1.555LeuCys: 1.555 ± 0.458
6.997LeuAsp: 6.997 ± 1.522
3.887LeuGlu: 3.887 ± 0.449
5.183LeuPhe: 5.183 ± 1.71
6.997LeuGly: 6.997 ± 1.691
2.073LeuHis: 2.073 ± 0.699
4.405LeuIle: 4.405 ± 0.821
4.924LeuLys: 4.924 ± 1.263
9.07LeuLeu: 9.07 ± 1.415
3.887LeuMet: 3.887 ± 1.602
3.369LeuAsn: 3.369 ± 1.222
3.369LeuPro: 3.369 ± 1.213
3.887LeuGln: 3.887 ± 1.017
5.442LeuArg: 5.442 ± 1.409
8.292LeuSer: 8.292 ± 0.97
5.96LeuThr: 5.96 ± 1.001
5.701LeuVal: 5.701 ± 1.34
2.332LeuTrp: 2.332 ± 0.514
2.332LeuTyr: 2.332 ± 0.872
0.0LeuXaa: 0.0 ± 0.0
Met
0.777MetAla: 0.777 ± 1.11
0.777MetCys: 0.777 ± 0.444
1.555MetAsp: 1.555 ± 0.465
3.11MetGlu: 3.11 ± 0.991
0.777MetPhe: 0.777 ± 0.4
1.037MetGly: 1.037 ± 0.616
0.777MetHis: 0.777 ± 0.318
1.555MetIle: 1.555 ± 0.462
2.591MetLys: 2.591 ± 1.19
3.628MetLeu: 3.628 ± 1.06
1.555MetMet: 1.555 ± 0.498
0.777MetAsn: 0.777 ± 0.462
0.777MetPro: 0.777 ± 0.462
0.777MetGln: 0.777 ± 0.462
2.073MetArg: 2.073 ± 0.934
2.332MetSer: 2.332 ± 0.403
3.628MetThr: 3.628 ± 0.985
2.073MetVal: 2.073 ± 0.698
0.259MetTrp: 0.259 ± 0.321
0.777MetTyr: 0.777 ± 0.444
0.0MetXaa: 0.0 ± 0.0
Asn
1.296AsnAla: 1.296 ± 0.406
0.518AsnCys: 0.518 ± 0.291
1.296AsnAsp: 1.296 ± 0.578
1.555AsnGlu: 1.555 ± 0.988
0.518AsnPhe: 0.518 ± 0.64
1.037AsnGly: 1.037 ± 0.444
1.037AsnHis: 1.037 ± 0.349
3.369AsnIle: 3.369 ± 1.105
4.405AsnLys: 4.405 ± 1.19
3.11AsnLeu: 3.11 ± 1.153
1.296AsnMet: 1.296 ± 0.592
2.591AsnAsn: 2.591 ± 2.648
3.369AsnPro: 3.369 ± 0.863
1.814AsnGln: 1.814 ± 0.862
2.591AsnArg: 2.591 ± 0.861
3.628AsnSer: 3.628 ± 2.932
2.332AsnThr: 2.332 ± 0.735
1.555AsnVal: 1.555 ± 0.958
0.777AsnTrp: 0.777 ± 0.318
1.555AsnTyr: 1.555 ± 0.663
0.0AsnXaa: 0.0 ± 0.0
Pro
2.073ProAla: 2.073 ± 1.028
0.259ProCys: 0.259 ± 0.154
3.628ProAsp: 3.628 ± 1.261
2.332ProGlu: 2.332 ± 0.74
1.814ProPhe: 1.814 ± 0.601
1.037ProGly: 1.037 ± 1.253
2.073ProHis: 2.073 ± 0.664
3.11ProIle: 3.11 ± 1.033
2.591ProLys: 2.591 ± 1.41
5.442ProLeu: 5.442 ± 1.621
0.0ProMet: 0.0 ± 0.0
1.555ProAsn: 1.555 ± 0.971
3.11ProPro: 3.11 ± 0.981
1.555ProGln: 1.555 ± 0.594
2.85ProArg: 2.85 ± 1.684
2.85ProSer: 2.85 ± 0.795
3.628ProThr: 3.628 ± 0.774
2.591ProVal: 2.591 ± 0.987
0.259ProTrp: 0.259 ± 0.154
0.777ProTyr: 0.777 ± 0.462
0.0ProXaa: 0.0 ± 0.0
Gln
1.296GlnAla: 1.296 ± 0.396
0.777GlnCys: 0.777 ± 0.419
1.555GlnAsp: 1.555 ± 0.666
1.814GlnGlu: 1.814 ± 0.697
1.037GlnPhe: 1.037 ± 0.374
1.555GlnGly: 1.555 ± 0.946
0.259GlnHis: 0.259 ± 0.321
1.814GlnIle: 1.814 ± 0.611
1.296GlnLys: 1.296 ± 0.382
3.887GlnLeu: 3.887 ± 1.497
1.555GlnMet: 1.555 ± 0.465
0.777GlnAsn: 0.777 ± 0.338
0.777GlnPro: 0.777 ± 1.11
1.814GlnGln: 1.814 ± 1.137
1.814GlnArg: 1.814 ± 0.795
3.628GlnSer: 3.628 ± 0.314
1.814GlnThr: 1.814 ± 0.609
4.146GlnVal: 4.146 ± 0.819
1.296GlnTrp: 1.296 ± 0.562
0.518GlnTyr: 0.518 ± 0.379
0.0GlnXaa: 0.0 ± 0.0
Arg
3.628ArgAla: 3.628 ± 1.315
1.037ArgCys: 1.037 ± 0.583
2.591ArgAsp: 2.591 ± 0.57
3.11ArgGlu: 3.11 ± 1.024
2.85ArgPhe: 2.85 ± 0.724
3.628ArgGly: 3.628 ± 0.724
0.777ArgHis: 0.777 ± 0.338
3.628ArgIle: 3.628 ± 1.21
2.591ArgLys: 2.591 ± 0.587
5.183ArgLeu: 5.183 ± 1.139
1.555ArgMet: 1.555 ± 0.859
2.332ArgAsn: 2.332 ± 0.741
1.296ArgPro: 1.296 ± 0.505
1.814ArgGln: 1.814 ± 0.538
2.332ArgArg: 2.332 ± 0.449
3.887ArgSer: 3.887 ± 1.04
2.85ArgThr: 2.85 ± 0.695
4.405ArgVal: 4.405 ± 1.35
1.814ArgTrp: 1.814 ± 0.773
1.814ArgTyr: 1.814 ± 0.562
0.0ArgXaa: 0.0 ± 0.0
Ser
4.924SerAla: 4.924 ± 1.082
1.555SerCys: 1.555 ± 0.874
5.442SerAsp: 5.442 ± 1.084
6.219SerGlu: 6.219 ± 0.982
2.591SerPhe: 2.591 ± 0.938
5.701SerGly: 5.701 ± 2.223
0.777SerHis: 0.777 ± 0.4
3.887SerIle: 3.887 ± 0.815
6.219SerLys: 6.219 ± 1.017
6.478SerLeu: 6.478 ± 1.645
3.11SerMet: 3.11 ± 1.144
3.11SerAsn: 3.11 ± 1.349
3.11SerPro: 3.11 ± 1.991
1.814SerGln: 1.814 ± 0.563
4.146SerArg: 4.146 ± 0.888
6.219SerSer: 6.219 ± 0.565
6.478SerThr: 6.478 ± 0.441
7.774SerVal: 7.774 ± 2.421
0.777SerTrp: 0.777 ± 0.419
2.85SerTyr: 2.85 ± 0.696
0.0SerXaa: 0.0 ± 0.0
Thr
3.369ThrAla: 3.369 ± 0.716
1.037ThrCys: 1.037 ± 0.438
3.628ThrAsp: 3.628 ± 0.962
5.183ThrGlu: 5.183 ± 1.616
2.85ThrPhe: 2.85 ± 0.593
4.146ThrGly: 4.146 ± 0.74
0.777ThrHis: 0.777 ± 0.444
3.628ThrIle: 3.628 ± 0.853
4.924ThrLys: 4.924 ± 0.993
6.219ThrLeu: 6.219 ± 2.17
2.073ThrMet: 2.073 ± 0.49
1.555ThrAsn: 1.555 ± 0.723
3.369ThrPro: 3.369 ± 0.759
2.591ThrGln: 2.591 ± 1.515
4.664ThrArg: 4.664 ± 1.442
5.183ThrSer: 5.183 ± 1.577
2.073ThrThr: 2.073 ± 0.377
4.924ThrVal: 4.924 ± 0.649
1.037ThrTrp: 1.037 ± 0.679
2.332ThrTyr: 2.332 ± 0.636
0.0ThrXaa: 0.0 ± 0.0
Val
4.664ValAla: 4.664 ± 2.567
1.814ValCys: 1.814 ± 0.579
3.887ValAsp: 3.887 ± 1.589
2.591ValGlu: 2.591 ± 0.563
2.332ValPhe: 2.332 ± 0.886
3.369ValGly: 3.369 ± 1.217
1.037ValHis: 1.037 ± 0.528
3.628ValIle: 3.628 ± 0.914
3.887ValLys: 3.887 ± 0.983
8.811ValLeu: 8.811 ± 0.925
1.555ValMet: 1.555 ± 0.799
2.85ValAsn: 2.85 ± 1.435
2.85ValPro: 2.85 ± 0.835
1.814ValGln: 1.814 ± 0.96
3.11ValArg: 3.11 ± 0.37
5.442ValSer: 5.442 ± 1.128
5.701ValThr: 5.701 ± 0.641
2.85ValVal: 2.85 ± 1.076
0.518ValTrp: 0.518 ± 0.435
1.814ValTyr: 1.814 ± 0.298
0.0ValXaa: 0.0 ± 0.0
Trp
1.037TrpAla: 1.037 ± 0.616
0.0TrpCys: 0.0 ± 0.0
1.555TrpAsp: 1.555 ± 0.62
1.296TrpGlu: 1.296 ± 0.612
0.777TrpPhe: 0.777 ± 0.4
1.296TrpGly: 1.296 ± 0.77
0.0TrpHis: 0.0 ± 0.0
1.555TrpIle: 1.555 ± 0.698
0.777TrpLys: 0.777 ± 0.462
0.518TrpLeu: 0.518 ± 0.308
0.777TrpMet: 0.777 ± 0.593
1.296TrpAsn: 1.296 ± 0.437
0.259TrpPro: 0.259 ± 0.154
0.0TrpGln: 0.0 ± 0.0
1.296TrpArg: 1.296 ± 0.361
0.518TrpSer: 0.518 ± 0.308
0.518TrpThr: 0.518 ± 0.291
1.814TrpVal: 1.814 ± 0.909
0.259TrpTrp: 0.259 ± 0.154
1.555TrpTyr: 1.555 ± 0.877
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.591TyrAla: 2.591 ± 0.561
0.259TyrCys: 0.259 ± 0.435
2.332TyrAsp: 2.332 ± 0.91
0.518TyrGlu: 0.518 ± 0.291
1.814TyrPhe: 1.814 ± 1.0
0.777TyrGly: 0.777 ± 0.318
1.555TyrHis: 1.555 ± 0.698
2.591TyrIle: 2.591 ± 1.146
2.332TyrLys: 2.332 ± 0.592
4.924TyrLeu: 4.924 ± 1.804
0.777TyrMet: 0.777 ± 0.593
1.037TyrAsn: 1.037 ± 0.401
1.814TyrPro: 1.814 ± 0.298
0.518TyrGln: 0.518 ± 0.308
1.296TyrArg: 1.296 ± 0.602
2.85TyrSer: 2.85 ± 0.903
0.777TyrThr: 0.777 ± 0.318
1.296TyrVal: 1.296 ± 0.652
0.518TyrTrp: 0.518 ± 0.435
0.518TyrTyr: 0.518 ± 0.379
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (3860 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski