Amino acid dipepetide frequency for Marinobacter sp. B9-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.561AlaAla: 9.561 ± 0.133	0.992AlaCys: 0.992 ± 0.033	5.527AlaAsp: 5.527 ± 0.077	6.732AlaGlu: 6.732 ± 0.101	3.68AlaPhe: 3.68 ± 0.068	8.425AlaGly: 8.425 ± 0.098	1.786AlaHis: 1.786 ± 0.044	5.505AlaIle: 5.505 ± 0.095	3.233AlaLys: 3.233 ± 0.061	11.048AlaLeu: 11.048 ± 0.145	3.022AlaMet: 3.022 ± 0.059	2.988AlaAsn: 2.988 ± 0.056	3.797AlaPro: 3.797 ± 0.072	3.203AlaGln: 3.203 ± 0.056	6.324AlaArg: 6.324 ± 0.084	5.814AlaSer: 5.814 ± 0.074	4.727AlaThr: 4.727 ± 0.067	7.02AlaVal: 7.02 ± 0.094	1.375AlaTrp: 1.375 ± 0.035	2.237AlaTyr: 2.237 ± 0.055	0.001AlaXaa: 0.001 ± 0.001
Cys	0.774CysAla: 0.774 ± 0.025	0.13CysCys: 0.13 ± 0.015	0.547CysAsp: 0.547 ± 0.025	0.596CysGlu: 0.596 ± 0.021	0.341CysPhe: 0.341 ± 0.019	0.913CysGly: 0.913 ± 0.036	0.287CysHis: 0.287 ± 0.019	0.414CysIle: 0.414 ± 0.024	0.302CysLys: 0.302 ± 0.02	0.94CysLeu: 0.94 ± 0.033	0.193CysMet: 0.193 ± 0.015	0.285CysAsn: 0.285 ± 0.017	0.511CysPro: 0.511 ± 0.024	0.353CysGln: 0.353 ± 0.022	0.611CysArg: 0.611 ± 0.025	0.558CysSer: 0.558 ± 0.029	0.408CysThr: 0.408 ± 0.02	0.604CysVal: 0.604 ± 0.024	0.135CysTrp: 0.135 ± 0.012	0.257CysTyr: 0.257 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.151AspAla: 5.151 ± 0.08	0.511AspCys: 0.511 ± 0.025	3.329AspAsp: 3.329 ± 0.085	4.186AspGlu: 4.186 ± 0.068	2.348AspPhe: 2.348 ± 0.055	4.432AspGly: 4.432 ± 0.091	1.278AspHis: 1.278 ± 0.037	3.268AspIle: 3.268 ± 0.062	2.002AspLys: 2.002 ± 0.049	5.811AspLeu: 5.811 ± 0.083	1.473AspMet: 1.473 ± 0.044	1.881AspAsn: 1.881 ± 0.05	2.758AspPro: 2.758 ± 0.058	2.535AspGln: 2.535 ± 0.053	3.695AspArg: 3.695 ± 0.07	3.122AspSer: 3.122 ± 0.07	2.739AspThr: 2.739 ± 0.051	3.983AspVal: 3.983 ± 0.059	0.951AspTrp: 0.951 ± 0.035	1.846AspTyr: 1.846 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.93GluAla: 6.93 ± 0.108	0.461GluCys: 0.461 ± 0.021	3.614GluAsp: 3.614 ± 0.071	4.457GluGlu: 4.457 ± 0.078	2.313GluPhe: 2.313 ± 0.049	4.672GluGly: 4.672 ± 0.075	1.555GluHis: 1.555 ± 0.044	3.481GluIle: 3.481 ± 0.06	3.167GluLys: 3.167 ± 0.076	6.964GluLeu: 6.964 ± 0.094	1.655GluMet: 1.655 ± 0.041	2.348GluAsn: 2.348 ± 0.055	2.994GluPro: 2.994 ± 0.071	3.537GluGln: 3.537 ± 0.074	4.678GluArg: 4.678 ± 0.074	3.757GluSer: 3.757 ± 0.062	3.687GluThr: 3.687 ± 0.068	4.662GluVal: 4.662 ± 0.077	0.823GluTrp: 0.823 ± 0.029	1.603GluTyr: 1.603 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.512PheAla: 3.512 ± 0.068	0.426PheCys: 0.426 ± 0.021	2.459PheAsp: 2.459 ± 0.053	2.46PheGlu: 2.46 ± 0.052	1.669PhePhe: 1.669 ± 0.051	3.356PheGly: 3.356 ± 0.062	0.837PheHis: 0.837 ± 0.029	2.042PheIle: 2.042 ± 0.049	1.275PheLys: 1.275 ± 0.043	3.846PheLeu: 3.846 ± 0.073	0.985PheMet: 0.985 ± 0.036	1.404PheAsn: 1.404 ± 0.043	1.666PhePro: 1.666 ± 0.041	1.298PheGln: 1.298 ± 0.037	2.515PheArg: 2.515 ± 0.049	2.74PheSer: 2.74 ± 0.052	2.046PheThr: 2.046 ± 0.047	2.739PheVal: 2.739 ± 0.063	0.584PheTrp: 0.584 ± 0.026	1.181PheTyr: 1.181 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.672GlyAla: 6.672 ± 0.102	0.868GlyCys: 0.868 ± 0.031	4.423GlyAsp: 4.423 ± 0.08	5.259GlyGlu: 5.259 ± 0.079	3.518GlyPhe: 3.518 ± 0.07	5.906GlyGly: 5.906 ± 0.101	1.885GlyHis: 1.885 ± 0.042	4.657GlyIle: 4.657 ± 0.066	3.496GlyLys: 3.496 ± 0.06	8.621GlyLeu: 8.621 ± 0.111	2.368GlyMet: 2.368 ± 0.057	2.519GlyAsn: 2.519 ± 0.055	2.603GlyPro: 2.603 ± 0.053	3.2GlyGln: 3.2 ± 0.059	4.584GlyArg: 4.584 ± 0.069	4.478GlySer: 4.478 ± 0.077	3.894GlyThr: 3.894 ± 0.073	5.708GlyVal: 5.708 ± 0.082	1.287GlyTrp: 1.287 ± 0.041	2.532GlyTyr: 2.532 ± 0.058	0.001GlyXaa: 0.001 ± 0.001
His	1.807HisAla: 1.807 ± 0.047	0.301HisCys: 0.301 ± 0.017	1.084HisAsp: 1.084 ± 0.04	1.318HisGlu: 1.318 ± 0.04	0.936HisPhe: 0.936 ± 0.033	1.841HisGly: 1.841 ± 0.042	0.676HisHis: 0.676 ± 0.03	1.097HisIle: 1.097 ± 0.033	0.735HisLys: 0.735 ± 0.027	2.309HisLeu: 2.309 ± 0.052	0.538HisMet: 0.538 ± 0.025	0.643HisAsn: 0.643 ± 0.026	1.354HisPro: 1.354 ± 0.038	0.952HisGln: 0.952 ± 0.033	1.538HisArg: 1.538 ± 0.04	1.283HisSer: 1.283 ± 0.035	0.958HisThr: 0.958 ± 0.032	1.243HisVal: 1.243 ± 0.037	0.411HisTrp: 0.411 ± 0.019	0.76HisTyr: 0.76 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.658IleAla: 5.658 ± 0.083	0.478IleCys: 0.478 ± 0.02	3.29IleAsp: 3.29 ± 0.062	3.696IleGlu: 3.696 ± 0.066	1.808IlePhe: 1.808 ± 0.055	4.493IleGly: 4.493 ± 0.084	1.178IleHis: 1.178 ± 0.033	2.621IleIle: 2.621 ± 0.067	1.857IleLys: 1.857 ± 0.048	4.926IleLeu: 4.926 ± 0.075	1.093IleMet: 1.093 ± 0.037	2.023IleAsn: 2.023 ± 0.053	2.677IlePro: 2.677 ± 0.057	1.768IleGln: 1.768 ± 0.049	3.642IleArg: 3.642 ± 0.065	3.472IleSer: 3.472 ± 0.059	3.001IleThr: 3.001 ± 0.051	3.737IleVal: 3.737 ± 0.071	0.567IleTrp: 0.567 ± 0.027	1.316IleTyr: 1.316 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.192LysAla: 4.192 ± 0.085	0.215LysCys: 0.215 ± 0.015	2.078LysAsp: 2.078 ± 0.054	2.38LysGlu: 2.38 ± 0.061	1.022LysPhe: 1.022 ± 0.035	2.725LysGly: 2.725 ± 0.062	0.849LysHis: 0.849 ± 0.029	1.803LysIle: 1.803 ± 0.043	1.855LysLys: 1.855 ± 0.06	3.92LysLeu: 3.92 ± 0.075	0.923LysMet: 0.923 ± 0.031	1.206LysAsn: 1.206 ± 0.038	2.113LysPro: 2.113 ± 0.053	1.627LysGln: 1.627 ± 0.044	2.479LysArg: 2.479 ± 0.058	2.263LysSer: 2.263 ± 0.057	2.182LysThr: 2.182 ± 0.055	2.814LysVal: 2.814 ± 0.064	0.448LysTrp: 0.448 ± 0.023	0.84LysTyr: 0.84 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.629LeuAla: 11.629 ± 0.144	0.954LeuCys: 0.954 ± 0.034	5.977LeuAsp: 5.977 ± 0.095	7.168LeuGlu: 7.168 ± 0.094	4.197LeuPhe: 4.197 ± 0.079	7.979LeuGly: 7.979 ± 0.1	1.947LeuHis: 1.947 ± 0.048	5.523LeuIle: 5.523 ± 0.099	4.432LeuLys: 4.432 ± 0.071	10.678LeuLeu: 10.678 ± 0.148	2.899LeuMet: 2.899 ± 0.064	3.685LeuAsn: 3.685 ± 0.059	5.294LeuPro: 5.294 ± 0.084	3.753LeuGln: 3.753 ± 0.059	6.344LeuArg: 6.344 ± 0.092	6.936LeuSer: 6.936 ± 0.093	5.699LeuThr: 5.699 ± 0.08	7.747LeuVal: 7.747 ± 0.103	1.286LeuTrp: 1.286 ± 0.043	2.402LeuTyr: 2.402 ± 0.054	0.002LeuXaa: 0.002 ± 0.002
Met	3.01MetAla: 3.01 ± 0.065	0.172MetCys: 0.172 ± 0.014	1.384MetAsp: 1.384 ± 0.037	1.532MetGlu: 1.532 ± 0.042	0.821MetPhe: 0.821 ± 0.032	1.999MetGly: 1.999 ± 0.054	0.484MetHis: 0.484 ± 0.02	1.369MetIle: 1.369 ± 0.041	1.176MetLys: 1.176 ± 0.036	2.702MetLeu: 2.702 ± 0.061	0.766MetMet: 0.766 ± 0.035	1.053MetAsn: 1.053 ± 0.033	1.37MetPro: 1.37 ± 0.037	0.894MetGln: 0.894 ± 0.033	1.415MetArg: 1.415 ± 0.041	1.75MetSer: 1.75 ± 0.048	1.672MetThr: 1.672 ± 0.047	1.912MetVal: 1.912 ± 0.047	0.158MetTrp: 0.158 ± 0.014	0.423MetTyr: 0.423 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.091AsnAla: 3.091 ± 0.06	0.271AsnCys: 0.271 ± 0.017	1.734AsnAsp: 1.734 ± 0.048	1.946AsnGlu: 1.946 ± 0.052	1.145AsnPhe: 1.145 ± 0.035	2.622AsnGly: 2.622 ± 0.058	0.78AsnHis: 0.78 ± 0.027	1.747AsnIle: 1.747 ± 0.043	1.12AsnLys: 1.12 ± 0.039	3.58AsnLeu: 3.58 ± 0.063	0.758AsnMet: 0.758 ± 0.03	1.138AsnAsn: 1.138 ± 0.033	2.085AsnPro: 2.085 ± 0.052	1.389AsnGln: 1.389 ± 0.038	2.411AsnArg: 2.411 ± 0.062	1.811AsnSer: 1.811 ± 0.051	1.728AsnThr: 1.728 ± 0.038	2.133AsnVal: 2.133 ± 0.048	0.504AsnTrp: 0.504 ± 0.023	0.912AsnTyr: 0.912 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.595ProAla: 4.595 ± 0.075	0.315ProCys: 0.315 ± 0.019	3.52ProAsp: 3.52 ± 0.063	4.547ProGlu: 4.547 ± 0.084	1.817ProPhe: 1.817 ± 0.044	4.025ProGly: 4.025 ± 0.064	0.88ProHis: 0.88 ± 0.033	2.085ProIle: 2.085 ± 0.047	1.674ProLys: 1.674 ± 0.048	4.586ProLeu: 4.586 ± 0.077	1.152ProMet: 1.152 ± 0.034	1.263ProAsn: 1.263 ± 0.033	1.753ProPro: 1.753 ± 0.053	1.506ProGln: 1.506 ± 0.04	2.261ProArg: 2.261 ± 0.059	2.507ProSer: 2.507 ± 0.055	2.002ProThr: 2.002 ± 0.051	4.209ProVal: 4.209 ± 0.068	0.689ProTrp: 0.689 ± 0.031	1.15ProTyr: 1.15 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.144GlnAla: 4.144 ± 0.071	0.327GlnCys: 0.327 ± 0.021	1.817GlnAsp: 1.817 ± 0.045	2.354GlnGlu: 2.354 ± 0.05	1.46GlnPhe: 1.46 ± 0.043	2.902GlnGly: 2.902 ± 0.05	0.887GlnHis: 0.887 ± 0.039	2.03GlnIle: 2.03 ± 0.046	1.638GlnLys: 1.638 ± 0.043	4.195GlnLeu: 4.195 ± 0.073	1.01GlnMet: 1.01 ± 0.033	1.22GlnAsn: 1.22 ± 0.038	1.961GlnPro: 1.961 ± 0.043	1.962GlnGln: 1.962 ± 0.066	2.65GlnArg: 2.65 ± 0.06	2.218GlnSer: 2.218 ± 0.048	1.975GlnThr: 1.975 ± 0.053	2.904GlnVal: 2.904 ± 0.054	0.649GlnTrp: 0.649 ± 0.027	0.952GlnTyr: 0.952 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	5.254ArgAla: 5.254 ± 0.078	0.555ArgCys: 0.555 ± 0.027	3.651ArgAsp: 3.651 ± 0.064	4.685ArgGlu: 4.685 ± 0.073	2.859ArgPhe: 2.859 ± 0.051	3.802ArgGly: 3.802 ± 0.07	1.588ArgHis: 1.588 ± 0.039	3.774ArgIle: 3.774 ± 0.057	2.879ArgLys: 2.879 ± 0.065	7.162ArgLeu: 7.162 ± 0.099	1.641ArgMet: 1.641 ± 0.041	2.201ArgAsn: 2.201 ± 0.049	2.681ArgPro: 2.681 ± 0.061	3.133ArgGln: 3.133 ± 0.058	4.174ArgArg: 4.174 ± 0.071	3.5ArgSer: 3.5 ± 0.053	2.817ArgThr: 2.817 ± 0.048	4.482ArgVal: 4.482 ± 0.078	0.973ArgTrp: 0.973 ± 0.037	2.04ArgTyr: 2.04 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.688SerAla: 5.688 ± 0.075	0.51SerCys: 0.51 ± 0.024	3.504SerAsp: 3.504 ± 0.07	3.944SerGlu: 3.944 ± 0.075	2.386SerPhe: 2.386 ± 0.053	5.629SerGly: 5.629 ± 0.09	1.327SerHis: 1.327 ± 0.04	3.015SerIle: 3.015 ± 0.06	1.969SerLys: 1.969 ± 0.053	6.583SerLeu: 6.583 ± 0.075	1.504SerMet: 1.504 ± 0.042	1.809SerAsn: 1.809 ± 0.049	2.679SerPro: 2.679 ± 0.06	2.272SerGln: 2.272 ± 0.05	3.928SerArg: 3.928 ± 0.067	3.601SerSer: 3.601 ± 0.078	2.691SerThr: 2.691 ± 0.058	4.43SerVal: 4.43 ± 0.067	0.855SerTrp: 0.855 ± 0.034	1.502SerTyr: 1.502 ± 0.042	0.001SerXaa: 0.001 ± 0.001
Thr	4.865ThrAla: 4.865 ± 0.073	0.476ThrCys: 0.476 ± 0.023	2.962ThrAsp: 2.962 ± 0.056	3.176ThrGlu: 3.176 ± 0.063	1.95ThrPhe: 1.95 ± 0.054	4.85ThrGly: 4.85 ± 0.071	1.085ThrHis: 1.085 ± 0.033	2.607ThrIle: 2.607 ± 0.06	1.322ThrLys: 1.322 ± 0.04	6.213ThrLeu: 6.213 ± 0.081	1.111ThrMet: 1.111 ± 0.032	1.463ThrAsn: 1.463 ± 0.042	2.797ThrPro: 2.797 ± 0.056	1.519ThrGln: 1.519 ± 0.039	3.208ThrArg: 3.208 ± 0.063	2.877ThrSer: 2.877 ± 0.064	2.638ThrThr: 2.638 ± 0.057	4.036ThrVal: 4.036 ± 0.064	0.67ThrTrp: 0.67 ± 0.03	1.175ThrTyr: 1.175 ± 0.038	0.001ThrXaa: 0.001 ± 0.001
Val	7.3ValAla: 7.3 ± 0.105	0.734ValCys: 0.734 ± 0.026	4.219ValAsp: 4.219 ± 0.065	4.646ValGlu: 4.646 ± 0.073	3.044ValPhe: 3.044 ± 0.065	4.948ValGly: 4.948 ± 0.08	1.471ValHis: 1.471 ± 0.04	4.412ValIle: 4.412 ± 0.086	2.478ValLys: 2.478 ± 0.059	7.474ValLeu: 7.474 ± 0.094	2.032ValMet: 2.032 ± 0.043	2.475ValAsn: 2.475 ± 0.056	3.467ValPro: 3.467 ± 0.062	2.228ValGln: 2.228 ± 0.048	4.367ValArg: 4.367 ± 0.06	4.79ValSer: 4.79 ± 0.077	4.221ValThr: 4.221 ± 0.057	5.831ValVal: 5.831 ± 0.098	0.868ValTrp: 0.868 ± 0.029	1.785ValTyr: 1.785 ± 0.044	0.001ValXaa: 0.001 ± 0.001
Trp	1.024TrpAla: 1.024 ± 0.035	0.161TrpCys: 0.161 ± 0.013	0.656TrpAsp: 0.656 ± 0.03	0.685TrpGlu: 0.685 ± 0.028	0.672TrpPhe: 0.672 ± 0.031	0.866TrpGly: 0.866 ± 0.032	0.393TrpHis: 0.393 ± 0.021	0.722TrpIle: 0.722 ± 0.028	0.477TrpLys: 0.477 ± 0.025	1.972TrpLeu: 1.972 ± 0.058	0.381TrpMet: 0.381 ± 0.019	0.415TrpAsn: 0.415 ± 0.022	0.643TrpPro: 0.643 ± 0.026	0.855TrpGln: 0.855 ± 0.036	0.966TrpArg: 0.966 ± 0.036	0.774TrpSer: 0.774 ± 0.026	0.618TrpThr: 0.618 ± 0.026	0.988TrpVal: 0.988 ± 0.034	0.234TrpTrp: 0.234 ± 0.015	0.352TrpTyr: 0.352 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.141TyrAla: 2.141 ± 0.052	0.302TyrCys: 0.302 ± 0.017	1.526TyrAsp: 1.526 ± 0.04	1.593TyrGlu: 1.593 ± 0.043	1.049TyrPhe: 1.049 ± 0.035	2.093TyrGly: 2.093 ± 0.056	0.611TyrHis: 0.611 ± 0.027	1.127TyrIle: 1.127 ± 0.033	0.844TyrLys: 0.844 ± 0.03	2.998TyrLeu: 2.998 ± 0.069	0.559TyrMet: 0.559 ± 0.023	0.888TyrAsn: 0.888 ± 0.031	1.332TyrPro: 1.332 ± 0.037	1.273TyrGln: 1.273 ± 0.036	2.059TyrArg: 2.059 ± 0.046	1.576TyrSer: 1.576 ± 0.044	1.296TyrThr: 1.296 ± 0.037	1.609TyrVal: 1.609 ± 0.041	0.389TyrTrp: 0.389 ± 0.022	0.755TyrTyr: 0.755 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.014XaaXaa: 0.014 ± 0.005

Statistics based on 3190 proteins (949678 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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