Amino acid dipepetide frequency for Humibacillus xanthopallidus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.456AlaAla: 20.456 ± 0.166	0.954AlaCys: 0.954 ± 0.029	8.141AlaAsp: 8.141 ± 0.079	7.106AlaGlu: 7.106 ± 0.095	3.389AlaPhe: 3.389 ± 0.051	12.574AlaGly: 12.574 ± 0.11	2.785AlaHis: 2.785 ± 0.043	4.472AlaIle: 4.472 ± 0.067	2.625AlaLys: 2.625 ± 0.057	13.81AlaLeu: 13.81 ± 0.134	2.622AlaMet: 2.622 ± 0.044	2.087AlaAsn: 2.087 ± 0.038	6.772AlaPro: 6.772 ± 0.08	3.732AlaGln: 3.732 ± 0.05	9.689AlaArg: 9.689 ± 0.105	7.216AlaSer: 7.216 ± 0.078	8.356AlaThr: 8.356 ± 0.103	12.022AlaVal: 12.022 ± 0.122	2.007AlaTrp: 2.007 ± 0.042	2.588AlaTyr: 2.588 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.836CysAla: 0.836 ± 0.026	0.071CysCys: 0.071 ± 0.007	0.446CysAsp: 0.446 ± 0.019	0.336CysGlu: 0.336 ± 0.016	0.216CysPhe: 0.216 ± 0.012	0.75CysGly: 0.75 ± 0.022	0.185CysHis: 0.185 ± 0.012	0.23CysIle: 0.23 ± 0.012	0.078CysLys: 0.078 ± 0.007	0.599CysLeu: 0.599 ± 0.022	0.101CysMet: 0.101 ± 0.008	0.125CysAsn: 0.125 ± 0.01	0.411CysPro: 0.411 ± 0.018	0.142CysGln: 0.142 ± 0.01	0.505CysArg: 0.505 ± 0.021	0.417CysSer: 0.417 ± 0.019	0.458CysThr: 0.458 ± 0.019	0.588CysVal: 0.588 ± 0.021	0.107CysTrp: 0.107 ± 0.007	0.151CysTyr: 0.151 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.017AspAla: 8.017 ± 0.077	0.379AspCys: 0.379 ± 0.015	4.549AspAsp: 4.549 ± 0.076	4.246AspGlu: 4.246 ± 0.055	1.638AspPhe: 1.638 ± 0.034	6.213AspGly: 6.213 ± 0.065	1.525AspHis: 1.525 ± 0.034	1.987AspIle: 1.987 ± 0.034	1.07AspLys: 1.07 ± 0.035	7.02AspLeu: 7.02 ± 0.077	0.759AspMet: 0.759 ± 0.025	0.967AspAsn: 0.967 ± 0.031	4.554AspPro: 4.554 ± 0.066	1.516AspGln: 1.516 ± 0.031	4.76AspArg: 4.76 ± 0.066	2.583AspSer: 2.583 ± 0.04	3.183AspThr: 3.183 ± 0.05	5.969AspVal: 5.969 ± 0.06	0.992AspTrp: 0.992 ± 0.024	1.237AspTyr: 1.237 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.044GluAla: 7.044 ± 0.088	0.312GluCys: 0.312 ± 0.013	2.492GluAsp: 2.492 ± 0.044	2.695GluGlu: 2.695 ± 0.049	1.308GluPhe: 1.308 ± 0.031	4.216GluGly: 4.216 ± 0.063	1.626GluHis: 1.626 ± 0.035	2.163GluIle: 2.163 ± 0.04	1.113GluLys: 1.113 ± 0.033	5.867GluLeu: 5.867 ± 0.066	0.876GluMet: 0.876 ± 0.024	0.793GluAsn: 0.793 ± 0.024	3.079GluPro: 3.079 ± 0.056	2.193GluGln: 2.193 ± 0.042	5.187GluArg: 5.187 ± 0.07	2.789GluSer: 2.789 ± 0.042	2.769GluThr: 2.769 ± 0.045	4.964GluVal: 4.964 ± 0.069	0.817GluTrp: 0.817 ± 0.024	0.784GluTyr: 0.784 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.504PheAla: 3.504 ± 0.058	0.232PheCys: 0.232 ± 0.013	2.084PheAsp: 2.084 ± 0.039	1.5PheGlu: 1.5 ± 0.031	0.955PhePhe: 0.955 ± 0.027	2.977PheGly: 2.977 ± 0.049	0.563PheHis: 0.563 ± 0.02	0.962PheIle: 0.962 ± 0.028	0.433PheLys: 0.433 ± 0.017	2.323PheLeu: 2.323 ± 0.043	0.404PheMet: 0.404 ± 0.018	0.575PheAsn: 0.575 ± 0.022	1.263PhePro: 1.263 ± 0.029	0.617PheGln: 0.617 ± 0.021	1.606PheArg: 1.606 ± 0.032	1.519PheSer: 1.519 ± 0.033	2.035PheThr: 2.035 ± 0.045	2.715PheVal: 2.715 ± 0.044	0.438PheTrp: 0.438 ± 0.016	0.631PheTyr: 0.631 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	11.285GlyAla: 11.285 ± 0.115	0.671GlyCys: 0.671 ± 0.023	5.51GlyAsp: 5.51 ± 0.076	4.579GlyGlu: 4.579 ± 0.059	2.885GlyPhe: 2.885 ± 0.048	8.349GlyGly: 8.349 ± 0.117	2.228GlyHis: 2.228 ± 0.035	3.8GlyIle: 3.8 ± 0.056	1.997GlyLys: 1.997 ± 0.04	9.451GlyLeu: 9.451 ± 0.09	1.848GlyMet: 1.848 ± 0.033	1.707GlyAsn: 1.707 ± 0.058	4.811GlyPro: 4.811 ± 0.06	2.729GlyGln: 2.729 ± 0.053	7.192GlyArg: 7.192 ± 0.083	6.063GlySer: 6.063 ± 0.071	5.976GlyThr: 5.976 ± 0.091	7.989GlyVal: 7.989 ± 0.09	1.831GlyTrp: 1.831 ± 0.039	2.071GlyTyr: 2.071 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.629HisAla: 2.629 ± 0.046	0.164HisCys: 0.164 ± 0.01	1.627HisAsp: 1.627 ± 0.033	1.311HisGlu: 1.311 ± 0.029	0.597HisPhe: 0.597 ± 0.019	2.263HisGly: 2.263 ± 0.039	0.703HisHis: 0.703 ± 0.023	0.593HisIle: 0.593 ± 0.021	0.283HisLys: 0.283 ± 0.012	2.475HisLeu: 2.475 ± 0.044	0.283HisMet: 0.283 ± 0.013	0.369HisAsn: 0.369 ± 0.016	1.674HisPro: 1.674 ± 0.034	0.581HisGln: 0.581 ± 0.02	1.814HisArg: 1.814 ± 0.041	0.944HisSer: 0.944 ± 0.024	1.223HisThr: 1.223 ± 0.03	2.163HisVal: 2.163 ± 0.041	0.366HisTrp: 0.366 ± 0.015	0.456HisTyr: 0.456 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.21IleAla: 5.21 ± 0.063	0.265IleCys: 0.265 ± 0.013	2.82IleAsp: 2.82 ± 0.049	2.303IleGlu: 2.303 ± 0.044	0.891IlePhe: 0.891 ± 0.027	3.806IleGly: 3.806 ± 0.052	0.694IleHis: 0.694 ± 0.02	1.267IleIle: 1.267 ± 0.034	0.667IleLys: 0.667 ± 0.024	2.634IleLeu: 2.634 ± 0.044	0.489IleMet: 0.489 ± 0.018	0.763IleAsn: 0.763 ± 0.024	1.851IlePro: 1.851 ± 0.036	0.742IleGln: 0.742 ± 0.022	2.239IleArg: 2.239 ± 0.041	1.881IleSer: 1.881 ± 0.037	2.445IleThr: 2.445 ± 0.045	3.452IleVal: 3.452 ± 0.056	0.455IleTrp: 0.455 ± 0.018	0.643IleTyr: 0.643 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.637LysAla: 2.637 ± 0.06	0.081LysCys: 0.081 ± 0.006	1.142LysAsp: 1.142 ± 0.033	0.933LysGlu: 0.933 ± 0.027	0.412LysPhe: 0.412 ± 0.014	1.664LysGly: 1.664 ± 0.037	0.378LysHis: 0.378 ± 0.015	0.733LysIle: 0.733 ± 0.023	0.648LysLys: 0.648 ± 0.031	1.527LysLeu: 1.527 ± 0.034	0.291LysMet: 0.291 ± 0.013	0.419LysAsn: 0.419 ± 0.02	1.105LysPro: 1.105 ± 0.033	0.603LysGln: 0.603 ± 0.023	1.312LysArg: 1.312 ± 0.034	1.009LysSer: 1.009 ± 0.026	1.165LysThr: 1.165 ± 0.033	1.836LysVal: 1.836 ± 0.043	0.237LysTrp: 0.237 ± 0.012	0.387LysTyr: 0.387 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.415LeuAla: 14.415 ± 0.127	0.658LeuCys: 0.658 ± 0.022	6.835LeuAsp: 6.835 ± 0.073	5.314LeuGlu: 5.314 ± 0.068	2.44LeuPhe: 2.44 ± 0.041	9.617LeuGly: 9.617 ± 0.103	2.138LeuHis: 2.138 ± 0.04	3.142LeuIle: 3.142 ± 0.052	1.606LeuLys: 1.606 ± 0.035	10.21LeuLeu: 10.21 ± 0.122	1.572LeuMet: 1.572 ± 0.04	1.459LeuAsn: 1.459 ± 0.035	5.686LeuPro: 5.686 ± 0.061	2.308LeuGln: 2.308 ± 0.043	7.66LeuArg: 7.66 ± 0.092	5.492LeuSer: 5.492 ± 0.07	6.713LeuThr: 6.713 ± 0.067	10.138LeuVal: 10.138 ± 0.11	1.318LeuTrp: 1.318 ± 0.034	1.547LeuTyr: 1.547 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.248MetAla: 2.248 ± 0.04	0.112MetCys: 0.112 ± 0.009	0.777MetAsp: 0.777 ± 0.024	0.689MetGlu: 0.689 ± 0.021	0.428MetPhe: 0.428 ± 0.017	1.389MetGly: 1.389 ± 0.028	0.339MetHis: 0.339 ± 0.015	0.613MetIle: 0.613 ± 0.022	0.412MetLys: 0.412 ± 0.017	1.688MetLeu: 1.688 ± 0.033	0.286MetMet: 0.286 ± 0.014	0.379MetAsn: 0.379 ± 0.014	1.198MetPro: 1.198 ± 0.029	0.477MetGln: 0.477 ± 0.016	1.391MetArg: 1.391 ± 0.03	1.528MetSer: 1.528 ± 0.034	1.773MetThr: 1.773 ± 0.037	1.396MetVal: 1.396 ± 0.034	0.212MetTrp: 0.212 ± 0.012	0.258MetTyr: 0.258 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.193AsnAla: 2.193 ± 0.045	0.134AsnCys: 0.134 ± 0.008	1.027AsnAsp: 1.027 ± 0.034	0.795AsnGlu: 0.795 ± 0.024	0.502AsnPhe: 0.502 ± 0.022	1.837AsnGly: 1.837 ± 0.049	0.394AsnHis: 0.394 ± 0.017	0.636AsnIle: 0.636 ± 0.021	0.358AsnLys: 0.358 ± 0.016	1.701AsnLeu: 1.701 ± 0.039	0.248AsnMet: 0.248 ± 0.015	0.42AsnAsn: 0.42 ± 0.021	1.428AsnPro: 1.428 ± 0.034	0.493AsnGln: 0.493 ± 0.02	1.172AsnArg: 1.172 ± 0.033	0.846AsnSer: 0.846 ± 0.027	1.059AsnThr: 1.059 ± 0.039	1.565AsnVal: 1.565 ± 0.037	0.273AsnTrp: 0.273 ± 0.015	0.401AsnTyr: 0.401 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.679ProAla: 7.679 ± 0.088	0.281ProCys: 0.281 ± 0.014	4.414ProAsp: 4.414 ± 0.056	3.724ProGlu: 3.724 ± 0.06	1.574ProPhe: 1.574 ± 0.03	5.838ProGly: 5.838 ± 0.075	1.293ProHis: 1.293 ± 0.034	1.732ProIle: 1.732 ± 0.032	1.04ProLys: 1.04 ± 0.03	4.792ProLeu: 4.792 ± 0.059	1.091ProMet: 1.091 ± 0.025	0.99ProAsn: 0.99 ± 0.027	3.233ProPro: 3.233 ± 0.059	1.594ProGln: 1.594 ± 0.034	3.663ProArg: 3.663 ± 0.056	3.687ProSer: 3.687 ± 0.059	4.235ProThr: 4.235 ± 0.064	5.293ProVal: 5.293 ± 0.06	0.983ProTrp: 0.983 ± 0.027	1.067ProTyr: 1.067 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.519GlnAla: 3.519 ± 0.055	0.177GlnCys: 0.177 ± 0.012	1.156GlnAsp: 1.156 ± 0.026	1.168GlnGlu: 1.168 ± 0.026	0.718GlnPhe: 0.718 ± 0.021	2.191GlnGly: 2.191 ± 0.035	0.64GlnHis: 0.64 ± 0.02	1.084GlnIle: 1.084 ± 0.025	0.529GlnLys: 0.529 ± 0.021	3.011GlnLeu: 3.011 ± 0.043	0.518GlnMet: 0.518 ± 0.02	0.464GlnAsn: 0.464 ± 0.019	1.769GlnPro: 1.769 ± 0.032	1.16GlnGln: 1.16 ± 0.03	2.419GlnArg: 2.419 ± 0.044	1.48GlnSer: 1.48 ± 0.027	1.553GlnThr: 1.553 ± 0.034	2.628GlnVal: 2.628 ± 0.039	0.521GlnTrp: 0.521 ± 0.019	0.466GlnTyr: 0.466 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.174ArgAla: 9.174 ± 0.1	0.454ArgCys: 0.454 ± 0.018	4.528ArgAsp: 4.528 ± 0.07	4.208ArgGlu: 4.208 ± 0.063	2.168ArgPhe: 2.168 ± 0.046	5.77ArgGly: 5.77 ± 0.07	1.934ArgHis: 1.934 ± 0.041	2.97ArgIle: 2.97 ± 0.048	1.211ArgLys: 1.211 ± 0.035	8.323ArgLeu: 8.323 ± 0.104	1.666ArgMet: 1.666 ± 0.034	1.204ArgAsn: 1.204 ± 0.032	4.47ArgPro: 4.47 ± 0.071	2.133ArgGln: 2.133 ± 0.044	7.195ArgArg: 7.195 ± 0.102	4.412ArgSer: 4.412 ± 0.054	4.526ArgThr: 4.526 ± 0.059	6.247ArgVal: 6.247 ± 0.065	1.409ArgTrp: 1.409 ± 0.029	1.516ArgTyr: 1.516 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.222SerAla: 7.222 ± 0.086	0.366SerCys: 0.366 ± 0.018	3.335SerAsp: 3.335 ± 0.049	2.576SerGlu: 2.576 ± 0.043	1.726SerPhe: 1.726 ± 0.035	6.189SerGly: 6.189 ± 0.095	1.145SerHis: 1.145 ± 0.027	2.001SerIle: 2.001 ± 0.041	1.013SerLys: 1.013 ± 0.032	5.342SerLeu: 5.342 ± 0.061	1.276SerMet: 1.276 ± 0.029	1.032SerAsn: 1.032 ± 0.03	3.498SerPro: 3.498 ± 0.048	1.435SerGln: 1.435 ± 0.029	4.188SerArg: 4.188 ± 0.06	3.766SerSer: 3.766 ± 0.069	3.94SerThr: 3.94 ± 0.062	4.798SerVal: 4.798 ± 0.062	1.013SerTrp: 1.013 ± 0.027	1.102SerTyr: 1.102 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.341ThrAla: 8.341 ± 0.116	0.482ThrCys: 0.482 ± 0.022	3.909ThrAsp: 3.909 ± 0.066	2.868ThrGlu: 2.868 ± 0.042	1.999ThrPhe: 1.999 ± 0.039	6.276ThrGly: 6.276 ± 0.083	1.258ThrHis: 1.258 ± 0.032	2.447ThrIle: 2.447 ± 0.054	1.237ThrLys: 1.237 ± 0.035	5.884ThrLeu: 5.884 ± 0.06	1.212ThrMet: 1.212 ± 0.03	1.274ThrAsn: 1.274 ± 0.044	4.426ThrPro: 4.426 ± 0.068	1.53ThrGln: 1.53 ± 0.033	4.055ThrArg: 4.055 ± 0.045	4.085ThrSer: 4.085 ± 0.075	5.0ThrThr: 5.0 ± 0.11	6.305ThrVal: 6.305 ± 0.09	1.093ThrTrp: 1.093 ± 0.026	1.372ThrTyr: 1.372 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	12.483ValAla: 12.483 ± 0.114	0.676ValCys: 0.676 ± 0.024	6.158ValAsp: 6.158 ± 0.07	5.107ValGlu: 5.107 ± 0.064	2.319ValPhe: 2.319 ± 0.046	8.068ValGly: 8.068 ± 0.084	1.949ValHis: 1.949 ± 0.036	3.651ValIle: 3.651 ± 0.051	1.613ValLys: 1.613 ± 0.035	9.737ValLeu: 9.737 ± 0.103	1.541ValMet: 1.541 ± 0.035	1.659ValAsn: 1.659 ± 0.039	5.18ValPro: 5.18 ± 0.07	2.083ValGln: 2.083 ± 0.037	6.622ValArg: 6.622 ± 0.081	5.205ValSer: 5.205 ± 0.063	6.562ValThr: 6.562 ± 0.085	10.422ValVal: 10.422 ± 0.125	1.245ValTrp: 1.245 ± 0.028	1.362ValTyr: 1.362 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.761TrpAla: 1.761 ± 0.039	0.144TrpCys: 0.144 ± 0.009	0.875TrpAsp: 0.875 ± 0.023	0.66TrpGlu: 0.66 ± 0.022	0.571TrpPhe: 0.571 ± 0.02	1.172TrpGly: 1.172 ± 0.027	0.403TrpHis: 0.403 ± 0.016	0.558TrpIle: 0.558 ± 0.021	0.292TrpLys: 0.292 ± 0.014	1.817TrpLeu: 1.817 ± 0.035	0.325TrpMet: 0.325 ± 0.016	0.375TrpAsn: 0.375 ± 0.017	0.845TrpPro: 0.845 ± 0.022	0.583TrpGln: 0.583 ± 0.018	1.341TrpArg: 1.341 ± 0.036	1.112TrpSer: 1.112 ± 0.028	1.064TrpThr: 1.064 ± 0.031	1.429TrpVal: 1.429 ± 0.034	0.42TrpTrp: 0.42 ± 0.015	0.317TrpTyr: 0.317 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.751TyrAla: 2.751 ± 0.04	0.139TyrCys: 0.139 ± 0.009	1.343TyrAsp: 1.343 ± 0.039	0.97TyrGlu: 0.97 ± 0.025	0.602TyrPhe: 0.602 ± 0.021	1.813TyrGly: 1.813 ± 0.039	0.337TyrHis: 0.337 ± 0.015	0.476TyrIle: 0.476 ± 0.019	0.296TyrLys: 0.296 ± 0.016	2.059TyrLeu: 2.059 ± 0.039	0.183TyrMet: 0.183 ± 0.012	0.419TyrAsn: 0.419 ± 0.018	0.948TyrPro: 0.948 ± 0.026	0.519TyrGln: 0.519 ± 0.02	1.503TyrArg: 1.503 ± 0.034	0.931TyrSer: 0.931 ± 0.022	1.018TyrThr: 1.018 ± 0.029	1.722TyrVal: 1.722 ± 0.03	0.326TyrTrp: 0.326 ± 0.015	0.429TyrTyr: 0.429 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4527 proteins (1567071 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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