Amino acid dipepetide frequency for Pseudomonas phage vB_Pae-SS2019XII

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.597AlaAla: 16.597 ± 2.435
0.944AlaCys: 0.944 ± 0.306
7.079AlaAsp: 7.079 ± 0.635
9.125AlaGlu: 9.125 ± 0.959
3.697AlaPhe: 3.697 ± 0.555
10.147AlaGly: 10.147 ± 1.007
1.652AlaHis: 1.652 ± 0.413
5.742AlaIle: 5.742 ± 0.696
4.012AlaLys: 4.012 ± 0.609
10.304AlaLeu: 10.304 ± 1.024
3.776AlaMet: 3.776 ± 0.829
2.91AlaAsn: 2.91 ± 0.456
5.821AlaPro: 5.821 ± 0.764
6.45AlaGln: 6.45 ± 0.659
8.181AlaArg: 8.181 ± 0.77
6.922AlaSer: 6.922 ± 1.341
6.765AlaThr: 6.765 ± 0.778
6.607AlaVal: 6.607 ± 0.669
2.517AlaTrp: 2.517 ± 0.295
2.989AlaTyr: 2.989 ± 0.5
0.0AlaXaa: 0.0 ± 0.0
Cys
0.708CysAla: 0.708 ± 0.348
0.157CysCys: 0.157 ± 0.116
0.629CysAsp: 0.629 ± 0.212
0.472CysGlu: 0.472 ± 0.187
0.315CysPhe: 0.315 ± 0.156
0.787CysGly: 0.787 ± 0.232
0.315CysHis: 0.315 ± 0.192
0.157CysIle: 0.157 ± 0.12
0.157CysLys: 0.157 ± 0.122
0.551CysLeu: 0.551 ± 0.245
0.157CysMet: 0.157 ± 0.125
0.551CysAsn: 0.551 ± 0.203
0.551CysPro: 0.551 ± 0.187
0.629CysGln: 0.629 ± 0.227
0.865CysArg: 0.865 ± 0.292
0.393CysSer: 0.393 ± 0.227
0.472CysThr: 0.472 ± 0.196
0.787CysVal: 0.787 ± 0.259
0.0CysTrp: 0.0 ± 0.0
0.236CysTyr: 0.236 ± 0.141
0.0CysXaa: 0.0 ± 0.0
Asp
6.607AspAla: 6.607 ± 0.703
0.472AspCys: 0.472 ± 0.178
3.225AspAsp: 3.225 ± 0.509
5.349AspGlu: 5.349 ± 0.663
2.124AspPhe: 2.124 ± 0.393
5.428AspGly: 5.428 ± 0.639
1.023AspHis: 1.023 ± 0.33
2.517AspIle: 2.517 ± 0.461
1.731AspLys: 1.731 ± 0.448
6.214AspLeu: 6.214 ± 0.696
0.472AspMet: 0.472 ± 0.234
1.888AspAsn: 1.888 ± 0.335
2.596AspPro: 2.596 ± 0.442
3.225AspGln: 3.225 ± 0.478
3.697AspArg: 3.697 ± 0.578
2.989AspSer: 2.989 ± 0.375
2.674AspThr: 2.674 ± 0.478
3.461AspVal: 3.461 ± 0.658
0.629AspTrp: 0.629 ± 0.205
1.573AspTyr: 1.573 ± 0.284
0.0AspXaa: 0.0 ± 0.0
Glu
7.315GluAla: 7.315 ± 1.2
1.023GluCys: 1.023 ± 0.251
3.697GluAsp: 3.697 ± 0.657
3.854GluGlu: 3.854 ± 0.545
2.517GluPhe: 2.517 ± 0.379
3.54GluGly: 3.54 ± 0.485
1.18GluHis: 1.18 ± 0.382
2.674GluIle: 2.674 ± 0.409
2.596GluLys: 2.596 ± 0.529
8.181GluLeu: 8.181 ± 0.89
1.652GluMet: 1.652 ± 0.359
1.809GluAsn: 1.809 ± 0.341
2.281GluPro: 2.281 ± 0.598
5.349GluGln: 5.349 ± 0.74
5.428GluArg: 5.428 ± 0.756
2.989GluSer: 2.989 ± 0.526
1.888GluThr: 1.888 ± 0.311
3.54GluVal: 3.54 ± 0.628
1.18GluTrp: 1.18 ± 0.332
1.495GluTyr: 1.495 ± 0.281
0.0GluXaa: 0.0 ± 0.0
Phe
2.989PheAla: 2.989 ± 0.524
0.236PheCys: 0.236 ± 0.129
2.596PheAsp: 2.596 ± 0.52
1.573PheGlu: 1.573 ± 0.343
1.023PhePhe: 1.023 ± 0.224
4.012PheGly: 4.012 ± 0.475
0.472PheHis: 0.472 ± 0.186
1.023PheIle: 1.023 ± 0.293
0.708PheLys: 0.708 ± 0.275
2.438PheLeu: 2.438 ± 0.432
0.551PheMet: 0.551 ± 0.194
1.18PheAsn: 1.18 ± 0.285
1.023PhePro: 1.023 ± 0.308
1.18PheGln: 1.18 ± 0.296
2.281PheArg: 2.281 ± 0.448
1.966PheSer: 1.966 ± 0.442
1.259PheThr: 1.259 ± 0.313
1.495PheVal: 1.495 ± 0.38
0.708PheTrp: 0.708 ± 0.268
0.708PheTyr: 0.708 ± 0.207
0.0PheXaa: 0.0 ± 0.0
Gly
8.653GlyAla: 8.653 ± 1.128
1.023GlyCys: 1.023 ± 0.305
4.326GlyAsp: 4.326 ± 0.543
3.461GlyGlu: 3.461 ± 0.423
2.674GlyPhe: 2.674 ± 0.355
6.135GlyGly: 6.135 ± 0.859
0.865GlyHis: 0.865 ± 0.276
2.989GlyIle: 2.989 ± 0.42
3.697GlyLys: 3.697 ± 0.579
7.158GlyLeu: 7.158 ± 0.888
2.517GlyMet: 2.517 ± 0.487
2.989GlyAsn: 2.989 ± 0.46
2.281GlyPro: 2.281 ± 0.478
4.169GlyGln: 4.169 ± 0.64
6.45GlyArg: 6.45 ± 0.659
4.405GlySer: 4.405 ± 0.673
5.034GlyThr: 5.034 ± 0.728
4.798GlyVal: 4.798 ± 0.525
2.596GlyTrp: 2.596 ± 0.452
2.124GlyTyr: 2.124 ± 0.5
0.0GlyXaa: 0.0 ± 0.0
His
2.202HisAla: 2.202 ± 0.438
0.0HisCys: 0.0 ± 0.0
0.708HisAsp: 0.708 ± 0.226
1.023HisGlu: 1.023 ± 0.247
0.157HisPhe: 0.157 ± 0.121
1.809HisGly: 1.809 ± 0.418
0.472HisHis: 0.472 ± 0.24
0.865HisIle: 0.865 ± 0.302
0.393HisLys: 0.393 ± 0.17
1.573HisLeu: 1.573 ± 0.401
0.079HisMet: 0.079 ± 0.077
0.472HisAsn: 0.472 ± 0.157
1.337HisPro: 1.337 ± 0.387
1.416HisGln: 1.416 ± 0.333
1.416HisArg: 1.416 ± 0.3
1.18HisSer: 1.18 ± 0.375
0.393HisThr: 0.393 ± 0.167
1.259HisVal: 1.259 ± 0.332
0.472HisTrp: 0.472 ± 0.205
0.393HisTyr: 0.393 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
5.349IleAla: 5.349 ± 0.663
0.393IleCys: 0.393 ± 0.183
2.91IleAsp: 2.91 ± 0.411
3.933IleGlu: 3.933 ± 0.554
0.393IlePhe: 0.393 ± 0.15
2.91IleGly: 2.91 ± 0.563
0.865IleHis: 0.865 ± 0.297
0.944IleIle: 0.944 ± 0.279
1.101IleLys: 1.101 ± 0.27
3.697IleLeu: 3.697 ± 0.614
0.472IleMet: 0.472 ± 0.216
1.495IleAsn: 1.495 ± 0.343
1.966IlePro: 1.966 ± 0.396
2.438IleGln: 2.438 ± 0.487
3.776IleArg: 3.776 ± 0.539
3.068IleSer: 3.068 ± 0.499
3.382IleThr: 3.382 ± 0.512
2.124IleVal: 2.124 ± 0.406
0.708IleTrp: 0.708 ± 0.312
1.259IleTyr: 1.259 ± 0.355
0.0IleXaa: 0.0 ± 0.0
Lys
5.821LysAla: 5.821 ± 0.623
0.236LysCys: 0.236 ± 0.134
1.888LysAsp: 1.888 ± 0.446
1.731LysGlu: 1.731 ± 0.312
1.337LysPhe: 1.337 ± 0.343
2.36LysGly: 2.36 ± 0.421
0.551LysHis: 0.551 ± 0.178
1.337LysIle: 1.337 ± 0.268
1.495LysLys: 1.495 ± 0.313
4.169LysLeu: 4.169 ± 0.755
0.551LysMet: 0.551 ± 0.22
1.259LysAsn: 1.259 ± 0.275
2.045LysPro: 2.045 ± 0.563
1.652LysGln: 1.652 ± 0.338
2.989LysArg: 2.989 ± 0.655
2.281LysSer: 2.281 ± 0.417
1.573LysThr: 1.573 ± 0.369
1.888LysVal: 1.888 ± 0.512
0.157LysTrp: 0.157 ± 0.11
0.787LysTyr: 0.787 ± 0.222
0.0LysXaa: 0.0 ± 0.0
Leu
11.956LeuAla: 11.956 ± 0.936
1.101LeuCys: 1.101 ± 0.345
7.158LeuAsp: 7.158 ± 0.701
5.742LeuGlu: 5.742 ± 0.589
1.966LeuPhe: 1.966 ± 0.437
7.079LeuGly: 7.079 ± 0.823
1.809LeuHis: 1.809 ± 0.369
5.113LeuIle: 5.113 ± 0.625
3.304LeuLys: 3.304 ± 0.481
8.653LeuLeu: 8.653 ± 0.842
1.888LeuMet: 1.888 ± 0.358
2.517LeuAsn: 2.517 ± 0.445
5.349LeuPro: 5.349 ± 0.723
6.765LeuGln: 6.765 ± 0.793
7.787LeuArg: 7.787 ± 0.763
5.742LeuSer: 5.742 ± 0.553
5.821LeuThr: 5.821 ± 0.674
6.765LeuVal: 6.765 ± 0.76
0.315LeuTrp: 0.315 ± 0.16
2.281LeuTyr: 2.281 ± 0.492
0.0LeuXaa: 0.0 ± 0.0
Met
3.618MetAla: 3.618 ± 0.569
0.079MetCys: 0.079 ± 0.09
1.416MetAsp: 1.416 ± 0.301
0.787MetGlu: 0.787 ± 0.28
0.551MetPhe: 0.551 ± 0.222
1.809MetGly: 1.809 ± 0.354
0.551MetHis: 0.551 ± 0.203
1.18MetIle: 1.18 ± 0.391
0.787MetLys: 0.787 ± 0.287
1.416MetLeu: 1.416 ± 0.329
0.079MetMet: 0.079 ± 0.079
1.023MetAsn: 1.023 ± 0.319
1.495MetPro: 1.495 ± 0.266
0.865MetGln: 0.865 ± 0.267
0.944MetArg: 0.944 ± 0.245
2.202MetSer: 2.202 ± 0.439
1.416MetThr: 1.416 ± 0.376
0.944MetVal: 0.944 ± 0.249
0.157MetTrp: 0.157 ± 0.11
0.079MetTyr: 0.079 ± 0.071
0.0MetXaa: 0.0 ± 0.0
Asn
3.382AsnAla: 3.382 ± 0.419
0.315AsnCys: 0.315 ± 0.189
0.944AsnAsp: 0.944 ± 0.291
1.888AsnGlu: 1.888 ± 0.326
0.787AsnPhe: 0.787 ± 0.219
2.832AsnGly: 2.832 ± 0.585
0.629AsnHis: 0.629 ± 0.229
1.337AsnIle: 1.337 ± 0.37
1.101AsnLys: 1.101 ± 0.266
3.225AsnLeu: 3.225 ± 0.534
0.629AsnMet: 0.629 ± 0.233
0.787AsnAsn: 0.787 ± 0.263
2.045AsnPro: 2.045 ± 0.346
2.281AsnGln: 2.281 ± 0.329
1.809AsnArg: 1.809 ± 0.278
1.337AsnSer: 1.337 ± 0.307
1.259AsnThr: 1.259 ± 0.35
1.652AsnVal: 1.652 ± 0.289
0.315AsnTrp: 0.315 ± 0.158
1.337AsnTyr: 1.337 ± 0.335
0.0AsnXaa: 0.0 ± 0.0
Pro
6.214ProAla: 6.214 ± 0.625
0.393ProCys: 0.393 ± 0.218
2.674ProAsp: 2.674 ± 0.523
3.854ProGlu: 3.854 ± 0.498
1.731ProPhe: 1.731 ± 0.382
4.169ProGly: 4.169 ± 0.535
0.708ProHis: 0.708 ± 0.247
1.652ProIle: 1.652 ± 0.28
1.888ProLys: 1.888 ± 0.322
3.304ProLeu: 3.304 ± 0.53
0.944ProMet: 0.944 ± 0.308
1.416ProAsn: 1.416 ± 0.5
2.124ProPro: 2.124 ± 0.452
2.124ProGln: 2.124 ± 0.386
2.989ProArg: 2.989 ± 0.518
2.674ProSer: 2.674 ± 0.433
2.124ProThr: 2.124 ± 0.405
4.641ProVal: 4.641 ± 0.81
0.708ProTrp: 0.708 ± 0.292
1.888ProTyr: 1.888 ± 0.46
0.0ProXaa: 0.0 ± 0.0
Gln
7.315GlnAla: 7.315 ± 1.06
0.315GlnCys: 0.315 ± 0.164
2.438GlnAsp: 2.438 ± 0.463
3.54GlnGlu: 3.54 ± 0.635
1.573GlnPhe: 1.573 ± 0.296
2.91GlnGly: 2.91 ± 0.544
1.18GlnHis: 1.18 ± 0.247
2.124GlnIle: 2.124 ± 0.439
1.731GlnLys: 1.731 ± 0.35
7.551GlnLeu: 7.551 ± 0.921
1.18GlnMet: 1.18 ± 0.278
0.708GlnAsn: 0.708 ± 0.176
3.068GlnPro: 3.068 ± 0.519
3.461GlnGln: 3.461 ± 0.842
4.956GlnArg: 4.956 ± 0.58
2.281GlnSer: 2.281 ± 0.332
2.596GlnThr: 2.596 ± 0.392
4.09GlnVal: 4.09 ± 0.535
0.629GlnTrp: 0.629 ± 0.299
1.18GlnTyr: 1.18 ± 0.266
0.0GlnXaa: 0.0 ± 0.0
Arg
7.63ArgAla: 7.63 ± 0.829
0.472ArgCys: 0.472 ± 0.212
4.169ArgAsp: 4.169 ± 0.604
4.169ArgGlu: 4.169 ± 0.638
1.809ArgPhe: 1.809 ± 0.367
5.27ArgGly: 5.27 ± 0.569
1.731ArgHis: 1.731 ± 0.393
3.854ArgIle: 3.854 ± 0.734
3.304ArgLys: 3.304 ± 0.75
8.181ArgLeu: 8.181 ± 0.761
1.809ArgMet: 1.809 ± 0.414
2.674ArgAsn: 2.674 ± 0.368
2.517ArgPro: 2.517 ± 0.493
3.933ArgGln: 3.933 ± 0.585
6.922ArgArg: 6.922 ± 0.969
4.169ArgSer: 4.169 ± 0.571
2.989ArgThr: 2.989 ± 0.403
4.012ArgVal: 4.012 ± 0.832
1.652ArgTrp: 1.652 ± 0.43
2.753ArgTyr: 2.753 ± 0.387
0.0ArgXaa: 0.0 ± 0.0
Ser
8.259SerAla: 8.259 ± 1.301
0.472SerCys: 0.472 ± 0.179
3.618SerAsp: 3.618 ± 0.422
3.304SerGlu: 3.304 ± 0.539
2.124SerPhe: 2.124 ± 0.299
4.248SerGly: 4.248 ± 0.392
0.708SerHis: 0.708 ± 0.222
2.124SerIle: 2.124 ± 0.394
2.124SerLys: 2.124 ± 0.465
6.293SerLeu: 6.293 ± 0.618
1.101SerMet: 1.101 ± 0.261
1.888SerAsn: 1.888 ± 0.297
2.596SerPro: 2.596 ± 0.477
2.124SerGln: 2.124 ± 0.383
3.382SerArg: 3.382 ± 0.446
3.225SerSer: 3.225 ± 0.511
3.618SerThr: 3.618 ± 0.51
3.933SerVal: 3.933 ± 0.485
0.393SerTrp: 0.393 ± 0.209
1.495SerTyr: 1.495 ± 0.239
0.0SerXaa: 0.0 ± 0.0
Thr
6.214ThrAla: 6.214 ± 0.739
0.315ThrCys: 0.315 ± 0.162
3.225ThrAsp: 3.225 ± 0.537
3.618ThrGlu: 3.618 ± 0.507
1.416ThrPhe: 1.416 ± 0.314
5.27ThrGly: 5.27 ± 0.757
1.023ThrHis: 1.023 ± 0.308
1.337ThrIle: 1.337 ± 0.375
1.416ThrLys: 1.416 ± 0.367
5.585ThrLeu: 5.585 ± 0.643
1.101ThrMet: 1.101 ± 0.251
1.495ThrAsn: 1.495 ± 0.28
3.54ThrPro: 3.54 ± 0.448
1.337ThrGln: 1.337 ± 0.269
2.674ThrArg: 2.674 ± 0.297
4.012ThrSer: 4.012 ± 0.479
2.753ThrThr: 2.753 ± 0.643
3.854ThrVal: 3.854 ± 0.522
0.865ThrTrp: 0.865 ± 0.234
1.573ThrTyr: 1.573 ± 0.294
0.0ThrXaa: 0.0 ± 0.0
Val
7.001ValAla: 7.001 ± 0.737
0.472ValCys: 0.472 ± 0.194
2.91ValAsp: 2.91 ± 0.415
4.877ValGlu: 4.877 ± 0.815
1.888ValPhe: 1.888 ± 0.308
4.248ValGly: 4.248 ± 0.556
0.865ValHis: 0.865 ± 0.285
4.09ValIle: 4.09 ± 0.671
2.989ValLys: 2.989 ± 0.516
5.899ValLeu: 5.899 ± 0.723
1.416ValMet: 1.416 ± 0.315
1.573ValAsn: 1.573 ± 0.377
3.225ValPro: 3.225 ± 0.632
3.304ValGln: 3.304 ± 0.596
3.697ValArg: 3.697 ± 0.438
3.225ValSer: 3.225 ± 0.386
4.09ValThr: 4.09 ± 0.551
4.641ValVal: 4.641 ± 0.686
1.18ValTrp: 1.18 ± 0.362
1.337ValTyr: 1.337 ± 0.347
0.0ValXaa: 0.0 ± 0.0
Trp
1.416TrpAla: 1.416 ± 0.382
0.236TrpCys: 0.236 ± 0.146
0.787TrpAsp: 0.787 ± 0.251
0.236TrpGlu: 0.236 ± 0.137
0.787TrpPhe: 0.787 ± 0.2
1.101TrpGly: 1.101 ± 0.305
0.393TrpHis: 0.393 ± 0.168
1.023TrpIle: 1.023 ± 0.285
0.551TrpLys: 0.551 ± 0.177
2.045TrpLeu: 2.045 ± 0.5
0.551TrpMet: 0.551 ± 0.192
0.551TrpAsn: 0.551 ± 0.212
0.629TrpPro: 0.629 ± 0.338
1.101TrpGln: 1.101 ± 0.3
1.101TrpArg: 1.101 ± 0.238
0.865TrpSer: 0.865 ± 0.278
1.259TrpThr: 1.259 ± 0.27
0.865TrpVal: 0.865 ± 0.28
0.393TrpTrp: 0.393 ± 0.171
0.157TrpTyr: 0.157 ± 0.094
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.989TyrAla: 2.989 ± 0.543
0.236TyrCys: 0.236 ± 0.158
1.495TyrAsp: 1.495 ± 0.318
1.652TyrGlu: 1.652 ± 0.344
0.551TyrPhe: 0.551 ± 0.218
2.281TyrGly: 2.281 ± 0.469
0.629TyrHis: 0.629 ± 0.269
1.101TyrIle: 1.101 ± 0.325
1.023TyrLys: 1.023 ± 0.226
2.674TyrLeu: 2.674 ± 0.393
0.393TyrMet: 0.393 ± 0.253
0.787TyrAsn: 0.787 ± 0.236
1.731TyrPro: 1.731 ± 0.429
1.023TyrGln: 1.023 ± 0.225
2.674TyrArg: 2.674 ± 0.406
1.101TyrSer: 1.101 ± 0.416
1.259TyrThr: 1.259 ± 0.308
1.573TyrVal: 1.573 ± 0.307
0.472TyrTrp: 0.472 ± 0.213
0.393TyrTyr: 0.393 ± 0.177
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (12714 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski