Amino acid dipepetide frequency for Human papillomavirus 205

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.96AlaAla: 3.96 ± 1.513
0.88AlaCys: 0.88 ± 0.662
6.159AlaAsp: 6.159 ± 1.006
5.279AlaGlu: 5.279 ± 1.072
1.76AlaPhe: 1.76 ± 0.969
1.76AlaGly: 1.76 ± 0.651
0.88AlaHis: 0.88 ± 0.444
3.96AlaIle: 3.96 ± 0.72
1.32AlaLys: 1.32 ± 0.691
4.399AlaLeu: 4.399 ± 1.182
1.32AlaMet: 1.32 ± 0.691
1.76AlaAsn: 1.76 ± 0.605
3.52AlaPro: 3.52 ± 0.683
3.08AlaGln: 3.08 ± 0.799
3.08AlaArg: 3.08 ± 1.138
2.64AlaSer: 2.64 ± 1.258
3.96AlaThr: 3.96 ± 0.479
3.96AlaVal: 3.96 ± 0.778
0.88AlaTrp: 0.88 ± 0.714
3.08AlaTyr: 3.08 ± 1.557
0.0AlaXaa: 0.0 ± 0.0
Cys
0.44CysAla: 0.44 ± 0.512
2.64CysCys: 2.64 ± 2.029
1.32CysAsp: 1.32 ± 0.71
0.0CysGlu: 0.0 ± 0.0
2.64CysPhe: 2.64 ± 1.055
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.88CysIle: 0.88 ± 0.826
2.2CysLys: 2.2 ± 1.566
1.32CysLeu: 1.32 ± 1.453
0.88CysMet: 0.88 ± 0.662
2.64CysAsn: 2.64 ± 1.396
1.76CysPro: 1.76 ± 0.84
0.44CysGln: 0.44 ± 0.349
0.88CysArg: 0.88 ± 1.358
2.2CysSer: 2.2 ± 1.377
1.32CysThr: 1.32 ± 0.71
0.88CysVal: 0.88 ± 0.662
1.32CysTrp: 1.32 ± 0.393
1.32CysTyr: 1.32 ± 0.746
0.0CysXaa: 0.0 ± 0.0
Asp
4.399AspAla: 4.399 ± 0.99
1.76AspCys: 1.76 ± 0.756
3.52AspAsp: 3.52 ± 1.53
3.08AspGlu: 3.08 ± 0.758
3.52AspPhe: 3.52 ± 1.222
2.2AspGly: 2.2 ± 0.912
0.44AspHis: 0.44 ± 0.416
6.599AspIle: 6.599 ± 1.852
0.88AspLys: 0.88 ± 0.435
5.279AspLeu: 5.279 ± 1.966
0.88AspMet: 0.88 ± 0.435
3.08AspAsn: 3.08 ± 0.799
5.719AspPro: 5.719 ± 1.231
2.64AspGln: 2.64 ± 0.97
1.32AspArg: 1.32 ± 0.84
3.52AspSer: 3.52 ± 1.016
4.399AspThr: 4.399 ± 0.56
5.279AspVal: 5.279 ± 2.075
0.88AspTrp: 0.88 ± 0.714
1.32AspTyr: 1.32 ± 0.85
0.0AspXaa: 0.0 ± 0.0
Glu
2.64GluAla: 2.64 ± 1.568
1.32GluCys: 1.32 ± 1.07
4.399GluAsp: 4.399 ± 0.672
5.719GluGlu: 5.719 ± 2.08
1.32GluPhe: 1.32 ± 0.647
0.88GluGly: 0.88 ± 0.39
1.32GluHis: 1.32 ± 0.618
2.2GluIle: 2.2 ± 0.914
1.76GluLys: 1.76 ± 1.401
4.399GluLeu: 4.399 ± 1.803
1.76GluMet: 1.76 ± 0.597
3.96GluAsn: 3.96 ± 0.614
3.08GluPro: 3.08 ± 1.064
2.64GluGln: 2.64 ± 0.825
2.64GluArg: 2.64 ± 0.77
5.719GluSer: 5.719 ± 1.523
3.08GluThr: 3.08 ± 0.904
5.279GluVal: 5.279 ± 1.685
0.44GluTrp: 0.44 ± 0.357
2.64GluTyr: 2.64 ± 0.998
0.0GluXaa: 0.0 ± 0.0
Phe
2.2PheAla: 2.2 ± 0.64
1.32PheCys: 1.32 ± 0.826
3.52PheAsp: 3.52 ± 0.645
4.399PheGlu: 4.399 ± 1.439
2.2PhePhe: 2.2 ± 0.855
3.96PheGly: 3.96 ± 0.851
1.32PheHis: 1.32 ± 0.638
0.88PheIle: 0.88 ± 0.444
2.2PheLys: 2.2 ± 0.912
4.399PheLeu: 4.399 ± 1.324
0.44PheMet: 0.44 ± 0.36
3.08PheAsn: 3.08 ± 1.609
1.32PhePro: 1.32 ± 0.374
3.08PheGln: 3.08 ± 1.297
2.64PheArg: 2.64 ± 0.608
2.64PheSer: 2.64 ± 0.453
2.2PheThr: 2.2 ± 0.682
5.279PheVal: 5.279 ± 1.151
0.88PheTrp: 0.88 ± 0.435
2.64PheTyr: 2.64 ± 1.167
0.0PheXaa: 0.0 ± 0.0
Gly
3.52GlyAla: 3.52 ± 0.833
1.76GlyCys: 1.76 ± 0.979
4.399GlyAsp: 4.399 ± 1.34
2.64GlyGlu: 2.64 ± 1.12
1.76GlyPhe: 1.76 ± 0.842
4.399GlyGly: 4.399 ± 2.048
1.76GlyHis: 1.76 ± 0.889
3.96GlyIle: 3.96 ± 1.038
3.08GlyLys: 3.08 ± 0.757
5.279GlyLeu: 5.279 ± 2.137
0.88GlyMet: 0.88 ± 0.49
5.279GlyAsn: 5.279 ± 0.976
2.2GlyPro: 2.2 ± 0.405
1.76GlyGln: 1.76 ± 0.652
3.08GlyArg: 3.08 ± 0.782
3.96GlySer: 3.96 ± 0.778
6.159GlyThr: 6.159 ± 1.785
1.76GlyVal: 1.76 ± 0.988
0.0GlyTrp: 0.0 ± 0.0
1.32GlyTyr: 1.32 ± 0.409
0.0GlyXaa: 0.0 ± 0.0
His
1.76HisAla: 1.76 ± 0.756
0.44HisCys: 0.44 ± 0.357
0.0HisAsp: 0.0 ± 0.0
0.44HisGlu: 0.44 ± 0.36
1.32HisPhe: 1.32 ± 0.661
0.44HisGly: 0.44 ± 0.512
0.0HisHis: 0.0 ± 0.0
0.88HisIle: 0.88 ± 0.49
1.32HisLys: 1.32 ± 0.691
2.2HisLeu: 2.2 ± 0.927
0.44HisMet: 0.44 ± 0.326
0.88HisAsn: 0.88 ± 0.421
2.2HisPro: 2.2 ± 0.749
0.44HisGln: 0.44 ± 0.357
0.44HisArg: 0.44 ± 0.416
1.76HisSer: 1.76 ± 0.617
0.88HisThr: 0.88 ± 0.832
0.88HisVal: 0.88 ± 0.435
0.44HisTrp: 0.44 ± 0.36
2.64HisTyr: 2.64 ± 1.062
0.0HisXaa: 0.0 ± 0.0
Ile
3.08IleAla: 3.08 ± 0.761
1.32IleCys: 1.32 ± 0.704
3.08IleAsp: 3.08 ± 0.891
6.159IleGlu: 6.159 ± 2.607
1.76IlePhe: 1.76 ± 0.647
4.399IleGly: 4.399 ± 1.732
0.44IleHis: 0.44 ± 0.349
1.32IleIle: 1.32 ± 0.393
1.32IleLys: 1.32 ± 0.409
1.76IleLeu: 1.76 ± 0.609
0.88IleMet: 0.88 ± 0.445
4.839IleAsn: 4.839 ± 0.762
2.64IlePro: 2.64 ± 0.581
2.2IleGln: 2.2 ± 0.733
3.08IleArg: 3.08 ± 1.529
3.52IleSer: 3.52 ± 0.645
3.52IleThr: 3.52 ± 0.976
3.52IleVal: 3.52 ± 0.644
0.44IleTrp: 0.44 ± 0.416
2.2IleTyr: 2.2 ± 0.405
0.0IleXaa: 0.0 ± 0.0
Lys
3.08LysAla: 3.08 ± 1.553
2.2LysCys: 2.2 ± 1.325
0.88LysAsp: 0.88 ± 0.826
3.96LysGlu: 3.96 ± 1.347
2.2LysPhe: 2.2 ± 1.122
3.96LysGly: 3.96 ± 0.614
1.32LysHis: 1.32 ± 0.393
2.64LysIle: 2.64 ± 1.005
2.64LysLys: 2.64 ± 0.77
4.399LysLeu: 4.399 ± 1.165
0.44LysMet: 0.44 ± 0.676
2.64LysAsn: 2.64 ± 0.73
0.88LysPro: 0.88 ± 0.39
1.76LysGln: 1.76 ± 1.396
5.719LysArg: 5.719 ± 1.033
4.399LysSer: 4.399 ± 1.439
1.76LysThr: 1.76 ± 0.609
2.2LysVal: 2.2 ± 1.06
1.32LysTrp: 1.32 ± 0.85
2.64LysTyr: 2.64 ± 1.306
0.0LysXaa: 0.0 ± 0.0
Leu
3.96LeuAla: 3.96 ± 1.179
0.44LeuCys: 0.44 ± 0.36
7.039LeuAsp: 7.039 ± 1.609
3.52LeuGlu: 3.52 ± 1.11
4.839LeuPhe: 4.839 ± 1.52
7.919LeuGly: 7.919 ± 2.714
1.32LeuHis: 1.32 ± 0.661
4.399LeuIle: 4.399 ± 1.284
5.719LeuLys: 5.719 ± 1.442
7.479LeuLeu: 7.479 ± 2.143
1.32LeuMet: 1.32 ± 0.408
3.52LeuAsn: 3.52 ± 1.22
5.719LeuPro: 5.719 ± 1.285
5.279LeuGln: 5.279 ± 0.865
3.08LeuArg: 3.08 ± 0.833
6.599LeuSer: 6.599 ± 1.582
4.839LeuThr: 4.839 ± 1.455
5.719LeuVal: 5.719 ± 1.288
0.0LeuTrp: 0.0 ± 0.0
3.96LeuTyr: 3.96 ± 1.024
0.0LeuXaa: 0.0 ± 0.0
Met
0.88MetAla: 0.88 ± 0.435
0.88MetCys: 0.88 ± 0.435
0.44MetAsp: 0.44 ± 0.36
0.88MetGlu: 0.88 ± 0.826
0.44MetPhe: 0.44 ± 0.357
0.88MetGly: 0.88 ± 0.435
0.44MetHis: 0.44 ± 0.416
0.44MetIle: 0.44 ± 0.679
1.32MetLys: 1.32 ± 1.07
0.88MetLeu: 0.88 ± 0.435
0.0MetMet: 0.0 ± 0.0
1.32MetAsn: 1.32 ± 0.702
0.44MetPro: 0.44 ± 0.357
0.44MetGln: 0.44 ± 0.416
0.44MetArg: 0.44 ± 0.512
2.64MetSer: 2.64 ± 0.73
0.88MetThr: 0.88 ± 0.39
1.32MetVal: 1.32 ± 0.691
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.399AsnAla: 4.399 ± 1.908
1.76AsnCys: 1.76 ± 0.707
2.64AsnAsp: 2.64 ± 0.97
1.32AsnGlu: 1.32 ± 0.652
3.96AsnPhe: 3.96 ± 1.247
1.76AsnGly: 1.76 ± 0.871
1.32AsnHis: 1.32 ± 0.629
3.52AsnIle: 3.52 ± 1.209
3.96AsnLys: 3.96 ± 1.555
5.279AsnLeu: 5.279 ± 1.128
0.0AsnMet: 0.0 ± 0.0
3.52AsnAsn: 3.52 ± 1.209
3.52AsnPro: 3.52 ± 1.499
2.64AsnGln: 2.64 ± 0.732
2.64AsnArg: 2.64 ± 0.506
6.159AsnSer: 6.159 ± 1.559
4.399AsnThr: 4.399 ± 0.937
3.96AsnVal: 3.96 ± 0.775
1.32AsnTrp: 1.32 ± 0.393
0.88AsnTyr: 0.88 ± 0.662
0.0AsnXaa: 0.0 ± 0.0
Pro
2.64ProAla: 2.64 ± 1.074
1.32ProCys: 1.32 ± 0.638
4.839ProAsp: 4.839 ± 1.773
2.64ProGlu: 2.64 ± 0.52
3.08ProPhe: 3.08 ± 0.724
2.64ProGly: 2.64 ± 0.964
0.44ProHis: 0.44 ± 0.349
3.96ProIle: 3.96 ± 0.6
1.76ProLys: 1.76 ± 0.622
6.599ProLeu: 6.599 ± 1.352
0.0ProMet: 0.0 ± 0.0
3.52ProAsn: 3.52 ± 1.362
6.599ProPro: 6.599 ± 1.254
3.52ProGln: 3.52 ± 0.866
2.2ProArg: 2.2 ± 0.914
3.96ProSer: 3.96 ± 1.569
4.839ProThr: 4.839 ± 1.784
2.2ProVal: 2.2 ± 1.1
0.44ProTrp: 0.44 ± 0.416
1.32ProTyr: 1.32 ± 1.081
0.0ProXaa: 0.0 ± 0.0
Gln
1.76GlnAla: 1.76 ± 1.036
1.32GlnCys: 1.32 ± 0.819
2.64GlnAsp: 2.64 ± 0.488
2.64GlnGlu: 2.64 ± 1.226
1.76GlnPhe: 1.76 ± 0.597
2.64GlnGly: 2.64 ± 0.585
0.88GlnHis: 0.88 ± 0.39
0.88GlnIle: 0.88 ± 0.826
0.0GlnLys: 0.0 ± 0.0
6.159GlnLeu: 6.159 ± 1.195
1.32GlnMet: 1.32 ± 0.577
2.64GlnAsn: 2.64 ± 0.732
2.64GlnPro: 2.64 ± 0.52
1.76GlnGln: 1.76 ± 0.591
1.76GlnArg: 1.76 ± 1.665
3.08GlnSer: 3.08 ± 1.119
2.64GlnThr: 2.64 ± 0.747
3.08GlnVal: 3.08 ± 1.075
0.88GlnTrp: 0.88 ± 0.445
0.88GlnTyr: 0.88 ± 0.444
0.0GlnXaa: 0.0 ± 0.0
Arg
3.52ArgAla: 3.52 ± 1.082
1.32ArgCys: 1.32 ± 0.638
1.76ArgAsp: 1.76 ± 0.223
1.76ArgGlu: 1.76 ± 0.223
3.52ArgPhe: 3.52 ± 1.534
4.399ArgGly: 4.399 ± 1.327
1.32ArgHis: 1.32 ± 0.694
2.64ArgIle: 2.64 ± 1.35
4.839ArgLys: 4.839 ± 1.358
5.279ArgLeu: 5.279 ± 1.124
0.0ArgMet: 0.0 ± 0.0
3.52ArgAsn: 3.52 ± 1.418
0.88ArgPro: 0.88 ± 0.721
1.76ArgGln: 1.76 ± 0.223
5.279ArgArg: 5.279 ± 1.73
3.96ArgSer: 3.96 ± 1.435
2.64ArgThr: 2.64 ± 0.754
1.76ArgVal: 1.76 ± 0.84
0.0ArgTrp: 0.0 ± 0.0
1.32ArgTyr: 1.32 ± 0.393
0.0ArgXaa: 0.0 ± 0.0
Ser
3.96SerAla: 3.96 ± 1.423
0.88SerCys: 0.88 ± 0.435
3.08SerAsp: 3.08 ± 0.907
4.399SerGlu: 4.399 ± 1.023
3.52SerPhe: 3.52 ± 0.954
7.039SerGly: 7.039 ± 2.005
2.64SerHis: 2.64 ± 0.818
3.08SerIle: 3.08 ± 0.551
3.96SerLys: 3.96 ± 1.418
7.919SerLeu: 7.919 ± 1.955
1.76SerMet: 1.76 ± 1.088
3.52SerAsn: 3.52 ± 0.902
3.52SerPro: 3.52 ± 1.862
2.2SerGln: 2.2 ± 0.717
5.279SerArg: 5.279 ± 1.189
8.799SerSer: 8.799 ± 2.261
6.599SerThr: 6.599 ± 1.569
3.52SerVal: 3.52 ± 1.086
0.88SerTrp: 0.88 ± 0.435
1.76SerTyr: 1.76 ± 0.597
0.0SerXaa: 0.0 ± 0.0
Thr
4.399ThrAla: 4.399 ± 0.734
1.76ThrCys: 1.76 ± 0.803
2.64ThrAsp: 2.64 ± 1.203
4.839ThrGlu: 4.839 ± 0.889
3.08ThrPhe: 3.08 ± 1.574
5.719ThrGly: 5.719 ± 1.194
0.88ThrHis: 0.88 ± 0.435
2.64ThrIle: 2.64 ± 1.005
1.76ThrLys: 1.76 ± 0.741
5.279ThrLeu: 5.279 ± 1.912
0.88ThrMet: 0.88 ± 0.714
2.64ThrAsn: 2.64 ± 1.246
6.599ThrPro: 6.599 ± 2.301
2.64ThrGln: 2.64 ± 0.968
3.08ThrArg: 3.08 ± 0.907
6.159ThrSer: 6.159 ± 1.605
7.479ThrThr: 7.479 ± 1.721
4.839ThrVal: 4.839 ± 0.837
0.0ThrTrp: 0.0 ± 0.0
1.76ThrTyr: 1.76 ± 0.682
0.0ThrXaa: 0.0 ± 0.0
Val
4.399ValAla: 4.399 ± 1.257
0.0ValCys: 0.0 ± 0.0
5.279ValAsp: 5.279 ± 0.906
1.76ValGlu: 1.76 ± 0.223
3.08ValPhe: 3.08 ± 0.758
2.64ValGly: 2.64 ± 0.585
1.32ValHis: 1.32 ± 0.85
3.52ValIle: 3.52 ± 1.055
5.719ValLys: 5.719 ± 0.695
4.399ValLeu: 4.399 ± 1.251
1.32ValMet: 1.32 ± 0.43
3.96ValAsn: 3.96 ± 1.293
3.08ValPro: 3.08 ± 1.108
1.76ValGln: 1.76 ± 1.005
2.2ValArg: 2.2 ± 0.469
5.719ValSer: 5.719 ± 0.891
4.399ValThr: 4.399 ± 1.329
3.08ValVal: 3.08 ± 1.034
0.88ValTrp: 0.88 ± 0.444
2.2ValTyr: 2.2 ± 0.834
0.0ValXaa: 0.0 ± 0.0
Trp
0.44TrpAla: 0.44 ± 0.357
0.0TrpCys: 0.0 ± 0.0
1.32TrpAsp: 1.32 ± 0.694
0.44TrpGlu: 0.44 ± 0.416
0.88TrpPhe: 0.88 ± 0.445
0.44TrpGly: 0.44 ± 0.36
0.44TrpHis: 0.44 ± 0.416
1.32TrpIle: 1.32 ± 0.71
1.76TrpLys: 1.76 ± 0.756
1.32TrpLeu: 1.32 ± 0.661
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.44TrpGln: 0.44 ± 0.36
0.44TrpArg: 0.44 ± 0.416
0.44TrpSer: 0.44 ± 0.36
0.88TrpThr: 0.88 ± 0.832
0.88TrpVal: 0.88 ± 0.445
0.0TrpTrp: 0.0 ± 0.0
0.44TrpTyr: 0.44 ± 0.357
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.2TyrAla: 2.2 ± 0.73
1.76TyrCys: 1.76 ± 1.956
1.76TyrAsp: 1.76 ± 0.617
1.32TyrGlu: 1.32 ± 0.393
3.96TyrPhe: 3.96 ± 1.608
0.88TyrGly: 0.88 ± 0.435
1.32TyrHis: 1.32 ± 1.07
1.76TyrIle: 1.76 ± 0.756
3.96TyrLys: 3.96 ± 1.54
2.64TyrLeu: 2.64 ± 1.247
0.0TyrMet: 0.0 ± 0.0
2.64TyrAsn: 2.64 ± 0.754
2.2TyrPro: 2.2 ± 0.854
0.88TyrGln: 0.88 ± 0.444
2.2TyrArg: 2.2 ± 0.736
0.44TyrSer: 0.44 ± 0.416
2.2TyrThr: 2.2 ± 0.882
1.32TyrVal: 1.32 ± 1.07
0.88TyrTrp: 0.88 ± 0.444
1.32TyrTyr: 1.32 ± 0.409
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski