Amino acid dipepetide frequency for Sulfitobacter sp. JL08

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.901AlaAla: 14.901 ± 0.151
1.104AlaCys: 1.104 ± 0.034
6.967AlaAsp: 6.967 ± 0.079
6.699AlaGlu: 6.699 ± 0.099
4.436AlaPhe: 4.436 ± 0.067
9.571AlaGly: 9.571 ± 0.107
2.392AlaHis: 2.392 ± 0.049
6.034AlaIle: 6.034 ± 0.077
3.979AlaLys: 3.979 ± 0.07
12.938AlaLeu: 12.938 ± 0.131
3.679AlaMet: 3.679 ± 0.053
2.838AlaAsn: 2.838 ± 0.047
5.333AlaPro: 5.333 ± 0.083
4.789AlaGln: 4.789 ± 0.061
7.949AlaArg: 7.949 ± 0.084
5.624AlaSer: 5.624 ± 0.074
5.815AlaThr: 5.815 ± 0.064
7.973AlaVal: 7.973 ± 0.084
1.345AlaTrp: 1.345 ± 0.034
2.623AlaTyr: 2.623 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.208CysAla: 1.208 ± 0.03
0.12CysCys: 0.12 ± 0.01
0.676CysAsp: 0.676 ± 0.021
0.486CysGlu: 0.486 ± 0.018
0.398CysPhe: 0.398 ± 0.017
0.964CysGly: 0.964 ± 0.029
0.278CysHis: 0.278 ± 0.014
0.482CysIle: 0.482 ± 0.02
0.252CysLys: 0.252 ± 0.015
0.881CysLeu: 0.881 ± 0.026
0.172CysMet: 0.172 ± 0.013
0.272CysAsn: 0.272 ± 0.015
0.507CysPro: 0.507 ± 0.02
0.256CysGln: 0.256 ± 0.014
0.517CysArg: 0.517 ± 0.021
0.503CysSer: 0.503 ± 0.022
0.507CysThr: 0.507 ± 0.02
0.703CysVal: 0.703 ± 0.027
0.131CysTrp: 0.131 ± 0.012
0.257CysTyr: 0.257 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.564AspAla: 7.564 ± 0.092
0.547AspCys: 0.547 ± 0.022
3.56AspAsp: 3.56 ± 0.067
3.352AspGlu: 3.352 ± 0.058
2.394AspPhe: 2.394 ± 0.047
5.511AspGly: 5.511 ± 0.088
1.447AspHis: 1.447 ± 0.035
3.71AspIle: 3.71 ± 0.06
1.874AspLys: 1.874 ± 0.039
6.483AspLeu: 6.483 ± 0.072
1.839AspMet: 1.839 ± 0.039
1.489AspAsn: 1.489 ± 0.036
3.689AspPro: 3.689 ± 0.056
2.226AspGln: 2.226 ± 0.043
4.182AspArg: 4.182 ± 0.058
2.242AspSer: 2.242 ± 0.047
3.328AspThr: 3.328 ± 0.057
4.811AspVal: 4.811 ± 0.06
1.181AspTrp: 1.181 ± 0.03
1.617AspTyr: 1.617 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.509GluAla: 6.509 ± 0.085
0.422GluCys: 0.422 ± 0.019
3.18GluAsp: 3.18 ± 0.061
2.93GluGlu: 2.93 ± 0.061
1.904GluPhe: 1.904 ± 0.041
3.931GluGly: 3.931 ± 0.06
1.144GluHis: 1.144 ± 0.032
3.548GluIle: 3.548 ± 0.062
2.352GluLys: 2.352 ± 0.047
4.931GluLeu: 4.931 ± 0.067
1.835GluMet: 1.835 ± 0.042
2.074GluAsn: 2.074 ± 0.041
2.384GluPro: 2.384 ± 0.052
2.083GluGln: 2.083 ± 0.049
3.739GluArg: 3.739 ± 0.061
2.149GluSer: 2.149 ± 0.046
3.853GluThr: 3.853 ± 0.052
3.809GluVal: 3.809 ± 0.06
0.73GluTrp: 0.73 ± 0.026
1.17GluTyr: 1.17 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.414PheAla: 4.414 ± 0.067
0.483PheCys: 0.483 ± 0.019
3.045PheAsp: 3.045 ± 0.047
2.378PheGlu: 2.378 ± 0.042
1.564PhePhe: 1.564 ± 0.037
3.843PheGly: 3.843 ± 0.065
0.79PheHis: 0.79 ± 0.025
1.758PheIle: 1.758 ± 0.035
1.12PheLys: 1.12 ± 0.03
3.465PheLeu: 3.465 ± 0.056
0.907PheMet: 0.907 ± 0.025
1.162PheAsn: 1.162 ± 0.033
1.562PhePro: 1.562 ± 0.037
1.187PheGln: 1.187 ± 0.031
2.129PheArg: 2.129 ± 0.042
2.479PheSer: 2.479 ± 0.047
2.073PheThr: 2.073 ± 0.043
2.904PheVal: 2.904 ± 0.051
0.621PheTrp: 0.621 ± 0.025
0.998PheTyr: 0.998 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.146GlyAla: 9.146 ± 0.097
0.913GlyCys: 0.913 ± 0.027
4.837GlyAsp: 4.837 ± 0.066
4.139GlyGlu: 4.139 ± 0.064
3.744GlyPhe: 3.744 ± 0.054
6.885GlyGly: 6.885 ± 0.1
1.948GlyHis: 1.948 ± 0.038
4.482GlyIle: 4.482 ± 0.067
3.276GlyLys: 3.276 ± 0.063
8.64GlyLeu: 8.64 ± 0.091
2.549GlyMet: 2.549 ± 0.044
2.265GlyAsn: 2.265 ± 0.045
3.495GlyPro: 3.495 ± 0.054
3.254GlyGln: 3.254 ± 0.053
5.005GlyArg: 5.005 ± 0.07
4.304GlySer: 4.304 ± 0.067
4.614GlyThr: 4.614 ± 0.062
6.265GlyVal: 6.265 ± 0.076
1.446GlyTrp: 1.446 ± 0.033
2.432GlyTyr: 2.432 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.324HisAla: 2.324 ± 0.043
0.266HisCys: 0.266 ± 0.014
1.287HisAsp: 1.287 ± 0.034
1.051HisGlu: 1.051 ± 0.029
0.847HisPhe: 0.847 ± 0.03
1.815HisGly: 1.815 ± 0.041
0.554HisHis: 0.554 ± 0.019
1.101HisIle: 1.101 ± 0.035
0.617HisLys: 0.617 ± 0.024
2.22HisLeu: 2.22 ± 0.042
0.582HisMet: 0.582 ± 0.022
0.547HisAsn: 0.547 ± 0.021
1.344HisPro: 1.344 ± 0.033
0.637HisGln: 0.637 ± 0.021
1.325HisArg: 1.325 ± 0.036
1.124HisSer: 1.124 ± 0.032
0.955HisThr: 0.955 ± 0.03
1.539HisVal: 1.539 ± 0.035
0.362HisTrp: 0.362 ± 0.019
0.605HisTyr: 0.605 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.115IleAla: 7.115 ± 0.082
0.678IleCys: 0.678 ± 0.024
3.704IleAsp: 3.704 ± 0.057
3.62IleGlu: 3.62 ± 0.061
1.752IlePhe: 1.752 ± 0.044
5.018IleGly: 5.018 ± 0.069
0.947IleHis: 0.947 ± 0.027
2.561IleIle: 2.561 ± 0.047
1.769IleLys: 1.769 ± 0.044
4.955IleLeu: 4.955 ± 0.069
1.217IleMet: 1.217 ± 0.035
1.599IleAsn: 1.599 ± 0.038
2.43IlePro: 2.43 ± 0.05
1.285IleGln: 1.285 ± 0.036
3.223IleArg: 3.223 ± 0.058
3.355IleSer: 3.355 ± 0.05
3.161IleThr: 3.161 ± 0.053
4.065IleVal: 4.065 ± 0.058
0.828IleTrp: 0.828 ± 0.026
1.222IleTyr: 1.222 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
4.179LysAla: 4.179 ± 0.066
0.236LysCys: 0.236 ± 0.012
2.089LysAsp: 2.089 ± 0.041
1.643LysGlu: 1.643 ± 0.043
1.03LysPhe: 1.03 ± 0.028
2.874LysGly: 2.874 ± 0.052
0.683LysHis: 0.683 ± 0.024
1.858LysIle: 1.858 ± 0.042
1.381LysLys: 1.381 ± 0.037
3.188LysLeu: 3.188 ± 0.055
1.05LysMet: 1.05 ± 0.035
1.023LysAsn: 1.023 ± 0.032
1.959LysPro: 1.959 ± 0.043
1.092LysGln: 1.092 ± 0.031
2.436LysArg: 2.436 ± 0.053
2.173LysSer: 2.173 ± 0.047
2.364LysThr: 2.364 ± 0.047
2.3LysVal: 2.3 ± 0.053
0.463LysTrp: 0.463 ± 0.02
0.761LysTyr: 0.761 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
11.769LeuAla: 11.769 ± 0.109
1.029LeuCys: 1.029 ± 0.027
6.108LeuAsp: 6.108 ± 0.07
5.17LeuGlu: 5.17 ± 0.062
3.697LeuPhe: 3.697 ± 0.058
8.113LeuGly: 8.113 ± 0.088
1.912LeuHis: 1.912 ± 0.039
5.539LeuIle: 5.539 ± 0.074
3.506LeuLys: 3.506 ± 0.058
8.453LeuLeu: 8.453 ± 0.096
2.704LeuMet: 2.704 ± 0.047
3.086LeuAsn: 3.086 ± 0.047
5.161LeuPro: 5.161 ± 0.067
2.939LeuGln: 2.939 ± 0.048
6.474LeuArg: 6.474 ± 0.081
6.705LeuSer: 6.705 ± 0.076
5.678LeuThr: 5.678 ± 0.073
6.718LeuVal: 6.718 ± 0.082
1.273LeuTrp: 1.273 ± 0.032
2.008LeuTyr: 2.008 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.454MetAla: 3.454 ± 0.053
0.21MetCys: 0.21 ± 0.013
1.484MetAsp: 1.484 ± 0.036
1.269MetGlu: 1.269 ± 0.034
0.921MetPhe: 0.921 ± 0.025
2.305MetGly: 2.305 ± 0.04
0.528MetHis: 0.528 ± 0.02
1.727MetIle: 1.727 ± 0.039
1.178MetLys: 1.178 ± 0.027
2.661MetLeu: 2.661 ± 0.045
0.869MetMet: 0.869 ± 0.029
0.952MetAsn: 0.952 ± 0.029
1.509MetPro: 1.509 ± 0.034
1.148MetGln: 1.148 ± 0.03
1.836MetArg: 1.836 ± 0.044
1.809MetSer: 1.809 ± 0.04
2.069MetThr: 2.069 ± 0.039
1.891MetVal: 1.891 ± 0.041
0.303MetTrp: 0.303 ± 0.016
0.435MetTyr: 0.435 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.445AsnAla: 3.445 ± 0.053
0.291AsnCys: 0.291 ± 0.015
1.573AsnAsp: 1.573 ± 0.038
1.385AsnGlu: 1.385 ± 0.034
1.026AsnPhe: 1.026 ± 0.029
2.646AsnGly: 2.646 ± 0.045
0.546AsnHis: 0.546 ± 0.021
1.629AsnIle: 1.629 ± 0.038
0.846AsnLys: 0.846 ± 0.028
2.798AsnLeu: 2.798 ± 0.046
0.769AsnMet: 0.769 ± 0.029
0.801AsnAsn: 0.801 ± 0.027
1.993AsnPro: 1.993 ± 0.045
0.83AsnGln: 0.83 ± 0.025
1.881AsnArg: 1.881 ± 0.041
1.457AsnSer: 1.457 ± 0.042
1.614AsnThr: 1.614 ± 0.04
2.075AsnVal: 2.075 ± 0.037
0.512AsnTrp: 0.512 ± 0.02
0.739AsnTyr: 0.739 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.247ProAla: 5.247 ± 0.073
0.36ProCys: 0.36 ± 0.015
4.472ProAsp: 4.472 ± 0.071
3.672ProGlu: 3.672 ± 0.071
2.058ProPhe: 2.058 ± 0.045
3.809ProGly: 3.809 ± 0.058
1.093ProHis: 1.093 ± 0.033
2.297ProIle: 2.297 ± 0.042
1.817ProLys: 1.817 ± 0.043
4.441ProLeu: 4.441 ± 0.061
1.366ProMet: 1.366 ± 0.038
1.431ProAsn: 1.431 ± 0.035
2.184ProPro: 2.184 ± 0.054
1.634ProGln: 1.634 ± 0.036
2.462ProArg: 2.462 ± 0.047
2.534ProSer: 2.534 ± 0.044
2.392ProThr: 2.392 ± 0.045
4.29ProVal: 4.29 ± 0.067
0.638ProTrp: 0.638 ± 0.024
1.237ProTyr: 1.237 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.109GlnAla: 4.109 ± 0.062
0.256GlnCys: 0.256 ± 0.014
2.108GlnAsp: 2.108 ± 0.039
1.666GlnGlu: 1.666 ± 0.038
1.197GlnPhe: 1.197 ± 0.03
2.681GlnGly: 2.681 ± 0.045
0.661GlnHis: 0.661 ± 0.021
2.237GlnIle: 2.237 ± 0.04
1.297GlnLys: 1.297 ± 0.034
2.86GlnLeu: 2.86 ± 0.047
1.18GlnMet: 1.18 ± 0.031
1.155GlnAsn: 1.155 ± 0.029
1.643GlnPro: 1.643 ± 0.035
1.124GlnGln: 1.124 ± 0.033
2.158GlnArg: 2.158 ± 0.04
2.118GlnSer: 2.118 ± 0.044
2.114GlnThr: 2.114 ± 0.04
2.48GlnVal: 2.48 ± 0.04
0.424GlnTrp: 0.424 ± 0.015
0.683GlnTyr: 0.683 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.337ArgAla: 7.337 ± 0.082
0.506ArgCys: 0.506 ± 0.021
4.189ArgAsp: 4.189 ± 0.059
3.349ArgGlu: 3.349 ± 0.061
2.702ArgPhe: 2.702 ± 0.051
4.089ArgGly: 4.089 ± 0.059
1.454ArgHis: 1.454 ± 0.04
3.838ArgIle: 3.838 ± 0.052
2.5ArgLys: 2.5 ± 0.05
6.551ArgLeu: 6.551 ± 0.081
1.94ArgMet: 1.94 ± 0.042
1.942ArgAsn: 1.942 ± 0.043
2.965ArgPro: 2.965 ± 0.05
2.186ArgGln: 2.186 ± 0.048
4.263ArgArg: 4.263 ± 0.062
3.239ArgSer: 3.239 ± 0.048
3.105ArgThr: 3.105 ± 0.054
4.361ArgVal: 4.361 ± 0.066
0.957ArgTrp: 0.957 ± 0.027
1.613ArgTyr: 1.613 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
5.954SerAla: 5.954 ± 0.071
0.471SerCys: 0.471 ± 0.02
3.767SerAsp: 3.767 ± 0.063
3.011SerGlu: 3.011 ± 0.051
2.407SerPhe: 2.407 ± 0.042
5.607SerGly: 5.607 ± 0.068
1.168SerHis: 1.168 ± 0.032
2.699SerIle: 2.699 ± 0.039
1.818SerLys: 1.818 ± 0.046
4.915SerLeu: 4.915 ± 0.066
1.458SerMet: 1.458 ± 0.034
1.573SerAsn: 1.573 ± 0.038
2.507SerPro: 2.507 ± 0.05
1.798SerGln: 1.798 ± 0.037
3.144SerArg: 3.144 ± 0.049
2.757SerSer: 2.757 ± 0.051
2.766SerThr: 2.766 ± 0.048
4.283SerVal: 4.283 ± 0.06
0.703SerTrp: 0.703 ± 0.027
1.405SerTyr: 1.405 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.023ThrAla: 6.023 ± 0.074
0.538ThrCys: 0.538 ± 0.02
3.34ThrAsp: 3.34 ± 0.049
2.792ThrGlu: 2.792 ± 0.048
2.011ThrPhe: 2.011 ± 0.041
5.493ThrGly: 5.493 ± 0.071
1.201ThrHis: 1.201 ± 0.027
2.827ThrIle: 2.827 ± 0.049
1.743ThrLys: 1.743 ± 0.039
6.078ThrLeu: 6.078 ± 0.071
1.388ThrMet: 1.388 ± 0.038
1.443ThrAsn: 1.443 ± 0.037
3.345ThrPro: 3.345 ± 0.053
1.887ThrGln: 1.887 ± 0.035
3.479ThrArg: 3.479 ± 0.054
2.972ThrSer: 2.972 ± 0.053
2.979ThrThr: 2.979 ± 0.05
4.169ThrVal: 4.169 ± 0.06
0.696ThrTrp: 0.696 ± 0.026
1.404ThrTyr: 1.404 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.295ValAla: 8.295 ± 0.093
0.711ValCys: 0.711 ± 0.024
4.081ValAsp: 4.081 ± 0.053
4.087ValGlu: 4.087 ± 0.065
3.149ValPhe: 3.149 ± 0.054
5.29ValGly: 5.29 ± 0.065
1.424ValHis: 1.424 ± 0.033
4.361ValIle: 4.361 ± 0.066
2.266ValLys: 2.266 ± 0.051
7.614ValLeu: 7.614 ± 0.085
2.084ValMet: 2.084 ± 0.045
2.03ValAsn: 2.03 ± 0.039
3.625ValPro: 3.625 ± 0.057
2.381ValGln: 2.381 ± 0.047
4.255ValArg: 4.255 ± 0.066
4.505ValSer: 4.505 ± 0.054
4.417ValThr: 4.417 ± 0.06
5.414ValVal: 5.414 ± 0.082
0.997ValTrp: 0.997 ± 0.029
1.63ValTyr: 1.63 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.436TrpAla: 1.436 ± 0.035
0.157TrpCys: 0.157 ± 0.011
0.806TrpAsp: 0.806 ± 0.026
0.637TrpGlu: 0.637 ± 0.024
0.607TrpPhe: 0.607 ± 0.022
1.031TrpGly: 1.031 ± 0.034
0.363TrpHis: 0.363 ± 0.017
0.774TrpIle: 0.774 ± 0.027
0.451TrpLys: 0.451 ± 0.022
1.558TrpLeu: 1.558 ± 0.046
0.45TrpMet: 0.45 ± 0.019
0.487TrpAsn: 0.487 ± 0.02
0.691TrpPro: 0.691 ± 0.025
0.613TrpGln: 0.613 ± 0.022
1.05TrpArg: 1.05 ± 0.032
0.855TrpSer: 0.855 ± 0.027
0.786TrpThr: 0.786 ± 0.024
0.914TrpVal: 0.914 ± 0.027
0.222TrpTrp: 0.222 ± 0.013
0.327TrpTyr: 0.327 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.558TyrAla: 2.558 ± 0.045
0.271TyrCys: 0.271 ± 0.015
1.771TyrAsp: 1.771 ± 0.037
1.343TyrGlu: 1.343 ± 0.038
1.042TyrPhe: 1.042 ± 0.029
2.162TyrGly: 2.162 ± 0.044
0.568TyrHis: 0.568 ± 0.021
1.043TyrIle: 1.043 ± 0.032
0.74TyrLys: 0.74 ± 0.024
2.415TyrLeu: 2.415 ± 0.043
0.517TyrMet: 0.517 ± 0.018
0.687TyrAsn: 0.687 ± 0.026
1.107TyrPro: 1.107 ± 0.026
0.801TyrGln: 0.801 ± 0.027
1.577TyrArg: 1.577 ± 0.034
1.31TyrSer: 1.31 ± 0.031
1.216TyrThr: 1.216 ± 0.028
1.654TyrVal: 1.654 ± 0.038
0.386TyrTrp: 0.386 ± 0.018
0.655TyrTyr: 0.655 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4063 proteins (1260259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski