Amino acid dipepetide frequency for Streptococcus phage JX01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.962AlaAla: 2.962 ± 1.145
0.39AlaCys: 0.39 ± 0.179
3.897AlaAsp: 3.897 ± 0.66
4.053AlaGlu: 4.053 ± 0.761
2.572AlaPhe: 2.572 ± 0.429
4.131AlaGly: 4.131 ± 0.626
0.857AlaHis: 0.857 ± 0.248
5.456AlaIle: 5.456 ± 0.823
6.703AlaLys: 6.703 ± 0.84
5.534AlaLeu: 5.534 ± 0.833
1.793AlaMet: 1.793 ± 0.355
4.287AlaAsn: 4.287 ± 0.567
1.325AlaPro: 1.325 ± 0.324
2.182AlaGln: 2.182 ± 0.306
2.104AlaArg: 2.104 ± 0.477
3.975AlaSer: 3.975 ± 0.575
3.741AlaThr: 3.741 ± 0.558
4.053AlaVal: 4.053 ± 0.415
1.169AlaTrp: 1.169 ± 0.362
2.416AlaTyr: 2.416 ± 0.404
0.0AlaXaa: 0.0 ± 0.0
Cys
0.39CysAla: 0.39 ± 0.213
0.078CysCys: 0.078 ± 0.091
0.39CysAsp: 0.39 ± 0.183
0.546CysGlu: 0.546 ± 0.196
0.312CysPhe: 0.312 ± 0.16
0.624CysGly: 0.624 ± 0.224
0.078CysHis: 0.078 ± 0.074
0.312CysIle: 0.312 ± 0.159
0.39CysLys: 0.39 ± 0.213
0.39CysLeu: 0.39 ± 0.153
0.234CysMet: 0.234 ± 0.161
0.312CysAsn: 0.312 ± 0.154
0.078CysPro: 0.078 ± 0.072
0.078CysGln: 0.078 ± 0.073
0.312CysArg: 0.312 ± 0.153
0.156CysSer: 0.156 ± 0.119
0.546CysThr: 0.546 ± 0.212
0.39CysVal: 0.39 ± 0.169
0.156CysTrp: 0.156 ± 0.101
0.39CysTyr: 0.39 ± 0.17
0.0CysXaa: 0.0 ± 0.0
Asp
2.182AspAla: 2.182 ± 0.382
0.312AspCys: 0.312 ± 0.141
3.741AspAsp: 3.741 ± 0.607
4.521AspGlu: 4.521 ± 0.747
3.819AspPhe: 3.819 ± 0.541
5.378AspGly: 5.378 ± 0.687
0.857AspHis: 0.857 ± 0.253
3.897AspIle: 3.897 ± 0.542
6.313AspLys: 6.313 ± 0.732
5.924AspLeu: 5.924 ± 0.769
1.637AspMet: 1.637 ± 0.265
3.274AspAsn: 3.274 ± 0.45
1.325AspPro: 1.325 ± 0.315
1.247AspGln: 1.247 ± 0.29
2.884AspArg: 2.884 ± 0.46
4.287AspSer: 4.287 ± 0.62
3.352AspThr: 3.352 ± 0.58
3.663AspVal: 3.663 ± 0.519
1.091AspTrp: 1.091 ± 0.335
3.663AspTyr: 3.663 ± 0.583
0.0AspXaa: 0.0 ± 0.0
Glu
4.443GluAla: 4.443 ± 0.893
0.078GluCys: 0.078 ± 0.072
3.507GluAsp: 3.507 ± 0.476
5.144GluGlu: 5.144 ± 0.677
2.728GluPhe: 2.728 ± 0.429
2.572GluGly: 2.572 ± 0.414
0.857GluHis: 0.857 ± 0.283
6.08GluIle: 6.08 ± 1.003
5.534GluLys: 5.534 ± 0.781
7.405GluLeu: 7.405 ± 0.874
1.637GluMet: 1.637 ± 0.382
3.585GluAsn: 3.585 ± 0.526
1.871GluPro: 1.871 ± 0.482
3.741GluGln: 3.741 ± 0.628
2.182GluArg: 2.182 ± 0.407
3.819GluSer: 3.819 ± 0.668
4.754GluThr: 4.754 ± 0.56
4.91GluVal: 4.91 ± 0.674
1.169GluTrp: 1.169 ± 0.298
2.728GluTyr: 2.728 ± 0.454
0.0GluXaa: 0.0 ± 0.0
Phe
2.806PheAla: 2.806 ± 0.392
0.234PheCys: 0.234 ± 0.123
3.196PheAsp: 3.196 ± 0.531
3.118PheGlu: 3.118 ± 0.559
1.715PhePhe: 1.715 ± 0.513
3.274PheGly: 3.274 ± 0.354
0.156PheHis: 0.156 ± 0.125
3.196PheIle: 3.196 ± 0.538
4.677PheLys: 4.677 ± 0.678
2.728PheLeu: 2.728 ± 0.636
1.169PheMet: 1.169 ± 0.322
2.728PheAsn: 2.728 ± 0.48
0.857PhePro: 0.857 ± 0.27
1.091PheGln: 1.091 ± 0.318
1.715PheArg: 1.715 ± 0.343
3.741PheSer: 3.741 ± 0.505
2.65PheThr: 2.65 ± 0.502
2.416PheVal: 2.416 ± 0.429
0.546PheTrp: 0.546 ± 0.218
2.104PheTyr: 2.104 ± 0.366
0.0PheXaa: 0.0 ± 0.0
Gly
4.287GlyAla: 4.287 ± 0.687
0.078GlyCys: 0.078 ± 0.078
3.975GlyAsp: 3.975 ± 0.586
2.572GlyGlu: 2.572 ± 0.469
3.429GlyPhe: 3.429 ± 0.452
4.832GlyGly: 4.832 ± 0.693
0.701GlyHis: 0.701 ± 0.21
4.677GlyIle: 4.677 ± 0.505
6.313GlyLys: 6.313 ± 0.792
5.378GlyLeu: 5.378 ± 0.748
1.559GlyMet: 1.559 ± 0.417
4.287GlyAsn: 4.287 ± 0.446
0.857GlyPro: 0.857 ± 0.355
1.793GlyGln: 1.793 ± 0.388
2.338GlyArg: 2.338 ± 0.423
2.962GlySer: 2.962 ± 0.522
3.975GlyThr: 3.975 ± 0.823
5.3GlyVal: 5.3 ± 0.653
1.169GlyTrp: 1.169 ± 0.256
3.585GlyTyr: 3.585 ± 0.586
0.0GlyXaa: 0.0 ± 0.0
His
0.468HisAla: 0.468 ± 0.268
0.078HisCys: 0.078 ± 0.074
0.779HisAsp: 0.779 ± 0.324
0.935HisGlu: 0.935 ± 0.26
0.546HisPhe: 0.546 ± 0.198
0.624HisGly: 0.624 ± 0.235
0.312HisHis: 0.312 ± 0.187
0.935HisIle: 0.935 ± 0.347
0.935HisLys: 0.935 ± 0.252
0.935HisLeu: 0.935 ± 0.257
0.156HisMet: 0.156 ± 0.143
0.935HisAsn: 0.935 ± 0.28
0.312HisPro: 0.312 ± 0.131
0.624HisGln: 0.624 ± 0.206
0.468HisArg: 0.468 ± 0.176
1.325HisSer: 1.325 ± 0.412
0.468HisThr: 0.468 ± 0.216
1.091HisVal: 1.091 ± 0.251
0.234HisTrp: 0.234 ± 0.14
0.779HisTyr: 0.779 ± 0.225
0.0HisXaa: 0.0 ± 0.0
Ile
6.469IleAla: 6.469 ± 0.721
0.546IleCys: 0.546 ± 0.241
6.157IleAsp: 6.157 ± 0.535
5.3IleGlu: 5.3 ± 0.753
2.962IlePhe: 2.962 ± 0.582
3.975IleGly: 3.975 ± 0.675
0.857IleHis: 0.857 ± 0.25
4.053IleIle: 4.053 ± 0.684
6.002IleLys: 6.002 ± 0.585
5.456IleLeu: 5.456 ± 0.883
1.169IleMet: 1.169 ± 0.299
4.677IleAsn: 4.677 ± 0.432
2.416IlePro: 2.416 ± 0.51
1.481IleGln: 1.481 ± 0.298
2.65IleArg: 2.65 ± 0.535
4.131IleSer: 4.131 ± 0.579
4.832IleThr: 4.832 ± 0.676
3.429IleVal: 3.429 ± 0.474
0.546IleTrp: 0.546 ± 0.233
3.04IleTyr: 3.04 ± 0.428
0.0IleXaa: 0.0 ± 0.0
Lys
6.547LysAla: 6.547 ± 0.97
0.546LysCys: 0.546 ± 0.214
5.144LysAsp: 5.144 ± 0.659
7.405LysGlu: 7.405 ± 1.011
3.274LysPhe: 3.274 ± 0.683
5.066LysGly: 5.066 ± 0.714
0.935LysHis: 0.935 ± 0.284
5.69LysIle: 5.69 ± 0.801
6.937LysLys: 6.937 ± 0.872
7.716LysLeu: 7.716 ± 0.747
1.637LysMet: 1.637 ± 0.374
6.235LysAsn: 6.235 ± 0.563
3.04LysPro: 3.04 ± 0.653
3.585LysGln: 3.585 ± 0.554
2.728LysArg: 2.728 ± 0.444
5.066LysSer: 5.066 ± 0.769
7.327LysThr: 7.327 ± 0.787
4.988LysVal: 4.988 ± 0.631
0.779LysTrp: 0.779 ± 0.227
3.585LysTyr: 3.585 ± 0.582
0.0LysXaa: 0.0 ± 0.0
Leu
5.378LeuAla: 5.378 ± 0.622
0.546LeuCys: 0.546 ± 0.198
4.988LeuAsp: 4.988 ± 0.511
5.846LeuGlu: 5.846 ± 0.753
3.352LeuPhe: 3.352 ± 0.685
4.832LeuGly: 4.832 ± 0.885
0.935LeuHis: 0.935 ± 0.283
5.612LeuIle: 5.612 ± 0.748
6.937LeuLys: 6.937 ± 0.953
5.768LeuLeu: 5.768 ± 0.686
2.338LeuMet: 2.338 ± 0.474
5.846LeuAsn: 5.846 ± 0.784
3.196LeuPro: 3.196 ± 0.457
3.507LeuGln: 3.507 ± 0.575
3.663LeuArg: 3.663 ± 0.714
5.768LeuSer: 5.768 ± 0.621
6.157LeuThr: 6.157 ± 0.939
4.677LeuVal: 4.677 ± 0.534
1.247LeuTrp: 1.247 ± 0.335
3.04LeuTyr: 3.04 ± 0.524
0.0LeuXaa: 0.0 ± 0.0
Met
1.871MetAla: 1.871 ± 0.351
0.234MetCys: 0.234 ± 0.147
1.325MetAsp: 1.325 ± 0.394
1.247MetGlu: 1.247 ± 0.289
1.169MetPhe: 1.169 ± 0.317
0.857MetGly: 0.857 ± 0.262
0.234MetHis: 0.234 ± 0.137
2.26MetIle: 2.26 ± 0.48
1.871MetLys: 1.871 ± 0.43
1.949MetLeu: 1.949 ± 0.334
0.546MetMet: 0.546 ± 0.178
1.637MetAsn: 1.637 ± 0.41
0.468MetPro: 0.468 ± 0.197
1.169MetGln: 1.169 ± 0.267
0.935MetArg: 0.935 ± 0.295
1.793MetSer: 1.793 ± 0.41
1.715MetThr: 1.715 ± 0.416
1.559MetVal: 1.559 ± 0.3
0.312MetTrp: 0.312 ± 0.15
0.701MetTyr: 0.701 ± 0.236
0.0MetXaa: 0.0 ± 0.0
Asn
3.507AsnAla: 3.507 ± 0.574
0.312AsnCys: 0.312 ± 0.143
3.274AsnAsp: 3.274 ± 0.552
4.754AsnGlu: 4.754 ± 0.642
2.728AsnPhe: 2.728 ± 0.423
5.69AsnGly: 5.69 ± 0.822
0.857AsnHis: 0.857 ± 0.284
4.677AsnIle: 4.677 ± 0.648
5.222AsnLys: 5.222 ± 0.666
4.287AsnLeu: 4.287 ± 0.49
1.481AsnMet: 1.481 ± 0.336
3.118AsnAsn: 3.118 ± 0.406
2.65AsnPro: 2.65 ± 0.35
1.871AsnGln: 1.871 ± 0.425
2.338AsnArg: 2.338 ± 0.494
4.131AsnSer: 4.131 ± 0.85
2.494AsnThr: 2.494 ± 0.538
3.819AsnVal: 3.819 ± 0.61
1.325AsnTrp: 1.325 ± 0.347
2.806AsnTyr: 2.806 ± 0.421
0.0AsnXaa: 0.0 ± 0.0
Pro
0.935ProAla: 0.935 ± 0.269
0.0ProCys: 0.0 ± 0.0
2.182ProAsp: 2.182 ± 0.357
2.027ProGlu: 2.027 ± 0.427
1.403ProPhe: 1.403 ± 0.301
1.091ProGly: 1.091 ± 0.413
0.468ProHis: 0.468 ± 0.191
1.559ProIle: 1.559 ± 0.319
2.494ProLys: 2.494 ± 0.463
2.416ProLeu: 2.416 ± 0.52
0.234ProMet: 0.234 ± 0.144
1.793ProAsn: 1.793 ± 0.438
0.546ProPro: 0.546 ± 0.211
1.091ProGln: 1.091 ± 0.345
0.701ProArg: 0.701 ± 0.336
2.338ProSer: 2.338 ± 0.49
2.027ProThr: 2.027 ± 0.44
2.572ProVal: 2.572 ± 0.469
0.0ProTrp: 0.0 ± 0.0
1.403ProTyr: 1.403 ± 0.455
0.0ProXaa: 0.0 ± 0.0
Gln
3.429GlnAla: 3.429 ± 0.597
0.234GlnCys: 0.234 ± 0.121
1.559GlnAsp: 1.559 ± 0.279
2.182GlnGlu: 2.182 ± 0.394
1.637GlnPhe: 1.637 ± 0.395
2.104GlnGly: 2.104 ± 0.377
0.468GlnHis: 0.468 ± 0.185
3.429GlnIle: 3.429 ± 0.524
3.196GlnLys: 3.196 ± 0.536
3.507GlnLeu: 3.507 ± 0.367
1.169GlnMet: 1.169 ± 0.363
1.715GlnAsn: 1.715 ± 0.416
1.013GlnPro: 1.013 ± 0.316
1.871GlnGln: 1.871 ± 0.499
1.091GlnArg: 1.091 ± 0.344
3.196GlnSer: 3.196 ± 0.592
1.637GlnThr: 1.637 ± 0.366
1.637GlnVal: 1.637 ± 0.343
0.779GlnTrp: 0.779 ± 0.215
1.091GlnTyr: 1.091 ± 0.275
0.0GlnXaa: 0.0 ± 0.0
Arg
1.247ArgAla: 1.247 ± 0.305
0.39ArgCys: 0.39 ± 0.242
2.728ArgAsp: 2.728 ± 0.473
2.728ArgGlu: 2.728 ± 0.469
2.104ArgPhe: 2.104 ± 0.331
1.949ArgGly: 1.949 ± 0.409
0.935ArgHis: 0.935 ± 0.306
3.585ArgIle: 3.585 ± 0.527
3.352ArgLys: 3.352 ± 0.602
2.728ArgLeu: 2.728 ± 0.441
1.325ArgMet: 1.325 ± 0.315
2.027ArgAsn: 2.027 ± 0.431
1.169ArgPro: 1.169 ± 0.349
1.481ArgGln: 1.481 ± 0.316
2.027ArgArg: 2.027 ± 0.457
1.403ArgSer: 1.403 ± 0.38
2.494ArgThr: 2.494 ± 0.312
2.26ArgVal: 2.26 ± 0.372
0.546ArgTrp: 0.546 ± 0.227
1.715ArgTyr: 1.715 ± 0.417
0.0ArgXaa: 0.0 ± 0.0
Ser
3.975SerAla: 3.975 ± 0.617
0.234SerCys: 0.234 ± 0.153
5.378SerAsp: 5.378 ± 0.76
3.585SerGlu: 3.585 ± 0.429
3.118SerPhe: 3.118 ± 0.644
4.988SerGly: 4.988 ± 0.854
1.403SerHis: 1.403 ± 0.332
3.975SerIle: 3.975 ± 0.496
5.924SerLys: 5.924 ± 0.8
4.832SerLeu: 4.832 ± 0.563
1.715SerMet: 1.715 ± 0.369
4.131SerAsn: 4.131 ± 0.731
1.013SerPro: 1.013 ± 0.329
2.572SerGln: 2.572 ± 0.392
2.104SerArg: 2.104 ± 0.39
4.599SerSer: 4.599 ± 0.522
3.352SerThr: 3.352 ± 0.746
4.209SerVal: 4.209 ± 0.561
0.546SerTrp: 0.546 ± 0.194
3.04SerTyr: 3.04 ± 0.475
0.0SerXaa: 0.0 ± 0.0
Thr
4.599ThrAla: 4.599 ± 0.727
0.39ThrCys: 0.39 ± 0.162
3.429ThrAsp: 3.429 ± 0.417
3.352ThrGlu: 3.352 ± 0.518
2.494ThrPhe: 2.494 ± 0.599
5.066ThrGly: 5.066 ± 0.726
0.701ThrHis: 0.701 ± 0.259
4.209ThrIle: 4.209 ± 0.756
6.002ThrLys: 6.002 ± 0.651
5.144ThrLeu: 5.144 ± 0.545
1.559ThrMet: 1.559 ± 0.415
3.429ThrAsn: 3.429 ± 0.572
2.104ThrPro: 2.104 ± 0.385
2.338ThrGln: 2.338 ± 0.431
2.416ThrArg: 2.416 ± 0.406
3.352ThrSer: 3.352 ± 0.589
4.131ThrThr: 4.131 ± 0.517
5.378ThrVal: 5.378 ± 0.838
0.779ThrTrp: 0.779 ± 0.251
2.572ThrTyr: 2.572 ± 0.513
0.0ThrXaa: 0.0 ± 0.0
Val
4.754ValAla: 4.754 ± 0.535
0.468ValCys: 0.468 ± 0.185
4.053ValAsp: 4.053 ± 0.545
5.222ValGlu: 5.222 ± 0.763
1.949ValPhe: 1.949 ± 0.418
4.209ValGly: 4.209 ± 0.527
0.468ValHis: 0.468 ± 0.215
3.507ValIle: 3.507 ± 0.521
4.91ValLys: 4.91 ± 0.637
6.469ValLeu: 6.469 ± 0.752
1.325ValMet: 1.325 ± 0.296
4.209ValAsn: 4.209 ± 0.407
1.091ValPro: 1.091 ± 0.267
1.715ValGln: 1.715 ± 0.495
2.806ValArg: 2.806 ± 0.462
5.69ValSer: 5.69 ± 0.883
4.365ValThr: 4.365 ± 0.541
3.897ValVal: 3.897 ± 0.565
0.312ValTrp: 0.312 ± 0.135
1.793ValTyr: 1.793 ± 0.343
0.0ValXaa: 0.0 ± 0.0
Trp
0.701TrpAla: 0.701 ± 0.233
0.234TrpCys: 0.234 ± 0.151
0.779TrpAsp: 0.779 ± 0.271
1.013TrpGlu: 1.013 ± 0.299
0.624TrpPhe: 0.624 ± 0.205
0.779TrpGly: 0.779 ± 0.283
0.078TrpHis: 0.078 ± 0.075
0.935TrpIle: 0.935 ± 0.276
1.247TrpLys: 1.247 ± 0.268
1.013TrpLeu: 1.013 ± 0.321
0.156TrpMet: 0.156 ± 0.104
0.546TrpAsn: 0.546 ± 0.27
0.234TrpPro: 0.234 ± 0.168
0.857TrpGln: 0.857 ± 0.237
0.779TrpArg: 0.779 ± 0.259
0.857TrpSer: 0.857 ± 0.228
0.935TrpThr: 0.935 ± 0.367
0.701TrpVal: 0.701 ± 0.204
0.156TrpTrp: 0.156 ± 0.106
0.468TrpTyr: 0.468 ± 0.177
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.65TyrAla: 2.65 ± 0.599
0.779TyrCys: 0.779 ± 0.23
2.884TyrAsp: 2.884 ± 0.426
3.196TyrGlu: 3.196 ± 0.554
2.26TyrPhe: 2.26 ± 0.453
2.027TyrGly: 2.027 ± 0.352
0.779TyrHis: 0.779 ± 0.233
2.104TyrIle: 2.104 ± 0.518
3.274TyrLys: 3.274 ± 0.69
4.053TyrLeu: 4.053 ± 0.509
0.935TyrMet: 0.935 ± 0.246
2.572TyrAsn: 2.572 ± 0.478
1.715TyrPro: 1.715 ± 0.387
2.65TyrGln: 2.65 ± 0.467
1.949TyrArg: 1.949 ± 0.472
2.104TyrSer: 2.104 ± 0.381
2.494TyrThr: 2.494 ± 0.479
2.26TyrVal: 2.26 ± 0.407
0.234TyrTrp: 0.234 ± 0.132
2.027TyrTyr: 2.027 ± 0.42
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (12831 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski