Amino acid dipepetide frequency for Oleispira antarctica RB-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.612AlaAla: 7.612 ± 0.099
0.96AlaCys: 0.96 ± 0.03
4.926AlaAsp: 4.926 ± 0.079
5.842AlaGlu: 5.842 ± 0.079
3.344AlaPhe: 3.344 ± 0.056
6.077AlaGly: 6.077 ± 0.09
1.624AlaHis: 1.624 ± 0.037
5.962AlaIle: 5.962 ± 0.079
4.88AlaLys: 4.88 ± 0.076
9.458AlaLeu: 9.458 ± 0.111
2.507AlaMet: 2.507 ± 0.052
3.592AlaAsn: 3.592 ± 0.075
2.641AlaPro: 2.641 ± 0.054
3.785AlaGln: 3.785 ± 0.055
3.369AlaArg: 3.369 ± 0.063
5.483AlaSer: 5.483 ± 0.065
4.295AlaThr: 4.295 ± 0.067
5.406AlaVal: 5.406 ± 0.079
0.984AlaTrp: 0.984 ± 0.032
2.336AlaTyr: 2.336 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.723CysAla: 0.723 ± 0.028
0.148CysCys: 0.148 ± 0.011
0.608CysAsp: 0.608 ± 0.023
0.602CysGlu: 0.602 ± 0.023
0.396CysPhe: 0.396 ± 0.017
0.801CysGly: 0.801 ± 0.027
0.34CysHis: 0.34 ± 0.018
0.666CysIle: 0.666 ± 0.022
0.44CysLys: 0.44 ± 0.02
1.008CysLeu: 1.008 ± 0.03
0.199CysMet: 0.199 ± 0.012
0.371CysAsn: 0.371 ± 0.015
0.429CysPro: 0.429 ± 0.02
0.45CysGln: 0.45 ± 0.02
0.408CysArg: 0.408 ± 0.019
0.686CysSer: 0.686 ± 0.028
0.437CysThr: 0.437 ± 0.019
0.591CysVal: 0.591 ± 0.022
0.114CysTrp: 0.114 ± 0.008
0.361CysTyr: 0.361 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.615AspAla: 4.615 ± 0.062
0.559AspCys: 0.559 ± 0.019
3.569AspAsp: 3.569 ± 0.066
3.977AspGlu: 3.977 ± 0.06
2.688AspPhe: 2.688 ± 0.049
3.748AspGly: 3.748 ± 0.081
1.269AspHis: 1.269 ± 0.031
4.396AspIle: 4.396 ± 0.062
3.255AspLys: 3.255 ± 0.05
5.658AspLeu: 5.658 ± 0.07
1.431AspMet: 1.431 ± 0.037
2.583AspAsn: 2.583 ± 0.046
2.035AspPro: 2.035 ± 0.05
2.404AspGln: 2.404 ± 0.048
2.291AspArg: 2.291 ± 0.047
3.725AspSer: 3.725 ± 0.071
2.694AspThr: 2.694 ± 0.046
4.011AspVal: 4.011 ± 0.07
0.86AspTrp: 0.86 ± 0.026
2.064AspTyr: 2.064 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.181GluAla: 5.181 ± 0.065
0.523GluCys: 0.523 ± 0.022
3.168GluAsp: 3.168 ± 0.055
4.03GluGlu: 4.03 ± 0.073
2.562GluPhe: 2.562 ± 0.043
3.921GluGly: 3.921 ± 0.057
1.556GluHis: 1.556 ± 0.037
4.167GluIle: 4.167 ± 0.063
4.084GluLys: 4.084 ± 0.064
7.007GluLeu: 7.007 ± 0.082
1.625GluMet: 1.625 ± 0.032
2.993GluAsn: 2.993 ± 0.045
1.803GluPro: 1.803 ± 0.039
3.602GluGln: 3.602 ± 0.069
3.101GluArg: 3.101 ± 0.055
3.888GluSer: 3.888 ± 0.061
3.127GluThr: 3.127 ± 0.057
4.222GluVal: 4.222 ± 0.069
0.749GluTrp: 0.749 ± 0.028
1.946GluTyr: 1.946 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.197PheAla: 3.197 ± 0.055
0.482PheCys: 0.482 ± 0.021
2.847PheAsp: 2.847 ± 0.046
2.505PheGlu: 2.505 ± 0.043
1.814PhePhe: 1.814 ± 0.048
2.864PheGly: 2.864 ± 0.052
0.832PheHis: 0.832 ± 0.026
3.061PheIle: 3.061 ± 0.057
2.232PheLys: 2.232 ± 0.044
3.663PheLeu: 3.663 ± 0.061
1.082PheMet: 1.082 ± 0.032
2.2PheAsn: 2.2 ± 0.053
1.529PhePro: 1.529 ± 0.038
1.368PheGln: 1.368 ± 0.031
1.492PheArg: 1.492 ± 0.036
3.695PheSer: 3.695 ± 0.061
2.268PheThr: 2.268 ± 0.048
2.416PheVal: 2.416 ± 0.046
0.538PheTrp: 0.538 ± 0.021
1.353PheTyr: 1.353 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.08GlyAla: 5.08 ± 0.079
0.829GlyCys: 0.829 ± 0.024
3.819GlyAsp: 3.819 ± 0.067
4.181GlyGlu: 4.181 ± 0.061
3.298GlyPhe: 3.298 ± 0.051
4.608GlyGly: 4.608 ± 0.091
1.548GlyHis: 1.548 ± 0.036
5.356GlyIle: 5.356 ± 0.067
3.781GlyLys: 3.781 ± 0.061
7.192GlyLeu: 7.192 ± 0.087
1.937GlyMet: 1.937 ± 0.04
2.646GlyAsn: 2.646 ± 0.051
1.663GlyPro: 1.663 ± 0.042
2.716GlyGln: 2.716 ± 0.047
3.076GlyArg: 3.076 ± 0.054
4.281GlySer: 4.281 ± 0.1
3.277GlyThr: 3.277 ± 0.093
4.219GlyVal: 4.219 ± 0.071
0.926GlyTrp: 0.926 ± 0.029
2.345GlyTyr: 2.345 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.592HisAla: 1.592 ± 0.035
0.327HisCys: 0.327 ± 0.018
1.141HisAsp: 1.141 ± 0.026
1.2HisGlu: 1.2 ± 0.031
1.055HisPhe: 1.055 ± 0.031
1.493HisGly: 1.493 ± 0.034
0.66HisHis: 0.66 ± 0.027
1.424HisIle: 1.424 ± 0.035
1.203HisLys: 1.203 ± 0.03
2.166HisLeu: 2.166 ± 0.043
0.527HisMet: 0.527 ± 0.02
0.933HisAsn: 0.933 ± 0.029
1.061HisPro: 1.061 ± 0.029
1.051HisGln: 1.051 ± 0.029
0.98HisArg: 0.98 ± 0.031
1.576HisSer: 1.576 ± 0.037
1.032HisThr: 1.032 ± 0.025
1.218HisVal: 1.218 ± 0.031
0.403HisTrp: 0.403 ± 0.015
0.852HisTyr: 0.852 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.643IleAla: 6.643 ± 0.08
0.6IleCys: 0.6 ± 0.021
4.619IleAsp: 4.619 ± 0.059
5.141IleGlu: 5.141 ± 0.065
2.492IlePhe: 2.492 ± 0.053
4.428IleGly: 4.428 ± 0.057
1.32IleHis: 1.32 ± 0.034
4.388IleIle: 4.388 ± 0.066
3.979IleLys: 3.979 ± 0.059
5.883IleLeu: 5.883 ± 0.084
1.465IleMet: 1.465 ± 0.039
3.74IleAsn: 3.74 ± 0.066
2.852IlePro: 2.852 ± 0.045
2.576IleGln: 2.576 ± 0.049
2.961IleArg: 2.961 ± 0.052
5.041IleSer: 5.041 ± 0.073
3.964IleThr: 3.964 ± 0.057
4.108IleVal: 4.108 ± 0.058
0.644IleTrp: 0.644 ± 0.021
1.753IleTyr: 1.753 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.961LysAla: 4.961 ± 0.078
0.309LysCys: 0.309 ± 0.016
3.109LysAsp: 3.109 ± 0.053
3.627LysGlu: 3.627 ± 0.062
1.749LysPhe: 1.749 ± 0.034
3.419LysGly: 3.419 ± 0.058
1.286LysHis: 1.286 ± 0.03
3.581LysIle: 3.581 ± 0.053
3.679LysLys: 3.679 ± 0.073
5.202LysLeu: 5.202 ± 0.079
1.404LysMet: 1.404 ± 0.04
2.822LysAsn: 2.822 ± 0.053
2.379LysPro: 2.379 ± 0.052
2.94LysGln: 2.94 ± 0.048
2.707LysArg: 2.707 ± 0.053
3.483LysSer: 3.483 ± 0.062
3.253LysThr: 3.253 ± 0.057
3.737LysVal: 3.737 ± 0.054
0.511LysTrp: 0.511 ± 0.021
1.471LysTyr: 1.471 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
9.746LeuAla: 9.746 ± 0.098
0.996LeuCys: 0.996 ± 0.029
5.804LeuAsp: 5.804 ± 0.067
6.258LeuGlu: 6.258 ± 0.086
4.049LeuPhe: 4.049 ± 0.07
6.84LeuGly: 6.84 ± 0.087
1.969LeuHis: 1.969 ± 0.037
6.966LeuIle: 6.966 ± 0.076
5.905LeuLys: 5.905 ± 0.092
10.799LeuLeu: 10.799 ± 0.135
2.738LeuMet: 2.738 ± 0.051
4.877LeuAsn: 4.877 ± 0.056
4.456LeuPro: 4.456 ± 0.066
4.045LeuGln: 4.045 ± 0.064
4.249LeuArg: 4.249 ± 0.064
7.981LeuSer: 7.981 ± 0.09
6.031LeuThr: 6.031 ± 0.072
6.52LeuVal: 6.52 ± 0.083
1.119LeuTrp: 1.119 ± 0.03
2.652LeuTyr: 2.652 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.434MetAla: 2.434 ± 0.042
0.177MetCys: 0.177 ± 0.01
1.308MetAsp: 1.308 ± 0.032
1.241MetGlu: 1.241 ± 0.033
0.86MetPhe: 0.86 ± 0.028
1.841MetGly: 1.841 ± 0.04
0.513MetHis: 0.513 ± 0.021
1.599MetIle: 1.599 ± 0.036
1.548MetLys: 1.548 ± 0.035
2.512MetLeu: 2.512 ± 0.051
0.716MetMet: 0.716 ± 0.027
1.287MetAsn: 1.287 ± 0.033
1.277MetPro: 1.277 ± 0.034
1.123MetGln: 1.123 ± 0.027
1.146MetArg: 1.146 ± 0.029
1.959MetSer: 1.959 ± 0.041
1.577MetThr: 1.577 ± 0.035
1.629MetVal: 1.629 ± 0.033
0.203MetTrp: 0.203 ± 0.014
0.485MetTyr: 0.485 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.643AsnAla: 3.643 ± 0.061
0.428AsnCys: 0.428 ± 0.018
2.74AsnAsp: 2.74 ± 0.048
2.669AsnGlu: 2.669 ± 0.047
1.709AsnPhe: 1.709 ± 0.045
2.94AsnGly: 2.94 ± 0.094
1.038AsnHis: 1.038 ± 0.026
3.358AsnIle: 3.358 ± 0.058
2.816AsnLys: 2.816 ± 0.055
4.17AsnLeu: 4.17 ± 0.067
0.981AsnMet: 0.981 ± 0.028
2.579AsnAsn: 2.579 ± 0.061
2.055AsnPro: 2.055 ± 0.044
2.118AsnGln: 2.118 ± 0.055
2.092AsnArg: 2.092 ± 0.04
3.238AsnSer: 3.238 ± 0.066
2.639AsnThr: 2.639 ± 0.056
2.591AsnVal: 2.591 ± 0.045
0.594AsnTrp: 0.594 ± 0.022
1.384AsnTyr: 1.384 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
3.131ProAla: 3.131 ± 0.052
0.301ProCys: 0.301 ± 0.017
2.232ProAsp: 2.232 ± 0.041
2.999ProGlu: 2.999 ± 0.049
1.662ProPhe: 1.662 ± 0.036
2.345ProGly: 2.345 ± 0.05
0.778ProHis: 0.778 ± 0.026
2.522ProIle: 2.522 ± 0.047
2.103ProLys: 2.103 ± 0.047
3.944ProLeu: 3.944 ± 0.06
0.997ProMet: 0.997 ± 0.027
1.725ProAsn: 1.725 ± 0.037
0.981ProPro: 0.981 ± 0.028
1.531ProGln: 1.531 ± 0.037
1.317ProArg: 1.317 ± 0.034
2.42ProSer: 2.42 ± 0.047
1.983ProThr: 1.983 ± 0.054
2.691ProVal: 2.691 ± 0.05
0.507ProTrp: 0.507 ± 0.021
1.187ProTyr: 1.187 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
4.428GlnAla: 4.428 ± 0.057
0.383GlnCys: 0.383 ± 0.018
2.134GlnAsp: 2.134 ± 0.045
2.362GlnGlu: 2.362 ± 0.054
1.749GlnPhe: 1.749 ± 0.038
3.063GlnGly: 3.063 ± 0.047
1.143GlnHis: 1.143 ± 0.032
2.505GlnIle: 2.505 ± 0.047
2.301GlnLys: 2.301 ± 0.047
5.245GlnLeu: 5.245 ± 0.083
0.954GlnMet: 0.954 ± 0.029
1.649GlnAsn: 1.649 ± 0.037
1.695GlnPro: 1.695 ± 0.04
3.453GlnGln: 3.453 ± 0.067
2.476GlnArg: 2.476 ± 0.048
2.762GlnSer: 2.762 ± 0.054
2.138GlnThr: 2.138 ± 0.039
3.138GlnVal: 3.138 ± 0.056
0.729GlnTrp: 0.729 ± 0.023
1.4GlnTyr: 1.4 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
3.125ArgAla: 3.125 ± 0.054
0.437ArgCys: 0.437 ± 0.019
2.501ArgAsp: 2.501 ± 0.045
2.68ArgGlu: 2.68 ± 0.053
2.124ArgPhe: 2.124 ± 0.037
2.484ArgGly: 2.484 ± 0.045
1.04ArgHis: 1.04 ± 0.027
3.433ArgIle: 3.433 ± 0.049
2.328ArgLys: 2.328 ± 0.042
5.066ArgLeu: 5.066 ± 0.066
1.189ArgMet: 1.189 ± 0.032
1.902ArgAsn: 1.902 ± 0.04
1.56ArgPro: 1.56 ± 0.041
2.054ArgGln: 2.054 ± 0.049
2.216ArgArg: 2.216 ± 0.048
2.792ArgSer: 2.792 ± 0.05
2.137ArgThr: 2.137 ± 0.037
2.608ArgVal: 2.608 ± 0.051
0.655ArgTrp: 0.655 ± 0.022
1.624ArgTyr: 1.624 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
5.68SerAla: 5.68 ± 0.072
0.633SerCys: 0.633 ± 0.022
4.009SerAsp: 4.009 ± 0.057
4.205SerGlu: 4.205 ± 0.05
3.099SerPhe: 3.099 ± 0.068
4.96SerGly: 4.96 ± 0.09
1.561SerHis: 1.561 ± 0.035
4.9SerIle: 4.9 ± 0.067
3.368SerLys: 3.368 ± 0.054
7.401SerLeu: 7.401 ± 0.104
1.765SerMet: 1.765 ± 0.037
3.143SerAsn: 3.143 ± 0.064
2.362SerPro: 2.362 ± 0.045
3.124SerGln: 3.124 ± 0.051
2.895SerArg: 2.895 ± 0.05
4.975SerSer: 4.975 ± 0.08
3.548SerThr: 3.548 ± 0.06
4.249SerVal: 4.249 ± 0.067
0.859SerTrp: 0.859 ± 0.028
2.085SerTyr: 2.085 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.571ThrAla: 4.571 ± 0.066
0.496ThrCys: 0.496 ± 0.023
3.09ThrAsp: 3.09 ± 0.066
3.278ThrGlu: 3.278 ± 0.05
2.105ThrPhe: 2.105 ± 0.05
4.05ThrGly: 4.05 ± 0.068
1.17ThrHis: 1.17 ± 0.033
3.307ThrIle: 3.307 ± 0.054
2.34ThrLys: 2.34 ± 0.042
6.041ThrLeu: 6.041 ± 0.073
1.113ThrMet: 1.113 ± 0.03
2.129ThrAsn: 2.129 ± 0.058
2.485ThrPro: 2.485 ± 0.046
2.366ThrGln: 2.366 ± 0.044
2.101ThrArg: 2.101 ± 0.045
3.465ThrSer: 3.465 ± 0.059
2.855ThrThr: 2.855 ± 0.077
3.486ThrVal: 3.486 ± 0.068
0.63ThrTrp: 0.63 ± 0.028
1.44ThrTyr: 1.44 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
5.641ValAla: 5.641 ± 0.077
0.687ValCys: 0.687 ± 0.023
3.898ValAsp: 3.898 ± 0.062
4.359ValGlu: 4.359 ± 0.07
2.715ValPhe: 2.715 ± 0.054
4.11ValGly: 4.11 ± 0.062
1.194ValHis: 1.194 ± 0.032
4.542ValIle: 4.542 ± 0.053
3.375ValLys: 3.375 ± 0.061
6.439ValLeu: 6.439 ± 0.076
1.833ValMet: 1.833 ± 0.034
2.874ValAsn: 2.874 ± 0.064
2.342ValPro: 2.342 ± 0.043
2.257ValGln: 2.257 ± 0.045
2.782ValArg: 2.782 ± 0.048
4.447ValSer: 4.447 ± 0.06
3.38ValThr: 3.38 ± 0.063
4.54ValVal: 4.54 ± 0.072
0.713ValTrp: 0.713 ± 0.025
1.747ValTyr: 1.747 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.88TrpAla: 0.88 ± 0.029
0.134TrpCys: 0.134 ± 0.01
0.629TrpAsp: 0.629 ± 0.027
0.513TrpGlu: 0.513 ± 0.022
0.545TrpPhe: 0.545 ± 0.021
0.754TrpGly: 0.754 ± 0.025
0.354TrpHis: 0.354 ± 0.016
0.686TrpIle: 0.686 ± 0.021
0.538TrpLys: 0.538 ± 0.02
1.768TrpLeu: 1.768 ± 0.046
0.362TrpMet: 0.362 ± 0.017
0.523TrpAsn: 0.523 ± 0.018
0.493TrpPro: 0.493 ± 0.02
0.98TrpGln: 0.98 ± 0.033
0.645TrpArg: 0.645 ± 0.023
0.747TrpSer: 0.747 ± 0.03
0.546TrpThr: 0.546 ± 0.024
0.803TrpVal: 0.803 ± 0.023
0.191TrpTrp: 0.191 ± 0.014
0.337TrpTyr: 0.337 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.197TyrAla: 2.197 ± 0.038
0.368TyrCys: 0.368 ± 0.018
1.68TyrAsp: 1.68 ± 0.035
1.587TyrGlu: 1.587 ± 0.038
1.423TyrPhe: 1.423 ± 0.037
2.032TyrGly: 2.032 ± 0.041
0.697TyrHis: 0.697 ± 0.025
1.78TyrIle: 1.78 ± 0.041
1.474TyrLys: 1.474 ± 0.04
3.377TyrLeu: 3.377 ± 0.063
0.611TyrMet: 0.611 ± 0.021
1.215TyrAsn: 1.215 ± 0.031
1.257TyrPro: 1.257 ± 0.032
1.769TyrGln: 1.769 ± 0.036
1.651TyrArg: 1.651 ± 0.038
2.176TyrSer: 2.176 ± 0.049
1.336TyrThr: 1.336 ± 0.036
1.693TyrVal: 1.693 ± 0.037
0.499TyrTrp: 0.499 ± 0.021
1.028TyrTyr: 1.028 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3895 proteins (1295253 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski