Amino acid dipepetide frequency for Pedobacter ginsengisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.617AlaAla: 5.617 ± 0.088
0.628AlaCys: 0.628 ± 0.023
4.113AlaAsp: 4.113 ± 0.049
4.318AlaGlu: 4.318 ± 0.06
3.359AlaPhe: 3.359 ± 0.048
5.175AlaGly: 5.175 ± 0.074
1.116AlaHis: 1.116 ± 0.026
5.455AlaIle: 5.455 ± 0.069
5.01AlaLys: 5.01 ± 0.067
6.718AlaLeu: 6.718 ± 0.076
1.596AlaMet: 1.596 ± 0.035
3.875AlaAsn: 3.875 ± 0.059
2.217AlaPro: 2.217 ± 0.042
2.706AlaGln: 2.706 ± 0.041
2.265AlaArg: 2.265 ± 0.043
4.501AlaSer: 4.501 ± 0.061
4.035AlaThr: 4.035 ± 0.113
4.453AlaVal: 4.453 ± 0.063
0.747AlaTrp: 0.747 ± 0.023
2.823AlaTyr: 2.823 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.487CysAla: 0.487 ± 0.019
0.109CysCys: 0.109 ± 0.008
0.364CysAsp: 0.364 ± 0.015
0.388CysGlu: 0.388 ± 0.017
0.445CysPhe: 0.445 ± 0.014
0.593CysGly: 0.593 ± 0.018
0.199CysHis: 0.199 ± 0.013
0.61CysIle: 0.61 ± 0.017
0.545CysLys: 0.545 ± 0.018
0.723CysLeu: 0.723 ± 0.023
0.18CysMet: 0.18 ± 0.01
0.396CysAsn: 0.396 ± 0.019
0.288CysPro: 0.288 ± 0.015
0.191CysGln: 0.191 ± 0.011
0.274CysArg: 0.274 ± 0.014
0.524CysSer: 0.524 ± 0.019
0.421CysThr: 0.421 ± 0.016
0.412CysVal: 0.412 ± 0.016
0.087CysTrp: 0.087 ± 0.006
0.297CysTyr: 0.297 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.797AspAla: 3.797 ± 0.062
0.369AspCys: 0.369 ± 0.015
2.498AspAsp: 2.498 ± 0.046
3.363AspGlu: 3.363 ± 0.054
3.115AspPhe: 3.115 ± 0.046
3.9AspGly: 3.9 ± 0.063
1.007AspHis: 1.007 ± 0.026
3.972AspIle: 3.972 ± 0.054
4.176AspLys: 4.176 ± 0.055
5.144AspLeu: 5.144 ± 0.065
1.135AspMet: 1.135 ± 0.025
2.814AspAsn: 2.814 ± 0.047
2.116AspPro: 2.116 ± 0.042
1.963AspGln: 1.963 ± 0.037
2.072AspArg: 2.072 ± 0.034
2.874AspSer: 2.874 ± 0.046
2.47AspThr: 2.47 ± 0.047
3.474AspVal: 3.474 ± 0.05
0.774AspTrp: 0.774 ± 0.025
2.566AspTyr: 2.566 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
3.963GluAla: 3.963 ± 0.06
0.318GluCys: 0.318 ± 0.015
2.791GluAsp: 2.791 ± 0.048
3.624GluGlu: 3.624 ± 0.065
2.531GluPhe: 2.531 ± 0.04
3.434GluGly: 3.434 ± 0.047
1.08GluHis: 1.08 ± 0.028
4.63GluIle: 4.63 ± 0.057
4.812GluLys: 4.812 ± 0.068
5.862GluLeu: 5.862 ± 0.072
1.465GluMet: 1.465 ± 0.035
3.498GluAsn: 3.498 ± 0.053
1.649GluPro: 1.649 ± 0.037
2.417GluGln: 2.417 ± 0.041
2.463GluArg: 2.463 ± 0.046
3.047GluSer: 3.047 ± 0.044
3.089GluThr: 3.089 ± 0.041
3.822GluVal: 3.822 ± 0.05
0.701GluTrp: 0.701 ± 0.023
2.096GluTyr: 2.096 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.247PheAla: 3.247 ± 0.049
0.468PheCys: 0.468 ± 0.017
2.91PheAsp: 2.91 ± 0.044
2.779PheGlu: 2.779 ± 0.05
2.434PhePhe: 2.434 ± 0.052
3.423PheGly: 3.423 ± 0.048
0.794PheHis: 0.794 ± 0.023
3.683PheIle: 3.683 ± 0.056
3.751PheLys: 3.751 ± 0.045
4.452PheLeu: 4.452 ± 0.07
1.082PheMet: 1.082 ± 0.028
3.235PheAsn: 3.235 ± 0.046
1.688PhePro: 1.688 ± 0.029
1.363PheGln: 1.363 ± 0.026
1.692PheArg: 1.692 ± 0.032
3.882PheSer: 3.882 ± 0.051
3.044PheThr: 3.044 ± 0.054
2.858PheVal: 2.858 ± 0.045
0.599PheTrp: 0.599 ± 0.022
2.118PheTyr: 2.118 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.624GlyAla: 4.624 ± 0.066
0.579GlyCys: 0.579 ± 0.02
3.379GlyAsp: 3.379 ± 0.051
3.253GlyGlu: 3.253 ± 0.055
3.674GlyPhe: 3.674 ± 0.053
4.886GlyGly: 4.886 ± 0.075
1.162GlyHis: 1.162 ± 0.031
5.436GlyIle: 5.436 ± 0.062
5.674GlyLys: 5.674 ± 0.067
6.407GlyLeu: 6.407 ± 0.07
1.671GlyMet: 1.671 ± 0.033
3.995GlyAsn: 3.995 ± 0.07
1.615GlyPro: 1.615 ± 0.038
2.162GlyGln: 2.162 ± 0.037
2.488GlyArg: 2.488 ± 0.045
4.486GlySer: 4.486 ± 0.067
4.163GlyThr: 4.163 ± 0.095
4.457GlyVal: 4.457 ± 0.061
0.961GlyTrp: 0.961 ± 0.026
3.175GlyTyr: 3.175 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.029HisAla: 1.029 ± 0.03
0.187HisCys: 0.187 ± 0.013
0.819HisAsp: 0.819 ± 0.022
0.911HisGlu: 0.911 ± 0.024
1.088HisPhe: 1.088 ± 0.027
1.091HisGly: 1.091 ± 0.031
0.47HisHis: 0.47 ± 0.018
1.335HisIle: 1.335 ± 0.03
1.062HisLys: 1.062 ± 0.027
1.799HisLeu: 1.799 ± 0.034
0.355HisMet: 0.355 ± 0.016
0.956HisAsn: 0.956 ± 0.027
0.88HisPro: 0.88 ± 0.028
0.718HisGln: 0.718 ± 0.021
0.669HisArg: 0.669 ± 0.019
1.055HisSer: 1.055 ± 0.025
0.923HisThr: 0.923 ± 0.024
0.869HisVal: 0.869 ± 0.022
0.237HisTrp: 0.237 ± 0.014
0.804HisTyr: 0.804 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.807IleAla: 5.807 ± 0.069
0.695IleCys: 0.695 ± 0.025
4.382IleAsp: 4.382 ± 0.061
4.543IleGlu: 4.543 ± 0.064
3.239IlePhe: 3.239 ± 0.056
5.015IleGly: 5.015 ± 0.068
1.267IleHis: 1.267 ± 0.03
5.394IleIle: 5.394 ± 0.084
5.728IleLys: 5.728 ± 0.071
6.547IleLeu: 6.547 ± 0.076
1.391IleMet: 1.391 ± 0.033
4.724IleAsn: 4.724 ± 0.059
3.128IlePro: 3.128 ± 0.043
2.328IleGln: 2.328 ± 0.037
2.882IleArg: 2.882 ± 0.052
5.537IleSer: 5.537 ± 0.065
4.639IleThr: 4.639 ± 0.061
4.371IleVal: 4.371 ± 0.056
0.788IleTrp: 0.788 ± 0.023
2.786IleTyr: 2.786 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.401LysAla: 5.401 ± 0.063
0.322LysCys: 0.322 ± 0.017
4.594LysAsp: 4.594 ± 0.062
5.088LysGlu: 5.088 ± 0.072
2.868LysPhe: 2.868 ± 0.043
5.065LysGly: 5.065 ± 0.057
1.337LysHis: 1.337 ± 0.031
5.605LysIle: 5.605 ± 0.066
5.988LysLys: 5.988 ± 0.077
6.683LysLeu: 6.683 ± 0.066
1.918LysMet: 1.918 ± 0.037
4.717LysAsn: 4.717 ± 0.061
2.878LysPro: 2.878 ± 0.042
3.001LysGln: 3.001 ± 0.045
2.82LysArg: 2.82 ± 0.044
4.5LysSer: 4.5 ± 0.063
4.531LysThr: 4.531 ± 0.061
4.845LysVal: 4.845 ± 0.063
0.887LysTrp: 0.887 ± 0.022
3.06LysTyr: 3.06 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
6.543LeuAla: 6.543 ± 0.067
0.819LeuCys: 0.819 ± 0.026
4.71LeuAsp: 4.71 ± 0.062
4.892LeuGlu: 4.892 ± 0.066
4.751LeuPhe: 4.751 ± 0.062
5.776LeuGly: 5.776 ± 0.079
1.524LeuHis: 1.524 ± 0.032
7.119LeuIle: 7.119 ± 0.084
7.962LeuLys: 7.962 ± 0.07
9.39LeuLeu: 9.39 ± 0.108
2.152LeuMet: 2.152 ± 0.035
6.198LeuAsn: 6.198 ± 0.073
3.994LeuPro: 3.994 ± 0.051
3.392LeuGln: 3.392 ± 0.052
3.467LeuArg: 3.467 ± 0.047
7.18LeuSer: 7.18 ± 0.075
5.49LeuThr: 5.49 ± 0.063
5.331LeuVal: 5.331 ± 0.06
0.977LeuTrp: 0.977 ± 0.029
3.227LeuTyr: 3.227 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
1.73MetAla: 1.73 ± 0.035
0.129MetCys: 0.129 ± 0.009
1.164MetAsp: 1.164 ± 0.029
1.329MetGlu: 1.329 ± 0.034
0.855MetPhe: 0.855 ± 0.024
1.468MetGly: 1.468 ± 0.032
0.387MetHis: 0.387 ± 0.017
1.563MetIle: 1.563 ± 0.035
1.964MetLys: 1.964 ± 0.034
2.132MetLeu: 2.132 ± 0.037
0.599MetMet: 0.599 ± 0.023
1.312MetAsn: 1.312 ± 0.03
1.032MetPro: 1.032 ± 0.024
0.872MetGln: 0.872 ± 0.024
0.935MetArg: 0.935 ± 0.025
1.356MetSer: 1.356 ± 0.027
1.034MetThr: 1.034 ± 0.026
1.432MetVal: 1.432 ± 0.028
0.191MetTrp: 0.191 ± 0.012
0.655MetTyr: 0.655 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
4.098AsnAla: 4.098 ± 0.049
0.407AsnCys: 0.407 ± 0.016
3.017AsnAsp: 3.017 ± 0.048
3.316AsnGlu: 3.316 ± 0.05
2.858AsnPhe: 2.858 ± 0.048
4.358AsnGly: 4.358 ± 0.068
1.019AsnHis: 1.019 ± 0.024
4.407AsnIle: 4.407 ± 0.052
4.323AsnLys: 4.323 ± 0.059
5.414AsnLeu: 5.414 ± 0.057
1.297AsnMet: 1.297 ± 0.03
3.671AsnAsn: 3.671 ± 0.056
2.823AsnPro: 2.823 ± 0.044
2.144AsnGln: 2.144 ± 0.044
2.275AsnArg: 2.275 ± 0.04
3.825AsnSer: 3.825 ± 0.058
3.43AsnThr: 3.43 ± 0.067
3.432AsnVal: 3.432 ± 0.046
0.804AsnTrp: 0.804 ± 0.023
2.865AsnTyr: 2.865 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.826ProAla: 2.826 ± 0.059
0.215ProCys: 0.215 ± 0.012
2.51ProAsp: 2.51 ± 0.04
2.815ProGlu: 2.815 ± 0.047
1.928ProPhe: 1.928 ± 0.034
2.697ProGly: 2.697 ± 0.044
0.619ProHis: 0.619 ± 0.022
2.518ProIle: 2.518 ± 0.038
2.403ProLys: 2.403 ± 0.04
3.358ProLeu: 3.358 ± 0.057
0.745ProMet: 0.745 ± 0.023
2.062ProAsn: 2.062 ± 0.04
0.954ProPro: 0.954 ± 0.031
1.304ProGln: 1.304 ± 0.029
1.047ProArg: 1.047 ± 0.027
2.33ProSer: 2.33 ± 0.042
1.913ProThr: 1.913 ± 0.041
2.99ProVal: 2.99 ± 0.051
0.418ProTrp: 0.418 ± 0.017
1.514ProTyr: 1.514 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
2.369GlnAla: 2.369 ± 0.041
0.183GlnCys: 0.183 ± 0.011
1.637GlnAsp: 1.637 ± 0.04
2.04GlnGlu: 2.04 ± 0.04
1.65GlnPhe: 1.65 ± 0.032
2.042GlnGly: 2.042 ± 0.035
0.645GlnHis: 0.645 ± 0.022
2.651GlnIle: 2.651 ± 0.043
2.751GlnLys: 2.751 ± 0.045
3.754GlnLeu: 3.754 ± 0.055
0.837GlnMet: 0.837 ± 0.024
2.147GlnAsn: 2.147 ± 0.037
1.29GlnPro: 1.29 ± 0.028
1.751GlnGln: 1.751 ± 0.039
1.411GlnArg: 1.411 ± 0.03
2.156GlnSer: 2.156 ± 0.037
2.065GlnThr: 2.065 ± 0.037
2.144GlnVal: 2.144 ± 0.041
0.432GlnTrp: 0.432 ± 0.016
1.449GlnTyr: 1.449 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.259ArgAla: 2.259 ± 0.039
0.221ArgCys: 0.221 ± 0.009
1.882ArgAsp: 1.882 ± 0.037
2.083ArgGlu: 2.083 ± 0.042
2.064ArgPhe: 2.064 ± 0.04
2.118ArgGly: 2.118 ± 0.038
0.594ArgHis: 0.594 ± 0.021
3.095ArgIle: 3.095 ± 0.05
2.914ArgLys: 2.914 ± 0.044
3.653ArgLeu: 3.653 ± 0.05
0.968ArgMet: 0.968 ± 0.026
2.29ArgAsn: 2.29 ± 0.037
1.312ArgPro: 1.312 ± 0.033
1.226ArgGln: 1.226 ± 0.029
1.461ArgArg: 1.461 ± 0.031
2.306ArgSer: 2.306 ± 0.041
1.976ArgThr: 1.976 ± 0.037
2.231ArgVal: 2.231 ± 0.039
0.472ArgTrp: 0.472 ± 0.017
1.728ArgTyr: 1.728 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.61SerAla: 4.61 ± 0.06
0.554SerCys: 0.554 ± 0.02
3.304SerAsp: 3.304 ± 0.047
3.33SerGlu: 3.33 ± 0.052
3.779SerPhe: 3.779 ± 0.057
5.107SerGly: 5.107 ± 0.068
1.073SerHis: 1.073 ± 0.028
5.085SerIle: 5.085 ± 0.063
4.62SerLys: 4.62 ± 0.053
6.4SerLeu: 6.4 ± 0.073
1.291SerMet: 1.291 ± 0.032
3.568SerAsn: 3.568 ± 0.05
2.299SerPro: 2.299 ± 0.041
1.935SerGln: 1.935 ± 0.042
2.455SerArg: 2.455 ± 0.041
4.47SerSer: 4.47 ± 0.062
3.614SerThr: 3.614 ± 0.05
4.432SerVal: 4.432 ± 0.062
0.821SerTrp: 0.821 ± 0.025
2.87SerTyr: 2.87 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
4.419ThrAla: 4.419 ± 0.128
0.35ThrCys: 0.35 ± 0.017
3.385ThrAsp: 3.385 ± 0.05
3.23ThrGlu: 3.23 ± 0.051
2.762ThrPhe: 2.762 ± 0.044
4.601ThrGly: 4.601 ± 0.085
0.903ThrHis: 0.903 ± 0.024
4.384ThrIle: 4.384 ± 0.059
3.592ThrLys: 3.592 ± 0.047
5.463ThrLeu: 5.463 ± 0.084
0.99ThrMet: 0.99 ± 0.026
3.056ThrAsn: 3.056 ± 0.054
2.501ThrPro: 2.501 ± 0.052
1.771ThrGln: 1.771 ± 0.035
1.756ThrArg: 1.756 ± 0.039
3.668ThrSer: 3.668 ± 0.044
3.445ThrThr: 3.445 ± 0.114
3.697ThrVal: 3.697 ± 0.065
0.676ThrTrp: 0.676 ± 0.024
2.397ThrTyr: 2.397 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
4.399ValAla: 4.399 ± 0.059
0.533ValCys: 0.533 ± 0.017
3.223ValAsp: 3.223 ± 0.044
3.284ValGlu: 3.284 ± 0.045
3.19ValPhe: 3.19 ± 0.046
3.801ValGly: 3.801 ± 0.06
1.017ValHis: 1.017 ± 0.025
4.791ValIle: 4.791 ± 0.059
4.944ValLys: 4.944 ± 0.062
6.012ValLeu: 6.012 ± 0.072
1.341ValMet: 1.341 ± 0.033
3.857ValAsn: 3.857 ± 0.047
2.404ValPro: 2.404 ± 0.04
2.012ValGln: 2.012 ± 0.038
2.161ValArg: 2.161 ± 0.038
4.46ValSer: 4.46 ± 0.05
3.597ValThr: 3.597 ± 0.071
4.183ValVal: 4.183 ± 0.057
0.698ValTrp: 0.698 ± 0.018
2.43ValTyr: 2.43 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.768TrpAla: 0.768 ± 0.021
0.112TrpCys: 0.112 ± 0.008
0.652TrpAsp: 0.652 ± 0.024
0.676TrpGlu: 0.676 ± 0.022
0.606TrpPhe: 0.606 ± 0.022
0.887TrpGly: 0.887 ± 0.028
0.247TrpHis: 0.247 ± 0.013
0.821TrpIle: 0.821 ± 0.024
0.919TrpLys: 0.919 ± 0.025
1.174TrpLeu: 1.174 ± 0.029
0.358TrpMet: 0.358 ± 0.017
0.733TrpAsn: 0.733 ± 0.023
0.384TrpPro: 0.384 ± 0.017
0.503TrpGln: 0.503 ± 0.019
0.477TrpArg: 0.477 ± 0.017
0.677TrpSer: 0.677 ± 0.023
0.641TrpThr: 0.641 ± 0.022
0.683TrpVal: 0.683 ± 0.02
0.188TrpTrp: 0.188 ± 0.012
0.53TrpTyr: 0.53 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.735TyrAla: 2.735 ± 0.047
0.333TyrCys: 0.333 ± 0.014
2.267TyrAsp: 2.267 ± 0.053
2.029TyrGlu: 2.029 ± 0.037
2.306TyrPhe: 2.306 ± 0.041
2.811TyrGly: 2.811 ± 0.041
0.793TyrHis: 0.793 ± 0.025
2.639TyrIle: 2.639 ± 0.04
2.971TyrLys: 2.971 ± 0.046
3.807TyrLeu: 3.807 ± 0.046
0.769TyrMet: 0.769 ± 0.024
2.677TyrAsn: 2.677 ± 0.046
1.713TyrPro: 1.713 ± 0.032
1.645TyrGln: 1.645 ± 0.033
1.784TyrArg: 1.784 ± 0.036
2.782TyrSer: 2.782 ± 0.049
2.53TyrThr: 2.53 ± 0.051
2.222TyrVal: 2.222 ± 0.041
0.58TyrTrp: 0.58 ± 0.017
1.882TyrTyr: 1.882 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4393 proteins (1605044 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski