Amino acid dipepetide frequency for Metallibacterium scheffleri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.615AlaAla: 21.615 ± 0.262	1.448AlaCys: 1.448 ± 0.039	6.637AlaAsp: 6.637 ± 0.094	6.729AlaGlu: 6.729 ± 0.102	3.919AlaPhe: 3.919 ± 0.069	11.024AlaGly: 11.024 ± 0.118	3.675AlaHis: 3.675 ± 0.062	5.315AlaIle: 5.315 ± 0.073	2.801AlaLys: 2.801 ± 0.066	19.146AlaLeu: 19.146 ± 0.203	3.398AlaMet: 3.398 ± 0.061	2.655AlaAsn: 2.655 ± 0.064	7.163AlaPro: 7.163 ± 0.101	6.929AlaGln: 6.929 ± 0.113	12.141AlaArg: 12.141 ± 0.157	6.613AlaSer: 6.613 ± 0.083	6.303AlaThr: 6.303 ± 0.093	8.853AlaVal: 8.853 ± 0.104	2.407AlaTrp: 2.407 ± 0.055	2.665AlaTyr: 2.665 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.437CysAla: 1.437 ± 0.039	0.144CysCys: 0.144 ± 0.011	0.532CysAsp: 0.532 ± 0.022	0.423CysGlu: 0.423 ± 0.021	0.278CysPhe: 0.278 ± 0.016	0.966CysGly: 0.966 ± 0.033	0.259CysHis: 0.259 ± 0.015	0.375CysIle: 0.375 ± 0.019	0.208CysLys: 0.208 ± 0.015	0.815CysLeu: 0.815 ± 0.029	0.207CysMet: 0.207 ± 0.013	0.229CysAsn: 0.229 ± 0.013	0.468CysPro: 0.468 ± 0.02	0.235CysGln: 0.235 ± 0.016	0.646CysArg: 0.646 ± 0.028	0.49CysSer: 0.49 ± 0.024	0.52CysThr: 0.52 ± 0.023	0.747CysVal: 0.747 ± 0.027	0.113CysTrp: 0.113 ± 0.01	0.203CysTyr: 0.203 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	8.847AspAla: 8.847 ± 0.105	0.477AspCys: 0.477 ± 0.024	2.765AspAsp: 2.765 ± 0.057	2.567AspGlu: 2.567 ± 0.048	1.981AspPhe: 1.981 ± 0.039	4.61AspGly: 4.61 ± 0.074	1.18AspHis: 1.18 ± 0.038	2.123AspIle: 2.123 ± 0.044	1.197AspLys: 1.197 ± 0.04	5.799AspLeu: 5.799 ± 0.082	1.007AspMet: 1.007 ± 0.032	1.181AspAsn: 1.181 ± 0.033	2.991AspPro: 2.991 ± 0.056	1.555AspGln: 1.555 ± 0.038	3.194AspArg: 3.194 ± 0.051	2.291AspSer: 2.291 ± 0.048	2.6AspThr: 2.6 ± 0.049	3.659AspVal: 3.659 ± 0.074	1.037AspTrp: 1.037 ± 0.038	1.499AspTyr: 1.499 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.122GluAla: 6.122 ± 0.106	0.398GluCys: 0.398 ± 0.021	2.045GluAsp: 2.045 ± 0.045	1.648GluGlu: 1.648 ± 0.056	1.568GluPhe: 1.568 ± 0.041	2.927GluGly: 2.927 ± 0.059	1.653GluHis: 1.653 ± 0.047	2.424GluIle: 2.424 ± 0.052	1.138GluLys: 1.138 ± 0.043	5.679GluLeu: 5.679 ± 0.094	0.984GluMet: 0.984 ± 0.035	1.027GluAsn: 1.027 ± 0.033	2.193GluPro: 2.193 ± 0.051	2.401GluGln: 2.401 ± 0.051	4.564GluArg: 4.564 ± 0.096	2.288GluSer: 2.288 ± 0.05	2.227GluThr: 2.227 ± 0.052	3.476GluVal: 3.476 ± 0.067	0.634GluTrp: 0.634 ± 0.028	0.958GluTyr: 0.958 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.496PheAla: 4.496 ± 0.069	0.316PheCys: 0.316 ± 0.018	2.244PheAsp: 2.244 ± 0.05	1.706PheGlu: 1.706 ± 0.039	1.119PhePhe: 1.119 ± 0.046	3.088PheGly: 3.088 ± 0.062	0.77PheHis: 0.77 ± 0.028	1.326PheIle: 1.326 ± 0.035	0.842PheLys: 0.842 ± 0.037	2.902PheLeu: 2.902 ± 0.062	0.684PheMet: 0.684 ± 0.03	1.057PheAsn: 1.057 ± 0.037	1.348PhePro: 1.348 ± 0.035	0.976PheGln: 0.976 ± 0.027	2.01PheArg: 2.01 ± 0.055	1.832PheSer: 1.832 ± 0.043	1.684PheThr: 1.684 ± 0.045	2.466PheVal: 2.466 ± 0.05	0.489PheTrp: 0.489 ± 0.024	0.851PheTyr: 0.851 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.253GlyAla: 10.253 ± 0.105	0.847GlyCys: 0.847 ± 0.031	3.996GlyAsp: 3.996 ± 0.062	3.812GlyGlu: 3.812 ± 0.059	3.183GlyPhe: 3.183 ± 0.063	6.611GlyGly: 6.611 ± 0.117	2.199GlyHis: 2.199 ± 0.042	3.825GlyIle: 3.825 ± 0.054	2.784GlyLys: 2.784 ± 0.057	8.645GlyLeu: 8.645 ± 0.09	2.385GlyMet: 2.385 ± 0.057	2.173GlyAsn: 2.173 ± 0.053	3.028GlyPro: 3.028 ± 0.052	3.074GlyGln: 3.074 ± 0.058	5.442GlyArg: 5.442 ± 0.078	4.61GlySer: 4.61 ± 0.078	4.247GlyThr: 4.247 ± 0.077	6.474GlyVal: 6.474 ± 0.09	1.505GlyTrp: 1.505 ± 0.041	2.411GlyTyr: 2.411 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	4.431HisAla: 4.431 ± 0.069	0.305HisCys: 0.305 ± 0.019	1.473HisAsp: 1.473 ± 0.037	1.235HisGlu: 1.235 ± 0.036	0.911HisPhe: 0.911 ± 0.026	2.68HisGly: 2.68 ± 0.054	0.659HisHis: 0.659 ± 0.027	0.989HisIle: 0.989 ± 0.03	0.508HisLys: 0.508 ± 0.023	2.654HisLeu: 2.654 ± 0.051	0.55HisMet: 0.55 ± 0.023	0.496HisAsn: 0.496 ± 0.024	1.583HisPro: 1.583 ± 0.039	0.737HisGln: 0.737 ± 0.025	1.647HisArg: 1.647 ± 0.044	1.107HisSer: 1.107 ± 0.032	1.093HisThr: 1.093 ± 0.034	1.851HisVal: 1.851 ± 0.044	0.625HisTrp: 0.625 ± 0.026	0.748HisTyr: 0.748 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.591IleAla: 6.591 ± 0.079	0.332IleCys: 0.332 ± 0.016	2.988IleAsp: 2.988 ± 0.046	3.136IleGlu: 3.136 ± 0.059	1.17IlePhe: 1.17 ± 0.036	4.145IleGly: 4.145 ± 0.074	0.884IleHis: 0.884 ± 0.033	1.459IleIle: 1.459 ± 0.039	1.147IleLys: 1.147 ± 0.035	3.408IleLeu: 3.408 ± 0.065	0.647IleMet: 0.647 ± 0.023	1.262IleAsn: 1.262 ± 0.04	1.975IlePro: 1.975 ± 0.039	1.159IleGln: 1.159 ± 0.031	2.498IleArg: 2.498 ± 0.051	2.297IleSer: 2.297 ± 0.049	2.297IleThr: 2.297 ± 0.048	3.355IleVal: 3.355 ± 0.063	0.477IleTrp: 0.477 ± 0.024	0.93IleTyr: 0.93 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.819LysAla: 2.819 ± 0.067	0.146LysCys: 0.146 ± 0.014	1.184LysAsp: 1.184 ± 0.039	0.896LysGlu: 0.896 ± 0.036	0.656LysPhe: 0.656 ± 0.027	1.66LysGly: 1.66 ± 0.046	0.609LysHis: 0.609 ± 0.024	0.996LysIle: 0.996 ± 0.03	0.76LysLys: 0.76 ± 0.042	2.891LysLeu: 2.891 ± 0.052	0.452LysMet: 0.452 ± 0.022	0.636LysAsn: 0.636 ± 0.028	1.805LysPro: 1.805 ± 0.049	1.075LysGln: 1.075 ± 0.033	2.007LysArg: 2.007 ± 0.05	1.314LysSer: 1.314 ± 0.038	1.458LysThr: 1.458 ± 0.045	1.726LysVal: 1.726 ± 0.047	0.245LysTrp: 0.245 ± 0.015	0.492LysTyr: 0.492 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	17.437LeuAla: 17.437 ± 0.183	1.03LeuCys: 1.03 ± 0.035	7.004LeuAsp: 7.004 ± 0.092	4.993LeuGlu: 4.993 ± 0.087	3.418LeuPhe: 3.418 ± 0.072	9.589LeuGly: 9.589 ± 0.115	3.209LeuHis: 3.209 ± 0.064	4.676LeuIle: 4.676 ± 0.068	2.865LeuLys: 2.865 ± 0.054	14.407LeuLeu: 14.407 ± 0.227	2.122LeuMet: 2.122 ± 0.047	2.356LeuAsn: 2.356 ± 0.048	7.165LeuPro: 7.165 ± 0.096	4.46LeuGln: 4.46 ± 0.067	10.285LeuArg: 10.285 ± 0.138	5.735LeuSer: 5.735 ± 0.073	5.162LeuThr: 5.162 ± 0.072	7.396LeuVal: 7.396 ± 0.091	1.624LeuTrp: 1.624 ± 0.05	2.315LeuTyr: 2.315 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.741MetAla: 2.741 ± 0.06	0.133MetCys: 0.133 ± 0.012	1.009MetAsp: 1.009 ± 0.033	0.793MetGlu: 0.793 ± 0.029	0.554MetPhe: 0.554 ± 0.021	1.455MetGly: 1.455 ± 0.039	0.616MetHis: 0.616 ± 0.023	0.891MetIle: 0.891 ± 0.03	0.637MetLys: 0.637 ± 0.023	2.818MetLeu: 2.818 ± 0.052	0.379MetMet: 0.379 ± 0.019	0.727MetAsn: 0.727 ± 0.024	1.486MetPro: 1.486 ± 0.042	1.175MetGln: 1.175 ± 0.036	2.027MetArg: 2.027 ± 0.048	1.429MetSer: 1.429 ± 0.034	1.185MetThr: 1.185 ± 0.039	1.383MetVal: 1.383 ± 0.036	0.175MetTrp: 0.175 ± 0.014	0.342MetTyr: 0.342 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.203AsnAla: 3.203 ± 0.062	0.19AsnCys: 0.19 ± 0.014	1.214AsnAsp: 1.214 ± 0.037	0.932AsnGlu: 0.932 ± 0.029	0.854AsnPhe: 0.854 ± 0.026	2.089AsnGly: 2.089 ± 0.057	0.51AsnHis: 0.51 ± 0.021	1.077AsnIle: 1.077 ± 0.039	0.519AsnLys: 0.519 ± 0.024	2.675AsnLeu: 2.675 ± 0.049	0.442AsnMet: 0.442 ± 0.021	0.642AsnAsn: 0.642 ± 0.031	1.787AsnPro: 1.787 ± 0.054	0.801AsnGln: 0.801 ± 0.029	1.498AsnArg: 1.498 ± 0.041	1.086AsnSer: 1.086 ± 0.037	1.294AsnThr: 1.294 ± 0.045	1.692AsnVal: 1.692 ± 0.041	0.36AsnTrp: 0.36 ± 0.019	0.712AsnTyr: 0.712 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	7.912ProAla: 7.912 ± 0.104	0.405ProCys: 0.405 ± 0.019	3.264ProAsp: 3.264 ± 0.054	2.923ProGlu: 2.923 ± 0.063	1.634ProPhe: 1.634 ± 0.04	5.002ProGly: 5.002 ± 0.074	1.266ProHis: 1.266 ± 0.031	2.012ProIle: 2.012 ± 0.05	1.143ProLys: 1.143 ± 0.035	5.802ProLeu: 5.802 ± 0.08	1.323ProMet: 1.323 ± 0.034	1.126ProAsn: 1.126 ± 0.039	3.07ProPro: 3.07 ± 0.075	2.236ProGln: 2.236 ± 0.053	4.0ProArg: 4.0 ± 0.068	2.538ProSer: 2.538 ± 0.058	2.295ProThr: 2.295 ± 0.05	3.874ProVal: 3.874 ± 0.064	0.978ProTrp: 0.978 ± 0.029	1.219ProTyr: 1.219 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.903GlnAla: 5.903 ± 0.083	0.344GlnCys: 0.344 ± 0.02	1.61GlnAsp: 1.61 ± 0.042	1.193GlnGlu: 1.193 ± 0.04	1.183GlnPhe: 1.183 ± 0.035	3.078GlnGly: 3.078 ± 0.053	1.284GlnHis: 1.284 ± 0.032	1.708GlnIle: 1.708 ± 0.038	0.818GlnLys: 0.818 ± 0.029	4.209GlnLeu: 4.209 ± 0.079	0.845GlnMet: 0.845 ± 0.029	0.792GlnAsn: 0.792 ± 0.031	2.555GlnPro: 2.555 ± 0.052	2.282GlnGln: 2.282 ± 0.056	4.375GlnArg: 4.375 ± 0.073	1.874GlnSer: 1.874 ± 0.041	1.799GlnThr: 1.799 ± 0.036	2.91GlnVal: 2.91 ± 0.065	0.626GlnTrp: 0.626 ± 0.024	0.808GlnTyr: 0.808 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	10.977ArgAla: 10.977 ± 0.154	0.75ArgCys: 0.75 ± 0.029	4.152ArgAsp: 4.152 ± 0.067	4.47ArgGlu: 4.47 ± 0.09	2.682ArgPhe: 2.682 ± 0.05	5.639ArgGly: 5.639 ± 0.071	2.3ArgHis: 2.3 ± 0.053	3.93ArgIle: 3.93 ± 0.058	2.001ArgLys: 2.001 ± 0.041	9.017ArgLeu: 9.017 ± 0.12	2.128ArgMet: 2.128 ± 0.044	1.811ArgAsn: 1.811 ± 0.043	3.193ArgPro: 3.193 ± 0.06	2.907ArgGln: 2.907 ± 0.06	6.301ArgArg: 6.301 ± 0.105	3.592ArgSer: 3.592 ± 0.065	3.259ArgThr: 3.259 ± 0.059	5.968ArgVal: 5.968 ± 0.08	1.487ArgTrp: 1.487 ± 0.042	2.265ArgTyr: 2.265 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	7.03SerAla: 7.03 ± 0.096	0.451SerCys: 0.451 ± 0.022	2.551SerAsp: 2.551 ± 0.05	2.258SerGlu: 2.258 ± 0.05	1.727SerPhe: 1.727 ± 0.042	5.131SerGly: 5.131 ± 0.085	1.077SerHis: 1.077 ± 0.03	2.303SerIle: 2.303 ± 0.05	1.241SerLys: 1.241 ± 0.039	5.167SerLeu: 5.167 ± 0.076	1.186SerMet: 1.186 ± 0.033	1.423SerAsn: 1.423 ± 0.047	2.524SerPro: 2.524 ± 0.05	1.499SerGln: 1.499 ± 0.04	3.116SerArg: 3.116 ± 0.061	2.907SerSer: 2.907 ± 0.066	2.848SerThr: 2.848 ± 0.068	3.733SerVal: 3.733 ± 0.051	0.68SerTrp: 0.68 ± 0.029	1.277SerTyr: 1.277 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.828ThrAla: 5.828 ± 0.085	0.414ThrCys: 0.414 ± 0.021	2.161ThrAsp: 2.161 ± 0.043	1.817ThrGlu: 1.817 ± 0.039	1.36ThrPhe: 1.36 ± 0.041	4.045ThrGly: 4.045 ± 0.073	1.336ThrHis: 1.336 ± 0.031	1.79ThrIle: 1.79 ± 0.057	0.772ThrLys: 0.772 ± 0.029	7.053ThrLeu: 7.053 ± 0.077	0.87ThrMet: 0.87 ± 0.027	1.006ThrAsn: 1.006 ± 0.039	3.619ThrPro: 3.619 ± 0.066	1.968ThrGln: 1.968 ± 0.05	4.023ThrArg: 4.023 ± 0.063	2.326ThrSer: 2.326 ± 0.053	2.601ThrThr: 2.601 ± 0.063	3.449ThrVal: 3.449 ± 0.073	0.774ThrTrp: 0.774 ± 0.026	1.105ThrTyr: 1.105 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.031ValAla: 9.031 ± 0.107	0.762ValCys: 0.762 ± 0.026	3.858ValAsp: 3.858 ± 0.074	3.476ValGlu: 3.476 ± 0.063	2.482ValPhe: 2.482 ± 0.054	4.859ValGly: 4.859 ± 0.089	1.776ValHis: 1.776 ± 0.036	3.402ValIle: 3.402 ± 0.06	1.578ValLys: 1.578 ± 0.045	9.124ValLeu: 9.124 ± 0.111	1.529ValMet: 1.529 ± 0.041	1.918ValAsn: 1.918 ± 0.044	4.049ValPro: 4.049 ± 0.056	2.876ValGln: 2.876 ± 0.056	5.433ValArg: 5.433 ± 0.08	3.695ValSer: 3.695 ± 0.069	3.428ValThr: 3.428 ± 0.067	5.293ValVal: 5.293 ± 0.09	0.886ValTrp: 0.886 ± 0.03	1.54ValTyr: 1.54 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.469TrpAla: 1.469 ± 0.04	0.168TrpCys: 0.168 ± 0.012	0.61TrpAsp: 0.61 ± 0.022	0.418TrpGlu: 0.418 ± 0.022	0.575TrpPhe: 0.575 ± 0.024	0.891TrpGly: 0.891 ± 0.027	0.475TrpHis: 0.475 ± 0.021	0.773TrpIle: 0.773 ± 0.03	0.365TrpLys: 0.365 ± 0.019	2.484TrpLeu: 2.484 ± 0.069	0.425TrpMet: 0.425 ± 0.021	0.438TrpAsn: 0.438 ± 0.019	0.858TrpPro: 0.858 ± 0.031	0.917TrpGln: 0.917 ± 0.034	1.632TrpArg: 1.632 ± 0.047	0.895TrpSer: 0.895 ± 0.032	0.773TrpThr: 0.773 ± 0.032	0.982TrpVal: 0.982 ± 0.037	0.279TrpTrp: 0.279 ± 0.018	0.355TrpTyr: 0.355 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.296TyrAla: 3.296 ± 0.057	0.237TyrCys: 0.237 ± 0.014	1.261TyrAsp: 1.261 ± 0.034	0.93TyrGlu: 0.93 ± 0.029	0.954TyrPhe: 0.954 ± 0.029	2.015TyrGly: 2.015 ± 0.051	0.542TyrHis: 0.542 ± 0.025	0.762TyrIle: 0.762 ± 0.028	0.501TyrLys: 0.501 ± 0.023	2.552TyrLeu: 2.552 ± 0.048	0.392TyrMet: 0.392 ± 0.022	0.622TyrAsn: 0.622 ± 0.031	1.163TyrPro: 1.163 ± 0.033	0.935TyrGln: 0.935 ± 0.031	1.993TyrArg: 1.993 ± 0.046	1.208TyrSer: 1.208 ± 0.037	1.246TyrThr: 1.246 ± 0.037	1.707TyrVal: 1.707 ± 0.042	0.379TyrTrp: 0.379 ± 0.018	0.629TyrTyr: 0.629 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3178 proteins (1048861 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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