Amino acid dipepetide frequency for Geodermatophilus sp. DSM 44513

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	26.372AlaAla: 26.372 ± 0.236	1.056AlaCys: 1.056 ± 0.029	9.462AlaAsp: 9.462 ± 0.101	8.966AlaGlu: 8.966 ± 0.098	3.33AlaPhe: 3.33 ± 0.058	16.332AlaGly: 16.332 ± 0.134	2.671AlaHis: 2.671 ± 0.047	3.037AlaIle: 3.037 ± 0.059	1.457AlaLys: 1.457 ± 0.038	15.977AlaLeu: 15.977 ± 0.154	2.259AlaMet: 2.259 ± 0.041	1.56AlaAsn: 1.56 ± 0.038	7.811AlaPro: 7.811 ± 0.094	3.752AlaGln: 3.752 ± 0.062	11.859AlaArg: 11.859 ± 0.113	5.308AlaSer: 5.308 ± 0.063	7.846AlaThr: 7.846 ± 0.072	15.515AlaVal: 15.515 ± 0.125	1.944AlaTrp: 1.944 ± 0.044	2.124AlaTyr: 2.124 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.977CysAla: 0.977 ± 0.03	0.109CysCys: 0.109 ± 0.011	0.459CysAsp: 0.459 ± 0.018	0.295CysGlu: 0.295 ± 0.014	0.17CysPhe: 0.17 ± 0.012	0.888CysGly: 0.888 ± 0.026	0.153CysHis: 0.153 ± 0.012	0.141CysIle: 0.141 ± 0.009	0.054CysLys: 0.054 ± 0.007	0.657CysLeu: 0.657 ± 0.023	0.099CysMet: 0.099 ± 0.009	0.101CysAsn: 0.101 ± 0.007	0.484CysPro: 0.484 ± 0.019	0.13CysGln: 0.13 ± 0.01	0.635CysArg: 0.635 ± 0.021	0.363CysSer: 0.363 ± 0.018	0.516CysThr: 0.516 ± 0.019	0.566CysVal: 0.566 ± 0.022	0.114CysTrp: 0.114 ± 0.011	0.124CysTyr: 0.124 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.603AspAla: 8.603 ± 0.091	0.341AspCys: 0.341 ± 0.016	4.053AspAsp: 4.053 ± 0.063	3.574AspGlu: 3.574 ± 0.056	1.291AspPhe: 1.291 ± 0.033	6.894AspGly: 6.894 ± 0.072	1.185AspHis: 1.185 ± 0.029	1.125AspIle: 1.125 ± 0.032	0.57AspLys: 0.57 ± 0.022	7.03AspLeu: 7.03 ± 0.076	0.618AspMet: 0.618 ± 0.019	0.625AspAsn: 0.625 ± 0.023	5.147AspPro: 5.147 ± 0.079	1.415AspGln: 1.415 ± 0.033	5.75AspArg: 5.75 ± 0.068	1.944AspSer: 1.944 ± 0.042	3.04AspThr: 3.04 ± 0.056	6.641AspVal: 6.641 ± 0.07	0.916AspTrp: 0.916 ± 0.024	0.93AspTyr: 0.93 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.768GluAla: 6.768 ± 0.077	0.286GluCys: 0.286 ± 0.013	3.085GluAsp: 3.085 ± 0.044	3.293GluGlu: 3.293 ± 0.061	1.228GluPhe: 1.228 ± 0.029	4.038GluGly: 4.038 ± 0.056	1.468GluHis: 1.468 ± 0.036	1.489GluIle: 1.489 ± 0.042	0.708GluLys: 0.708 ± 0.025	6.82GluLeu: 6.82 ± 0.081	0.716GluMet: 0.716 ± 0.023	0.662GluAsn: 0.662 ± 0.021	3.226GluPro: 3.226 ± 0.057	2.341GluGln: 2.341 ± 0.049	5.159GluArg: 5.159 ± 0.072	1.878GluSer: 1.878 ± 0.04	2.516GluThr: 2.516 ± 0.044	5.717GluVal: 5.717 ± 0.072	0.679GluTrp: 0.679 ± 0.021	0.885GluTyr: 0.885 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.542PheAla: 3.542 ± 0.054	0.217PheCys: 0.217 ± 0.012	1.751PheAsp: 1.751 ± 0.039	1.09PheGlu: 1.09 ± 0.026	0.728PhePhe: 0.728 ± 0.028	2.76PheGly: 2.76 ± 0.052	0.434PheHis: 0.434 ± 0.016	0.528PheIle: 0.528 ± 0.023	0.265PheLys: 0.265 ± 0.015	2.444PheLeu: 2.444 ± 0.055	0.273PheMet: 0.273 ± 0.016	0.382PheAsn: 0.382 ± 0.016	1.288PhePro: 1.288 ± 0.033	0.53PheGln: 0.53 ± 0.022	1.563PheArg: 1.563 ± 0.037	1.226PheSer: 1.226 ± 0.032	1.772PheThr: 1.772 ± 0.044	2.336PheVal: 2.336 ± 0.048	0.388PheTrp: 0.388 ± 0.016	0.476PheTyr: 0.476 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	12.32GlyAla: 12.32 ± 0.107	0.853GlyCys: 0.853 ± 0.029	5.745GlyAsp: 5.745 ± 0.078	5.323GlyGlu: 5.323 ± 0.067	2.638GlyPhe: 2.638 ± 0.043	9.612GlyGly: 9.612 ± 0.102	2.195GlyHis: 2.195 ± 0.042	2.892GlyIle: 2.892 ± 0.058	1.366GlyLys: 1.366 ± 0.034	10.463GlyLeu: 10.463 ± 0.11	1.916GlyMet: 1.916 ± 0.033	1.337GlyAsn: 1.337 ± 0.038	5.944GlyPro: 5.944 ± 0.066	2.861GlyGln: 2.861 ± 0.05	8.929GlyArg: 8.929 ± 0.088	5.283GlySer: 5.283 ± 0.07	6.528GlyThr: 6.528 ± 0.082	9.242GlyVal: 9.242 ± 0.083	1.864GlyTrp: 1.864 ± 0.042	2.201GlyTyr: 2.201 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.581HisAla: 2.581 ± 0.054	0.177HisCys: 0.177 ± 0.012	1.23HisAsp: 1.23 ± 0.033	1.02HisGlu: 1.02 ± 0.025	0.494HisPhe: 0.494 ± 0.02	2.272HisGly: 2.272 ± 0.044	0.591HisHis: 0.591 ± 0.021	0.337HisIle: 0.337 ± 0.015	0.198HisLys: 0.198 ± 0.012	2.378HisLeu: 2.378 ± 0.047	0.228HisMet: 0.228 ± 0.014	0.285HisAsn: 0.285 ± 0.012	1.78HisPro: 1.78 ± 0.04	0.478HisGln: 0.478 ± 0.019	2.103HisArg: 2.103 ± 0.043	0.786HisSer: 0.786 ± 0.026	1.029HisThr: 1.029 ± 0.027	1.917HisVal: 1.917 ± 0.038	0.312HisTrp: 0.312 ± 0.017	0.326HisTyr: 0.326 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.821IleAla: 3.821 ± 0.064	0.198IleCys: 0.198 ± 0.012	1.73IleAsp: 1.73 ± 0.041	1.465IleGlu: 1.465 ± 0.038	0.356IlePhe: 0.356 ± 0.018	2.942IleGly: 2.942 ± 0.051	0.303IleHis: 0.303 ± 0.015	0.506IleIle: 0.506 ± 0.025	0.346IleLys: 0.346 ± 0.017	1.492IleLeu: 1.492 ± 0.039	0.267IleMet: 0.267 ± 0.014	0.427IleAsn: 0.427 ± 0.02	1.273IlePro: 1.273 ± 0.031	0.448IleGln: 0.448 ± 0.018	1.642IleArg: 1.642 ± 0.035	1.236IleSer: 1.236 ± 0.031	1.621IleThr: 1.621 ± 0.041	2.144IleVal: 2.144 ± 0.048	0.253IleTrp: 0.253 ± 0.014	0.312IleTyr: 0.312 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.508LysAla: 1.508 ± 0.033	0.054LysCys: 0.054 ± 0.006	0.622LysAsp: 0.622 ± 0.022	0.552LysGlu: 0.552 ± 0.024	0.207LysPhe: 0.207 ± 0.013	0.907LysGly: 0.907 ± 0.032	0.226LysHis: 0.226 ± 0.013	0.356LysIle: 0.356 ± 0.019	0.311LysLys: 0.311 ± 0.019	1.075LysLeu: 1.075 ± 0.027	0.199LysMet: 0.199 ± 0.013	0.237LysAsn: 0.237 ± 0.012	0.686LysPro: 0.686 ± 0.024	0.367LysGln: 0.367 ± 0.018	0.892LysArg: 0.892 ± 0.028	0.563LysSer: 0.563 ± 0.022	0.767LysThr: 0.767 ± 0.027	1.093LysVal: 1.093 ± 0.034	0.141LysTrp: 0.141 ± 0.011	0.229LysTyr: 0.229 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	18.06LeuAla: 18.06 ± 0.158	0.708LeuCys: 0.708 ± 0.025	7.078LeuAsp: 7.078 ± 0.081	4.694LeuGlu: 4.694 ± 0.063	2.45LeuPhe: 2.45 ± 0.047	10.233LeuGly: 10.233 ± 0.103	2.154LeuHis: 2.154 ± 0.045	2.001LeuIle: 2.001 ± 0.049	0.968LeuLys: 0.968 ± 0.032	12.694LeuLeu: 12.694 ± 0.136	1.267LeuMet: 1.267 ± 0.029	1.168LeuAsn: 1.168 ± 0.031	7.039LeuPro: 7.039 ± 0.077	2.65LeuGln: 2.65 ± 0.05	8.986LeuArg: 8.986 ± 0.105	5.017LeuSer: 5.017 ± 0.06	6.965LeuThr: 6.965 ± 0.071	11.631LeuVal: 11.631 ± 0.114	1.182LeuTrp: 1.182 ± 0.031	1.478LeuTyr: 1.478 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.226MetAla: 2.226 ± 0.042	0.111MetCys: 0.111 ± 0.009	0.764MetAsp: 0.764 ± 0.024	0.528MetGlu: 0.528 ± 0.02	0.284MetPhe: 0.284 ± 0.015	1.229MetGly: 1.229 ± 0.035	0.267MetHis: 0.267 ± 0.015	0.385MetIle: 0.385 ± 0.017	0.202MetLys: 0.202 ± 0.012	1.282MetLeu: 1.282 ± 0.032	0.194MetMet: 0.194 ± 0.013	0.237MetAsn: 0.237 ± 0.013	0.917MetPro: 0.917 ± 0.027	0.388MetGln: 0.388 ± 0.017	1.206MetArg: 1.206 ± 0.028	1.21MetSer: 1.21 ± 0.029	1.577MetThr: 1.577 ± 0.035	1.277MetVal: 1.277 ± 0.034	0.149MetTrp: 0.149 ± 0.01	0.215MetTyr: 0.215 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	1.773AsnAla: 1.773 ± 0.036	0.118AsnCys: 0.118 ± 0.009	0.682AsnAsp: 0.682 ± 0.024	0.567AsnGlu: 0.567 ± 0.022	0.332AsnPhe: 0.332 ± 0.018	1.278AsnGly: 1.278 ± 0.039	0.281AsnHis: 0.281 ± 0.014	0.381AsnIle: 0.381 ± 0.02	0.179AsnLys: 0.179 ± 0.012	1.302AsnLeu: 1.302 ± 0.033	0.18AsnMet: 0.18 ± 0.014	0.262AsnAsn: 0.262 ± 0.015	1.073AsnPro: 1.073 ± 0.029	0.37AsnGln: 0.37 ± 0.019	1.0AsnArg: 1.0 ± 0.025	0.564AsnSer: 0.564 ± 0.023	0.812AsnThr: 0.812 ± 0.029	1.182AsnVal: 1.182 ± 0.032	0.181AsnTrp: 0.181 ± 0.013	0.251AsnTyr: 0.251 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	10.576ProAla: 10.576 ± 0.105	0.316ProCys: 0.316 ± 0.018	4.794ProAsp: 4.794 ± 0.067	4.035ProGlu: 4.035 ± 0.058	1.446ProPhe: 1.446 ± 0.036	7.524ProGly: 7.524 ± 0.085	1.271ProHis: 1.271 ± 0.034	1.18ProIle: 1.18 ± 0.034	0.55ProLys: 0.55 ± 0.024	5.689ProLeu: 5.689 ± 0.064	0.95ProMet: 0.95 ± 0.028	0.689ProAsn: 0.689 ± 0.025	4.201ProPro: 4.201 ± 0.08	1.59ProGln: 1.59 ± 0.037	4.536ProArg: 4.536 ± 0.06	2.936ProSer: 2.936 ± 0.053	3.546ProThr: 3.546 ± 0.056	6.769ProVal: 6.769 ± 0.073	1.013ProTrp: 1.013 ± 0.025	0.988ProTyr: 0.988 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.82GlnAla: 3.82 ± 0.06	0.132GlnCys: 0.132 ± 0.009	1.188GlnAsp: 1.188 ± 0.033	1.325GlnGlu: 1.325 ± 0.035	0.617GlnPhe: 0.617 ± 0.023	1.974GlnGly: 1.974 ± 0.047	0.618GlnHis: 0.618 ± 0.022	0.723GlnIle: 0.723 ± 0.027	0.327GlnLys: 0.327 ± 0.016	3.227GlnLeu: 3.227 ± 0.049	0.415GlnMet: 0.415 ± 0.02	0.325GlnAsn: 0.325 ± 0.016	1.708GlnPro: 1.708 ± 0.042	1.16GlnGln: 1.16 ± 0.036	2.601GlnArg: 2.601 ± 0.045	0.982GlnSer: 0.982 ± 0.029	1.334GlnThr: 1.334 ± 0.033	3.02GlnVal: 3.02 ± 0.052	0.371GlnTrp: 0.371 ± 0.02	0.516GlnTyr: 0.516 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	11.381ArgAla: 11.381 ± 0.121	0.609ArgCys: 0.609 ± 0.023	4.567ArgAsp: 4.567 ± 0.072	4.499ArgGlu: 4.499 ± 0.06	2.18ArgPhe: 2.18 ± 0.039	6.639ArgGly: 6.639 ± 0.078	1.893ArgHis: 1.893 ± 0.038	2.322ArgIle: 2.322 ± 0.043	0.843ArgLys: 0.843 ± 0.025	9.451ArgLeu: 9.451 ± 0.106	1.739ArgMet: 1.739 ± 0.035	1.062ArgAsn: 1.062 ± 0.03	6.116ArgPro: 6.116 ± 0.082	2.278ArgGln: 2.278 ± 0.046	9.41ArgArg: 9.41 ± 0.12	4.217ArgSer: 4.217 ± 0.055	5.305ArgThr: 5.305 ± 0.063	7.533ArgVal: 7.533 ± 0.093	1.634ArgTrp: 1.634 ± 0.038	1.636ArgTyr: 1.636 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.306SerAla: 6.306 ± 0.073	0.345SerCys: 0.345 ± 0.015	2.266SerAsp: 2.266 ± 0.043	1.843SerGlu: 1.843 ± 0.041	1.234SerPhe: 1.234 ± 0.033	5.286SerGly: 5.286 ± 0.064	0.815SerHis: 0.815 ± 0.022	1.263SerIle: 1.263 ± 0.032	0.511SerLys: 0.511 ± 0.022	4.423SerLeu: 4.423 ± 0.071	0.911SerMet: 0.911 ± 0.025	0.601SerAsn: 0.601 ± 0.022	3.215SerPro: 3.215 ± 0.053	0.919SerGln: 0.919 ± 0.026	3.667SerArg: 3.667 ± 0.062	2.582SerSer: 2.582 ± 0.045	2.963SerThr: 2.963 ± 0.049	4.21SerVal: 4.21 ± 0.056	0.826SerTrp: 0.826 ± 0.026	0.917SerTyr: 0.917 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.301ThrAla: 9.301 ± 0.085	0.401ThrCys: 0.401 ± 0.017	3.659ThrAsp: 3.659 ± 0.057	2.923ThrGlu: 2.923 ± 0.048	1.452ThrPhe: 1.452 ± 0.036	7.128ThrGly: 7.128 ± 0.075	1.053ThrHis: 1.053 ± 0.027	1.415ThrIle: 1.415 ± 0.038	0.641ThrLys: 0.641 ± 0.023	5.672ThrLeu: 5.672 ± 0.059	0.845ThrMet: 0.845 ± 0.026	0.839ThrAsn: 0.839 ± 0.027	4.302ThrPro: 4.302 ± 0.058	1.216ThrGln: 1.216 ± 0.033	4.344ThrArg: 4.344 ± 0.056	2.963ThrSer: 2.963 ± 0.053	4.018ThrThr: 4.018 ± 0.073	6.691ThrVal: 6.691 ± 0.087	0.903ThrTrp: 0.903 ± 0.028	0.999ThrTyr: 0.999 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	14.488ValAla: 14.488 ± 0.122	0.722ValCys: 0.722 ± 0.022	6.58ValAsp: 6.58 ± 0.077	5.492ValGlu: 5.492 ± 0.059	2.645ValPhe: 2.645 ± 0.048	8.69ValGly: 8.69 ± 0.093	2.303ValHis: 2.303 ± 0.045	2.117ValIle: 2.117 ± 0.046	1.11ValLys: 1.11 ± 0.03	12.581ValLeu: 12.581 ± 0.119	1.196ValMet: 1.196 ± 0.032	1.47ValAsn: 1.47 ± 0.032	6.634ValPro: 6.634 ± 0.085	2.518ValGln: 2.518 ± 0.047	8.106ValArg: 8.106 ± 0.092	4.358ValSer: 4.358 ± 0.057	6.575ValThr: 6.575 ± 0.077	12.165ValVal: 12.165 ± 0.114	1.151ValTrp: 1.151 ± 0.027	1.573ValTyr: 1.573 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.834TrpAla: 1.834 ± 0.04	0.139TrpCys: 0.139 ± 0.01	0.752TrpAsp: 0.752 ± 0.024	0.582TrpGlu: 0.582 ± 0.021	0.468TrpPhe: 0.468 ± 0.02	1.024TrpGly: 1.024 ± 0.025	0.37TrpHis: 0.37 ± 0.016	0.3TrpIle: 0.3 ± 0.014	0.171TrpLys: 0.171 ± 0.012	1.914TrpLeu: 1.914 ± 0.039	0.226TrpMet: 0.226 ± 0.012	0.255TrpAsn: 0.255 ± 0.016	0.873TrpPro: 0.873 ± 0.027	0.519TrpGln: 0.519 ± 0.018	1.39TrpArg: 1.39 ± 0.03	0.916TrpSer: 0.916 ± 0.024	1.027TrpThr: 1.027 ± 0.031	1.246TrpVal: 1.246 ± 0.026	0.33TrpTrp: 0.33 ± 0.017	0.274TrpTyr: 0.274 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.382TyrAla: 2.382 ± 0.042	0.144TyrCys: 0.144 ± 0.012	1.225TyrAsp: 1.225 ± 0.031	0.894TyrGlu: 0.894 ± 0.026	0.445TyrPhe: 0.445 ± 0.018	1.863TyrGly: 1.863 ± 0.038	0.272TyrHis: 0.272 ± 0.013	0.284TyrIle: 0.284 ± 0.015	0.212TyrLys: 0.212 ± 0.013	1.856TyrLeu: 1.856 ± 0.042	0.15TyrMet: 0.15 ± 0.011	0.245TyrAsn: 0.245 ± 0.015	0.881TyrPro: 0.881 ± 0.03	0.451TyrGln: 0.451 ± 0.021	1.536TyrArg: 1.536 ± 0.036	0.768TyrSer: 0.768 ± 0.024	1.008TyrThr: 1.008 ± 0.03	1.578TyrVal: 1.578 ± 0.04	0.26TyrTrp: 0.26 ± 0.014	0.325TyrTyr: 0.325 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4421 proteins (1365029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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