Amino acid dipepetide frequency for Mycoplasma meleagridis ATCC 25294

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.806AlaAla: 2.806 ± 0.145
0.228AlaCys: 0.228 ± 0.035
2.293AlaAsp: 2.293 ± 0.104
2.785AlaGlu: 2.785 ± 0.142
2.738AlaPhe: 2.738 ± 0.129
2.485AlaGly: 2.485 ± 0.143
0.652AlaHis: 0.652 ± 0.061
5.301AlaIle: 5.301 ± 0.183
5.932AlaLys: 5.932 ± 0.289
5.824AlaLeu: 5.824 ± 0.19
0.885AlaMet: 0.885 ± 0.072
4.524AlaAsn: 4.524 ± 0.22
1.175AlaPro: 1.175 ± 0.087
1.745AlaGln: 1.745 ± 0.136
1.776AlaArg: 1.776 ± 0.12
3.329AlaSer: 3.329 ± 0.122
2.702AlaThr: 2.702 ± 0.117
2.511AlaVal: 2.511 ± 0.126
0.326AlaTrp: 0.326 ± 0.048
2.174AlaTyr: 2.174 ± 0.115
0.0AlaXaa: 0.0 ± 0.0
Cys
0.217CysAla: 0.217 ± 0.036
0.016CysCys: 0.016 ± 0.01
0.248CysAsp: 0.248 ± 0.041
0.285CysGlu: 0.285 ± 0.041
0.248CysPhe: 0.248 ± 0.034
0.248CysGly: 0.248 ± 0.039
0.088CysHis: 0.088 ± 0.017
0.347CysIle: 0.347 ± 0.049
0.326CysLys: 0.326 ± 0.046
0.476CysLeu: 0.476 ± 0.052
0.052CysMet: 0.052 ± 0.017
0.342CysAsn: 0.342 ± 0.048
0.16CysPro: 0.16 ± 0.031
0.119CysGln: 0.119 ± 0.024
0.129CysArg: 0.129 ± 0.024
0.342CysSer: 0.342 ± 0.038
0.202CysThr: 0.202 ± 0.033
0.186CysVal: 0.186 ± 0.032
0.052CysTrp: 0.052 ± 0.016
0.181CysTyr: 0.181 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
2.609AspAla: 2.609 ± 0.13
0.202AspCys: 0.202 ± 0.033
2.842AspAsp: 2.842 ± 0.159
4.229AspGlu: 4.229 ± 0.173
3.422AspPhe: 3.422 ± 0.151
2.143AspGly: 2.143 ± 0.124
0.569AspHis: 0.569 ± 0.062
4.933AspIle: 4.933 ± 0.16
6.227AspLys: 6.227 ± 0.252
5.798AspLeu: 5.798 ± 0.223
0.564AspMet: 0.564 ± 0.06
5.032AspAsn: 5.032 ± 0.239
1.558AspPro: 1.558 ± 0.092
1.615AspGln: 1.615 ± 0.123
1.32AspArg: 1.32 ± 0.088
3.505AspSer: 3.505 ± 0.208
2.117AspThr: 2.117 ± 0.116
2.723AspVal: 2.723 ± 0.115
0.414AspTrp: 0.414 ± 0.044
2.821AspTyr: 2.821 ± 0.118
0.0AspXaa: 0.0 ± 0.0
Glu
3.448GluAla: 3.448 ± 0.174
0.197GluCys: 0.197 ± 0.028
2.526GluAsp: 2.526 ± 0.132
5.85GluGlu: 5.85 ± 0.238
3.033GluPhe: 3.033 ± 0.139
2.392GluGly: 2.392 ± 0.145
0.766GluHis: 0.766 ± 0.077
8.464GluIle: 8.464 ± 0.26
8.459GluLys: 8.459 ± 0.23
7.019GluLeu: 7.019 ± 0.197
1.305GluMet: 1.305 ± 0.099
7.071GluAsn: 7.071 ± 0.184
1.16GluPro: 1.16 ± 0.108
2.159GluGln: 2.159 ± 0.124
1.719GluArg: 1.719 ± 0.127
2.889GluSer: 2.889 ± 0.115
3.147GluThr: 3.147 ± 0.103
3.256GluVal: 3.256 ± 0.129
0.507GluTrp: 0.507 ± 0.054
2.863GluTyr: 2.863 ± 0.129
0.0GluXaa: 0.0 ± 0.0
Phe
2.92PheAla: 2.92 ± 0.138
0.29PheCys: 0.29 ± 0.045
3.437PheAsp: 3.437 ± 0.125
3.008PheGlu: 3.008 ± 0.143
2.64PhePhe: 2.64 ± 0.168
2.34PheGly: 2.34 ± 0.135
0.668PheHis: 0.668 ± 0.058
5.482PheIle: 5.482 ± 0.265
4.949PheLys: 4.949 ± 0.225
5.197PheLeu: 5.197 ± 0.231
0.74PheMet: 0.74 ± 0.073
4.762PheAsn: 4.762 ± 0.209
1.217PhePro: 1.217 ± 0.085
1.154PheGln: 1.154 ± 0.082
1.206PheArg: 1.206 ± 0.081
4.209PheSer: 4.209 ± 0.182
2.537PheThr: 2.537 ± 0.117
3.178PheVal: 3.178 ± 0.153
0.518PheTrp: 0.518 ± 0.054
2.288PheTyr: 2.288 ± 0.126
0.0PheXaa: 0.0 ± 0.0
Gly
2.49GlyAla: 2.49 ± 0.15
0.202GlyCys: 0.202 ± 0.029
2.304GlyAsp: 2.304 ± 0.114
2.645GlyGlu: 2.645 ± 0.12
2.428GlyPhe: 2.428 ± 0.13
2.5GlyGly: 2.5 ± 0.158
0.776GlyHis: 0.776 ± 0.079
4.452GlyIle: 4.452 ± 0.184
4.224GlyLys: 4.224 ± 0.197
3.908GlyLeu: 3.908 ± 0.146
0.937GlyMet: 0.937 ± 0.072
2.728GlyAsn: 2.728 ± 0.118
0.947GlyPro: 0.947 ± 0.079
1.641GlyGln: 1.641 ± 0.12
1.481GlyArg: 1.481 ± 0.117
2.474GlySer: 2.474 ± 0.125
2.402GlyThr: 2.402 ± 0.116
2.226GlyVal: 2.226 ± 0.116
0.373GlyTrp: 0.373 ± 0.046
2.107GlyTyr: 2.107 ± 0.11
0.0GlyXaa: 0.0 ± 0.0
His
0.616HisAla: 0.616 ± 0.056
0.062HisCys: 0.062 ± 0.022
0.678HisAsp: 0.678 ± 0.062
0.828HisGlu: 0.828 ± 0.071
0.787HisPhe: 0.787 ± 0.066
0.73HisGly: 0.73 ± 0.069
0.243HisHis: 0.243 ± 0.044
1.123HisIle: 1.123 ± 0.076
1.087HisLys: 1.087 ± 0.086
1.242HisLeu: 1.242 ± 0.092
0.197HisMet: 0.197 ± 0.03
1.051HisAsn: 1.051 ± 0.077
0.476HisPro: 0.476 ± 0.058
0.347HisGln: 0.347 ± 0.043
0.352HisArg: 0.352 ± 0.044
0.854HisSer: 0.854 ± 0.068
0.626HisThr: 0.626 ± 0.057
0.616HisVal: 0.616 ± 0.052
0.104HisTrp: 0.104 ± 0.023
0.528HisTyr: 0.528 ± 0.058
0.0HisXaa: 0.0 ± 0.0
Ile
5.42IleAla: 5.42 ± 0.22
0.657IleCys: 0.657 ± 0.067
6.792IleAsp: 6.792 ± 0.206
6.393IleGlu: 6.393 ± 0.258
5.622IlePhe: 5.622 ± 0.266
4.214IleGly: 4.214 ± 0.205
1.222IleHis: 1.222 ± 0.081
9.199IleIle: 9.199 ± 0.381
10.25IleLys: 10.25 ± 0.218
8.422IleLeu: 8.422 ± 0.258
1.377IleMet: 1.377 ± 0.083
9.794IleAsn: 9.794 ± 0.359
2.656IlePro: 2.656 ± 0.136
2.449IleGln: 2.449 ± 0.108
2.542IleArg: 2.542 ± 0.123
7.527IleSer: 7.527 ± 0.202
4.887IleThr: 4.887 ± 0.144
5.57IleVal: 5.57 ± 0.195
0.642IleTrp: 0.642 ± 0.062
3.898IleTyr: 3.898 ± 0.158
0.0IleXaa: 0.0 ± 0.0
Lys
5.182LysAla: 5.182 ± 0.239
0.357LysCys: 0.357 ± 0.049
5.694LysAsp: 5.694 ± 0.248
9.318LysGlu: 9.318 ± 0.259
4.286LysPhe: 4.286 ± 0.172
3.479LysGly: 3.479 ± 0.164
1.201LysHis: 1.201 ± 0.068
11.29LysIle: 11.29 ± 0.257
10.762LysLys: 10.762 ± 0.254
9.654LysLeu: 9.654 ± 0.253
2.423LysMet: 2.423 ± 0.136
12.217LysAsn: 12.217 ± 0.358
2.143LysPro: 2.143 ± 0.121
3.235LysGln: 3.235 ± 0.153
2.889LysArg: 2.889 ± 0.126
4.949LysSer: 4.949 ± 0.152
5.234LysThr: 5.234 ± 0.231
5.239LysVal: 5.239 ± 0.169
0.89LysTrp: 0.89 ± 0.076
5.078LysTyr: 5.078 ± 0.15
0.0LysXaa: 0.0 ± 0.0
Leu
5.834LeuAla: 5.834 ± 0.194
0.373LeuCys: 0.373 ± 0.053
5.927LeuAsp: 5.927 ± 0.251
6.693LeuGlu: 6.693 ± 0.222
4.954LeuPhe: 4.954 ± 0.251
4.276LeuGly: 4.276 ± 0.183
1.144LeuHis: 1.144 ± 0.082
10.151LeuIle: 10.151 ± 0.297
9.608LeuLys: 9.608 ± 0.224
8.738LeuLeu: 8.738 ± 0.304
1.481LeuMet: 1.481 ± 0.081
9.685LeuAsn: 9.685 ± 0.386
2.593LeuPro: 2.593 ± 0.126
2.122LeuGln: 2.122 ± 0.103
2.557LeuArg: 2.557 ± 0.132
6.895LeuSer: 6.895 ± 0.209
5.741LeuThr: 5.741 ± 0.289
5.736LeuVal: 5.736 ± 0.195
0.569LeuTrp: 0.569 ± 0.05
3.018LeuTyr: 3.018 ± 0.116
0.0LeuXaa: 0.0 ± 0.0
Met
0.978MetAla: 0.978 ± 0.074
0.083MetCys: 0.083 ± 0.02
0.802MetAsp: 0.802 ± 0.078
0.787MetGlu: 0.787 ± 0.068
0.932MetPhe: 0.932 ± 0.067
0.699MetGly: 0.699 ± 0.07
0.233MetHis: 0.233 ± 0.035
1.356MetIle: 1.356 ± 0.088
1.61MetLys: 1.61 ± 0.089
1.532MetLeu: 1.532 ± 0.098
0.248MetMet: 0.248 ± 0.039
1.279MetAsn: 1.279 ± 0.077
0.823MetPro: 0.823 ± 0.075
0.766MetGln: 0.766 ± 0.065
0.481MetArg: 0.481 ± 0.051
1.051MetSer: 1.051 ± 0.085
0.595MetThr: 0.595 ± 0.058
0.751MetVal: 0.751 ± 0.06
0.104MetTrp: 0.104 ± 0.02
0.461MetTyr: 0.461 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.97AsnAla: 3.97 ± 0.169
0.336AsnCys: 0.336 ± 0.039
5.378AsnAsp: 5.378 ± 0.265
6.554AsnGlu: 6.554 ± 0.191
5.208AsnPhe: 5.208 ± 0.199
3.831AsnGly: 3.831 ± 0.151
1.066AsnHis: 1.066 ± 0.078
8.479AsnIle: 8.479 ± 0.257
10.876AsnLys: 10.876 ± 0.278
9.846AsnLeu: 9.846 ± 0.423
1.108AsnMet: 1.108 ± 0.084
10.54AsnAsn: 10.54 ± 0.455
2.397AsnPro: 2.397 ± 0.121
2.801AsnGln: 2.801 ± 0.141
2.2AsnArg: 2.2 ± 0.1
7.17AsnSer: 7.17 ± 0.384
3.634AsnThr: 3.634 ± 0.174
4.514AsnVal: 4.514 ± 0.19
0.683AsnTrp: 0.683 ± 0.065
4.612AsnTyr: 4.612 ± 0.181
0.0AsnXaa: 0.0 ± 0.0
Pro
1.201ProAla: 1.201 ± 0.076
0.078ProCys: 0.078 ± 0.02
1.113ProAsp: 1.113 ± 0.076
1.719ProGlu: 1.719 ± 0.161
1.31ProPhe: 1.31 ± 0.092
1.16ProGly: 1.16 ± 0.086
0.409ProHis: 0.409 ± 0.049
2.402ProIle: 2.402 ± 0.128
2.454ProLys: 2.454 ± 0.143
2.48ProLeu: 2.48 ± 0.118
0.311ProMet: 0.311 ± 0.034
2.065ProAsn: 2.065 ± 0.123
0.497ProPro: 0.497 ± 0.052
0.663ProGln: 0.663 ± 0.061
0.637ProArg: 0.637 ± 0.064
1.884ProSer: 1.884 ± 0.088
1.465ProThr: 1.465 ± 0.095
1.336ProVal: 1.336 ± 0.091
0.238ProTrp: 0.238 ± 0.033
1.211ProTyr: 1.211 ± 0.079
0.0ProXaa: 0.0 ± 0.0
Gln
1.796GlnAla: 1.796 ± 0.104
0.041GlnCys: 0.041 ± 0.017
1.315GlnAsp: 1.315 ± 0.08
1.977GlnGlu: 1.977 ± 0.115
1.403GlnPhe: 1.403 ± 0.088
1.211GlnGly: 1.211 ± 0.083
0.321GlnHis: 0.321 ± 0.042
3.587GlnIle: 3.587 ± 0.137
3.515GlnLys: 3.515 ± 0.159
2.692GlnLeu: 2.692 ± 0.132
0.523GlnMet: 0.523 ± 0.056
2.656GlnAsn: 2.656 ± 0.152
0.59GlnPro: 0.59 ± 0.045
0.844GlnGln: 0.844 ± 0.068
0.958GlnArg: 0.958 ± 0.068
1.579GlnSer: 1.579 ± 0.096
1.418GlnThr: 1.418 ± 0.076
1.444GlnVal: 1.444 ± 0.079
0.233GlnTrp: 0.233 ± 0.045
1.139GlnTyr: 1.139 ± 0.075
0.0GlnXaa: 0.0 ± 0.0
Arg
1.46ArgAla: 1.46 ± 0.104
0.129ArgCys: 0.129 ± 0.024
1.449ArgAsp: 1.449 ± 0.094
2.293ArgGlu: 2.293 ± 0.135
1.17ArgPhe: 1.17 ± 0.083
1.439ArgGly: 1.439 ± 0.095
0.326ArgHis: 0.326 ± 0.043
2.666ArgIle: 2.666 ± 0.126
2.956ArgLys: 2.956 ± 0.121
2.671ArgLeu: 2.671 ± 0.11
0.668ArgMet: 0.668 ± 0.067
2.143ArgAsn: 2.143 ± 0.111
0.688ArgPro: 0.688 ± 0.07
0.937ArgGln: 0.937 ± 0.081
0.978ArgArg: 0.978 ± 0.084
1.444ArgSer: 1.444 ± 0.101
1.253ArgThr: 1.253 ± 0.08
1.284ArgVal: 1.284 ± 0.106
0.259ArgTrp: 0.259 ± 0.035
1.227ArgTyr: 1.227 ± 0.089
0.0ArgXaa: 0.0 ± 0.0
Ser
3.282SerAla: 3.282 ± 0.149
0.368SerCys: 0.368 ± 0.046
3.417SerAsp: 3.417 ± 0.165
3.789SerGlu: 3.789 ± 0.151
3.872SerPhe: 3.872 ± 0.156
3.07SerGly: 3.07 ± 0.125
0.808SerHis: 0.808 ± 0.068
5.808SerIle: 5.808 ± 0.222
6.828SerLys: 6.828 ± 0.207
7.698SerLeu: 7.698 ± 0.289
0.808SerMet: 0.808 ± 0.077
5.705SerAsn: 5.705 ± 0.248
1.532SerPro: 1.532 ± 0.095
2.412SerGln: 2.412 ± 0.134
1.662SerArg: 1.662 ± 0.101
5.451SerSer: 5.451 ± 0.233
3.059SerThr: 3.059 ± 0.149
2.966SerVal: 2.966 ± 0.161
0.621SerTrp: 0.621 ± 0.06
3.173SerTyr: 3.173 ± 0.117
0.0SerXaa: 0.0 ± 0.0
Thr
2.288ThrAla: 2.288 ± 0.123
0.171ThrCys: 0.171 ± 0.034
2.179ThrAsp: 2.179 ± 0.136
2.252ThrGlu: 2.252 ± 0.121
2.925ThrPhe: 2.925 ± 0.125
2.485ThrGly: 2.485 ± 0.122
0.709ThrHis: 0.709 ± 0.055
5.156ThrIle: 5.156 ± 0.203
4.84ThrLys: 4.84 ± 0.174
4.628ThrLeu: 4.628 ± 0.17
0.533ThrMet: 0.533 ± 0.054
4.944ThrAsn: 4.944 ± 0.281
1.398ThrPro: 1.398 ± 0.084
1.201ThrGln: 1.201 ± 0.095
1.367ThrArg: 1.367 ± 0.093
3.37ThrSer: 3.37 ± 0.156
2.63ThrThr: 2.63 ± 0.143
2.304ThrVal: 2.304 ± 0.119
0.393ThrTrp: 0.393 ± 0.047
2.329ThrTyr: 2.329 ± 0.12
0.0ThrXaa: 0.0 ± 0.0
Val
3.075ValAla: 3.075 ± 0.142
0.238ValCys: 0.238 ± 0.033
3.308ValAsp: 3.308 ± 0.139
3.313ValGlu: 3.313 ± 0.143
2.702ValPhe: 2.702 ± 0.134
2.49ValGly: 2.49 ± 0.137
0.683ValHis: 0.683 ± 0.07
5.026ValIle: 5.026 ± 0.174
5.177ValLys: 5.177 ± 0.206
4.804ValLeu: 4.804 ± 0.171
0.704ValMet: 0.704 ± 0.067
4.856ValAsn: 4.856 ± 0.224
1.31ValPro: 1.31 ± 0.096
1.232ValGln: 1.232 ± 0.065
1.543ValArg: 1.543 ± 0.104
3.748ValSer: 3.748 ± 0.129
2.21ValThr: 2.21 ± 0.119
3.241ValVal: 3.241 ± 0.14
0.357ValTrp: 0.357 ± 0.046
1.672ValTyr: 1.672 ± 0.088
0.0ValXaa: 0.0 ± 0.0
Trp
0.414TrpAla: 0.414 ± 0.049
0.041TrpCys: 0.041 ± 0.014
0.409TrpAsp: 0.409 ± 0.051
0.533TrpGlu: 0.533 ± 0.056
0.507TrpPhe: 0.507 ± 0.051
0.295TrpGly: 0.295 ± 0.039
0.072TrpHis: 0.072 ± 0.019
0.833TrpIle: 0.833 ± 0.067
0.745TrpLys: 0.745 ± 0.063
0.756TrpLeu: 0.756 ± 0.066
0.207TrpMet: 0.207 ± 0.034
0.688TrpAsn: 0.688 ± 0.061
0.197TrpPro: 0.197 ± 0.031
0.166TrpGln: 0.166 ± 0.03
0.274TrpArg: 0.274 ± 0.036
0.435TrpSer: 0.435 ± 0.044
0.445TrpThr: 0.445 ± 0.047
0.373TrpVal: 0.373 ± 0.041
0.083TrpTrp: 0.083 ± 0.021
0.362TrpTyr: 0.362 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.185TyrAla: 2.185 ± 0.099
0.197TyrCys: 0.197 ± 0.03
2.531TyrAsp: 2.531 ± 0.12
2.977TyrGlu: 2.977 ± 0.153
2.552TyrPhe: 2.552 ± 0.123
1.76TyrGly: 1.76 ± 0.097
0.59TyrHis: 0.59 ± 0.062
3.473TyrIle: 3.473 ± 0.156
4.695TyrLys: 4.695 ± 0.157
4.716TyrLeu: 4.716 ± 0.18
0.497TyrMet: 0.497 ± 0.05
3.121TyrAsn: 3.121 ± 0.118
1.113TyrPro: 1.113 ± 0.076
1.636TyrGln: 1.636 ± 0.118
1.372TyrArg: 1.372 ± 0.081
3.225TyrSer: 3.225 ± 0.129
1.796TyrThr: 1.796 ± 0.101
2.236TyrVal: 2.236 ± 0.09
0.471TyrTrp: 0.471 ± 0.05
1.807TyrTyr: 1.807 ± 0.093
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 505 proteins (193178 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski