Amino acid dipepetide frequency for Desulfocarbo indianensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.899AlaAla: 14.899 ± 0.172	1.538AlaCys: 1.538 ± 0.037	5.132AlaAsp: 5.132 ± 0.065	7.303AlaGlu: 7.303 ± 0.092	3.703AlaPhe: 3.703 ± 0.052	10.978AlaGly: 10.978 ± 0.116	1.957AlaHis: 1.957 ± 0.045	4.337AlaIle: 4.337 ± 0.059	4.971AlaLys: 4.971 ± 0.074	13.522AlaLeu: 13.522 ± 0.137	3.369AlaMet: 3.369 ± 0.058	2.508AlaAsn: 2.508 ± 0.047	4.809AlaPro: 4.809 ± 0.084	4.931AlaGln: 4.931 ± 0.079	7.718AlaArg: 7.718 ± 0.107	5.559AlaSer: 5.559 ± 0.071	4.027AlaThr: 4.027 ± 0.058	7.905AlaVal: 7.905 ± 0.091	1.75AlaTrp: 1.75 ± 0.045	2.635AlaTyr: 2.635 ± 0.051	0.008AlaXaa: 0.008 ± 0.002
Cys	1.149CysAla: 1.149 ± 0.031	0.253CysCys: 0.253 ± 0.017	0.52CysAsp: 0.52 ± 0.018	0.51CysGlu: 0.51 ± 0.022	0.467CysPhe: 0.467 ± 0.021	1.377CysGly: 1.377 ± 0.038	0.398CysHis: 0.398 ± 0.022	0.399CysIle: 0.399 ± 0.018	0.364CysLys: 0.364 ± 0.02	1.617CysLeu: 1.617 ± 0.041	0.246CysMet: 0.246 ± 0.014	0.31CysAsn: 0.31 ± 0.016	0.901CysPro: 0.901 ± 0.03	0.575CysGln: 0.575 ± 0.021	0.928CysArg: 0.928 ± 0.026	0.632CysSer: 0.632 ± 0.027	0.518CysThr: 0.518 ± 0.019	0.75CysVal: 0.75 ± 0.03	0.143CysTrp: 0.143 ± 0.012	0.328CysTyr: 0.328 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.502AspAla: 4.502 ± 0.065	0.612AspCys: 0.612 ± 0.023	2.469AspAsp: 2.469 ± 0.058	3.089AspGlu: 3.089 ± 0.055	2.184AspPhe: 2.184 ± 0.038	3.906AspGly: 3.906 ± 0.061	1.169AspHis: 1.169 ± 0.032	2.554AspIle: 2.554 ± 0.041	2.261AspLys: 2.261 ± 0.054	6.603AspLeu: 6.603 ± 0.077	1.356AspMet: 1.356 ± 0.035	1.275AspAsn: 1.275 ± 0.033	3.204AspPro: 3.204 ± 0.059	2.228AspGln: 2.228 ± 0.043	3.177AspArg: 3.177 ± 0.046	2.219AspSer: 2.219 ± 0.045	1.915AspThr: 1.915 ± 0.042	3.01AspVal: 3.01 ± 0.06	0.816AspTrp: 0.816 ± 0.027	1.728AspTyr: 1.728 ± 0.039	0.002AspXaa: 0.002 ± 0.001
Glu	7.746GluAla: 7.746 ± 0.095	0.514GluCys: 0.514 ± 0.019	2.989GluAsp: 2.989 ± 0.055	4.618GluGlu: 4.618 ± 0.074	1.905GluPhe: 1.905 ± 0.037	4.446GluGly: 4.446 ± 0.053	1.216GluHis: 1.216 ± 0.03	3.354GluIle: 3.354 ± 0.056	3.211GluLys: 3.211 ± 0.057	7.446GluLeu: 7.446 ± 0.09	1.893GluMet: 1.893 ± 0.045	1.805GluAsn: 1.805 ± 0.042	3.093GluPro: 3.093 ± 0.053	2.38GluGln: 2.38 ± 0.051	4.714GluArg: 4.714 ± 0.063	2.837GluSer: 2.837 ± 0.05	2.843GluThr: 2.843 ± 0.044	4.967GluVal: 4.967 ± 0.071	0.597GluTrp: 0.597 ± 0.024	1.43GluTyr: 1.43 ± 0.035	0.001GluXaa: 0.001 ± 0.001
Phe	3.4PheAla: 3.4 ± 0.057	0.571PheCys: 0.571 ± 0.022	1.979PheAsp: 1.979 ± 0.042	1.86PheGlu: 1.86 ± 0.041	1.678PhePhe: 1.678 ± 0.039	2.915PheGly: 2.915 ± 0.051	0.772PheHis: 0.772 ± 0.023	1.816PheIle: 1.816 ± 0.035	1.523PheLys: 1.523 ± 0.036	4.024PheLeu: 4.024 ± 0.063	1.061PheMet: 1.061 ± 0.029	1.165PheAsn: 1.165 ± 0.032	1.546PhePro: 1.546 ± 0.036	1.266PheGln: 1.266 ± 0.034	2.048PheArg: 2.048 ± 0.043	2.344PheSer: 2.344 ± 0.045	1.861PheThr: 1.861 ± 0.044	2.337PheVal: 2.337 ± 0.048	0.57PheTrp: 0.57 ± 0.026	1.105PheTyr: 1.105 ± 0.028	0.002PheXaa: 0.002 ± 0.001
Gly	8.316GlyAla: 8.316 ± 0.089	1.223GlyCys: 1.223 ± 0.033	3.951GlyAsp: 3.951 ± 0.06	5.226GlyGlu: 5.226 ± 0.059	3.356GlyPhe: 3.356 ± 0.058	7.729GlyGly: 7.729 ± 0.108	1.815GlyHis: 1.815 ± 0.037	3.714GlyIle: 3.714 ± 0.062	3.955GlyLys: 3.955 ± 0.059	10.999GlyLeu: 10.999 ± 0.122	2.321GlyMet: 2.321 ± 0.047	2.028GlyAsn: 2.028 ± 0.048	3.856GlyPro: 3.856 ± 0.063	3.95GlyGln: 3.95 ± 0.062	6.408GlyArg: 6.408 ± 0.075	4.225GlySer: 4.225 ± 0.066	3.106GlyThr: 3.106 ± 0.052	6.519GlyVal: 6.519 ± 0.076	1.31GlyTrp: 1.31 ± 0.039	2.513GlyTyr: 2.513 ± 0.05	0.004GlyXaa: 0.004 ± 0.002
His	1.845HisAla: 1.845 ± 0.043	0.313HisCys: 0.313 ± 0.017	1.065HisAsp: 1.065 ± 0.034	1.114HisGlu: 1.114 ± 0.026	0.844HisPhe: 0.844 ± 0.023	1.853HisGly: 1.853 ± 0.036	0.517HisHis: 0.517 ± 0.021	0.822HisIle: 0.822 ± 0.028	0.661HisLys: 0.661 ± 0.022	2.336HisLeu: 2.336 ± 0.044	0.423HisMet: 0.423 ± 0.021	0.551HisAsn: 0.551 ± 0.018	1.351HisPro: 1.351 ± 0.033	0.827HisGln: 0.827 ± 0.027	1.263HisArg: 1.263 ± 0.031	0.946HisSer: 0.946 ± 0.027	0.91HisThr: 0.91 ± 0.03	1.095HisVal: 1.095 ± 0.03	0.304HisTrp: 0.304 ± 0.017	0.651HisTyr: 0.651 ± 0.024	0.001HisXaa: 0.001 ± 0.001
Ile	4.384IleAla: 4.384 ± 0.065	0.68IleCys: 0.68 ± 0.027	2.308IleAsp: 2.308 ± 0.053	2.59IleGlu: 2.59 ± 0.053	1.684IlePhe: 1.684 ± 0.042	3.283IleGly: 3.283 ± 0.057	0.899IleHis: 0.899 ± 0.029	2.384IleIle: 2.384 ± 0.046	2.429IleLys: 2.429 ± 0.042	4.669IleLeu: 4.669 ± 0.062	1.292IleMet: 1.292 ± 0.035	1.709IleAsn: 1.709 ± 0.043	2.202IlePro: 2.202 ± 0.048	1.531IleGln: 1.531 ± 0.037	2.458IleArg: 2.458 ± 0.047	2.888IleSer: 2.888 ± 0.05	2.533IleThr: 2.533 ± 0.05	2.782IleVal: 2.782 ± 0.048	0.552IleTrp: 0.552 ± 0.021	1.309IleTyr: 1.309 ± 0.036	0.005IleXaa: 0.005 ± 0.002
Lys	5.11LysAla: 5.11 ± 0.072	0.36LysCys: 0.36 ± 0.02	2.346LysAsp: 2.346 ± 0.043	3.095LysGlu: 3.095 ± 0.064	1.044LysPhe: 1.044 ± 0.028	3.559LysGly: 3.559 ± 0.054	0.711LysHis: 0.711 ± 0.022	2.037LysIle: 2.037 ± 0.038	2.545LysLys: 2.545 ± 0.058	4.416LysLeu: 4.416 ± 0.06	1.119LysMet: 1.119 ± 0.03	1.256LysAsn: 1.256 ± 0.031	2.528LysPro: 2.528 ± 0.041	1.383LysGln: 1.383 ± 0.036	2.723LysArg: 2.723 ± 0.046	2.008LysSer: 2.008 ± 0.041	2.087LysThr: 2.087 ± 0.042	3.52LysVal: 3.52 ± 0.056	0.426LysTrp: 0.426 ± 0.019	0.973LysTyr: 0.973 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	16.359LeuAla: 16.359 ± 0.183	1.352LeuCys: 1.352 ± 0.034	6.211LeuAsp: 6.211 ± 0.081	7.689LeuGlu: 7.689 ± 0.101	3.73LeuPhe: 3.73 ± 0.066	10.353LeuGly: 10.353 ± 0.107	1.95LeuHis: 1.95 ± 0.042	4.833LeuIle: 4.833 ± 0.062	5.167LeuLys: 5.167 ± 0.075	11.32LeuLeu: 11.32 ± 0.136	2.774LeuMet: 2.774 ± 0.047	3.141LeuAsn: 3.141 ± 0.048	5.878LeuPro: 5.878 ± 0.081	3.269LeuGln: 3.269 ± 0.055	6.854LeuArg: 6.854 ± 0.083	6.589LeuSer: 6.589 ± 0.087	5.203LeuThr: 5.203 ± 0.066	8.043LeuVal: 8.043 ± 0.09	1.506LeuTrp: 1.506 ± 0.037	2.439LeuTyr: 2.439 ± 0.042	0.003LeuXaa: 0.003 ± 0.002
Met	3.56MetAla: 3.56 ± 0.055	0.224MetCys: 0.224 ± 0.012	1.443MetAsp: 1.443 ± 0.035	1.725MetGlu: 1.725 ± 0.036	0.697MetPhe: 0.697 ± 0.028	2.308MetGly: 2.308 ± 0.049	0.445MetHis: 0.445 ± 0.02	1.184MetIle: 1.184 ± 0.034	1.186MetLys: 1.186 ± 0.032	2.524MetLeu: 2.524 ± 0.046	0.595MetMet: 0.595 ± 0.024	0.782MetAsn: 0.782 ± 0.024	1.438MetPro: 1.438 ± 0.035	0.874MetGln: 0.874 ± 0.025	1.639MetArg: 1.639 ± 0.038	1.503MetSer: 1.503 ± 0.035	1.266MetThr: 1.266 ± 0.033	1.997MetVal: 1.997 ± 0.045	0.192MetTrp: 0.192 ± 0.013	0.406MetTyr: 0.406 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	2.448AsnAla: 2.448 ± 0.046	0.356AsnCys: 0.356 ± 0.016	1.201AsnAsp: 1.201 ± 0.031	1.3AsnGlu: 1.3 ± 0.035	0.944AsnPhe: 0.944 ± 0.026	1.991AsnGly: 1.991 ± 0.049	0.595AsnHis: 0.595 ± 0.022	1.372AsnIle: 1.372 ± 0.035	1.037AsnLys: 1.037 ± 0.032	3.564AsnLeu: 3.564 ± 0.06	0.614AsnMet: 0.614 ± 0.02	0.759AsnAsn: 0.759 ± 0.026	1.961AsnPro: 1.961 ± 0.044	1.347AsnGln: 1.347 ± 0.039	1.801AsnArg: 1.801 ± 0.038	1.227AsnSer: 1.227 ± 0.032	1.103AsnThr: 1.103 ± 0.035	1.761AsnVal: 1.761 ± 0.041	0.397AsnTrp: 0.397 ± 0.019	0.859AsnTyr: 0.859 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.215ProAla: 6.215 ± 0.098	0.515ProCys: 0.515 ± 0.02	2.892ProAsp: 2.892 ± 0.048	4.179ProGlu: 4.179 ± 0.06	1.854ProPhe: 1.854 ± 0.039	5.167ProGly: 5.167 ± 0.078	1.022ProHis: 1.022 ± 0.033	1.763ProIle: 1.763 ± 0.038	1.946ProLys: 1.946 ± 0.045	5.285ProLeu: 5.285 ± 0.075	1.181ProMet: 1.181 ± 0.029	1.211ProAsn: 1.211 ± 0.032	3.091ProPro: 3.091 ± 0.059	2.43ProGln: 2.43 ± 0.049	3.089ProArg: 3.089 ± 0.054	2.513ProSer: 2.513 ± 0.046	1.863ProThr: 1.863 ± 0.041	3.757ProVal: 3.757 ± 0.054	0.79ProTrp: 0.79 ± 0.025	1.289ProTyr: 1.289 ± 0.035	0.002ProXaa: 0.002 ± 0.001
Gln	6.138GlnAla: 6.138 ± 0.09	0.416GlnCys: 0.416 ± 0.019	2.027GlnAsp: 2.027 ± 0.042	2.943GlnGlu: 2.943 ± 0.053	0.963GlnPhe: 0.963 ± 0.025	3.781GlnGly: 3.781 ± 0.059	0.546GlnHis: 0.546 ± 0.021	1.673GlnIle: 1.673 ± 0.036	1.709GlnLys: 1.709 ± 0.044	3.183GlnLeu: 3.183 ± 0.054	0.973GlnMet: 0.973 ± 0.025	0.989GlnAsn: 0.989 ± 0.029	1.954GlnPro: 1.954 ± 0.043	1.164GlnGln: 1.164 ± 0.035	2.696GlnArg: 2.696 ± 0.05	1.727GlnSer: 1.727 ± 0.041	1.703GlnThr: 1.703 ± 0.038	3.369GlnVal: 3.369 ± 0.055	0.48GlnTrp: 0.48 ± 0.019	0.817GlnTyr: 0.817 ± 0.027	0.002GlnXaa: 0.002 ± 0.001
Arg	6.743ArgAla: 6.743 ± 0.091	0.73ArgCys: 0.73 ± 0.025	3.305ArgAsp: 3.305 ± 0.046	4.857ArgGlu: 4.857 ± 0.073	2.608ArgPhe: 2.608 ± 0.046	4.738ArgGly: 4.738 ± 0.062	1.463ArgHis: 1.463 ± 0.037	2.937ArgIle: 2.937 ± 0.045	2.503ArgLys: 2.503 ± 0.049	8.915ArgLeu: 8.915 ± 0.126	1.504ArgMet: 1.504 ± 0.028	1.548ArgAsn: 1.548 ± 0.037	3.444ArgPro: 3.444 ± 0.06	3.204ArgGln: 3.204 ± 0.049	5.391ArgArg: 5.391 ± 0.078	2.875ArgSer: 2.875 ± 0.054	2.311ArgThr: 2.311 ± 0.044	4.758ArgVal: 4.758 ± 0.064	0.93ArgTrp: 0.93 ± 0.027	1.764ArgTyr: 1.764 ± 0.037	0.004ArgXaa: 0.004 ± 0.002
Ser	4.906SerAla: 4.906 ± 0.065	0.635SerCys: 0.635 ± 0.023	2.443SerAsp: 2.443 ± 0.044	2.753SerGlu: 2.753 ± 0.051	2.139SerPhe: 2.139 ± 0.045	5.026SerGly: 5.026 ± 0.064	1.167SerHis: 1.167 ± 0.031	2.085SerIle: 2.085 ± 0.042	1.733SerLys: 1.733 ± 0.04	6.756SerLeu: 6.756 ± 0.095	1.315SerMet: 1.315 ± 0.031	1.159SerAsn: 1.159 ± 0.035	2.967SerPro: 2.967 ± 0.052	2.5SerGln: 2.5 ± 0.051	3.569SerArg: 3.569 ± 0.054	2.603SerSer: 2.603 ± 0.042	1.952SerThr: 1.952 ± 0.042	3.251SerVal: 3.251 ± 0.054	0.793SerTrp: 0.793 ± 0.027	1.429SerTyr: 1.429 ± 0.037	0.004SerXaa: 0.004 ± 0.002
Thr	4.447ThrAla: 4.447 ± 0.062	0.591ThrCys: 0.591 ± 0.023	1.959ThrAsp: 1.959 ± 0.041	2.058ThrGlu: 2.058 ± 0.044	1.499ThrPhe: 1.499 ± 0.035	4.242ThrGly: 4.242 ± 0.065	0.895ThrHis: 0.895 ± 0.025	2.14ThrIle: 2.14 ± 0.051	1.535ThrLys: 1.535 ± 0.036	4.632ThrLeu: 4.632 ± 0.069	1.084ThrMet: 1.084 ± 0.031	1.164ThrAsn: 1.164 ± 0.036	2.764ThrPro: 2.764 ± 0.045	1.427ThrGln: 1.427 ± 0.032	2.439ThrArg: 2.439 ± 0.046	2.204ThrSer: 2.204 ± 0.041	2.051ThrThr: 2.051 ± 0.043	3.341ThrVal: 3.341 ± 0.06	0.569ThrTrp: 0.569 ± 0.026	1.196ThrTyr: 1.196 ± 0.034	0.001ThrXaa: 0.001 ± 0.001
Val	7.653ValAla: 7.653 ± 0.075	0.976ValCys: 0.976 ± 0.031	3.902ValAsp: 3.902 ± 0.063	4.946ValGlu: 4.946 ± 0.064	2.945ValPhe: 2.945 ± 0.053	5.495ValGly: 5.495 ± 0.077	1.235ValHis: 1.235 ± 0.034	3.725ValIle: 3.725 ± 0.057	3.114ValLys: 3.114 ± 0.052	7.725ValLeu: 7.725 ± 0.091	2.024ValMet: 2.024 ± 0.046	2.166ValAsn: 2.166 ± 0.044	3.005ValPro: 3.005 ± 0.051	2.014ValGln: 2.014 ± 0.041	4.502ValArg: 4.502 ± 0.062	4.238ValSer: 4.238 ± 0.053	3.382ValThr: 3.382 ± 0.058	5.987ValVal: 5.987 ± 0.094	0.879ValTrp: 0.879 ± 0.028	1.832ValTyr: 1.832 ± 0.037	0.003ValXaa: 0.003 ± 0.001
Trp	1.334TrpAla: 1.334 ± 0.04	0.152TrpCys: 0.152 ± 0.012	0.663TrpAsp: 0.663 ± 0.023	0.766TrpGlu: 0.766 ± 0.028	0.478TrpPhe: 0.478 ± 0.021	1.155TrpGly: 1.155 ± 0.034	0.278TrpHis: 0.278 ± 0.015	0.48TrpIle: 0.48 ± 0.02	0.422TrpLys: 0.422 ± 0.019	1.954TrpLeu: 1.954 ± 0.046	0.307TrpMet: 0.307 ± 0.015	0.36TrpAsn: 0.36 ± 0.017	0.763TrpPro: 0.763 ± 0.027	0.69TrpGln: 0.69 ± 0.026	1.25TrpArg: 1.25 ± 0.034	0.718TrpSer: 0.718 ± 0.023	0.503TrpThr: 0.503 ± 0.023	0.877TrpVal: 0.877 ± 0.026	0.249TrpTrp: 0.249 ± 0.015	0.274TrpTyr: 0.274 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.402TyrAla: 2.402 ± 0.042	0.371TyrCys: 0.371 ± 0.018	1.468TyrAsp: 1.468 ± 0.039	1.384TyrGlu: 1.384 ± 0.032	1.119TyrPhe: 1.119 ± 0.029	2.22TyrGly: 2.22 ± 0.044	0.64TyrHis: 0.64 ± 0.021	0.962TyrIle: 0.962 ± 0.031	0.976TyrLys: 0.976 ± 0.031	3.172TyrLeu: 3.172 ± 0.047	0.53TyrMet: 0.53 ± 0.02	0.75TyrAsn: 0.75 ± 0.026	1.296TyrPro: 1.296 ± 0.031	1.258TyrGln: 1.258 ± 0.031	1.864TyrArg: 1.864 ± 0.037	1.329TyrSer: 1.329 ± 0.034	1.101TyrThr: 1.101 ± 0.038	1.718TyrVal: 1.718 ± 0.042	0.417TyrTrp: 0.417 ± 0.017	0.901TyrTyr: 0.901 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.002XaaCys: 0.002 ± 0.001	0.006XaaAsp: 0.006 ± 0.003	0.001XaaGlu: 0.001 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.004XaaGly: 0.004 ± 0.002	0.002XaaHis: 0.002 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.003XaaSer: 0.003 ± 0.002	0.002XaaThr: 0.002 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.003XaaTrp: 0.003 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4217 proteins (1279174 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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