Amino acid dipepetide frequency for Aeoliella mucimassa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.242AlaAla: 11.242 ± 0.104	1.133AlaCys: 1.133 ± 0.027	6.223AlaAsp: 6.223 ± 0.063	7.398AlaGlu: 7.398 ± 0.084	3.07AlaPhe: 3.07 ± 0.045	7.982AlaGly: 7.982 ± 0.086	1.601AlaHis: 1.601 ± 0.032	5.471AlaIle: 5.471 ± 0.065	3.894AlaLys: 3.894 ± 0.055	8.348AlaLeu: 8.348 ± 0.087	2.818AlaMet: 2.818 ± 0.052	3.343AlaAsn: 3.343 ± 0.044	4.2AlaPro: 4.2 ± 0.063	3.177AlaGln: 3.177 ± 0.047	5.253AlaArg: 5.253 ± 0.062	6.638AlaSer: 6.638 ± 0.074	6.335AlaThr: 6.335 ± 0.073	6.994AlaVal: 6.994 ± 0.075	1.455AlaTrp: 1.455 ± 0.032	2.336AlaTyr: 2.336 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.758CysAla: 0.758 ± 0.023	0.292CysCys: 0.292 ± 0.028	0.73CysAsp: 0.73 ± 0.022	0.703CysGlu: 0.703 ± 0.022	0.398CysPhe: 0.398 ± 0.016	1.031CysGly: 1.031 ± 0.025	0.346CysHis: 0.346 ± 0.017	0.436CysIle: 0.436 ± 0.017	0.336CysLys: 0.336 ± 0.017	1.129CysLeu: 1.129 ± 0.023	0.237CysMet: 0.237 ± 0.011	0.334CysAsn: 0.334 ± 0.013	0.607CysPro: 0.607 ± 0.023	0.473CysGln: 0.473 ± 0.017	0.755CysArg: 0.755 ± 0.021	0.657CysSer: 0.657 ± 0.02	0.57CysThr: 0.57 ± 0.019	0.774CysVal: 0.774 ± 0.021	0.198CysTrp: 0.198 ± 0.011	0.374CysTyr: 0.374 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.561AspAla: 5.561 ± 0.061	0.632AspCys: 0.632 ± 0.019	4.128AspAsp: 4.128 ± 0.059	4.324AspGlu: 4.324 ± 0.052	2.443AspPhe: 2.443 ± 0.042	5.518AspGly: 5.518 ± 0.11	1.328AspHis: 1.328 ± 0.03	2.632AspIle: 2.632 ± 0.041	1.777AspLys: 1.777 ± 0.039	5.981AspLeu: 5.981 ± 0.07	1.137AspMet: 1.137 ± 0.025	2.004AspAsn: 2.004 ± 0.037	3.364AspPro: 3.364 ± 0.05	2.462AspGln: 2.462 ± 0.042	3.725AspArg: 3.725 ± 0.05	3.996AspSer: 3.996 ± 0.053	3.144AspThr: 3.144 ± 0.043	3.842AspVal: 3.842 ± 0.052	1.193AspTrp: 1.193 ± 0.026	2.174AspTyr: 2.174 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.282GluAla: 6.282 ± 0.064	0.602GluCys: 0.602 ± 0.02	2.815GluAsp: 2.815 ± 0.044	3.933GluGlu: 3.933 ± 0.068	2.389GluPhe: 2.389 ± 0.037	4.288GluGly: 4.288 ± 0.059	1.529GluHis: 1.529 ± 0.032	3.106GluIle: 3.106 ± 0.044	2.267GluLys: 2.267 ± 0.046	7.37GluLeu: 7.37 ± 0.079	1.634GluMet: 1.634 ± 0.03	1.943GluAsn: 1.943 ± 0.031	3.375GluPro: 3.375 ± 0.052	3.772GluGln: 3.772 ± 0.05	4.096GluArg: 4.096 ± 0.052	4.36GluSer: 4.36 ± 0.059	3.367GluThr: 3.367 ± 0.052	4.835GluVal: 4.835 ± 0.045	0.987GluTrp: 0.987 ± 0.023	1.742GluTyr: 1.742 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.777PheAla: 3.777 ± 0.047	0.451PheCys: 0.451 ± 0.017	2.919PheAsp: 2.919 ± 0.045	2.265PheGlu: 2.265 ± 0.033	1.194PhePhe: 1.194 ± 0.033	3.207PheGly: 3.207 ± 0.043	0.74PheHis: 0.74 ± 0.021	1.316PheIle: 1.316 ± 0.034	0.914PheLys: 0.914 ± 0.023	2.869PheLeu: 2.869 ± 0.045	0.649PheMet: 0.649 ± 0.02	1.2PheAsn: 1.2 ± 0.03	1.401PhePro: 1.401 ± 0.03	1.128PheGln: 1.128 ± 0.025	2.102PheArg: 2.102 ± 0.034	2.294PheSer: 2.294 ± 0.036	2.189PheThr: 2.189 ± 0.039	2.676PheVal: 2.676 ± 0.043	0.557PheTrp: 0.557 ± 0.02	1.036PheTyr: 1.036 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	6.084GlyAla: 6.084 ± 0.075	1.004GlyCys: 1.004 ± 0.026	5.361GlyAsp: 5.361 ± 0.115	5.119GlyGlu: 5.119 ± 0.061	2.951GlyPhe: 2.951 ± 0.044	6.662GlyGly: 6.662 ± 0.093	1.703GlyHis: 1.703 ± 0.031	3.932GlyIle: 3.932 ± 0.052	3.136GlyLys: 3.136 ± 0.052	6.817GlyLeu: 6.817 ± 0.071	2.022GlyMet: 2.022 ± 0.038	2.985GlyAsn: 2.985 ± 0.063	3.1GlyPro: 3.1 ± 0.046	3.058GlyGln: 3.058 ± 0.048	4.397GlyArg: 4.397 ± 0.06	5.392GlySer: 5.392 ± 0.078	4.995GlyThr: 4.995 ± 0.085	5.728GlyVal: 5.728 ± 0.056	1.463GlyTrp: 1.463 ± 0.033	2.491GlyTyr: 2.491 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.917HisAla: 1.917 ± 0.033	0.304HisCys: 0.304 ± 0.012	1.293HisAsp: 1.293 ± 0.027	1.303HisGlu: 1.303 ± 0.028	0.873HisPhe: 0.873 ± 0.024	1.717HisGly: 1.717 ± 0.029	0.682HisHis: 0.682 ± 0.02	0.84HisIle: 0.84 ± 0.021	0.54HisLys: 0.54 ± 0.017	2.26HisLeu: 2.26 ± 0.036	0.392HisMet: 0.392 ± 0.016	0.634HisAsn: 0.634 ± 0.018	1.311HisPro: 1.311 ± 0.029	0.958HisGln: 0.958 ± 0.022	1.575HisArg: 1.575 ± 0.031	1.29HisSer: 1.29 ± 0.027	1.068HisThr: 1.068 ± 0.025	1.465HisVal: 1.465 ± 0.029	0.443HisTrp: 0.443 ± 0.016	0.712HisTyr: 0.712 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.664IleAla: 5.664 ± 0.065	0.535IleCys: 0.535 ± 0.017	4.02IleAsp: 4.02 ± 0.05	3.825IleGlu: 3.825 ± 0.052	1.161IlePhe: 1.161 ± 0.028	3.977IleGly: 3.977 ± 0.052	0.962IleHis: 0.962 ± 0.022	1.626IleIle: 1.626 ± 0.036	1.315IleLys: 1.315 ± 0.03	3.379IleLeu: 3.379 ± 0.044	0.706IleMet: 0.706 ± 0.022	1.519IleAsn: 1.519 ± 0.035	2.129IlePro: 2.129 ± 0.035	1.399IleGln: 1.399 ± 0.03	2.88IleArg: 2.88 ± 0.04	2.748IleSer: 2.748 ± 0.04	2.89IleThr: 2.89 ± 0.047	3.786IleVal: 3.786 ± 0.046	0.562IleTrp: 0.562 ± 0.019	1.219IleTyr: 1.219 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.966LysAla: 2.966 ± 0.054	0.337LysCys: 0.337 ± 0.015	1.413LysAsp: 1.413 ± 0.033	1.777LysGlu: 1.777 ± 0.035	1.108LysPhe: 1.108 ± 0.028	1.87LysGly: 1.87 ± 0.034	0.835LysHis: 0.835 ± 0.02	1.551LysIle: 1.551 ± 0.034	1.512LysLys: 1.512 ± 0.045	3.948LysLeu: 3.948 ± 0.058	0.843LysMet: 0.843 ± 0.025	0.976LysAsn: 0.976 ± 0.026	2.026LysPro: 2.026 ± 0.038	1.879LysGln: 1.879 ± 0.036	2.176LysArg: 2.176 ± 0.039	2.124LysSer: 2.124 ± 0.039	1.828LysThr: 1.828 ± 0.032	2.451LysVal: 2.451 ± 0.038	0.509LysTrp: 0.509 ± 0.017	0.99LysTyr: 0.99 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.875LeuAla: 11.875 ± 0.107	1.051LeuCys: 1.051 ± 0.024	5.896LeuAsp: 5.896 ± 0.058	6.013LeuGlu: 6.013 ± 0.063	3.292LeuPhe: 3.292 ± 0.046	7.585LeuGly: 7.585 ± 0.078	2.023LeuHis: 2.023 ± 0.035	4.042LeuIle: 4.042 ± 0.045	3.166LeuLys: 3.166 ± 0.053	10.519LeuLeu: 10.519 ± 0.11	2.119LeuMet: 2.119 ± 0.036	2.955LeuAsn: 2.955 ± 0.045	5.408LeuPro: 5.408 ± 0.063	3.598LeuGln: 3.598 ± 0.055	5.944LeuArg: 5.944 ± 0.071	6.37LeuSer: 6.37 ± 0.071	5.699LeuThr: 5.699 ± 0.064	7.966LeuVal: 7.966 ± 0.083	1.346LeuTrp: 1.346 ± 0.028	2.267LeuTyr: 2.267 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.482MetAla: 2.482 ± 0.042	0.191MetCys: 0.191 ± 0.01	0.961MetAsp: 0.961 ± 0.024	1.149MetGlu: 1.149 ± 0.029	0.81MetPhe: 0.81 ± 0.023	1.525MetGly: 1.525 ± 0.034	0.517MetHis: 0.517 ± 0.016	1.099MetIle: 1.099 ± 0.028	0.825MetLys: 0.825 ± 0.022	2.589MetLeu: 2.589 ± 0.042	0.521MetMet: 0.521 ± 0.017	0.822MetAsn: 0.822 ± 0.022	1.45MetPro: 1.45 ± 0.027	1.074MetGln: 1.074 ± 0.027	1.358MetArg: 1.358 ± 0.03	1.539MetSer: 1.539 ± 0.029	1.306MetThr: 1.306 ± 0.029	1.767MetVal: 1.767 ± 0.033	0.267MetTrp: 0.267 ± 0.012	0.488MetTyr: 0.488 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.879AsnAla: 2.879 ± 0.039	0.383AsnCys: 0.383 ± 0.015	2.079AsnAsp: 2.079 ± 0.051	1.929AsnGlu: 1.929 ± 0.031	1.111AsnPhe: 1.111 ± 0.024	2.932AsnGly: 2.932 ± 0.058	0.749AsnHis: 0.749 ± 0.019	1.411AsnIle: 1.411 ± 0.033	0.927AsnLys: 0.927 ± 0.025	3.211AsnLeu: 3.211 ± 0.05	0.668AsnMet: 0.668 ± 0.019	1.314AsnAsn: 1.314 ± 0.037	1.951AsnPro: 1.951 ± 0.035	1.436AsnGln: 1.436 ± 0.027	2.165AsnArg: 2.165 ± 0.037	2.22AsnSer: 2.22 ± 0.039	1.959AsnThr: 1.959 ± 0.042	2.22AsnVal: 2.22 ± 0.046	0.65AsnTrp: 0.65 ± 0.02	1.088AsnTyr: 1.088 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.458ProAla: 5.458 ± 0.073	0.437ProCys: 0.437 ± 0.022	2.967ProAsp: 2.967 ± 0.038	4.131ProGlu: 4.131 ± 0.049	1.627ProPhe: 1.627 ± 0.029	3.875ProGly: 3.875 ± 0.054	1.08ProHis: 1.08 ± 0.027	2.253ProIle: 2.253 ± 0.036	1.749ProLys: 1.749 ± 0.031	4.545ProLeu: 4.545 ± 0.062	1.161ProMet: 1.161 ± 0.029	1.834ProAsn: 1.834 ± 0.035	2.673ProPro: 2.673 ± 0.054	2.024ProGln: 2.024 ± 0.037	2.533ProArg: 2.533 ± 0.045	3.433ProSer: 3.433 ± 0.049	3.457ProThr: 3.457 ± 0.05	3.772ProVal: 3.772 ± 0.047	0.731ProTrp: 0.731 ± 0.021	1.274ProTyr: 1.274 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.403GlnAla: 4.403 ± 0.059	0.353GlnCys: 0.353 ± 0.014	1.557GlnAsp: 1.557 ± 0.032	2.048GlnGlu: 2.048 ± 0.039	1.515GlnPhe: 1.515 ± 0.029	2.729GlnGly: 2.729 ± 0.04	0.979GlnHis: 0.979 ± 0.025	1.916GlnIle: 1.916 ± 0.035	1.172GlnLys: 1.172 ± 0.027	5.06GlnLeu: 5.06 ± 0.059	0.972GlnMet: 0.972 ± 0.025	1.084GlnAsn: 1.084 ± 0.023	2.342GlnPro: 2.342 ± 0.04	2.649GlnGln: 2.649 ± 0.055	2.629GlnArg: 2.629 ± 0.041	2.565GlnSer: 2.565 ± 0.041	2.102GlnThr: 2.102 ± 0.038	3.359GlnVal: 3.359 ± 0.044	0.672GlnTrp: 0.672 ± 0.02	1.043GlnTyr: 1.043 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.645ArgAla: 4.645 ± 0.064	0.666ArgCys: 0.666 ± 0.02	3.507ArgAsp: 3.507 ± 0.045	4.1ArgGlu: 4.1 ± 0.052	2.386ArgPhe: 2.386 ± 0.039	4.006ArgGly: 4.006 ± 0.058	1.303ArgHis: 1.303 ± 0.027	3.033ArgIle: 3.033 ± 0.04	2.175ArgLys: 2.175 ± 0.038	6.391ArgLeu: 6.391 ± 0.069	1.669ArgMet: 1.669 ± 0.029	1.878ArgAsn: 1.878 ± 0.029	2.749ArgPro: 2.749 ± 0.055	2.761ArgGln: 2.761 ± 0.045	4.484ArgArg: 4.484 ± 0.06	3.514ArgSer: 3.514 ± 0.042	3.2ArgThr: 3.2 ± 0.04	4.348ArgVal: 4.348 ± 0.051	1.19ArgTrp: 1.19 ± 0.029	1.852ArgTyr: 1.852 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.679SerAla: 5.679 ± 0.066	0.646SerCys: 0.646 ± 0.023	4.19SerAsp: 4.19 ± 0.045	3.81SerGlu: 3.81 ± 0.05	2.217SerPhe: 2.217 ± 0.036	5.643SerGly: 5.643 ± 0.08	1.411SerHis: 1.411 ± 0.027	3.273SerIle: 3.273 ± 0.044	2.064SerLys: 2.064 ± 0.035	6.663SerLeu: 6.663 ± 0.064	1.505SerMet: 1.505 ± 0.03	2.319SerAsn: 2.319 ± 0.04	3.581SerPro: 3.581 ± 0.049	2.657SerGln: 2.657 ± 0.038	3.596SerArg: 3.596 ± 0.049	4.62SerSer: 4.62 ± 0.072	4.35SerThr: 4.35 ± 0.055	4.383SerVal: 4.383 ± 0.057	0.938SerTrp: 0.938 ± 0.024	1.728SerTyr: 1.728 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.699ThrAla: 5.699 ± 0.055	0.639ThrCys: 0.639 ± 0.022	3.469ThrAsp: 3.469 ± 0.049	3.232ThrGlu: 3.232 ± 0.045	2.063ThrPhe: 2.063 ± 0.041	5.104ThrGly: 5.104 ± 0.073	1.158ThrHis: 1.158 ± 0.023	3.182ThrIle: 3.182 ± 0.048	1.864ThrLys: 1.864 ± 0.037	6.187ThrLeu: 6.187 ± 0.072	1.15ThrMet: 1.15 ± 0.025	2.181ThrAsn: 2.181 ± 0.041	3.694ThrPro: 3.694 ± 0.055	1.92ThrGln: 1.92 ± 0.032	2.818ThrArg: 2.818 ± 0.044	4.14ThrSer: 4.14 ± 0.055	4.061ThrThr: 4.061 ± 0.056	4.212ThrVal: 4.212 ± 0.059	0.929ThrTrp: 0.929 ± 0.026	1.612ThrTyr: 1.612 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.997ValAla: 7.997 ± 0.066	0.888ValCys: 0.888 ± 0.025	5.102ValAsp: 5.102 ± 0.062	5.142ValGlu: 5.142 ± 0.054	2.541ValPhe: 2.541 ± 0.04	5.521ValGly: 5.521 ± 0.055	1.474ValHis: 1.474 ± 0.025	3.453ValIle: 3.453 ± 0.043	2.081ValLys: 2.081 ± 0.037	7.229ValLeu: 7.229 ± 0.071	1.615ValMet: 1.615 ± 0.032	2.296ValAsn: 2.296 ± 0.041	3.67ValPro: 3.67 ± 0.05	2.434ValGln: 2.434 ± 0.034	4.207ValArg: 4.207 ± 0.047	4.508ValSer: 4.508 ± 0.055	4.333ValThr: 4.333 ± 0.056	6.558ValVal: 6.558 ± 0.08	1.137ValTrp: 1.137 ± 0.031	1.85ValTyr: 1.85 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.144TrpAla: 1.144 ± 0.026	0.224TrpCys: 0.224 ± 0.012	0.834TrpAsp: 0.834 ± 0.02	0.733TrpGlu: 0.733 ± 0.023	0.612TrpPhe: 0.612 ± 0.018	1.044TrpGly: 1.044 ± 0.025	0.468TrpHis: 0.468 ± 0.017	0.782TrpIle: 0.782 ± 0.02	0.666TrpLys: 0.666 ± 0.02	1.805TrpLeu: 1.805 ± 0.037	0.44TrpMet: 0.44 ± 0.015	0.653TrpAsn: 0.653 ± 0.02	0.743TrpPro: 0.743 ± 0.021	0.988TrpGln: 0.988 ± 0.026	1.15TrpArg: 1.15 ± 0.026	1.063TrpSer: 1.063 ± 0.025	0.91TrpThr: 0.91 ± 0.025	1.033TrpVal: 1.033 ± 0.025	0.347TrpTrp: 0.347 ± 0.017	0.435TrpTyr: 0.435 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.4TyrAla: 2.4 ± 0.034	0.369TyrCys: 0.369 ± 0.015	1.902TyrAsp: 1.902 ± 0.049	1.759TyrGlu: 1.759 ± 0.029	1.123TyrPhe: 1.123 ± 0.025	2.183TyrGly: 2.183 ± 0.04	0.692TyrHis: 0.692 ± 0.019	0.949TyrIle: 0.949 ± 0.023	0.738TyrLys: 0.738 ± 0.022	2.836TyrLeu: 2.836 ± 0.041	0.481TyrMet: 0.481 ± 0.017	1.005TyrAsn: 1.005 ± 0.027	1.237TyrPro: 1.237 ± 0.027	1.303TyrGln: 1.303 ± 0.028	2.013TyrArg: 2.013 ± 0.033	1.8TyrSer: 1.8 ± 0.028	1.553TyrThr: 1.553 ± 0.036	1.868TyrVal: 1.868 ± 0.03	0.499TyrTrp: 0.499 ± 0.019	1.023TyrTyr: 1.023 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5127 proteins (1840367 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---