Amino acid dipepetide frequency for Paenibacillus spiritus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.656AlaAla: 13.656 ± 0.231	0.779AlaCys: 0.779 ± 0.026	5.115AlaAsp: 5.115 ± 0.073	7.193AlaGlu: 7.193 ± 0.103	3.275AlaPhe: 3.275 ± 0.053	9.597AlaGly: 9.597 ± 0.144	1.384AlaHis: 1.384 ± 0.039	4.584AlaIle: 4.584 ± 0.063	3.947AlaLys: 3.947 ± 0.072	9.838AlaLeu: 9.838 ± 0.131	2.305AlaMet: 2.305 ± 0.043	2.302AlaAsn: 2.302 ± 0.056	3.741AlaPro: 3.741 ± 0.086	2.696AlaGln: 2.696 ± 0.048	4.919AlaArg: 4.919 ± 0.079	5.949AlaSer: 5.949 ± 0.09	3.492AlaThr: 3.492 ± 0.08	7.879AlaVal: 7.879 ± 0.101	1.034AlaTrp: 1.034 ± 0.034	2.934AlaTyr: 2.934 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.604CysAla: 0.604 ± 0.023	0.128CysCys: 0.128 ± 0.01	0.387CysAsp: 0.387 ± 0.019	0.458CysGlu: 0.458 ± 0.019	0.275CysPhe: 0.275 ± 0.014	0.882CysGly: 0.882 ± 0.035	0.161CysHis: 0.161 ± 0.013	0.434CysIle: 0.434 ± 0.017	0.249CysLys: 0.249 ± 0.014	0.82CysLeu: 0.82 ± 0.025	0.185CysMet: 0.185 ± 0.012	0.238CysAsn: 0.238 ± 0.013	0.404CysPro: 0.404 ± 0.019	0.198CysGln: 0.198 ± 0.014	0.637CysArg: 0.637 ± 0.027	0.507CysSer: 0.507 ± 0.02	0.376CysThr: 0.376 ± 0.019	0.438CysVal: 0.438 ± 0.02	0.097CysTrp: 0.097 ± 0.009	0.247CysTyr: 0.247 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.242AspAla: 4.242 ± 0.064	0.41AspCys: 0.41 ± 0.021	2.215AspAsp: 2.215 ± 0.047	3.679AspGlu: 3.679 ± 0.063	2.042AspPhe: 2.042 ± 0.042	4.421AspGly: 4.421 ± 0.067	0.956AspHis: 0.956 ± 0.028	3.236AspIle: 3.236 ± 0.058	2.513AspLys: 2.513 ± 0.058	5.117AspLeu: 5.117 ± 0.068	1.266AspMet: 1.266 ± 0.035	1.656AspAsn: 1.656 ± 0.048	2.494AspPro: 2.494 ± 0.049	1.518AspGln: 1.518 ± 0.037	3.484AspArg: 3.484 ± 0.056	2.956AspSer: 2.956 ± 0.059	2.532AspThr: 2.532 ± 0.046	3.124AspVal: 3.124 ± 0.06	0.793AspTrp: 0.793 ± 0.027	2.14AspTyr: 2.14 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.467GluAla: 7.467 ± 0.101	0.411GluCys: 0.411 ± 0.021	3.255GluAsp: 3.255 ± 0.052	6.39GluGlu: 6.39 ± 0.1	2.126GluPhe: 2.126 ± 0.051	5.138GluGly: 5.138 ± 0.08	1.331GluHis: 1.331 ± 0.039	4.182GluIle: 4.182 ± 0.075	3.419GluLys: 3.419 ± 0.059	7.705GluLeu: 7.705 ± 0.091	1.958GluMet: 1.958 ± 0.046	2.339GluAsn: 2.339 ± 0.055	2.672GluPro: 2.672 ± 0.054	3.032GluGln: 3.032 ± 0.059	4.974GluArg: 4.974 ± 0.087	3.602GluSer: 3.602 ± 0.062	3.359GluThr: 3.359 ± 0.056	4.445GluVal: 4.445 ± 0.07	0.913GluTrp: 0.913 ± 0.026	1.967GluTyr: 1.967 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.271PheAla: 3.271 ± 0.059	0.357PheCys: 0.357 ± 0.017	2.073PheAsp: 2.073 ± 0.043	2.091PheGlu: 2.091 ± 0.044	1.515PhePhe: 1.515 ± 0.04	3.283PheGly: 3.283 ± 0.055	0.73PheHis: 0.73 ± 0.027	2.239PheIle: 2.239 ± 0.05	1.552PheLys: 1.552 ± 0.037	3.474PheLeu: 3.474 ± 0.067	0.99PheMet: 0.99 ± 0.03	1.417PheAsn: 1.417 ± 0.036	1.438PhePro: 1.438 ± 0.037	1.135PheGln: 1.135 ± 0.03	2.373PheArg: 2.373 ± 0.046	2.452PheSer: 2.452 ± 0.05	2.16PheThr: 2.16 ± 0.045	2.53PheVal: 2.53 ± 0.051	0.44PheTrp: 0.44 ± 0.017	1.355PheTyr: 1.355 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.98GlyAla: 6.98 ± 0.096	0.801GlyCys: 0.801 ± 0.022	3.984GlyAsp: 3.984 ± 0.057	5.606GlyGlu: 5.606 ± 0.07	3.151GlyPhe: 3.151 ± 0.054	7.107GlyGly: 7.107 ± 0.114	1.521GlyHis: 1.521 ± 0.035	5.409GlyIle: 5.409 ± 0.073	3.978GlyLys: 3.978 ± 0.068	8.266GlyLeu: 8.266 ± 0.1	2.433GlyMet: 2.433 ± 0.048	2.612GlyAsn: 2.612 ± 0.057	2.513GlyPro: 2.513 ± 0.055	2.774GlyGln: 2.774 ± 0.055	5.477GlyArg: 5.477 ± 0.086	5.836GlySer: 5.836 ± 0.108	4.954GlyThr: 4.954 ± 0.091	5.641GlyVal: 5.641 ± 0.065	1.12GlyTrp: 1.12 ± 0.035	3.021GlyTyr: 3.021 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.463HisAla: 1.463 ± 0.034	0.164HisCys: 0.164 ± 0.013	0.862HisAsp: 0.862 ± 0.028	1.107HisGlu: 1.107 ± 0.032	0.834HisPhe: 0.834 ± 0.024	1.449HisGly: 1.449 ± 0.038	0.479HisHis: 0.479 ± 0.022	1.098HisIle: 1.098 ± 0.029	0.665HisLys: 0.665 ± 0.025	1.94HisLeu: 1.94 ± 0.054	0.48HisMet: 0.48 ± 0.018	0.61HisAsn: 0.61 ± 0.023	1.236HisPro: 1.236 ± 0.036	0.584HisGln: 0.584 ± 0.021	1.182HisArg: 1.182 ± 0.032	1.16HisSer: 1.16 ± 0.035	1.007HisThr: 1.007 ± 0.029	1.186HisVal: 1.186 ± 0.03	0.252HisTrp: 0.252 ± 0.015	0.772HisTyr: 0.772 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.77IleAla: 5.77 ± 0.076	0.552IleCys: 0.552 ± 0.023	3.189IleAsp: 3.189 ± 0.052	3.63IleGlu: 3.63 ± 0.067	1.875IlePhe: 1.875 ± 0.048	5.069IleGly: 5.069 ± 0.065	1.181IleHis: 1.181 ± 0.035	3.095IleIle: 3.095 ± 0.051	2.346IleLys: 2.346 ± 0.049	5.137IleLeu: 5.137 ± 0.073	1.238IleMet: 1.238 ± 0.034	1.891IleAsn: 1.891 ± 0.046	2.738IlePro: 2.738 ± 0.05	2.044IleGln: 2.044 ± 0.042	3.941IleArg: 3.941 ± 0.061	3.635IleSer: 3.635 ± 0.059	3.144IleThr: 3.144 ± 0.057	4.32IleVal: 4.32 ± 0.065	0.575IleTrp: 0.575 ± 0.02	1.812IleTyr: 1.812 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	3.961LysAla: 3.961 ± 0.071	0.234LysCys: 0.234 ± 0.014	2.513LysAsp: 2.513 ± 0.053	3.678LysGlu: 3.678 ± 0.063	1.286LysPhe: 1.286 ± 0.038	3.255LysGly: 3.255 ± 0.059	0.823LysHis: 0.823 ± 0.026	2.529LysIle: 2.529 ± 0.055	2.594LysLys: 2.594 ± 0.062	4.836LysLeu: 4.836 ± 0.066	1.247LysMet: 1.247 ± 0.036	1.755LysAsn: 1.755 ± 0.041	2.097LysPro: 2.097 ± 0.048	1.741LysGln: 1.741 ± 0.039	2.675LysArg: 2.675 ± 0.049	2.618LysSer: 2.618 ± 0.047	2.677LysThr: 2.677 ± 0.052	2.99LysVal: 2.99 ± 0.058	0.563LysTrp: 0.563 ± 0.021	1.565LysTyr: 1.565 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	10.077LeuAla: 10.077 ± 0.126	0.811LeuCys: 0.811 ± 0.028	5.425LeuAsp: 5.425 ± 0.081	7.01LeuGlu: 7.01 ± 0.093	4.086LeuPhe: 4.086 ± 0.076	7.663LeuGly: 7.663 ± 0.089	2.045LeuHis: 2.045 ± 0.049	5.781LeuIle: 5.781 ± 0.083	4.921LeuLys: 4.921 ± 0.057	12.231LeuLeu: 12.231 ± 0.182	2.55LeuMet: 2.55 ± 0.056	3.653LeuAsn: 3.653 ± 0.065	5.127LeuPro: 5.127 ± 0.083	3.484LeuGln: 3.484 ± 0.056	6.351LeuArg: 6.351 ± 0.097	6.957LeuSer: 6.957 ± 0.081	5.801LeuThr: 5.801 ± 0.081	6.287LeuVal: 6.287 ± 0.073	1.03LeuTrp: 1.03 ± 0.036	3.308LeuTyr: 3.308 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.334MetAla: 2.334 ± 0.051	0.154MetCys: 0.154 ± 0.011	1.451MetAsp: 1.451 ± 0.036	1.886MetGlu: 1.886 ± 0.041	0.823MetPhe: 0.823 ± 0.025	1.659MetGly: 1.659 ± 0.036	0.373MetHis: 0.373 ± 0.017	1.578MetIle: 1.578 ± 0.04	1.752MetLys: 1.752 ± 0.036	2.744MetLeu: 2.744 ± 0.052	0.764MetMet: 0.764 ± 0.028	1.378MetAsn: 1.378 ± 0.035	1.076MetPro: 1.076 ± 0.031	0.842MetGln: 0.842 ± 0.026	1.393MetArg: 1.393 ± 0.033	1.599MetSer: 1.599 ± 0.039	1.563MetThr: 1.563 ± 0.036	1.477MetVal: 1.477 ± 0.038	0.171MetTrp: 0.171 ± 0.012	0.665MetTyr: 0.665 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.823AsnAla: 2.823 ± 0.05	0.231AsnCys: 0.231 ± 0.015	1.608AsnAsp: 1.608 ± 0.034	2.161AsnGlu: 2.161 ± 0.048	1.14AsnPhe: 1.14 ± 0.031	3.038AsnGly: 3.038 ± 0.062	0.708AsnHis: 0.708 ± 0.026	1.865AsnIle: 1.865 ± 0.046	1.574AsnLys: 1.574 ± 0.042	3.191AsnLeu: 3.191 ± 0.054	0.83AsnMet: 0.83 ± 0.025	1.328AsnAsn: 1.328 ± 0.051	1.949AsnPro: 1.949 ± 0.042	1.142AsnGln: 1.142 ± 0.035	2.332AsnArg: 2.332 ± 0.046	1.836AsnSer: 1.836 ± 0.051	1.724AsnThr: 1.724 ± 0.042	2.238AsnVal: 2.238 ± 0.052	0.463AsnTrp: 0.463 ± 0.019	1.172AsnTyr: 1.172 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.037ProAla: 5.037 ± 0.105	0.278ProCys: 0.278 ± 0.015	2.802ProAsp: 2.802 ± 0.048	3.99ProGlu: 3.99 ± 0.066	1.717ProPhe: 1.717 ± 0.04	4.159ProGly: 4.159 ± 0.064	0.748ProHis: 0.748 ± 0.024	1.875ProIle: 1.875 ± 0.043	1.716ProLys: 1.716 ± 0.039	4.348ProLeu: 4.348 ± 0.06	0.928ProMet: 0.928 ± 0.031	1.246ProAsn: 1.246 ± 0.032	1.602ProPro: 1.602 ± 0.048	1.47ProGln: 1.47 ± 0.036	1.827ProArg: 1.827 ± 0.041	2.756ProSer: 2.756 ± 0.066	1.704ProThr: 1.704 ± 0.056	3.7ProVal: 3.7 ± 0.059	0.499ProTrp: 0.499 ± 0.022	1.498ProTyr: 1.498 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.477GlnAla: 3.477 ± 0.061	0.181GlnCys: 0.181 ± 0.013	1.482GlnAsp: 1.482 ± 0.033	2.505GlnGlu: 2.505 ± 0.048	1.194GlnPhe: 1.194 ± 0.03	2.587GlnGly: 2.587 ± 0.053	0.585GlnHis: 0.585 ± 0.024	2.012GlnIle: 2.012 ± 0.044	1.592GlnLys: 1.592 ± 0.04	3.358GlnLeu: 3.358 ± 0.062	1.005GlnMet: 1.005 ± 0.031	1.111GlnAsn: 1.111 ± 0.032	1.502GlnPro: 1.502 ± 0.036	1.383GlnGln: 1.383 ± 0.039	2.004GlnArg: 2.004 ± 0.047	2.014GlnSer: 2.014 ± 0.046	1.776GlnThr: 1.776 ± 0.044	2.127GlnVal: 2.127 ± 0.041	0.414GlnTrp: 0.414 ± 0.018	1.167GlnTyr: 1.167 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.544ArgAla: 4.544 ± 0.065	0.453ArgCys: 0.453 ± 0.024	2.871ArgAsp: 2.871 ± 0.051	5.079ArgGlu: 5.079 ± 0.087	2.367ArgPhe: 2.367 ± 0.049	4.107ArgGly: 4.107 ± 0.071	1.322ArgHis: 1.322 ± 0.035	4.06ArgIle: 4.06 ± 0.068	2.818ArgLys: 2.818 ± 0.054	7.174ArgLeu: 7.174 ± 0.106	1.876ArgMet: 1.876 ± 0.043	1.959ArgAsn: 1.959 ± 0.042	2.464ArgPro: 2.464 ± 0.058	2.341ArgGln: 2.341 ± 0.048	4.695ArgArg: 4.695 ± 0.095	4.096ArgSer: 4.096 ± 0.061	3.368ArgThr: 3.368 ± 0.052	3.732ArgVal: 3.732 ± 0.059	0.758ArgTrp: 0.758 ± 0.026	2.24ArgTyr: 2.24 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.203SerAla: 6.203 ± 0.108	0.445SerCys: 0.445 ± 0.019	3.027SerAsp: 3.027 ± 0.051	3.724SerGlu: 3.724 ± 0.063	2.644SerPhe: 2.644 ± 0.05	6.63SerGly: 6.63 ± 0.087	1.058SerHis: 1.058 ± 0.033	3.549SerIle: 3.549 ± 0.069	2.567SerLys: 2.567 ± 0.047	6.591SerLeu: 6.591 ± 0.088	1.552SerMet: 1.552 ± 0.033	1.861SerAsn: 1.861 ± 0.058	2.881SerPro: 2.881 ± 0.06	1.839SerGln: 1.839 ± 0.043	3.989SerArg: 3.989 ± 0.06	4.259SerSer: 4.259 ± 0.083	2.783SerThr: 2.783 ± 0.054	4.617SerVal: 4.617 ± 0.085	0.743SerTrp: 0.743 ± 0.024	2.049SerTyr: 2.049 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.452ThrAla: 5.452 ± 0.099	0.308ThrCys: 0.308 ± 0.017	2.736ThrAsp: 2.736 ± 0.058	3.3ThrGlu: 3.3 ± 0.05	2.003ThrPhe: 2.003 ± 0.047	5.089ThrGly: 5.089 ± 0.069	0.903ThrHis: 0.903 ± 0.026	2.823ThrIle: 2.823 ± 0.056	1.928ThrLys: 1.928 ± 0.048	5.538ThrLeu: 5.538 ± 0.082	1.143ThrMet: 1.143 ± 0.033	1.58ThrAsn: 1.58 ± 0.045	2.715ThrPro: 2.715 ± 0.063	1.299ThrGln: 1.299 ± 0.038	2.593ThrArg: 2.593 ± 0.051	2.962ThrSer: 2.962 ± 0.055	2.54ThrThr: 2.54 ± 0.069	4.68ThrVal: 4.68 ± 0.079	0.551ThrTrp: 0.551 ± 0.022	1.725ThrTyr: 1.725 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	5.543ValAla: 5.543 ± 0.075	0.651ValCys: 0.651 ± 0.024	3.345ValAsp: 3.345 ± 0.06	4.152ValGlu: 4.152 ± 0.063	2.682ValPhe: 2.682 ± 0.052	4.491ValGly: 4.491 ± 0.089	1.332ValHis: 1.332 ± 0.032	4.246ValIle: 4.246 ± 0.066	3.39ValLys: 3.39 ± 0.058	7.642ValLeu: 7.642 ± 0.1	1.786ValMet: 1.786 ± 0.038	2.516ValAsn: 2.516 ± 0.05	3.321ValPro: 3.321 ± 0.058	2.44ValGln: 2.44 ± 0.038	4.324ValArg: 4.324 ± 0.065	4.837ValSer: 4.837 ± 0.07	4.336ValThr: 4.336 ± 0.08	4.724ValVal: 4.724 ± 0.073	0.847ValTrp: 0.847 ± 0.029	2.405ValTyr: 2.405 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.837TrpAla: 0.837 ± 0.025	0.092TrpCys: 0.092 ± 0.009	0.581TrpAsp: 0.581 ± 0.022	0.788TrpGlu: 0.788 ± 0.027	0.486TrpPhe: 0.486 ± 0.019	0.809TrpGly: 0.809 ± 0.023	0.214TrpHis: 0.214 ± 0.013	0.76TrpIle: 0.76 ± 0.024	0.627TrpLys: 0.627 ± 0.025	1.364TrpLeu: 1.364 ± 0.038	0.381TrpMet: 0.381 ± 0.018	0.621TrpAsn: 0.621 ± 0.023	0.357TrpPro: 0.357 ± 0.019	0.43TrpGln: 0.43 ± 0.019	0.72TrpArg: 0.72 ± 0.026	0.84TrpSer: 0.84 ± 0.028	0.691TrpThr: 0.691 ± 0.028	0.724TrpVal: 0.724 ± 0.024	0.157TrpTrp: 0.157 ± 0.011	0.349TrpTyr: 0.349 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.878TyrAla: 2.878 ± 0.053	0.282TyrCys: 0.282 ± 0.017	1.873TyrAsp: 1.873 ± 0.05	2.258TyrGlu: 2.258 ± 0.051	1.356TyrPhe: 1.356 ± 0.032	2.755TyrGly: 2.755 ± 0.048	0.676TyrHis: 0.676 ± 0.023	1.833TyrIle: 1.833 ± 0.04	1.486TyrLys: 1.486 ± 0.039	3.285TyrLeu: 3.285 ± 0.06	0.765TyrMet: 0.765 ± 0.022	1.28TyrAsn: 1.28 ± 0.041	1.571TyrPro: 1.571 ± 0.035	1.084TyrGln: 1.084 ± 0.032	2.432TyrArg: 2.432 ± 0.051	2.14TyrSer: 2.14 ± 0.049	1.881TyrThr: 1.881 ± 0.048	2.151TyrVal: 2.151 ± 0.041	0.405TyrTrp: 0.405 ± 0.019	1.328TyrTyr: 1.328 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3778 proteins (1245279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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