Amino acid dipepetide frequency for Halobonum sp. Gai3-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.525AlaAla: 13.525 ± 0.169
0.716AlaCys: 0.716 ± 0.031
10.129AlaAsp: 10.129 ± 0.126
9.086AlaGlu: 9.086 ± 0.112
4.013AlaPhe: 4.013 ± 0.066
10.409AlaGly: 10.409 ± 0.123
1.899AlaHis: 1.899 ± 0.043
4.317AlaIle: 4.317 ± 0.076
1.698AlaLys: 1.698 ± 0.042
10.542AlaLeu: 10.542 ± 0.125
2.135AlaMet: 2.135 ± 0.046
2.462AlaAsn: 2.462 ± 0.05
4.048AlaPro: 4.048 ± 0.059
1.916AlaGln: 1.916 ± 0.038
6.392AlaArg: 6.392 ± 0.077
5.366AlaSer: 5.366 ± 0.077
6.808AlaThr: 6.808 ± 0.072
10.756AlaVal: 10.756 ± 0.115
1.13AlaTrp: 1.13 ± 0.032
2.705AlaTyr: 2.705 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.608CysAla: 0.608 ± 0.027
0.08CysCys: 0.08 ± 0.008
0.571CysAsp: 0.571 ± 0.024
0.639CysGlu: 0.639 ± 0.026
0.192CysPhe: 0.192 ± 0.012
0.831CysGly: 0.831 ± 0.03
0.196CysHis: 0.196 ± 0.014
0.259CysIle: 0.259 ± 0.014
0.099CysLys: 0.099 ± 0.009
0.533CysLeu: 0.533 ± 0.023
0.101CysMet: 0.101 ± 0.011
0.176CysAsn: 0.176 ± 0.011
0.513CysPro: 0.513 ± 0.022
0.135CysGln: 0.135 ± 0.011
0.453CysArg: 0.453 ± 0.02
0.407CysSer: 0.407 ± 0.016
0.396CysThr: 0.396 ± 0.02
0.528CysVal: 0.528 ± 0.023
0.085CysTrp: 0.085 ± 0.008
0.193CysTyr: 0.193 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
10.374AspAla: 10.374 ± 0.114
0.62AspCys: 0.62 ± 0.025
7.405AspAsp: 7.405 ± 0.107
8.07AspGlu: 8.07 ± 0.111
1.958AspPhe: 1.958 ± 0.05
8.811AspGly: 8.811 ± 0.14
1.751AspHis: 1.751 ± 0.042
2.66AspIle: 2.66 ± 0.054
0.855AspLys: 0.855 ± 0.031
7.263AspLeu: 7.263 ± 0.094
1.244AspMet: 1.244 ± 0.035
1.163AspAsn: 1.163 ± 0.037
4.79AspPro: 4.79 ± 0.073
1.505AspGln: 1.505 ± 0.035
6.376AspArg: 6.376 ± 0.088
3.541AspSer: 3.541 ± 0.065
3.947AspThr: 3.947 ± 0.074
8.315AspVal: 8.315 ± 0.109
1.03AspTrp: 1.03 ± 0.031
1.811AspTyr: 1.811 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
8.74GluAla: 8.74 ± 0.105
0.547GluCys: 0.547 ± 0.026
5.604GluAsp: 5.604 ± 0.095
7.384GluGlu: 7.384 ± 0.124
3.23GluPhe: 3.23 ± 0.051
6.327GluGly: 6.327 ± 0.086
2.221GluHis: 2.221 ± 0.044
3.083GluIle: 3.083 ± 0.057
1.599GluLys: 1.599 ± 0.043
7.651GluLeu: 7.651 ± 0.106
1.803GluMet: 1.803 ± 0.039
2.192GluAsn: 2.192 ± 0.05
3.981GluPro: 3.981 ± 0.067
2.264GluGln: 2.264 ± 0.052
7.741GluArg: 7.741 ± 0.105
4.783GluSer: 4.783 ± 0.077
5.687GluThr: 5.687 ± 0.085
6.195GluVal: 6.195 ± 0.087
1.188GluTrp: 1.188 ± 0.034
2.798GluTyr: 2.798 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.902PheAla: 3.902 ± 0.064
0.246PheCys: 0.246 ± 0.016
3.352PheAsp: 3.352 ± 0.056
3.057PheGlu: 3.057 ± 0.06
1.03PhePhe: 1.03 ± 0.036
3.398PheGly: 3.398 ± 0.065
0.686PheHis: 0.686 ± 0.027
1.029PheIle: 1.029 ± 0.033
0.476PheLys: 0.476 ± 0.019
2.998PheLeu: 2.998 ± 0.065
0.485PheMet: 0.485 ± 0.021
0.697PheAsn: 0.697 ± 0.024
1.532PhePro: 1.532 ± 0.032
0.751PheGln: 0.751 ± 0.027
1.962PheArg: 1.962 ± 0.042
1.821PheSer: 1.821 ± 0.04
1.985PheThr: 1.985 ± 0.044
3.311PheVal: 3.311 ± 0.064
0.395PheTrp: 0.395 ± 0.019
0.85PheTyr: 0.85 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
8.8GlyAla: 8.8 ± 0.099
0.756GlyCys: 0.756 ± 0.029
7.179GlyAsp: 7.179 ± 0.104
7.725GlyGlu: 7.725 ± 0.097
3.316GlyPhe: 3.316 ± 0.061
8.548GlyGly: 8.548 ± 0.114
1.744GlyHis: 1.744 ± 0.047
3.902GlyIle: 3.902 ± 0.064
1.79GlyLys: 1.79 ± 0.041
7.691GlyLeu: 7.691 ± 0.094
1.903GlyMet: 1.903 ± 0.044
2.283GlyAsn: 2.283 ± 0.053
3.689GlyPro: 3.689 ± 0.06
1.88GlyGln: 1.88 ± 0.045
5.631GlyArg: 5.631 ± 0.071
5.319GlySer: 5.319 ± 0.07
6.482GlyThr: 6.482 ± 0.097
8.459GlyVal: 8.459 ± 0.099
1.193GlyTrp: 1.193 ± 0.033
2.795GlyTyr: 2.795 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.142HisAla: 2.142 ± 0.049
0.188HisCys: 0.188 ± 0.014
1.878HisAsp: 1.878 ± 0.038
1.739HisGlu: 1.739 ± 0.043
0.581HisPhe: 0.581 ± 0.021
2.058HisGly: 2.058 ± 0.044
0.541HisHis: 0.541 ± 0.027
0.588HisIle: 0.588 ± 0.019
0.284HisLys: 0.284 ± 0.016
1.822HisLeu: 1.822 ± 0.043
0.279HisMet: 0.279 ± 0.018
0.428HisAsn: 0.428 ± 0.02
1.289HisPro: 1.289 ± 0.037
0.436HisGln: 0.436 ± 0.017
1.33HisArg: 1.33 ± 0.035
0.849HisSer: 0.849 ± 0.029
1.044HisThr: 1.044 ± 0.035
2.03HisVal: 2.03 ± 0.046
0.254HisTrp: 0.254 ± 0.016
0.561HisTyr: 0.561 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
4.129IleAla: 4.129 ± 0.063
0.23IleCys: 0.23 ± 0.014
3.281IleAsp: 3.281 ± 0.059
3.542IleGlu: 3.542 ± 0.063
0.807IlePhe: 0.807 ± 0.03
3.464IleGly: 3.464 ± 0.062
0.766IleHis: 0.766 ± 0.027
1.113IleIle: 1.113 ± 0.041
0.576IleLys: 0.576 ± 0.021
2.64IleLeu: 2.64 ± 0.055
0.461IleMet: 0.461 ± 0.021
0.814IleAsn: 0.814 ± 0.028
1.908IlePro: 1.908 ± 0.038
0.881IleGln: 0.881 ± 0.033
2.353IleArg: 2.353 ± 0.043
1.88IleSer: 1.88 ± 0.044
2.105IleThr: 2.105 ± 0.048
3.394IleVal: 3.394 ± 0.072
0.303IleTrp: 0.303 ± 0.018
0.741IleTyr: 0.741 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
1.571LysAla: 1.571 ± 0.043
0.111LysCys: 0.111 ± 0.01
0.976LysAsp: 0.976 ± 0.032
1.22LysGlu: 1.22 ± 0.03
0.521LysPhe: 0.521 ± 0.021
1.301LysGly: 1.301 ± 0.036
0.431LysHis: 0.431 ± 0.02
0.59LysIle: 0.59 ± 0.022
0.451LysLys: 0.451 ± 0.022
1.621LysLeu: 1.621 ± 0.044
0.33LysMet: 0.33 ± 0.02
0.467LysAsn: 0.467 ± 0.021
0.874LysPro: 0.874 ± 0.03
0.601LysGln: 0.601 ± 0.026
1.578LysArg: 1.578 ± 0.042
0.998LysSer: 0.998 ± 0.033
1.122LysThr: 1.122 ± 0.036
1.235LysVal: 1.235 ± 0.036
0.224LysTrp: 0.224 ± 0.015
0.562LysTyr: 0.562 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
11.47LeuAla: 11.47 ± 0.128
0.585LeuCys: 0.585 ± 0.021
7.685LeuAsp: 7.685 ± 0.094
6.477LeuGlu: 6.477 ± 0.081
3.168LeuPhe: 3.168 ± 0.063
8.012LeuGly: 8.012 ± 0.118
1.624LeuHis: 1.624 ± 0.041
2.539LeuIle: 2.539 ± 0.058
1.46LeuLys: 1.46 ± 0.042
8.888LeuLeu: 8.888 ± 0.136
1.323LeuMet: 1.323 ± 0.035
1.806LeuAsn: 1.806 ± 0.041
4.338LeuPro: 4.338 ± 0.065
1.863LeuGln: 1.863 ± 0.043
5.891LeuArg: 5.891 ± 0.077
5.468LeuSer: 5.468 ± 0.075
5.172LeuThr: 5.172 ± 0.061
8.944LeuVal: 8.944 ± 0.108
0.872LeuTrp: 0.872 ± 0.03
2.21LeuTyr: 2.21 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
1.914MetAla: 1.914 ± 0.046
0.108MetCys: 0.108 ± 0.011
1.332MetAsp: 1.332 ± 0.031
1.133MetGlu: 1.133 ± 0.033
0.573MetPhe: 0.573 ± 0.023
1.498MetGly: 1.498 ± 0.043
0.351MetHis: 0.351 ± 0.018
0.557MetIle: 0.557 ± 0.023
0.447MetLys: 0.447 ± 0.022
1.558MetLeu: 1.558 ± 0.043
0.34MetMet: 0.34 ± 0.019
0.6MetAsn: 0.6 ± 0.021
0.852MetPro: 0.852 ± 0.028
0.45MetGln: 0.45 ± 0.021
1.217MetArg: 1.217 ± 0.037
1.47MetSer: 1.47 ± 0.036
1.424MetThr: 1.424 ± 0.033
1.336MetVal: 1.336 ± 0.033
0.18MetTrp: 0.18 ± 0.014
0.439MetTyr: 0.439 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.616AsnAla: 2.616 ± 0.051
0.222AsnCys: 0.222 ± 0.015
1.649AsnAsp: 1.649 ± 0.04
1.725AsnGlu: 1.725 ± 0.044
0.652AsnPhe: 0.652 ± 0.024
2.179AsnGly: 2.179 ± 0.057
0.518AsnHis: 0.518 ± 0.024
0.746AsnIle: 0.746 ± 0.024
0.361AsnLys: 0.361 ± 0.02
1.94AsnLeu: 1.94 ± 0.04
0.416AsnMet: 0.416 ± 0.017
0.56AsnAsn: 0.56 ± 0.025
1.57AsnPro: 1.57 ± 0.035
0.622AsnGln: 0.622 ± 0.024
1.589AsnArg: 1.589 ± 0.036
1.091AsnSer: 1.091 ± 0.033
1.246AsnThr: 1.246 ± 0.034
2.457AsnVal: 2.457 ± 0.053
0.342AsnTrp: 0.342 ± 0.018
0.646AsnTyr: 0.646 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
4.827ProAla: 4.827 ± 0.07
0.229ProCys: 0.229 ± 0.015
4.935ProAsp: 4.935 ± 0.062
4.576ProGlu: 4.576 ± 0.068
1.77ProPhe: 1.77 ± 0.043
4.24ProGly: 4.24 ± 0.058
0.944ProHis: 0.944 ± 0.027
1.712ProIle: 1.712 ± 0.041
0.834ProLys: 0.834 ± 0.027
3.88ProLeu: 3.88 ± 0.058
0.925ProMet: 0.925 ± 0.026
1.215ProAsn: 1.215 ± 0.034
2.324ProPro: 2.324 ± 0.051
0.921ProGln: 0.921 ± 0.036
2.44ProArg: 2.44 ± 0.051
2.705ProSer: 2.705 ± 0.051
3.391ProThr: 3.391 ± 0.07
4.366ProVal: 4.366 ± 0.064
0.559ProTrp: 0.559 ± 0.023
1.218ProTyr: 1.218 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.066GlnAla: 2.066 ± 0.043
0.162GlnCys: 0.162 ± 0.011
1.21GlnAsp: 1.21 ± 0.031
1.624GlnGlu: 1.624 ± 0.04
0.996GlnPhe: 0.996 ± 0.027
1.624GlnGly: 1.624 ± 0.042
0.516GlnHis: 0.516 ± 0.02
0.856GlnIle: 0.856 ± 0.028
0.476GlnLys: 0.476 ± 0.021
2.121GlnLeu: 2.121 ± 0.048
0.444GlnMet: 0.444 ± 0.019
0.638GlnAsn: 0.638 ± 0.025
1.008GlnPro: 1.008 ± 0.033
0.875GlnGln: 0.875 ± 0.043
1.747GlnArg: 1.747 ± 0.045
1.41GlnSer: 1.41 ± 0.038
1.279GlnThr: 1.279 ± 0.034
1.755GlnVal: 1.755 ± 0.038
0.328GlnTrp: 0.328 ± 0.016
0.721GlnTyr: 0.721 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
6.645ArgAla: 6.645 ± 0.09
0.473ArgCys: 0.473 ± 0.023
5.217ArgAsp: 5.217 ± 0.075
6.94ArgGlu: 6.94 ± 0.097
2.455ArgPhe: 2.455 ± 0.041
5.106ArgGly: 5.106 ± 0.071
1.244ArgHis: 1.244 ± 0.029
2.836ArgIle: 2.836 ± 0.049
1.291ArgLys: 1.291 ± 0.035
6.038ArgLeu: 6.038 ± 0.089
1.505ArgMet: 1.505 ± 0.033
1.688ArgAsn: 1.688 ± 0.042
2.863ArgPro: 2.863 ± 0.054
1.616ArgGln: 1.616 ± 0.038
5.277ArgArg: 5.277 ± 0.089
3.554ArgSer: 3.554 ± 0.062
4.335ArgThr: 4.335 ± 0.063
6.008ArgVal: 6.008 ± 0.069
0.814ArgTrp: 0.814 ± 0.027
1.954ArgTyr: 1.954 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.332SerAla: 5.332 ± 0.069
0.317SerCys: 0.317 ± 0.018
4.263SerAsp: 4.263 ± 0.073
4.076SerGlu: 4.076 ± 0.065
2.039SerPhe: 2.039 ± 0.04
5.403SerGly: 5.403 ± 0.076
1.023SerHis: 1.023 ± 0.034
2.135SerIle: 2.135 ± 0.051
1.015SerLys: 1.015 ± 0.027
4.771SerLeu: 4.771 ± 0.067
1.115SerMet: 1.115 ± 0.033
1.328SerAsn: 1.328 ± 0.037
2.621SerPro: 2.621 ± 0.049
1.227SerGln: 1.227 ± 0.037
3.25SerArg: 3.25 ± 0.054
3.023SerSer: 3.023 ± 0.06
3.478SerThr: 3.478 ± 0.06
5.023SerVal: 5.023 ± 0.07
0.641SerTrp: 0.641 ± 0.022
1.469SerTyr: 1.469 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
6.735ThrAla: 6.735 ± 0.081
0.367ThrCys: 0.367 ± 0.02
5.571ThrAsp: 5.571 ± 0.084
4.491ThrGlu: 4.491 ± 0.07
2.336ThrPhe: 2.336 ± 0.044
6.015ThrGly: 6.015 ± 0.075
1.182ThrHis: 1.182 ± 0.033
2.409ThrIle: 2.409 ± 0.043
0.947ThrLys: 0.947 ± 0.027
5.689ThrLeu: 5.689 ± 0.076
1.014ThrMet: 1.014 ± 0.033
1.5ThrAsn: 1.5 ± 0.038
3.32ThrPro: 3.32 ± 0.064
1.146ThrGln: 1.146 ± 0.035
3.449ThrArg: 3.449 ± 0.058
2.975ThrSer: 2.975 ± 0.056
4.035ThrThr: 4.035 ± 0.073
6.941ThrVal: 6.941 ± 0.094
0.699ThrTrp: 0.699 ± 0.026
1.645ThrTyr: 1.645 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
10.859ValAla: 10.859 ± 0.112
0.709ValCys: 0.709 ± 0.024
7.771ValAsp: 7.771 ± 0.087
8.255ValGlu: 8.255 ± 0.101
3.011ValPhe: 3.011 ± 0.058
8.482ValGly: 8.482 ± 0.101
1.804ValHis: 1.804 ± 0.038
2.905ValIle: 2.905 ± 0.052
1.452ValLys: 1.452 ± 0.042
8.5ValLeu: 8.5 ± 0.108
1.353ValMet: 1.353 ± 0.037
2.133ValAsn: 2.133 ± 0.043
4.663ValPro: 4.663 ± 0.058
1.78ValGln: 1.78 ± 0.038
6.234ValArg: 6.234 ± 0.086
5.099ValSer: 5.099 ± 0.069
6.282ValThr: 6.282 ± 0.076
9.68ValVal: 9.68 ± 0.134
0.887ValTrp: 0.887 ± 0.03
2.196ValTyr: 2.196 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
1.021TrpAla: 1.021 ± 0.032
0.083TrpCys: 0.083 ± 0.008
0.848TrpAsp: 0.848 ± 0.028
0.872TrpGlu: 0.872 ± 0.029
0.463TrpPhe: 0.463 ± 0.02
0.936TrpGly: 0.936 ± 0.027
0.255TrpHis: 0.255 ± 0.014
0.437TrpIle: 0.437 ± 0.022
0.283TrpLys: 0.283 ± 0.015
1.175TrpLeu: 1.175 ± 0.038
0.237TrpMet: 0.237 ± 0.013
0.405TrpAsn: 0.405 ± 0.021
0.484TrpPro: 0.484 ± 0.022
0.332TrpGln: 0.332 ± 0.016
0.92TrpArg: 0.92 ± 0.03
0.593TrpSer: 0.593 ± 0.024
0.855TrpThr: 0.855 ± 0.033
0.92TrpVal: 0.92 ± 0.028
0.21TrpTrp: 0.21 ± 0.015
0.36TrpTyr: 0.36 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.777TyrAla: 2.777 ± 0.052
0.248TyrCys: 0.248 ± 0.014
2.633TyrAsp: 2.633 ± 0.06
2.385TyrGlu: 2.385 ± 0.05
0.852TyrPhe: 0.852 ± 0.03
2.44TyrGly: 2.44 ± 0.044
0.626TyrHis: 0.626 ± 0.024
0.715TyrIle: 0.715 ± 0.023
0.391TyrLys: 0.391 ± 0.017
2.474TyrLeu: 2.474 ± 0.045
0.367TyrMet: 0.367 ± 0.019
0.593TyrAsn: 0.593 ± 0.023
1.345TyrPro: 1.345 ± 0.034
0.651TyrGln: 0.651 ± 0.03
2.03TyrArg: 2.03 ± 0.042
1.194TyrSer: 1.194 ± 0.032
1.395TyrThr: 1.395 ± 0.037
2.401TyrVal: 2.401 ± 0.045
0.356TyrTrp: 0.356 ± 0.021
0.818TyrTyr: 0.818 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4176 proteins (1181044 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski