Amino acid dipepetide frequency for Leptospirillum sp. Group IV UBA BS

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.703AlaAla: 6.703 ± 0.161	0.805AlaCys: 0.805 ± 0.049	3.614AlaAsp: 3.614 ± 0.092	4.486AlaGlu: 4.486 ± 0.112	3.516AlaPhe: 3.516 ± 0.087	7.98AlaGly: 7.98 ± 0.143	1.752AlaHis: 1.752 ± 0.056	4.376AlaIle: 4.376 ± 0.11	2.751AlaLys: 2.751 ± 0.085	10.027AlaLeu: 10.027 ± 0.167	2.272AlaMet: 2.272 ± 0.078	1.968AlaAsn: 1.968 ± 0.082	4.096AlaPro: 4.096 ± 0.103	2.279AlaGln: 2.279 ± 0.072	7.142AlaArg: 7.142 ± 0.153	5.2AlaSer: 5.2 ± 0.117	3.758AlaThr: 3.758 ± 0.108	5.548AlaVal: 5.548 ± 0.13	0.875AlaTrp: 0.875 ± 0.046	1.778AlaTyr: 1.778 ± 0.072	0.007AlaXaa: 0.007 ± 0.004
Cys	0.628CysAla: 0.628 ± 0.041	0.091CysCys: 0.091 ± 0.014	0.415CysAsp: 0.415 ± 0.032	0.477CysGlu: 0.477 ± 0.033	0.302CysPhe: 0.302 ± 0.028	0.88CysGly: 0.88 ± 0.046	0.321CysHis: 0.321 ± 0.032	0.256CysIle: 0.256 ± 0.022	0.192CysLys: 0.192 ± 0.02	0.951CysLeu: 0.951 ± 0.05	0.173CysMet: 0.173 ± 0.023	0.156CysAsn: 0.156 ± 0.02	0.724CysPro: 0.724 ± 0.045	0.3CysGln: 0.3 ± 0.024	0.901CysArg: 0.901 ± 0.057	0.618CysSer: 0.618 ± 0.042	0.328CysThr: 0.328 ± 0.03	0.47CysVal: 0.47 ± 0.032	0.079CysTrp: 0.079 ± 0.015	0.199CysTyr: 0.199 ± 0.025	0.005CysXaa: 0.005 ± 0.004
Asp	3.132AspAla: 3.132 ± 0.091	0.417AspCys: 0.417 ± 0.032	1.872AspAsp: 1.872 ± 0.069	2.588AspGlu: 2.588 ± 0.086	2.241AspPhe: 2.241 ± 0.075	3.837AspGly: 3.837 ± 0.103	1.289AspHis: 1.289 ± 0.056	2.464AspIle: 2.464 ± 0.078	1.551AspLys: 1.551 ± 0.068	6.739AspLeu: 6.739 ± 0.149	0.997AspMet: 0.997 ± 0.051	1.196AspAsn: 1.196 ± 0.052	4.575AspPro: 4.575 ± 0.112	1.397AspGln: 1.397 ± 0.06	5.085AspArg: 5.085 ± 0.115	2.921AspSer: 2.921 ± 0.085	2.013AspThr: 2.013 ± 0.076	2.691AspVal: 2.691 ± 0.083	0.796AspTrp: 0.796 ± 0.048	1.256AspTyr: 1.256 ± 0.056	0.005AspXaa: 0.005 ± 0.003
Glu	6.109GluAla: 6.109 ± 0.15	0.429GluCys: 0.429 ± 0.034	3.123GluAsp: 3.123 ± 0.098	5.536GluGlu: 5.536 ± 0.143	2.169GluPhe: 2.169 ± 0.073	6.066GluGly: 6.066 ± 0.14	1.064GluHis: 1.064 ± 0.05	5.033GluIle: 5.033 ± 0.122	4.275GluLys: 4.275 ± 0.106	4.915GluLeu: 4.915 ± 0.123	1.608GluMet: 1.608 ± 0.061	2.217GluAsn: 2.217 ± 0.079	2.473GluPro: 2.473 ± 0.092	1.459GluGln: 1.459 ± 0.062	5.323GluArg: 5.323 ± 0.124	4.141GluSer: 4.141 ± 0.104	4.081GluThr: 4.081 ± 0.108	3.916GluVal: 3.916 ± 0.094	0.779GluTrp: 0.779 ± 0.045	1.124GluTyr: 1.124 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.921PheAla: 2.921 ± 0.086	0.446PheCys: 0.446 ± 0.033	2.205PheAsp: 2.205 ± 0.075	2.315PheGlu: 2.315 ± 0.075	2.296PhePhe: 2.296 ± 0.083	3.544PheGly: 3.544 ± 0.087	1.007PheHis: 1.007 ± 0.047	1.598PheIle: 1.598 ± 0.072	1.09PheLys: 1.09 ± 0.063	5.531PheLeu: 5.531 ± 0.138	0.81PheMet: 0.81 ± 0.045	0.937PheAsn: 0.937 ± 0.041	2.67PhePro: 2.67 ± 0.093	1.174PheGln: 1.174 ± 0.054	3.609PheArg: 3.609 ± 0.104	3.724PheSer: 3.724 ± 0.1	1.62PheThr: 1.62 ± 0.064	2.912PheVal: 2.912 ± 0.08	0.64PheTrp: 0.64 ± 0.037	1.217PheTyr: 1.217 ± 0.059	0.01PheXaa: 0.01 ± 0.005
Gly	6.356GlyAla: 6.356 ± 0.147	0.824GlyCys: 0.824 ± 0.048	4.069GlyAsp: 4.069 ± 0.111	5.809GlyGlu: 5.809 ± 0.135	3.763GlyPhe: 3.763 ± 0.094	7.556GlyGly: 7.556 ± 0.207	2.047GlyHis: 2.047 ± 0.08	5.644GlyIle: 5.644 ± 0.118	4.232GlyLys: 4.232 ± 0.11	9.037GlyLeu: 9.037 ± 0.177	2.166GlyMet: 2.166 ± 0.07	2.234GlyAsn: 2.234 ± 0.087	4.086GlyPro: 4.086 ± 0.103	2.816GlyGln: 2.816 ± 0.079	6.871GlyArg: 6.871 ± 0.153	5.716GlySer: 5.716 ± 0.131	5.27GlyThr: 5.27 ± 0.133	5.833GlyVal: 5.833 ± 0.114	1.102GlyTrp: 1.102 ± 0.065	2.154GlyTyr: 2.154 ± 0.084	0.007GlyXaa: 0.007 ± 0.004
His	1.577HisAla: 1.577 ± 0.065	0.223HisCys: 0.223 ± 0.025	0.906HisAsp: 0.906 ± 0.045	1.129HisGlu: 1.129 ± 0.049	1.093HisPhe: 1.093 ± 0.057	1.807HisGly: 1.807 ± 0.067	0.597HisHis: 0.597 ± 0.05	0.956HisIle: 0.956 ± 0.054	0.743HisLys: 0.743 ± 0.045	2.545HisLeu: 2.545 ± 0.082	0.417HisMet: 0.417 ± 0.033	0.527HisAsn: 0.527 ± 0.036	1.879HisPro: 1.879 ± 0.062	0.707HisGln: 0.707 ± 0.039	1.831HisArg: 1.831 ± 0.071	1.186HisSer: 1.186 ± 0.055	0.817HisThr: 0.817 ± 0.047	1.424HisVal: 1.424 ± 0.061	0.264HisTrp: 0.264 ± 0.027	0.676HisTyr: 0.676 ± 0.045	0.002HisXaa: 0.002 ± 0.003
Ile	4.695IleAla: 4.695 ± 0.1	0.417IleCys: 0.417 ± 0.029	3.0IleAsp: 3.0 ± 0.078	3.269IleGlu: 3.269 ± 0.083	2.186IlePhe: 2.186 ± 0.069	4.319IleGly: 4.319 ± 0.107	1.325IleHis: 1.325 ± 0.057	1.977IleIle: 1.977 ± 0.079	1.503IleLys: 1.503 ± 0.072	6.955IleLeu: 6.955 ± 0.141	0.836IleMet: 0.836 ± 0.045	1.244IleAsn: 1.244 ± 0.058	3.489IlePro: 3.489 ± 0.082	1.366IleGln: 1.366 ± 0.06	4.757IleArg: 4.757 ± 0.119	3.604IleSer: 3.604 ± 0.101	2.159IleThr: 2.159 ± 0.072	3.863IleVal: 3.863 ± 0.113	0.419IleTrp: 0.419 ± 0.031	1.074IleTyr: 1.074 ± 0.056	0.01IleXaa: 0.01 ± 0.005
Lys	3.669LysAla: 3.669 ± 0.094	0.206LysCys: 0.206 ± 0.022	2.202LysAsp: 2.202 ± 0.076	3.216LysGlu: 3.216 ± 0.094	0.949LysPhe: 0.949 ± 0.048	3.705LysGly: 3.705 ± 0.103	0.556LysHis: 0.556 ± 0.039	2.806LysIle: 2.806 ± 0.091	3.187LysLys: 3.187 ± 0.104	2.897LysLeu: 2.897 ± 0.087	0.992LysMet: 0.992 ± 0.048	1.862LysAsn: 1.862 ± 0.066	1.821LysPro: 1.821 ± 0.073	0.769LysGln: 0.769 ± 0.049	2.615LysArg: 2.615 ± 0.087	2.703LysSer: 2.703 ± 0.094	2.833LysThr: 2.833 ± 0.086	2.552LysVal: 2.552 ± 0.093	0.383LysTrp: 0.383 ± 0.03	0.812LysTyr: 0.812 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	10.135LeuAla: 10.135 ± 0.186	0.911LeuCys: 0.911 ± 0.047	5.421LeuAsp: 5.421 ± 0.114	7.101LeuGlu: 7.101 ± 0.147	5.287LeuPhe: 5.287 ± 0.12	8.254LeuGly: 8.254 ± 0.143	2.303LeuHis: 2.303 ± 0.085	4.189LeuIle: 4.189 ± 0.112	4.115LeuLys: 4.115 ± 0.099	13.399LeuLeu: 13.399 ± 0.272	2.15LeuMet: 2.15 ± 0.081	2.291LeuAsn: 2.291 ± 0.079	7.48LeuPro: 7.48 ± 0.145	2.32LeuGln: 2.32 ± 0.08	7.551LeuArg: 7.551 ± 0.163	10.672LeuSer: 10.672 ± 0.165	5.193LeuThr: 5.193 ± 0.115	7.959LeuVal: 7.959 ± 0.146	1.495LeuTrp: 1.495 ± 0.072	2.586LeuTyr: 2.586 ± 0.083	0.0LeuXaa: 0.0 ± 0.0
Met	2.715MetAla: 2.715 ± 0.084	0.11MetCys: 0.11 ± 0.018	1.241MetAsp: 1.241 ± 0.053	1.702MetGlu: 1.702 ± 0.065	0.525MetPhe: 0.525 ± 0.033	2.262MetGly: 2.262 ± 0.068	0.302MetHis: 0.302 ± 0.029	1.44MetIle: 1.44 ± 0.061	1.301MetLys: 1.301 ± 0.058	1.551MetLeu: 1.551 ± 0.068	0.477MetMet: 0.477 ± 0.033	0.822MetAsn: 0.822 ± 0.042	1.054MetPro: 1.054 ± 0.054	0.46MetGln: 0.46 ± 0.034	1.203MetArg: 1.203 ± 0.052	1.414MetSer: 1.414 ± 0.062	1.809MetThr: 1.809 ± 0.062	1.79MetVal: 1.79 ± 0.073	0.168MetTrp: 0.168 ± 0.02	0.259MetTyr: 0.259 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.159AsnAla: 2.159 ± 0.088	0.204AsnCys: 0.204 ± 0.022	1.126AsnAsp: 1.126 ± 0.051	1.299AsnGlu: 1.299 ± 0.065	1.078AsnPhe: 1.078 ± 0.06	2.246AsnGly: 2.246 ± 0.088	0.652AsnHis: 0.652 ± 0.038	1.483AsnIle: 1.483 ± 0.067	0.829AsnLys: 0.829 ± 0.045	3.135AsnLeu: 3.135 ± 0.1	0.599AsnMet: 0.599 ± 0.032	0.776AsnAsn: 0.776 ± 0.047	2.265AsnPro: 2.265 ± 0.077	0.939AsnGln: 0.939 ± 0.044	2.322AsnArg: 2.322 ± 0.072	1.452AsnSer: 1.452 ± 0.062	1.301AsnThr: 1.301 ± 0.061	1.608AsnVal: 1.608 ± 0.067	0.319AsnTrp: 0.319 ± 0.026	0.659AsnTyr: 0.659 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.625ProAla: 4.625 ± 0.119	0.486ProCys: 0.486 ± 0.043	3.985ProAsp: 3.985 ± 0.119	5.315ProGlu: 5.315 ± 0.13	2.857ProPhe: 2.857 ± 0.067	6.288ProGly: 6.288 ± 0.165	1.143ProHis: 1.143 ± 0.056	2.212ProIle: 2.212 ± 0.077	1.944ProLys: 1.944 ± 0.08	6.109ProLeu: 6.109 ± 0.129	1.273ProMet: 1.273 ± 0.058	1.22ProAsn: 1.22 ± 0.049	3.957ProPro: 3.957 ± 0.125	1.39ProGln: 1.39 ± 0.065	3.425ProArg: 3.425 ± 0.109	4.64ProSer: 4.64 ± 0.101	2.464ProThr: 2.464 ± 0.076	5.38ProVal: 5.38 ± 0.118	0.748ProTrp: 0.748 ± 0.041	1.246ProTyr: 1.246 ± 0.052	0.012ProXaa: 0.012 ± 0.005
Gln	2.701GlnAla: 2.701 ± 0.083	0.206GlnCys: 0.206 ± 0.025	1.282GlnAsp: 1.282 ± 0.056	2.107GlnGlu: 2.107 ± 0.067	0.815GlnPhe: 0.815 ± 0.046	2.471GlnGly: 2.471 ± 0.08	0.472GlnHis: 0.472 ± 0.037	1.699GlnIle: 1.699 ± 0.069	1.783GlnLys: 1.783 ± 0.072	1.721GlnLeu: 1.721 ± 0.063	0.685GlnMet: 0.685 ± 0.039	1.038GlnAsn: 1.038 ± 0.047	1.011GlnPro: 1.011 ± 0.05	0.678GlnGln: 0.678 ± 0.046	1.467GlnArg: 1.467 ± 0.057	1.797GlnSer: 1.797 ± 0.07	1.733GlnThr: 1.733 ± 0.06	1.96GlnVal: 1.96 ± 0.07	0.316GlnTrp: 0.316 ± 0.026	0.558GlnTyr: 0.558 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	5.33ArgAla: 5.33 ± 0.123	0.566ArgCys: 0.566 ± 0.038	3.772ArgAsp: 3.772 ± 0.098	6.667ArgGlu: 6.667 ± 0.139	3.202ArgPhe: 3.202 ± 0.091	5.167ArgGly: 5.167 ± 0.112	1.714ArgHis: 1.714 ± 0.076	5.546ArgIle: 5.546 ± 0.126	4.316ArgLys: 4.316 ± 0.117	8.163ArgLeu: 8.163 ± 0.158	2.166ArgMet: 2.166 ± 0.084	2.224ArgAsn: 2.224 ± 0.073	4.328ArgPro: 4.328 ± 0.137	2.317ArgGln: 2.317 ± 0.077	5.898ArgArg: 5.898 ± 0.151	5.363ArgSer: 5.363 ± 0.115	4.446ArgThr: 4.446 ± 0.106	4.776ArgVal: 4.776 ± 0.122	1.035ArgTrp: 1.035 ± 0.054	1.867ArgTyr: 1.867 ± 0.075	0.005ArgXaa: 0.005 ± 0.003
Ser	5.196SerAla: 5.196 ± 0.103	0.724SerCys: 0.724 ± 0.049	3.276SerAsp: 3.276 ± 0.095	3.971SerGlu: 3.971 ± 0.109	3.353SerPhe: 3.353 ± 0.099	7.604SerGly: 7.604 ± 0.169	1.402SerHis: 1.402 ± 0.054	2.799SerIle: 2.799 ± 0.09	1.896SerLys: 1.896 ± 0.077	8.834SerLeu: 8.834 ± 0.168	1.651SerMet: 1.651 ± 0.059	1.541SerAsn: 1.541 ± 0.067	5.078SerPro: 5.078 ± 0.118	2.054SerGln: 2.054 ± 0.073	6.298SerArg: 6.298 ± 0.138	5.033SerSer: 5.033 ± 0.14	2.802SerThr: 2.802 ± 0.09	4.513SerVal: 4.513 ± 0.099	0.983SerTrp: 0.983 ± 0.055	1.606SerTyr: 1.606 ± 0.069	0.002SerXaa: 0.002 ± 0.002
Thr	3.842ThrAla: 3.842 ± 0.104	0.422ThrCys: 0.422 ± 0.033	2.222ThrAsp: 2.222 ± 0.072	2.675ThrGlu: 2.675 ± 0.079	2.183ThrPhe: 2.183 ± 0.08	5.476ThrGly: 5.476 ± 0.128	1.124ThrHis: 1.124 ± 0.052	2.814ThrIle: 2.814 ± 0.097	1.534ThrLys: 1.534 ± 0.075	6.463ThrLeu: 6.463 ± 0.128	1.081ThrMet: 1.081 ± 0.052	1.203ThrAsn: 1.203 ± 0.058	3.573ThrPro: 3.573 ± 0.097	1.225ThrGln: 1.225 ± 0.051	3.413ThrArg: 3.413 ± 0.096	2.842ThrSer: 2.842 ± 0.086	2.634ThrThr: 2.634 ± 0.104	4.18ThrVal: 4.18 ± 0.118	0.518ThrTrp: 0.518 ± 0.031	1.141ThrTyr: 1.141 ± 0.06	0.012ThrXaa: 0.012 ± 0.005
Val	5.847ValAla: 5.847 ± 0.12	0.664ValCys: 0.664 ± 0.046	3.561ValAsp: 3.561 ± 0.103	4.055ValGlu: 4.055 ± 0.102	2.871ValPhe: 2.871 ± 0.086	5.169ValGly: 5.169 ± 0.132	1.356ValHis: 1.356 ± 0.051	3.307ValIle: 3.307 ± 0.098	2.181ValLys: 2.181 ± 0.079	8.071ValLeu: 8.071 ± 0.143	1.558ValMet: 1.558 ± 0.065	1.821ValAsn: 1.821 ± 0.075	4.18ValPro: 4.18 ± 0.118	1.548ValGln: 1.548 ± 0.067	6.102ValArg: 6.102 ± 0.12	5.244ValSer: 5.244 ± 0.124	3.688ValThr: 3.688 ± 0.098	5.49ValVal: 5.49 ± 0.14	0.863ValTrp: 0.863 ± 0.049	1.507ValTyr: 1.507 ± 0.064	0.007ValXaa: 0.007 ± 0.004
Trp	0.923TrpAla: 0.923 ± 0.051	0.105TrpCys: 0.105 ± 0.017	0.602TrpAsp: 0.602 ± 0.039	0.841TrpGlu: 0.841 ± 0.05	0.532TrpPhe: 0.532 ± 0.036	1.038TrpGly: 1.038 ± 0.051	0.228TrpHis: 0.228 ± 0.022	0.927TrpIle: 0.927 ± 0.049	0.654TrpLys: 0.654 ± 0.038	1.028TrpLeu: 1.028 ± 0.042	0.304TrpMet: 0.304 ± 0.025	0.489TrpAsn: 0.489 ± 0.036	0.585TrpPro: 0.585 ± 0.042	0.371TrpGln: 0.371 ± 0.031	0.69TrpArg: 0.69 ± 0.044	0.911TrpSer: 0.911 ± 0.048	0.738TrpThr: 0.738 ± 0.049	0.836TrpVal: 0.836 ± 0.046	0.141TrpTrp: 0.141 ± 0.017	0.302TrpTyr: 0.302 ± 0.033	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.668TyrAla: 1.668 ± 0.078	0.208TyrCys: 0.208 ± 0.021	1.167TyrAsp: 1.167 ± 0.062	1.28TyrGlu: 1.28 ± 0.053	1.064TyrPhe: 1.064 ± 0.055	1.905TyrGly: 1.905 ± 0.061	0.649TyrHis: 0.649 ± 0.037	0.932TyrIle: 0.932 ± 0.05	0.657TyrLys: 0.657 ± 0.04	2.737TyrLeu: 2.737 ± 0.083	0.386TyrMet: 0.386 ± 0.028	0.688TyrAsn: 0.688 ± 0.042	1.39TyrPro: 1.39 ± 0.063	0.93TyrGln: 0.93 ± 0.051	2.353TyrArg: 2.353 ± 0.075	1.419TyrSer: 1.419 ± 0.061	0.884TyrThr: 0.884 ± 0.049	1.385TyrVal: 1.385 ± 0.053	0.321TyrTrp: 0.321 ± 0.026	0.736TyrTyr: 0.736 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.019XaaGly: 0.019 ± 0.006	0.002XaaHis: 0.002 ± 0.002	0.007XaaIle: 0.007 ± 0.004	0.005XaaLys: 0.005 ± 0.003	0.002XaaLeu: 0.002 ± 0.002	0.002XaaMet: 0.002 ± 0.003	0.0XaaAsn: 0.0 ± 0.0	0.005XaaPro: 0.005 ± 0.003	0.0XaaGln: 0.0 ± 0.0	0.012XaaArg: 0.012 ± 0.005	0.012XaaSer: 0.012 ± 0.005	0.002XaaThr: 0.002 ± 0.003	0.005XaaVal: 0.005 ± 0.004	0.002XaaTrp: 0.002 ± 0.002	0.002XaaTyr: 0.002 ± 0.002	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1878 proteins (417274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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