Amino acid dipepetide frequency for Saccharomyces kudriavzevii (strain ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889) (Yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.297AlaAla: 4.297 ± 0.086	0.729AlaCys: 0.729 ± 0.021	2.788AlaAsp: 2.788 ± 0.051	3.139AlaGlu: 3.139 ± 0.048	2.336AlaPhe: 2.336 ± 0.046	3.09AlaGly: 3.09 ± 0.058	1.143AlaHis: 1.143 ± 0.03	3.663AlaIle: 3.663 ± 0.049	4.074AlaLys: 4.074 ± 0.051	5.345AlaLeu: 5.345 ± 0.073	1.262AlaMet: 1.262 ± 0.035	3.17AlaAsn: 3.17 ± 0.047	2.369AlaPro: 2.369 ± 0.05	2.24AlaGln: 2.24 ± 0.053	2.609AlaArg: 2.609 ± 0.042	5.074AlaSer: 5.074 ± 0.064	3.634AlaThr: 3.634 ± 0.054	3.326AlaVal: 3.326 ± 0.052	0.511AlaTrp: 0.511 ± 0.021	1.706AlaTyr: 1.706 ± 0.034	0.001AlaXaa: 0.001 ± 0.001
Cys	0.664CysAla: 0.664 ± 0.022	0.315CysCys: 0.315 ± 0.018	0.72CysAsp: 0.72 ± 0.023	0.623CysGlu: 0.623 ± 0.021	0.71CysPhe: 0.71 ± 0.023	0.876CysGly: 0.876 ± 0.03	0.341CysHis: 0.341 ± 0.015	0.94CysIle: 0.94 ± 0.026	0.794CysLys: 0.794 ± 0.024	1.385CysLeu: 1.385 ± 0.032	0.297CysMet: 0.297 ± 0.013	0.599CysAsn: 0.599 ± 0.02	0.547CysPro: 0.547 ± 0.02	0.491CysGln: 0.491 ± 0.018	0.551CysArg: 0.551 ± 0.02	1.121CysSer: 1.121 ± 0.028	0.667CysThr: 0.667 ± 0.023	0.788CysVal: 0.788 ± 0.021	0.153CysTrp: 0.153 ± 0.01	0.521CysTyr: 0.521 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.306AspAla: 3.306 ± 0.047	0.718AspCys: 0.718 ± 0.023	4.754AspAsp: 4.754 ± 0.073	5.059AspGlu: 5.059 ± 0.056	2.745AspPhe: 2.745 ± 0.037	3.083AspGly: 3.083 ± 0.053	1.167AspHis: 1.167 ± 0.027	4.141AspIle: 4.141 ± 0.057	3.548AspLys: 3.548 ± 0.053	5.699AspLeu: 5.699 ± 0.067	1.219AspMet: 1.219 ± 0.029	3.218AspAsn: 3.218 ± 0.046	2.479AspPro: 2.479 ± 0.036	1.755AspGln: 1.755 ± 0.036	2.078AspArg: 2.078 ± 0.037	4.824AspSer: 4.824 ± 0.061	2.99AspThr: 2.99 ± 0.045	3.564AspVal: 3.564 ± 0.052	0.657AspTrp: 0.657 ± 0.021	2.125AspTyr: 2.125 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	3.558GluAla: 3.558 ± 0.049	0.705GluCys: 0.705 ± 0.022	4.384GluAsp: 4.384 ± 0.057	5.896GluGlu: 5.896 ± 0.095	2.797GluPhe: 2.797 ± 0.051	2.91GluGly: 2.91 ± 0.047	1.257GluHis: 1.257 ± 0.029	4.262GluIle: 4.262 ± 0.059	5.19GluLys: 5.19 ± 0.068	6.345GluLeu: 6.345 ± 0.074	1.425GluMet: 1.425 ± 0.031	4.431GluAsn: 4.431 ± 0.061	2.124GluPro: 2.124 ± 0.041	2.629GluGln: 2.629 ± 0.049	3.084GluArg: 3.084 ± 0.039	4.703GluSer: 4.703 ± 0.067	3.607GluThr: 3.607 ± 0.05	3.484GluVal: 3.484 ± 0.052	0.637GluTrp: 0.637 ± 0.023	2.179GluTyr: 2.179 ± 0.039	0.001GluXaa: 0.001 ± 0.001
Phe	2.427PheAla: 2.427 ± 0.039	0.597PheCys: 0.597 ± 0.021	2.734PheAsp: 2.734 ± 0.047	2.769PheGlu: 2.769 ± 0.041	2.149PhePhe: 2.149 ± 0.049	2.647PheGly: 2.647 ± 0.066	1.065PheHis: 1.065 ± 0.024	2.951PheIle: 2.951 ± 0.056	3.12PheLys: 3.12 ± 0.045	4.202PheLeu: 4.202 ± 0.062	0.894PheMet: 0.894 ± 0.026	2.509PheAsn: 2.509 ± 0.042	1.915PhePro: 1.915 ± 0.035	2.041PheGln: 2.041 ± 0.032	1.692PheArg: 1.692 ± 0.037	3.607PheSer: 3.607 ± 0.047	2.461PheThr: 2.461 ± 0.045	2.533PheVal: 2.533 ± 0.043	0.517PheTrp: 0.517 ± 0.021	1.637PheTyr: 1.637 ± 0.035	0.001PheXaa: 0.001 ± 0.001
Gly	2.999GlyAla: 2.999 ± 0.057	0.773GlyCys: 0.773 ± 0.024	2.87GlyAsp: 2.87 ± 0.045	3.019GlyGlu: 3.019 ± 0.049	2.36GlyPhe: 2.36 ± 0.045	3.359GlyGly: 3.359 ± 0.079	1.182GlyHis: 1.182 ± 0.036	3.46GlyIle: 3.46 ± 0.059	3.814GlyLys: 3.814 ± 0.054	4.675GlyLeu: 4.675 ± 0.059	1.026GlyMet: 1.026 ± 0.03	3.016GlyAsn: 3.016 ± 0.046	1.818GlyPro: 1.818 ± 0.035	1.729GlyGln: 1.729 ± 0.04	2.272GlyArg: 2.272 ± 0.037	4.833GlySer: 4.833 ± 0.063	3.055GlyThr: 3.055 ± 0.049	3.218GlyVal: 3.218 ± 0.057	0.598GlyTrp: 0.598 ± 0.023	1.886GlyTyr: 1.886 ± 0.041	0.001GlyXaa: 0.001 ± 0.001
His	1.099HisAla: 1.099 ± 0.031	0.345HisCys: 0.345 ± 0.015	1.338HisAsp: 1.338 ± 0.03	1.314HisGlu: 1.314 ± 0.03	0.976HisPhe: 0.976 ± 0.021	1.242HisGly: 1.242 ± 0.026	0.738HisHis: 0.738 ± 0.029	1.39HisIle: 1.39 ± 0.03	1.263HisLys: 1.263 ± 0.029	2.143HisLeu: 2.143 ± 0.041	0.437HisMet: 0.437 ± 0.016	1.121HisAsn: 1.121 ± 0.029	1.128HisPro: 1.128 ± 0.024	0.868HisGln: 0.868 ± 0.024	1.063HisArg: 1.063 ± 0.027	1.973HisSer: 1.973 ± 0.038	1.098HisThr: 1.098 ± 0.025	1.202HisVal: 1.202 ± 0.027	0.247HisTrp: 0.247 ± 0.014	0.821HisTyr: 0.821 ± 0.021	0.001HisXaa: 0.001 ± 0.001
Ile	3.645IleAla: 3.645 ± 0.058	0.954IleCys: 0.954 ± 0.028	4.013IleAsp: 4.013 ± 0.061	4.022IleGlu: 4.022 ± 0.056	2.897IlePhe: 2.897 ± 0.051	3.174IleGly: 3.174 ± 0.045	1.386IleHis: 1.386 ± 0.029	4.146IleIle: 4.146 ± 0.057	4.457IleLys: 4.457 ± 0.062	6.14IleLeu: 6.14 ± 0.069	1.325IleMet: 1.325 ± 0.031	3.685IleAsn: 3.685 ± 0.059	3.238IlePro: 3.238 ± 0.052	2.309IleGln: 2.309 ± 0.04	2.747IleArg: 2.747 ± 0.048	5.844IleSer: 5.844 ± 0.064	3.653IleThr: 3.653 ± 0.054	3.705IleVal: 3.705 ± 0.05	0.76IleTrp: 0.76 ± 0.024	2.067IleTyr: 2.067 ± 0.038	0.002IleXaa: 0.002 ± 0.001
Lys	3.614LysAla: 3.614 ± 0.05	0.873LysCys: 0.873 ± 0.028	4.129LysAsp: 4.129 ± 0.07	5.164LysGlu: 5.164 ± 0.063	3.269LysPhe: 3.269 ± 0.045	3.094LysGly: 3.094 ± 0.05	1.536LysHis: 1.536 ± 0.03	4.752LysIle: 4.752 ± 0.066	6.599LysLys: 6.599 ± 0.095	7.038LysLeu: 7.038 ± 0.081	1.46LysMet: 1.46 ± 0.029	4.536LysAsn: 4.536 ± 0.055	2.875LysPro: 2.875 ± 0.048	2.858LysGln: 2.858 ± 0.05	4.102LysArg: 4.102 ± 0.06	5.585LysSer: 5.585 ± 0.067	3.903LysThr: 3.903 ± 0.052	3.923LysVal: 3.923 ± 0.053	0.759LysTrp: 0.759 ± 0.022	2.66LysTyr: 2.66 ± 0.043	0.003LysXaa: 0.003 ± 0.001
Leu	5.306LeuAla: 5.306 ± 0.066	1.299LeuCys: 1.299 ± 0.028	5.368LeuAsp: 5.368 ± 0.066	6.135LeuGlu: 6.135 ± 0.078	4.148LeuPhe: 4.148 ± 0.065	4.503LeuGly: 4.503 ± 0.062	2.084LeuHis: 2.084 ± 0.032	5.663LeuIle: 5.663 ± 0.061	7.442LeuLys: 7.442 ± 0.083	9.413LeuLeu: 9.413 ± 0.1	1.976LeuMet: 1.976 ± 0.037	5.686LeuAsn: 5.686 ± 0.069	4.609LeuPro: 4.609 ± 0.049	4.491LeuGln: 4.491 ± 0.06	4.538LeuArg: 4.538 ± 0.052	8.305LeuSer: 8.305 ± 0.075	5.145LeuThr: 5.145 ± 0.062	5.148LeuVal: 5.148 ± 0.069	0.905LeuTrp: 0.905 ± 0.027	3.085LeuTyr: 3.085 ± 0.045	0.003LeuXaa: 0.003 ± 0.002
Met	1.416MetAla: 1.416 ± 0.031	0.265MetCys: 0.265 ± 0.013	1.345MetAsp: 1.345 ± 0.031	1.336MetGlu: 1.336 ± 0.032	0.855MetPhe: 0.855 ± 0.024	1.259MetGly: 1.259 ± 0.033	0.374MetHis: 0.374 ± 0.014	1.235MetIle: 1.235 ± 0.029	1.539MetLys: 1.539 ± 0.037	1.806MetLeu: 1.806 ± 0.04	0.493MetMet: 0.493 ± 0.02	1.345MetAsn: 1.345 ± 0.03	0.843MetPro: 0.843 ± 0.024	0.697MetGln: 0.697 ± 0.022	0.905MetArg: 0.905 ± 0.028	1.953MetSer: 1.953 ± 0.033	1.243MetThr: 1.243 ± 0.028	1.186MetVal: 1.186 ± 0.029	0.17MetTrp: 0.17 ± 0.011	0.575MetTyr: 0.575 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.31AsnAla: 3.31 ± 0.051	0.716AsnCys: 0.716 ± 0.024	4.126AsnAsp: 4.126 ± 0.058	4.312AsnGlu: 4.312 ± 0.064	2.591AsnPhe: 2.591 ± 0.042	3.473AsnGly: 3.473 ± 0.052	1.251AsnHis: 1.251 ± 0.033	3.804AsnIle: 3.804 ± 0.046	4.106AsnLys: 4.106 ± 0.049	5.105AsnLeu: 5.105 ± 0.056	1.25AsnMet: 1.25 ± 0.03	4.408AsnAsn: 4.408 ± 0.117	2.37AsnPro: 2.37 ± 0.043	1.934AsnGln: 1.934 ± 0.036	2.227AsnArg: 2.227 ± 0.041	5.591AsnSer: 5.591 ± 0.072	3.237AsnThr: 3.237 ± 0.057	3.335AsnVal: 3.335 ± 0.046	0.631AsnTrp: 0.631 ± 0.02	1.974AsnTyr: 1.974 ± 0.038	0.001AsnXaa: 0.001 ± 0.001
Pro	2.344ProAla: 2.344 ± 0.046	0.398ProCys: 0.398 ± 0.02	2.155ProAsp: 2.155 ± 0.037	2.933ProGlu: 2.933 ± 0.037	1.93ProPhe: 1.93 ± 0.038	1.976ProGly: 1.976 ± 0.045	0.996ProHis: 0.996 ± 0.027	2.808ProIle: 2.808 ± 0.044	2.879ProLys: 2.879 ± 0.039	4.173ProLeu: 4.173 ± 0.05	0.879ProMet: 0.879 ± 0.024	2.418ProAsn: 2.418 ± 0.047	2.381ProPro: 2.381 ± 0.081	1.93ProGln: 1.93 ± 0.046	1.885ProArg: 1.885 ± 0.038	4.172ProSer: 4.172 ± 0.069	2.717ProThr: 2.717 ± 0.046	2.583ProVal: 2.583 ± 0.04	0.436ProTrp: 0.436 ± 0.015	1.419ProTyr: 1.419 ± 0.03	0.001ProXaa: 0.001 ± 0.001
Gln	1.997GlnAla: 1.997 ± 0.055	0.461GlnCys: 0.461 ± 0.018	2.185GlnAsp: 2.185 ± 0.041	2.817GlnGlu: 2.817 ± 0.04	1.728GlnPhe: 1.728 ± 0.032	1.833GlnGly: 1.833 ± 0.039	0.851GlnHis: 0.851 ± 0.028	2.394GlnIle: 2.394 ± 0.043	2.638GlnLys: 2.638 ± 0.045	4.086GlnLeu: 4.086 ± 0.054	0.841GlnMet: 0.841 ± 0.024	2.428GlnAsn: 2.428 ± 0.038	1.613GlnPro: 1.613 ± 0.044	2.908GlnGln: 2.908 ± 0.141	2.093GlnArg: 2.093 ± 0.042	2.945GlnSer: 2.945 ± 0.045	2.003GlnThr: 2.003 ± 0.038	2.074GlnVal: 2.074 ± 0.035	0.432GlnTrp: 0.432 ± 0.019	1.365GlnTyr: 1.365 ± 0.031	0.002GlnXaa: 0.002 ± 0.001
Arg	2.312ArgAla: 2.312 ± 0.043	0.627ArgCys: 0.627 ± 0.02	2.55ArgAsp: 2.55 ± 0.043	2.918ArgGlu: 2.918 ± 0.049	1.963ArgPhe: 1.963 ± 0.032	2.252ArgGly: 2.252 ± 0.046	1.005ArgHis: 1.005 ± 0.029	3.07ArgIle: 3.07 ± 0.042	3.766ArgLys: 3.766 ± 0.058	4.33ArgLeu: 4.33 ± 0.057	0.997ArgMet: 0.997 ± 0.024	2.697ArgAsn: 2.697 ± 0.039	1.796ArgPro: 1.796 ± 0.037	1.767ArgGln: 1.767 ± 0.033	2.945ArgArg: 2.945 ± 0.061	3.8ArgSer: 3.8 ± 0.053	2.467ArgThr: 2.467 ± 0.038	2.283ArgVal: 2.283 ± 0.04	0.495ArgTrp: 0.495 ± 0.018	1.618ArgTyr: 1.618 ± 0.033	0.001ArgXaa: 0.001 ± 0.001
Ser	4.845SerAla: 4.845 ± 0.065	1.028SerCys: 1.028 ± 0.029	4.519SerAsp: 4.519 ± 0.066	4.667SerGlu: 4.667 ± 0.073	3.737SerPhe: 3.737 ± 0.049	4.62SerGly: 4.62 ± 0.061	1.973SerHis: 1.973 ± 0.045	5.578SerIle: 5.578 ± 0.067	6.445SerLys: 6.445 ± 0.064	8.43SerLeu: 8.43 ± 0.092	1.81SerMet: 1.81 ± 0.033	5.592SerAsn: 5.592 ± 0.076	3.897SerPro: 3.897 ± 0.065	3.369SerGln: 3.369 ± 0.054	3.991SerArg: 3.991 ± 0.054	10.409SerSer: 10.409 ± 0.163	5.75SerThr: 5.75 ± 0.075	4.633SerVal: 4.633 ± 0.067	0.831SerTrp: 0.831 ± 0.027	2.435SerTyr: 2.435 ± 0.042	0.001SerXaa: 0.001 ± 0.001
Thr	3.59ThrAla: 3.59 ± 0.049	0.68ThrCys: 0.68 ± 0.027	2.929ThrAsp: 2.929 ± 0.042	3.147ThrGlu: 3.147 ± 0.047	2.536ThrPhe: 2.536 ± 0.037	3.112ThrGly: 3.112 ± 0.046	1.163ThrHis: 1.163 ± 0.027	3.669ThrIle: 3.669 ± 0.046	3.994ThrLys: 3.994 ± 0.05	5.409ThrLeu: 5.409 ± 0.062	1.148ThrMet: 1.148 ± 0.027	3.259ThrAsn: 3.259 ± 0.056	2.894ThrPro: 2.894 ± 0.048	1.911ThrGln: 1.911 ± 0.039	2.487ThrArg: 2.487 ± 0.039	5.449ThrSer: 5.449 ± 0.075	3.916ThrThr: 3.916 ± 0.086	3.5ThrVal: 3.5 ± 0.045	0.573ThrTrp: 0.573 ± 0.022	1.657ThrTyr: 1.657 ± 0.035	0.003ThrXaa: 0.003 ± 0.001
Val	3.489ValAla: 3.489 ± 0.055	0.788ValCys: 0.788 ± 0.025	3.449ValAsp: 3.449 ± 0.049	3.611ValGlu: 3.611 ± 0.051	2.551ValPhe: 2.551 ± 0.042	3.01ValGly: 3.01 ± 0.054	1.21ValHis: 1.21 ± 0.027	3.536ValIle: 3.536 ± 0.052	3.92ValLys: 3.92 ± 0.053	5.297ValLeu: 5.297 ± 0.063	1.191ValMet: 1.191 ± 0.03	3.118ValAsn: 3.118 ± 0.046	2.872ValPro: 2.872 ± 0.046	2.049ValGln: 2.049 ± 0.034	2.391ValArg: 2.391 ± 0.039	4.781ValSer: 4.781 ± 0.051	3.218ValThr: 3.218 ± 0.043	3.588ValVal: 3.588 ± 0.054	0.563ValTrp: 0.563 ± 0.021	1.869ValTyr: 1.869 ± 0.036	0.001ValXaa: 0.001 ± 0.001
Trp	0.515TrpAla: 0.515 ± 0.022	0.248TrpCys: 0.248 ± 0.011	0.654TrpAsp: 0.654 ± 0.024	0.631TrpGlu: 0.631 ± 0.02	0.532TrpPhe: 0.532 ± 0.02	0.538TrpGly: 0.538 ± 0.024	0.229TrpHis: 0.229 ± 0.013	0.603TrpIle: 0.603 ± 0.023	0.92TrpLys: 0.92 ± 0.025	0.96TrpLeu: 0.96 ± 0.028	0.216TrpMet: 0.216 ± 0.013	0.653TrpAsn: 0.653 ± 0.022	0.311TrpPro: 0.311 ± 0.015	0.394TrpGln: 0.394 ± 0.016	0.51TrpArg: 0.51 ± 0.019	0.89TrpSer: 0.89 ± 0.025	0.542TrpThr: 0.542 ± 0.021	0.567TrpVal: 0.567 ± 0.02	0.159TrpTrp: 0.159 ± 0.01	0.36TrpTyr: 0.36 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.771TyrAla: 1.771 ± 0.032	0.581TyrCys: 0.581 ± 0.02	2.118TyrAsp: 2.118 ± 0.039	2.092TyrGlu: 2.092 ± 0.038	1.657TyrPhe: 1.657 ± 0.035	1.911TyrGly: 1.911 ± 0.04	0.855TyrHis: 0.855 ± 0.024	2.102TyrIle: 2.102 ± 0.039	2.223TyrLys: 2.223 ± 0.042	3.27TyrLeu: 3.27 ± 0.049	0.694TyrMet: 0.694 ± 0.022	1.858TyrAsn: 1.858 ± 0.036	1.337TyrPro: 1.337 ± 0.032	1.325TyrGln: 1.325 ± 0.032	1.488TyrArg: 1.488 ± 0.032	2.699TyrSer: 2.699 ± 0.044	1.716TyrThr: 1.716 ± 0.037	1.863TyrVal: 1.863 ± 0.034	0.396TyrTrp: 0.396 ± 0.02	1.406TyrTyr: 1.406 ± 0.033	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.004XaaAsn: 0.004 ± 0.002	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3745 proteins (1538632 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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