Amino acid dipepetide frequency for [Eubacterium] cellulosolvens 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.794AlaAla: 7.794 ± 0.122	1.07AlaCys: 1.07 ± 0.036	5.301AlaAsp: 5.301 ± 0.08	6.133AlaGlu: 6.133 ± 0.09	3.061AlaPhe: 3.061 ± 0.066	6.702AlaGly: 6.702 ± 0.099	1.172AlaHis: 1.172 ± 0.037	4.702AlaIle: 4.702 ± 0.073	4.691AlaLys: 4.691 ± 0.069	6.758AlaLeu: 6.758 ± 0.081	2.27AlaMet: 2.27 ± 0.049	2.648AlaAsn: 2.648 ± 0.068	2.272AlaPro: 2.272 ± 0.068	2.299AlaGln: 2.299 ± 0.061	3.135AlaArg: 3.135 ± 0.065	4.585AlaSer: 4.585 ± 0.076	3.569AlaThr: 3.569 ± 0.076	6.22AlaVal: 6.22 ± 0.086	0.686AlaTrp: 0.686 ± 0.031	2.759AlaTyr: 2.759 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.997CysAla: 0.997 ± 0.031	0.271CysCys: 0.271 ± 0.018	0.874CysAsp: 0.874 ± 0.033	0.914CysGlu: 0.914 ± 0.029	0.59CysPhe: 0.59 ± 0.025	1.459CysGly: 1.459 ± 0.047	0.28CysHis: 0.28 ± 0.019	0.96CysIle: 0.96 ± 0.031	0.624CysLys: 0.624 ± 0.031	1.013CysLeu: 1.013 ± 0.034	0.436CysMet: 0.436 ± 0.024	0.505CysAsn: 0.505 ± 0.024	0.566CysPro: 0.566 ± 0.029	0.324CysGln: 0.324 ± 0.019	0.763CysArg: 0.763 ± 0.031	0.894CysSer: 0.894 ± 0.031	0.76CysThr: 0.76 ± 0.032	1.055CysVal: 1.055 ± 0.033	0.137CysTrp: 0.137 ± 0.012	0.531CysTyr: 0.531 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.801AspAla: 4.801 ± 0.094	0.783AspCys: 0.783 ± 0.029	3.533AspAsp: 3.533 ± 0.062	5.385AspGlu: 5.385 ± 0.088	2.825AspPhe: 2.825 ± 0.062	5.015AspGly: 5.015 ± 0.117	1.138AspHis: 1.138 ± 0.034	4.119AspIle: 4.119 ± 0.071	3.463AspLys: 3.463 ± 0.063	5.251AspLeu: 5.251 ± 0.081	1.836AspMet: 1.836 ± 0.047	2.3AspAsn: 2.3 ± 0.055	2.424AspPro: 2.424 ± 0.062	1.714AspGln: 1.714 ± 0.042	3.2AspArg: 3.2 ± 0.06	3.395AspSer: 3.395 ± 0.068	3.135AspThr: 3.135 ± 0.065	4.277AspVal: 4.277 ± 0.069	0.666AspTrp: 0.666 ± 0.031	2.915AspTyr: 2.915 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	6.101GluAla: 6.101 ± 0.098	0.735GluCys: 0.735 ± 0.027	4.821GluAsp: 4.821 ± 0.075	7.21GluGlu: 7.21 ± 0.122	2.441GluPhe: 2.441 ± 0.053	4.654GluGly: 4.654 ± 0.085	1.277GluHis: 1.277 ± 0.041	5.641GluIle: 5.641 ± 0.078	6.641GluLys: 6.641 ± 0.103	6.604GluLeu: 6.604 ± 0.102	2.478GluMet: 2.478 ± 0.058	4.129GluAsn: 4.129 ± 0.063	1.81GluPro: 1.81 ± 0.045	2.688GluGln: 2.688 ± 0.057	3.405GluArg: 3.405 ± 0.077	3.605GluSer: 3.605 ± 0.067	3.827GluThr: 3.827 ± 0.065	4.425GluVal: 4.425 ± 0.07	0.611GluTrp: 0.611 ± 0.029	3.044GluTyr: 3.044 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.957PheAla: 2.957 ± 0.063	0.669PheCys: 0.669 ± 0.029	2.692PheAsp: 2.692 ± 0.061	2.615PheGlu: 2.615 ± 0.054	1.854PhePhe: 1.854 ± 0.056	3.082PheGly: 3.082 ± 0.065	0.79PheHis: 0.79 ± 0.027	2.349PheIle: 2.349 ± 0.056	1.808PheLys: 1.808 ± 0.052	3.487PheLeu: 3.487 ± 0.075	1.06PheMet: 1.06 ± 0.038	1.468PheAsn: 1.468 ± 0.039	1.315PhePro: 1.315 ± 0.04	1.025PheGln: 1.025 ± 0.038	2.208PheArg: 2.208 ± 0.054	2.78PheSer: 2.78 ± 0.057	2.373PheThr: 2.373 ± 0.062	2.853PheVal: 2.853 ± 0.055	0.386PheTrp: 0.386 ± 0.025	1.612PheTyr: 1.612 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.172GlyAla: 5.172 ± 0.095	1.266GlyCys: 1.266 ± 0.043	4.243GlyAsp: 4.243 ± 0.092	5.101GlyGlu: 5.101 ± 0.09	3.07GlyPhe: 3.07 ± 0.063	5.084GlyGly: 5.084 ± 0.109	1.302GlyHis: 1.302 ± 0.035	5.721GlyIle: 5.721 ± 0.087	5.502GlyLys: 5.502 ± 0.083	5.642GlyLeu: 5.642 ± 0.088	2.448GlyMet: 2.448 ± 0.046	3.233GlyAsn: 3.233 ± 0.082	1.313GlyPro: 1.313 ± 0.048	2.174GlyGln: 2.174 ± 0.047	3.753GlyArg: 3.753 ± 0.067	4.57GlySer: 4.57 ± 0.098	4.51GlyThr: 4.51 ± 0.095	4.911GlyVal: 4.911 ± 0.066	0.838GlyTrp: 0.838 ± 0.04	3.281GlyTyr: 3.281 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.27HisAla: 1.27 ± 0.039	0.316HisCys: 0.316 ± 0.021	0.947HisAsp: 0.947 ± 0.034	1.133HisGlu: 1.133 ± 0.032	0.838HisPhe: 0.838 ± 0.027	1.267HisGly: 1.267 ± 0.037	0.472HisHis: 0.472 ± 0.037	1.201HisIle: 1.201 ± 0.04	0.922HisLys: 0.922 ± 0.032	1.507HisLeu: 1.507 ± 0.042	0.533HisMet: 0.533 ± 0.022	0.711HisAsn: 0.711 ± 0.029	0.917HisPro: 0.917 ± 0.03	0.529HisGln: 0.529 ± 0.024	1.002HisArg: 1.002 ± 0.036	0.983HisSer: 0.983 ± 0.031	0.978HisThr: 0.978 ± 0.036	1.166HisVal: 1.166 ± 0.04	0.162HisTrp: 0.162 ± 0.014	0.773HisTyr: 0.773 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.172IleAla: 5.172 ± 0.08	1.268IleCys: 1.268 ± 0.037	4.237IleAsp: 4.237 ± 0.083	4.308IleGlu: 4.308 ± 0.075	2.491IlePhe: 2.491 ± 0.057	4.828IleGly: 4.828 ± 0.076	1.328IleHis: 1.328 ± 0.041	4.164IleIle: 4.164 ± 0.072	3.259IleLys: 3.259 ± 0.067	6.216IleLeu: 6.216 ± 0.099	1.731IleMet: 1.731 ± 0.055	2.737IleAsn: 2.737 ± 0.055	3.12IlePro: 3.12 ± 0.059	1.961IleGln: 1.961 ± 0.051	4.526IleArg: 4.526 ± 0.082	4.503IleSer: 4.503 ± 0.062	4.082IleThr: 4.082 ± 0.073	4.471IleVal: 4.471 ± 0.073	0.594IleTrp: 0.594 ± 0.029	2.616IleTyr: 2.616 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.258LysAla: 5.258 ± 0.096	0.687LysCys: 0.687 ± 0.026	4.081LysAsp: 4.081 ± 0.069	5.685LysGlu: 5.685 ± 0.095	1.782LysPhe: 1.782 ± 0.039	4.068LysGly: 4.068 ± 0.074	0.993LysHis: 0.993 ± 0.034	4.357LysIle: 4.357 ± 0.071	5.956LysLys: 5.956 ± 0.102	5.17LysLeu: 5.17 ± 0.076	1.952LysMet: 1.952 ± 0.047	3.32LysAsn: 3.32 ± 0.063	2.146LysPro: 2.146 ± 0.066	2.009LysGln: 2.009 ± 0.045	2.959LysArg: 2.959 ± 0.061	3.326LysSer: 3.326 ± 0.06	3.894LysThr: 3.894 ± 0.075	4.209LysVal: 4.209 ± 0.068	0.598LysTrp: 0.598 ± 0.028	2.809LysTyr: 2.809 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.838LeuAla: 6.838 ± 0.088	1.298LeuCys: 1.298 ± 0.038	5.183LeuAsp: 5.183 ± 0.076	5.786LeuGlu: 5.786 ± 0.085	3.379LeuPhe: 3.379 ± 0.078	5.645LeuGly: 5.645 ± 0.093	1.544LeuHis: 1.544 ± 0.039	5.582LeuIle: 5.582 ± 0.095	5.631LeuLys: 5.631 ± 0.071	7.809LeuLeu: 7.809 ± 0.111	2.453LeuMet: 2.453 ± 0.056	3.531LeuAsn: 3.531 ± 0.063	3.302LeuPro: 3.302 ± 0.064	2.683LeuGln: 2.683 ± 0.057	4.442LeuArg: 4.442 ± 0.072	5.831LeuSer: 5.831 ± 0.081	5.049LeuThr: 5.049 ± 0.069	5.53LeuVal: 5.53 ± 0.076	0.687LeuTrp: 0.687 ± 0.031	3.139LeuTyr: 3.139 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.263MetAla: 2.263 ± 0.05	0.3MetCys: 0.3 ± 0.019	1.921MetAsp: 1.921 ± 0.05	2.214MetGlu: 2.214 ± 0.054	0.955MetPhe: 0.955 ± 0.036	1.841MetGly: 1.841 ± 0.054	0.48MetHis: 0.48 ± 0.023	2.237MetIle: 2.237 ± 0.047	2.434MetLys: 2.434 ± 0.052	2.528MetLeu: 2.528 ± 0.054	0.961MetMet: 0.961 ± 0.034	1.568MetAsn: 1.568 ± 0.043	1.091MetPro: 1.091 ± 0.033	1.042MetGln: 1.042 ± 0.037	1.411MetArg: 1.411 ± 0.044	1.808MetSer: 1.808 ± 0.042	1.813MetThr: 1.813 ± 0.042	1.785MetVal: 1.785 ± 0.05	0.195MetTrp: 0.195 ± 0.013	0.961MetTyr: 0.961 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.382AsnAla: 3.382 ± 0.071	0.623AsnCys: 0.623 ± 0.027	2.297AsnAsp: 2.297 ± 0.055	2.745AsnGlu: 2.745 ± 0.06	1.516AsnPhe: 1.516 ± 0.041	3.827AsnGly: 3.827 ± 0.096	0.808AsnHis: 0.808 ± 0.029	2.931AsnIle: 2.931 ± 0.054	2.251AsnLys: 2.251 ± 0.053	3.499AsnLeu: 3.499 ± 0.068	1.244AsnMet: 1.244 ± 0.046	1.839AsnAsn: 1.839 ± 0.056	2.055AsnPro: 2.055 ± 0.048	1.294AsnGln: 1.294 ± 0.039	2.388AsnArg: 2.388 ± 0.051	2.444AsnSer: 2.444 ± 0.061	2.344AsnThr: 2.344 ± 0.059	2.923AsnVal: 2.923 ± 0.049	0.438AsnTrp: 0.438 ± 0.02	1.835AsnTyr: 1.835 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.885ProAla: 2.885 ± 0.074	0.41ProCys: 0.41 ± 0.02	2.51ProAsp: 2.51 ± 0.063	3.781ProGlu: 3.781 ± 0.073	1.448ProPhe: 1.448 ± 0.042	2.477ProGly: 2.477 ± 0.064	0.536ProHis: 0.536 ± 0.024	1.732ProIle: 1.732 ± 0.048	1.907ProLys: 1.907 ± 0.045	2.562ProLeu: 2.562 ± 0.053	0.876ProMet: 0.876 ± 0.031	1.137ProAsn: 1.137 ± 0.037	0.634ProPro: 0.634 ± 0.03	1.005ProGln: 1.005 ± 0.031	1.033ProArg: 1.033 ± 0.033	1.954ProSer: 1.954 ± 0.05	1.961ProThr: 1.961 ± 0.081	3.204ProVal: 3.204 ± 0.063	0.323ProTrp: 0.323 ± 0.017	1.378ProTyr: 1.378 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.293GlnAla: 2.293 ± 0.057	0.297GlnCys: 0.297 ± 0.02	1.578GlnAsp: 1.578 ± 0.043	2.315GlnGlu: 2.315 ± 0.054	1.017GlnPhe: 1.017 ± 0.036	1.843GlnGly: 1.843 ± 0.044	0.443GlnHis: 0.443 ± 0.022	2.417GlnIle: 2.417 ± 0.056	2.576GlnLys: 2.576 ± 0.058	2.537GlnLeu: 2.537 ± 0.054	1.107GlnMet: 1.107 ± 0.037	1.5GlnAsn: 1.5 ± 0.044	0.882GlnPro: 0.882 ± 0.037	1.044GlnGln: 1.044 ± 0.036	1.515GlnArg: 1.515 ± 0.044	1.591GlnSer: 1.591 ± 0.047	1.76GlnThr: 1.76 ± 0.043	1.943GlnVal: 1.943 ± 0.048	0.267GlnTrp: 0.267 ± 0.018	1.243GlnTyr: 1.243 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.045ArgAla: 3.045 ± 0.069	0.632ArgCys: 0.632 ± 0.028	2.901ArgAsp: 2.901 ± 0.059	4.464ArgGlu: 4.464 ± 0.084	2.061ArgPhe: 2.061 ± 0.047	2.855ArgGly: 2.855 ± 0.06	0.897ArgHis: 0.897 ± 0.032	3.994ArgIle: 3.994 ± 0.069	4.043ArgLys: 4.043 ± 0.067	4.165ArgLeu: 4.165 ± 0.074	1.765ArgMet: 1.765 ± 0.049	2.385ArgAsn: 2.385 ± 0.056	1.498ArgPro: 1.498 ± 0.044	1.751ArgGln: 1.751 ± 0.05	2.959ArgArg: 2.959 ± 0.067	2.685ArgSer: 2.685 ± 0.055	2.562ArgThr: 2.562 ± 0.05	3.082ArgVal: 3.082 ± 0.069	0.424ArgTrp: 0.424 ± 0.023	2.049ArgTyr: 2.049 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.571SerAla: 4.571 ± 0.078	0.813SerCys: 0.813 ± 0.033	3.692SerAsp: 3.692 ± 0.082	4.119SerGlu: 4.119 ± 0.076	2.734SerPhe: 2.734 ± 0.054	5.673SerGly: 5.673 ± 0.114	1.036SerHis: 1.036 ± 0.032	3.714SerIle: 3.714 ± 0.067	3.094SerLys: 3.094 ± 0.058	5.029SerLeu: 5.029 ± 0.074	1.804SerMet: 1.804 ± 0.045	2.293SerAsn: 2.293 ± 0.05	1.812SerPro: 1.812 ± 0.045	1.611SerGln: 1.611 ± 0.041	2.983SerArg: 2.983 ± 0.054	3.986SerSer: 3.986 ± 0.088	3.135SerThr: 3.135 ± 0.064	4.67SerVal: 4.67 ± 0.078	0.654SerTrp: 0.654 ± 0.031	2.442SerTyr: 2.442 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.818ThrAla: 4.818 ± 0.092	0.649ThrCys: 0.649 ± 0.027	3.787ThrAsp: 3.787 ± 0.078	4.215ThrGlu: 4.215 ± 0.073	2.179ThrPhe: 2.179 ± 0.065	5.07ThrGly: 5.07 ± 0.09	0.859ThrHis: 0.859 ± 0.028	3.653ThrIle: 3.653 ± 0.071	3.176ThrLys: 3.176 ± 0.068	4.565ThrLeu: 4.565 ± 0.071	1.565ThrMet: 1.565 ± 0.043	1.966ThrAsn: 1.966 ± 0.056	2.388ThrPro: 2.388 ± 0.074	1.406ThrGln: 1.406 ± 0.043	2.272ThrArg: 2.272 ± 0.052	3.191ThrSer: 3.191 ± 0.062	2.964ThrThr: 2.964 ± 0.072	4.51ThrVal: 4.51 ± 0.094	0.5ThrTrp: 0.5 ± 0.026	2.159ThrTyr: 2.159 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.83ValAla: 4.83 ± 0.075	1.169ValCys: 1.169 ± 0.032	4.265ValAsp: 4.265 ± 0.077	4.6ValGlu: 4.6 ± 0.076	3.046ValPhe: 3.046 ± 0.057	4.141ValGly: 4.141 ± 0.064	1.164ValHis: 1.164 ± 0.033	4.963ValIle: 4.963 ± 0.073	4.38ValLys: 4.38 ± 0.082	6.411ValLeu: 6.411 ± 0.093	1.931ValMet: 1.931 ± 0.042	3.085ValAsn: 3.085 ± 0.073	2.535ValPro: 2.535 ± 0.056	1.975ValGln: 1.975 ± 0.043	3.416ValArg: 3.416 ± 0.06	4.761ValSer: 4.761 ± 0.075	4.353ValThr: 4.353 ± 0.1	4.826ValVal: 4.826 ± 0.07	0.598ValTrp: 0.598 ± 0.027	2.79ValTyr: 2.79 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.588TrpAla: 0.588 ± 0.028	0.127TrpCys: 0.127 ± 0.013	0.536TrpAsp: 0.536 ± 0.026	0.569TrpGlu: 0.569 ± 0.024	0.402TrpPhe: 0.402 ± 0.024	0.624TrpGly: 0.624 ± 0.028	0.193TrpHis: 0.193 ± 0.015	0.705TrpIle: 0.705 ± 0.028	0.766TrpLys: 0.766 ± 0.027	0.862TrpLeu: 0.862 ± 0.031	0.317TrpMet: 0.317 ± 0.017	0.55TrpAsn: 0.55 ± 0.026	0.223TrpPro: 0.223 ± 0.015	0.358TrpGln: 0.358 ± 0.02	0.413TrpArg: 0.413 ± 0.022	0.51TrpSer: 0.51 ± 0.031	0.472TrpThr: 0.472 ± 0.028	0.463TrpVal: 0.463 ± 0.021	0.111TrpTrp: 0.111 ± 0.01	0.45TrpTyr: 0.45 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.794TyrAla: 2.794 ± 0.055	0.571TyrCys: 0.571 ± 0.024	2.775TyrAsp: 2.775 ± 0.079	2.856TyrGlu: 2.856 ± 0.059	1.697TyrPhe: 1.697 ± 0.048	2.976TyrGly: 2.976 ± 0.053	0.915TyrHis: 0.915 ± 0.032	2.471TyrIle: 2.471 ± 0.06	2.134TyrLys: 2.134 ± 0.053	3.728TyrLeu: 3.728 ± 0.075	1.04TyrMet: 1.04 ± 0.037	1.781TyrAsn: 1.781 ± 0.049	1.451TyrPro: 1.451 ± 0.038	1.274TyrGln: 1.274 ± 0.034	2.431TyrArg: 2.431 ± 0.058	2.462TyrSer: 2.462 ± 0.061	2.349TyrThr: 2.349 ± 0.063	2.716TyrVal: 2.716 ± 0.058	0.367TyrTrp: 0.367 ± 0.019	1.886TyrTyr: 1.886 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2716 proteins (943410 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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