Amino acid dipepetide frequency for human papillomavirus 153

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.981AlaAla: 4.981 ± 0.689
0.415AlaCys: 0.415 ± 0.555
5.812AlaAsp: 5.812 ± 0.671
5.812AlaGlu: 5.812 ± 1.585
4.981AlaPhe: 4.981 ± 1.497
1.66AlaGly: 1.66 ± 0.766
0.83AlaHis: 0.83 ± 0.57
2.491AlaIle: 2.491 ± 0.888
4.566AlaLys: 4.566 ± 1.208
5.812AlaLeu: 5.812 ± 1.689
0.0AlaMet: 0.0 ± 0.0
1.66AlaAsn: 1.66 ± 0.584
2.906AlaPro: 2.906 ± 0.727
0.83AlaGln: 0.83 ± 0.445
2.906AlaArg: 2.906 ± 1.15
2.491AlaSer: 2.491 ± 0.969
3.321AlaThr: 3.321 ± 1.138
2.906AlaVal: 2.906 ± 0.929
0.415AlaTrp: 0.415 ± 0.353
1.245AlaTyr: 1.245 ± 0.68
0.0AlaXaa: 0.0 ± 0.0
Cys
1.66CysAla: 1.66 ± 1.114
1.245CysCys: 1.245 ± 1.055
1.245CysAsp: 1.245 ± 0.491
0.83CysGlu: 0.83 ± 0.445
1.245CysPhe: 1.245 ± 0.551
0.83CysGly: 0.83 ± 0.906
0.0CysHis: 0.0 ± 0.0
1.66CysIle: 1.66 ± 1.114
2.076CysLys: 2.076 ± 0.955
2.906CysLeu: 2.906 ± 2.076
0.0CysMet: 0.0 ± 0.0
1.245CysAsn: 1.245 ± 0.68
1.245CysPro: 1.245 ± 0.758
1.245CysGln: 1.245 ± 0.616
0.83CysArg: 0.83 ± 0.557
2.076CysSer: 2.076 ± 0.905
0.83CysThr: 0.83 ± 0.445
1.245CysVal: 1.245 ± 0.749
0.83CysTrp: 0.83 ± 0.465
0.415CysTyr: 0.415 ± 0.353
0.0CysXaa: 0.0 ± 0.0
Asp
4.566AspAla: 4.566 ± 0.813
2.906AspCys: 2.906 ± 0.923
7.057AspAsp: 7.057 ± 1.726
4.981AspGlu: 4.981 ± 1.578
2.076AspPhe: 2.076 ± 0.546
2.906AspGly: 2.906 ± 1.22
1.245AspHis: 1.245 ± 0.725
5.396AspIle: 5.396 ± 1.389
1.66AspLys: 1.66 ± 0.746
7.472AspLeu: 7.472 ± 2.351
0.415AspMet: 0.415 ± 0.333
2.906AspAsn: 2.906 ± 0.842
4.151AspPro: 4.151 ± 0.618
2.491AspGln: 2.491 ± 0.937
2.076AspArg: 2.076 ± 0.941
5.396AspSer: 5.396 ± 1.186
3.321AspThr: 3.321 ± 0.556
5.396AspVal: 5.396 ± 2.02
0.83AspTrp: 0.83 ± 0.706
0.415AspTyr: 0.415 ± 0.555
0.0AspXaa: 0.0 ± 0.0
Glu
4.151GluAla: 4.151 ± 1.222
1.245GluCys: 1.245 ± 0.731
3.321GluAsp: 3.321 ± 1.206
7.472GluGlu: 7.472 ± 1.339
2.491GluPhe: 2.491 ± 0.704
2.906GluGly: 2.906 ± 0.81
1.245GluHis: 1.245 ± 0.583
2.491GluIle: 2.491 ± 0.952
2.076GluLys: 2.076 ± 0.62
6.227GluLeu: 6.227 ± 0.857
0.0GluMet: 0.0 ± 0.0
3.321GluAsn: 3.321 ± 1.557
3.321GluPro: 3.321 ± 1.049
2.491GluGln: 2.491 ± 0.987
3.321GluArg: 3.321 ± 1.2
6.642GluSer: 6.642 ± 1.687
3.736GluThr: 3.736 ± 1.567
2.906GluVal: 2.906 ± 0.96
0.415GluTrp: 0.415 ± 0.353
1.245GluTyr: 1.245 ± 1.145
0.0GluXaa: 0.0 ± 0.0
Phe
2.076PheAla: 2.076 ± 1.206
0.83PheCys: 0.83 ± 0.557
2.076PheAsp: 2.076 ± 0.62
4.151PheGlu: 4.151 ± 1.4
3.321PhePhe: 3.321 ± 0.946
3.321PheGly: 3.321 ± 0.556
1.245PheHis: 1.245 ± 0.823
1.66PheIle: 1.66 ± 0.58
3.321PheLys: 3.321 ± 0.834
5.396PheLeu: 5.396 ± 1.833
0.0PheMet: 0.0 ± 0.0
0.83PheAsn: 0.83 ± 0.526
2.076PhePro: 2.076 ± 0.63
2.076PheGln: 2.076 ± 0.706
2.491PheArg: 2.491 ± 0.791
3.736PheSer: 3.736 ± 0.68
1.66PheThr: 1.66 ± 0.569
3.736PheVal: 3.736 ± 1.49
1.245PheTrp: 1.245 ± 0.703
2.491PheTyr: 2.491 ± 0.752
0.0PheXaa: 0.0 ± 0.0
Gly
3.321GlyAla: 3.321 ± 1.009
0.83GlyCys: 0.83 ± 0.465
4.566GlyAsp: 4.566 ± 0.995
3.321GlyGlu: 3.321 ± 0.665
0.415GlyPhe: 0.415 ± 0.356
3.736GlyGly: 3.736 ± 1.019
2.076GlyHis: 2.076 ± 0.848
2.491GlyIle: 2.491 ± 0.775
2.491GlyLys: 2.491 ± 0.457
5.396GlyLeu: 5.396 ± 1.262
0.83GlyMet: 0.83 ± 0.465
2.491GlyAsn: 2.491 ± 0.878
2.906GlyPro: 2.906 ± 0.527
2.076GlyGln: 2.076 ± 0.51
2.491GlyArg: 2.491 ± 0.897
4.151GlySer: 4.151 ± 1.482
4.981GlyThr: 4.981 ± 1.203
1.66GlyVal: 1.66 ± 0.771
0.0GlyTrp: 0.0 ± 0.0
1.66GlyTyr: 1.66 ± 0.278
0.0GlyXaa: 0.0 ± 0.0
His
0.415HisAla: 0.415 ± 0.555
1.66HisCys: 1.66 ± 1.114
0.415HisAsp: 0.415 ± 0.353
0.83HisGlu: 0.83 ± 0.555
2.076HisPhe: 2.076 ± 0.425
0.83HisGly: 0.83 ± 0.705
0.83HisHis: 0.83 ± 0.705
1.245HisIle: 1.245 ± 0.342
1.245HisLys: 1.245 ± 0.469
2.491HisLeu: 2.491 ± 1.189
0.0HisMet: 0.0 ± 0.296
0.415HisAsn: 0.415 ± 0.356
1.245HisPro: 1.245 ± 0.638
2.076HisGln: 2.076 ± 1.329
1.245HisArg: 1.245 ± 1.136
0.83HisSer: 0.83 ± 0.706
2.491HisThr: 2.491 ± 0.865
0.415HisVal: 0.415 ± 0.356
2.076HisTrp: 2.076 ± 1.298
0.415HisTyr: 0.415 ± 0.555
0.0HisXaa: 0.0 ± 0.0
Ile
2.906IleAla: 2.906 ± 0.897
2.076IleCys: 2.076 ± 0.938
8.302IleAsp: 8.302 ± 2.801
3.736IleGlu: 3.736 ± 2.081
2.491IlePhe: 2.491 ± 0.704
2.906IleGly: 2.906 ± 1.257
0.83IleHis: 0.83 ± 0.445
4.566IleIle: 4.566 ± 1.432
1.66IleLys: 1.66 ± 0.687
3.736IleLeu: 3.736 ± 1.063
0.0IleMet: 0.0 ± 0.0
2.906IleAsn: 2.906 ± 0.874
3.736IlePro: 3.736 ± 1.657
1.245IleGln: 1.245 ± 0.347
3.321IleArg: 3.321 ± 0.955
7.057IleSer: 7.057 ± 1.653
1.66IleThr: 1.66 ± 1.058
1.66IleVal: 1.66 ± 0.498
0.0IleTrp: 0.0 ± 0.0
2.491IleTyr: 2.491 ± 0.67
0.0IleXaa: 0.0 ± 0.0
Lys
2.491LysAla: 2.491 ± 0.694
2.076LysCys: 2.076 ± 1.072
0.83LysAsp: 0.83 ± 0.465
1.66LysGlu: 1.66 ± 0.596
2.906LysPhe: 2.906 ± 1.066
2.076LysGly: 2.076 ± 0.613
1.66LysHis: 1.66 ± 0.738
3.321LysIle: 3.321 ± 0.89
2.076LysLys: 2.076 ± 0.62
4.566LysLeu: 4.566 ± 0.935
1.245LysMet: 1.245 ± 0.731
2.076LysAsn: 2.076 ± 0.826
2.076LysPro: 2.076 ± 0.908
2.491LysGln: 2.491 ± 1.091
6.642LysArg: 6.642 ± 0.83
4.151LysSer: 4.151 ± 1.638
2.906LysThr: 2.906 ± 0.82
3.321LysVal: 3.321 ± 1.071
0.83LysTrp: 0.83 ± 0.465
2.076LysTyr: 2.076 ± 0.842
0.0LysXaa: 0.0 ± 0.0
Leu
5.812LeuAla: 5.812 ± 1.325
0.83LeuCys: 0.83 ± 0.526
6.227LeuAsp: 6.227 ± 1.458
4.981LeuGlu: 4.981 ± 1.333
3.736LeuPhe: 3.736 ± 1.026
5.396LeuGly: 5.396 ± 1.85
4.151LeuHis: 4.151 ± 2.563
5.812LeuIle: 5.812 ± 1.507
4.981LeuLys: 4.981 ± 0.928
10.378LeuLeu: 10.378 ± 2.36
0.83LeuMet: 0.83 ± 0.401
5.812LeuAsn: 5.812 ± 1.019
6.642LeuPro: 6.642 ± 1.4
7.887LeuGln: 7.887 ± 1.18
1.66LeuArg: 1.66 ± 0.738
7.472LeuSer: 7.472 ± 1.962
5.396LeuThr: 5.396 ± 1.145
3.736LeuVal: 3.736 ± 1.589
0.0LeuTrp: 0.0 ± 0.0
4.151LeuTyr: 4.151 ± 1.582
0.0LeuXaa: 0.0 ± 0.0
Met
0.415MetAla: 0.415 ± 0.333
1.245MetCys: 1.245 ± 0.703
0.415MetAsp: 0.415 ± 0.333
0.415MetGlu: 0.415 ± 0.555
0.415MetPhe: 0.415 ± 0.356
1.66MetGly: 1.66 ± 0.569
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
0.83MetLeu: 0.83 ± 0.465
0.0MetMet: 0.0 ± 0.0
1.245MetAsn: 1.245 ± 0.676
0.415MetPro: 0.415 ± 0.353
0.415MetGln: 0.415 ± 0.384
1.66MetArg: 1.66 ± 0.812
1.245MetSer: 1.245 ± 0.455
0.415MetThr: 0.415 ± 0.353
0.83MetVal: 0.83 ± 0.706
0.0MetTrp: 0.0 ± 0.0
0.83MetTyr: 0.83 ± 0.644
0.0MetXaa: 0.0 ± 0.0
Asn
1.66AsnAla: 1.66 ± 0.687
2.076AsnCys: 2.076 ± 0.954
2.491AsnAsp: 2.491 ± 0.856
3.736AsnGlu: 3.736 ± 0.91
2.076AsnPhe: 2.076 ± 0.7
2.906AsnGly: 2.906 ± 0.842
0.83AsnHis: 0.83 ± 0.706
2.076AsnIle: 2.076 ± 1.247
5.396AsnLys: 5.396 ± 0.964
3.321AsnLeu: 3.321 ± 1.349
1.245AsnMet: 1.245 ± 0.634
4.151AsnAsn: 4.151 ± 1.042
2.906AsnPro: 2.906 ± 1.142
2.906AsnGln: 2.906 ± 0.926
2.906AsnArg: 2.906 ± 0.897
2.491AsnSer: 2.491 ± 0.951
3.736AsnThr: 3.736 ± 1.135
2.906AsnVal: 2.906 ± 0.82
1.245AsnTrp: 1.245 ± 0.469
0.415AsnTyr: 0.415 ± 0.333
0.0AsnXaa: 0.0 ± 0.0
Pro
2.076ProAla: 2.076 ± 1.176
0.415ProCys: 0.415 ± 0.333
6.227ProAsp: 6.227 ± 1.664
3.321ProGlu: 3.321 ± 1.081
0.83ProPhe: 0.83 ± 0.578
1.245ProGly: 1.245 ± 0.676
0.83ProHis: 0.83 ± 0.873
4.151ProIle: 4.151 ± 1.482
2.906ProLys: 2.906 ± 1.136
7.057ProLeu: 7.057 ± 1.956
0.0ProMet: 0.0 ± 0.0
3.736ProAsn: 3.736 ± 1.268
7.887ProPro: 7.887 ± 1.892
1.245ProGln: 1.245 ± 0.583
3.321ProArg: 3.321 ± 0.801
4.981ProSer: 4.981 ± 2.027
5.396ProThr: 5.396 ± 1.141
1.66ProVal: 1.66 ± 1.006
0.0ProTrp: 0.0 ± 0.0
2.906ProTyr: 2.906 ± 0.827
0.0ProXaa: 0.0 ± 0.0
Gln
2.076GlnAla: 2.076 ± 0.987
0.415GlnCys: 0.415 ± 0.555
3.321GlnAsp: 3.321 ± 1.196
1.66GlnGlu: 1.66 ± 0.876
2.491GlnPhe: 2.491 ± 1.223
2.076GlnGly: 2.076 ± 0.994
0.83GlnHis: 0.83 ± 0.445
2.491GlnIle: 2.491 ± 0.985
1.66GlnLys: 1.66 ± 0.853
3.736GlnLeu: 3.736 ± 1.021
2.491GlnMet: 2.491 ± 0.865
2.076GlnAsn: 2.076 ± 1.072
2.076GlnPro: 2.076 ± 1.039
3.736GlnGln: 3.736 ± 1.304
2.076GlnArg: 2.076 ± 0.85
1.66GlnSer: 1.66 ± 0.775
3.321GlnThr: 3.321 ± 1.217
4.981GlnVal: 4.981 ± 1.08
1.66GlnTrp: 1.66 ± 0.775
0.83GlnTyr: 0.83 ± 0.666
0.0GlnXaa: 0.0 ± 0.0
Arg
2.906ArgAla: 2.906 ± 0.625
2.076ArgCys: 2.076 ± 0.905
2.906ArgAsp: 2.906 ± 0.896
0.415ArgGlu: 0.415 ± 0.333
2.906ArgPhe: 2.906 ± 1.238
3.736ArgGly: 3.736 ± 1.29
3.321ArgHis: 3.321 ± 1.128
1.66ArgIle: 1.66 ± 1.123
4.151ArgLys: 4.151 ± 1.299
6.227ArgLeu: 6.227 ± 1.103
0.83ArgMet: 0.83 ± 0.629
2.491ArgAsn: 2.491 ± 1.177
4.151ArgPro: 4.151 ± 1.093
4.151ArgGln: 4.151 ± 1.081
4.566ArgArg: 4.566 ± 1.363
4.566ArgSer: 4.566 ± 0.953
0.0ArgThr: 0.0 ± 0.0
2.076ArgVal: 2.076 ± 0.732
0.415ArgTrp: 0.415 ± 0.356
2.076ArgTyr: 2.076 ± 0.787
0.0ArgXaa: 0.0 ± 0.0
Ser
5.812SerAla: 5.812 ± 1.368
1.245SerCys: 1.245 ± 0.896
2.491SerAsp: 2.491 ± 0.722
4.981SerGlu: 4.981 ± 0.634
3.736SerPhe: 3.736 ± 1.345
5.396SerGly: 5.396 ± 1.655
0.415SerHis: 0.415 ± 0.384
3.736SerIle: 3.736 ± 1.447
3.321SerLys: 3.321 ± 1.374
7.057SerLeu: 7.057 ± 1.799
0.83SerMet: 0.83 ± 0.566
4.151SerAsn: 4.151 ± 1.4
3.321SerPro: 3.321 ± 0.915
2.906SerGln: 2.906 ± 1.149
6.642SerArg: 6.642 ± 1.735
6.642SerSer: 6.642 ± 3.239
7.057SerThr: 7.057 ± 2.057
5.812SerVal: 5.812 ± 1.246
0.415SerTrp: 0.415 ± 0.353
1.245SerTyr: 1.245 ± 0.616
0.0SerXaa: 0.0 ± 0.0
Thr
3.321ThrAla: 3.321 ± 0.613
1.245ThrCys: 1.245 ± 0.813
3.736ThrAsp: 3.736 ± 1.691
4.151ThrGlu: 4.151 ± 1.056
2.906ThrPhe: 2.906 ± 0.727
3.321ThrGly: 3.321 ± 0.7
0.83ThrHis: 0.83 ± 0.633
4.151ThrIle: 4.151 ± 1.431
1.245ThrLys: 1.245 ± 0.731
5.812ThrLeu: 5.812 ± 2.12
0.83ThrMet: 0.83 ± 0.445
3.736ThrAsn: 3.736 ± 1.41
4.151ThrPro: 4.151 ± 1.456
2.491ThrGln: 2.491 ± 0.613
2.076ThrArg: 2.076 ± 0.718
6.642ThrSer: 6.642 ± 2.075
5.812ThrThr: 5.812 ± 1.875
4.566ThrVal: 4.566 ± 1.479
0.83ThrTrp: 0.83 ± 0.409
1.66ThrTyr: 1.66 ± 0.59
0.0ThrXaa: 0.0 ± 0.0
Val
2.491ValAla: 2.491 ± 0.852
0.0ValCys: 0.0 ± 0.0
2.906ValAsp: 2.906 ± 0.445
2.491ValGlu: 2.491 ± 0.652
4.151ValPhe: 4.151 ± 0.887
2.906ValGly: 2.906 ± 1.311
1.66ValHis: 1.66 ± 0.59
4.981ValIle: 4.981 ± 1.411
2.491ValLys: 2.491 ± 0.525
3.321ValLeu: 3.321 ± 0.778
1.245ValMet: 1.245 ± 0.703
2.906ValAsn: 2.906 ± 1.253
3.736ValPro: 3.736 ± 0.951
2.076ValGln: 2.076 ± 0.948
2.491ValArg: 2.491 ± 0.714
3.321ValSer: 3.321 ± 0.832
4.981ValThr: 4.981 ± 1.607
2.491ValVal: 2.491 ± 0.768
0.415ValTrp: 0.415 ± 0.333
2.906ValTyr: 2.906 ± 0.517
0.0ValXaa: 0.0 ± 0.0
Trp
0.83TrpAla: 0.83 ± 0.588
0.0TrpCys: 0.0 ± 0.0
1.245TrpAsp: 1.245 ± 0.758
0.83TrpGlu: 0.83 ± 1.084
0.415TrpPhe: 0.415 ± 0.353
0.0TrpGly: 0.0 ± 0.0
0.415TrpHis: 0.415 ± 0.356
1.245TrpIle: 1.245 ± 1.059
1.66TrpLys: 1.66 ± 0.891
1.66TrpLeu: 1.66 ± 0.891
0.0TrpMet: 0.0 ± 0.0
0.83TrpAsn: 0.83 ± 0.666
0.415TrpPro: 0.415 ± 0.333
0.0TrpGln: 0.0 ± 0.0
0.83TrpArg: 0.83 ± 0.641
0.0TrpSer: 0.0 ± 0.0
0.83TrpThr: 0.83 ± 0.711
0.83TrpVal: 0.83 ± 0.409
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.076TyrAla: 2.076 ± 0.608
0.83TyrCys: 0.83 ± 1.111
2.076TyrAsp: 2.076 ± 0.536
1.245TyrGlu: 1.245 ± 1.145
2.076TyrPhe: 2.076 ± 0.443
2.076TyrGly: 2.076 ± 0.536
0.415TyrHis: 0.415 ± 0.542
1.66TyrIle: 1.66 ± 0.569
2.491TyrLys: 2.491 ± 0.822
2.491TyrLeu: 2.491 ± 0.663
1.245TyrMet: 1.245 ± 0.344
2.491TyrAsn: 2.491 ± 0.585
0.83TyrPro: 0.83 ± 0.767
0.83TyrGln: 0.83 ± 0.465
2.076TyrArg: 2.076 ± 0.546
1.66TyrSer: 1.66 ± 0.59
1.66TyrThr: 1.66 ± 0.523
0.83TyrVal: 0.83 ± 0.706
0.415TyrTrp: 0.415 ± 0.333
2.491TyrTyr: 2.491 ± 0.568
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2410 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski