Amino acid dipepetide frequency for Plantactinospora sp. CNZ320

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.198AlaAla: 21.198 ± 0.168
0.925AlaCys: 0.925 ± 0.02
8.423AlaAsp: 8.423 ± 0.07
9.065AlaGlu: 9.065 ± 0.077
3.076AlaPhe: 3.076 ± 0.043
14.896AlaGly: 14.896 ± 0.097
2.274AlaHis: 2.274 ± 0.034
4.059AlaIle: 4.059 ± 0.046
2.089AlaLys: 2.089 ± 0.04
13.802AlaLeu: 13.802 ± 0.1
2.243AlaMet: 2.243 ± 0.031
2.235AlaAsn: 2.235 ± 0.035
7.014AlaPro: 7.014 ± 0.067
3.557AlaGln: 3.557 ± 0.046
10.518AlaArg: 10.518 ± 0.084
5.616AlaSer: 5.616 ± 0.056
7.753AlaThr: 7.753 ± 0.056
12.358AlaVal: 12.358 ± 0.09
1.815AlaTrp: 1.815 ± 0.028
2.605AlaTyr: 2.605 ± 0.034
0.0AlaXaa: 0.0 ± 0.0
Cys
0.978CysAla: 0.978 ± 0.023
0.104CysCys: 0.104 ± 0.007
0.461CysAsp: 0.461 ± 0.016
0.32CysGlu: 0.32 ± 0.012
0.195CysPhe: 0.195 ± 0.01
0.905CysGly: 0.905 ± 0.022
0.185CysHis: 0.185 ± 0.009
0.155CysIle: 0.155 ± 0.009
0.086CysLys: 0.086 ± 0.007
0.715CysLeu: 0.715 ± 0.019
0.089CysMet: 0.089 ± 0.006
0.141CysAsn: 0.141 ± 0.008
0.495CysPro: 0.495 ± 0.016
0.22CysGln: 0.22 ± 0.01
0.677CysArg: 0.677 ± 0.018
0.37CysSer: 0.37 ± 0.013
0.465CysThr: 0.465 ± 0.014
0.621CysVal: 0.621 ± 0.017
0.141CysTrp: 0.141 ± 0.007
0.2CysTyr: 0.2 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.88AspAla: 6.88 ± 0.059
0.409AspCys: 0.409 ± 0.016
3.691AspAsp: 3.691 ± 0.049
3.793AspGlu: 3.793 ± 0.052
1.462AspPhe: 1.462 ± 0.024
6.66AspGly: 6.66 ± 0.065
1.181AspHis: 1.181 ± 0.025
1.627AspIle: 1.627 ± 0.029
0.746AspLys: 0.746 ± 0.022
6.384AspLeu: 6.384 ± 0.061
0.688AspMet: 0.688 ± 0.017
1.01AspAsn: 1.01 ± 0.023
5.138AspPro: 5.138 ± 0.05
1.742AspGln: 1.742 ± 0.032
6.035AspArg: 6.035 ± 0.064
2.431AspSer: 2.431 ± 0.032
2.598AspThr: 2.598 ± 0.037
4.626AspVal: 4.626 ± 0.041
1.045AspTrp: 1.045 ± 0.019
1.15AspTyr: 1.15 ± 0.024
0.0AspXaa: 0.0 ± 0.0
Glu
6.52GluAla: 6.52 ± 0.072
0.339GluCys: 0.339 ± 0.012
1.959GluAsp: 1.959 ± 0.03
2.578GluGlu: 2.578 ± 0.041
1.506GluPhe: 1.506 ± 0.025
3.046GluGly: 3.046 ± 0.043
1.324GluHis: 1.324 ± 0.026
2.344GluIle: 2.344 ± 0.038
0.877GluLys: 0.877 ± 0.025
6.876GluLeu: 6.876 ± 0.068
0.841GluMet: 0.841 ± 0.017
0.854GluAsn: 0.854 ± 0.022
3.812GluPro: 3.812 ± 0.045
2.198GluGln: 2.198 ± 0.037
5.224GluArg: 5.224 ± 0.059
2.419GluSer: 2.419 ± 0.031
2.682GluThr: 2.682 ± 0.032
4.853GluVal: 4.853 ± 0.056
0.741GluTrp: 0.741 ± 0.02
1.145GluTyr: 1.145 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.525PheAla: 3.525 ± 0.036
0.253PheCys: 0.253 ± 0.01
1.971PheAsp: 1.971 ± 0.033
1.202PheGlu: 1.202 ± 0.022
0.816PhePhe: 0.816 ± 0.019
3.055PheGly: 3.055 ± 0.042
0.513PheHis: 0.513 ± 0.014
0.621PheIle: 0.621 ± 0.015
0.378PheLys: 0.378 ± 0.014
2.515PheLeu: 2.515 ± 0.038
0.31PheMet: 0.31 ± 0.012
0.574PheAsn: 0.574 ± 0.017
1.315PhePro: 1.315 ± 0.024
0.669PheGln: 0.669 ± 0.017
1.899PheArg: 1.899 ± 0.031
1.293PheSer: 1.293 ± 0.029
1.806PheThr: 1.806 ± 0.032
2.467PheVal: 2.467 ± 0.034
0.424PheTrp: 0.424 ± 0.016
0.586PheTyr: 0.586 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
11.052GlyAla: 11.052 ± 0.1
0.869GlyCys: 0.869 ± 0.021
5.159GlyAsp: 5.159 ± 0.05
4.598GlyGlu: 4.598 ± 0.044
2.785GlyPhe: 2.785 ± 0.033
8.994GlyGly: 8.994 ± 0.092
2.011GlyHis: 2.011 ± 0.028
3.371GlyIle: 3.371 ± 0.04
1.742GlyLys: 1.742 ± 0.028
9.709GlyLeu: 9.709 ± 0.068
1.965GlyMet: 1.965 ± 0.035
1.944GlyAsn: 1.944 ± 0.036
5.802GlyPro: 5.802 ± 0.069
3.047GlyGln: 3.047 ± 0.042
8.623GlyArg: 8.623 ± 0.079
5.332GlySer: 5.332 ± 0.066
6.324GlyThr: 6.324 ± 0.078
7.857GlyVal: 7.857 ± 0.067
2.063GlyTrp: 2.063 ± 0.034
2.662GlyTyr: 2.662 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.239HisAla: 2.239 ± 0.033
0.201HisCys: 0.201 ± 0.01
1.25HisAsp: 1.25 ± 0.025
0.971HisGlu: 0.971 ± 0.022
0.537HisPhe: 0.537 ± 0.015
2.022HisGly: 2.022 ± 0.03
0.532HisHis: 0.532 ± 0.017
0.512HisIle: 0.512 ± 0.016
0.211HisLys: 0.211 ± 0.01
2.355HisLeu: 2.355 ± 0.033
0.257HisMet: 0.257 ± 0.01
0.39HisAsn: 0.39 ± 0.015
1.704HisPro: 1.704 ± 0.032
0.625HisGln: 0.625 ± 0.015
2.201HisArg: 2.201 ± 0.036
0.872HisSer: 0.872 ± 0.021
1.034HisThr: 1.034 ± 0.024
1.501HisVal: 1.501 ± 0.024
0.339HisTrp: 0.339 ± 0.012
0.437HisTyr: 0.437 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
4.668IleAla: 4.668 ± 0.047
0.312IleCys: 0.312 ± 0.013
2.303IleAsp: 2.303 ± 0.038
1.995IleGlu: 1.995 ± 0.028
0.875IlePhe: 0.875 ± 0.021
3.667IleGly: 3.667 ± 0.042
0.537IleHis: 0.537 ± 0.014
0.905IleIle: 0.905 ± 0.024
0.535IleLys: 0.535 ± 0.017
2.569IleLeu: 2.569 ± 0.031
0.431IleMet: 0.431 ± 0.015
0.708IleAsn: 0.708 ± 0.018
1.749IlePro: 1.749 ± 0.03
0.704IleGln: 0.704 ± 0.02
2.749IleArg: 2.749 ± 0.038
1.731IleSer: 1.731 ± 0.027
2.036IleThr: 2.036 ± 0.029
2.968IleVal: 2.968 ± 0.038
0.464IleTrp: 0.464 ± 0.015
0.629IleTyr: 0.629 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
1.854LysAla: 1.854 ± 0.037
0.098LysCys: 0.098 ± 0.007
0.713LysAsp: 0.713 ± 0.021
0.721LysGlu: 0.721 ± 0.021
0.335LysPhe: 0.335 ± 0.011
1.09LysGly: 1.09 ± 0.028
0.306LysHis: 0.306 ± 0.013
0.718LysIle: 0.718 ± 0.021
0.434LysLys: 0.434 ± 0.019
1.603LysLeu: 1.603 ± 0.026
0.269LysMet: 0.269 ± 0.013
0.323LysAsn: 0.323 ± 0.012
1.038LysPro: 1.038 ± 0.023
0.52LysGln: 0.52 ± 0.016
1.136LysArg: 1.136 ± 0.024
0.811LysSer: 0.811 ± 0.019
0.931LysThr: 0.931 ± 0.024
1.382LysVal: 1.382 ± 0.03
0.219LysTrp: 0.219 ± 0.01
0.326LysTyr: 0.326 ± 0.012
0.0LysXaa: 0.0 ± 0.0
Leu
16.685LeuAla: 16.685 ± 0.103
0.774LeuCys: 0.774 ± 0.016
7.033LeuAsp: 7.033 ± 0.061
3.869LeuGlu: 3.869 ± 0.049
2.607LeuPhe: 2.607 ± 0.034
9.742LeuGly: 9.742 ± 0.081
2.274LeuHis: 2.274 ± 0.035
3.118LeuIle: 3.118 ± 0.036
1.229LeuLys: 1.229 ± 0.029
12.157LeuLeu: 12.157 ± 0.11
1.31LeuMet: 1.31 ± 0.023
1.649LeuAsn: 1.649 ± 0.025
6.776LeuPro: 6.776 ± 0.061
1.781LeuGln: 1.781 ± 0.033
9.583LeuArg: 9.583 ± 0.086
4.912LeuSer: 4.912 ± 0.043
6.674LeuThr: 6.674 ± 0.054
10.179LeuVal: 10.179 ± 0.09
1.317LeuTrp: 1.317 ± 0.027
1.741LeuTyr: 1.741 ± 0.023
0.0LeuXaa: 0.0 ± 0.0
Met
2.037MetAla: 2.037 ± 0.028
0.104MetCys: 0.104 ± 0.007
0.7MetAsp: 0.7 ± 0.017
0.558MetGlu: 0.558 ± 0.016
0.435MetPhe: 0.435 ± 0.013
0.999MetGly: 0.999 ± 0.022
0.291MetHis: 0.291 ± 0.012
0.665MetIle: 0.665 ± 0.018
0.296MetLys: 0.296 ± 0.011
1.754MetLeu: 1.754 ± 0.033
0.262MetMet: 0.262 ± 0.012
0.351MetAsn: 0.351 ± 0.012
1.115MetPro: 1.115 ± 0.019
0.38MetGln: 0.38 ± 0.014
1.384MetArg: 1.384 ± 0.025
1.197MetSer: 1.197 ± 0.022
1.503MetThr: 1.503 ± 0.024
1.333MetVal: 1.333 ± 0.024
0.193MetTrp: 0.193 ± 0.008
0.267MetTyr: 0.267 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
2.156AsnAla: 2.156 ± 0.036
0.178AsnCys: 0.178 ± 0.009
0.915AsnAsp: 0.915 ± 0.02
0.771AsnGlu: 0.771 ± 0.02
0.515AsnPhe: 0.515 ± 0.017
1.984AsnGly: 1.984 ± 0.042
0.384AsnHis: 0.384 ± 0.012
0.629AsnIle: 0.629 ± 0.019
0.315AsnLys: 0.315 ± 0.014
1.906AsnLeu: 1.906 ± 0.031
0.295AsnMet: 0.295 ± 0.011
0.474AsnAsn: 0.474 ± 0.018
1.564AsnPro: 1.564 ± 0.032
0.573AsnGln: 0.573 ± 0.017
1.526AsnArg: 1.526 ± 0.027
0.992AsnSer: 0.992 ± 0.024
1.044AsnThr: 1.044 ± 0.026
1.417AsnVal: 1.417 ± 0.026
0.388AsnTrp: 0.388 ± 0.012
0.476AsnTyr: 0.476 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
10.149ProAla: 10.149 ± 0.09
0.323ProCys: 0.323 ± 0.012
4.962ProAsp: 4.962 ± 0.045
4.36ProGlu: 4.36 ± 0.05
1.41ProPhe: 1.41 ± 0.026
7.251ProGly: 7.251 ± 0.079
1.139ProHis: 1.139 ± 0.023
1.729ProIle: 1.729 ± 0.029
0.915ProLys: 0.915 ± 0.021
5.283ProLeu: 5.283 ± 0.047
0.973ProMet: 0.973 ± 0.021
1.091ProAsn: 1.091 ± 0.023
4.592ProPro: 4.592 ± 0.074
1.547ProGln: 1.547 ± 0.029
3.942ProArg: 3.942 ± 0.046
3.216ProSer: 3.216 ± 0.047
4.109ProThr: 4.109 ± 0.051
6.141ProVal: 6.141 ± 0.055
0.921ProTrp: 0.921 ± 0.02
1.365ProTyr: 1.365 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.612GlnAla: 3.612 ± 0.049
0.147GlnCys: 0.147 ± 0.008
1.096GlnAsp: 1.096 ± 0.024
1.157GlnGlu: 1.157 ± 0.024
0.737GlnPhe: 0.737 ± 0.02
1.91GlnGly: 1.91 ± 0.032
0.634GlnHis: 0.634 ± 0.018
1.171GlnIle: 1.171 ± 0.025
0.431GlnLys: 0.431 ± 0.014
3.2GlnLeu: 3.2 ± 0.037
0.461GlnMet: 0.461 ± 0.014
0.496GlnAsn: 0.496 ± 0.013
2.086GlnPro: 2.086 ± 0.032
1.152GlnGln: 1.152 ± 0.028
2.843GlnArg: 2.843 ± 0.034
1.222GlnSer: 1.222 ± 0.024
1.406GlnThr: 1.406 ± 0.024
2.821GlnVal: 2.821 ± 0.039
0.488GlnTrp: 0.488 ± 0.015
0.558GlnTyr: 0.558 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
10.301ArgAla: 10.301 ± 0.082
0.656ArgCys: 0.656 ± 0.019
4.732ArgAsp: 4.732 ± 0.051
4.328ArgGlu: 4.328 ± 0.053
2.475ArgPhe: 2.475 ± 0.028
5.764ArgGly: 5.764 ± 0.054
2.223ArgHis: 2.223 ± 0.032
3.567ArgIle: 3.567 ± 0.044
1.26ArgLys: 1.26 ± 0.025
10.023ArgLeu: 10.023 ± 0.088
1.9ArgMet: 1.9 ± 0.028
1.572ArgAsn: 1.572 ± 0.027
5.897ArgPro: 5.897 ± 0.063
2.941ArgGln: 2.941 ± 0.038
9.258ArgArg: 9.258 ± 0.085
4.54ArgSer: 4.54 ± 0.048
5.085ArgThr: 5.085 ± 0.046
6.69ArgVal: 6.69 ± 0.053
1.733ArgTrp: 1.733 ± 0.03
2.231ArgTyr: 2.231 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.498SerAla: 6.498 ± 0.063
0.374SerCys: 0.374 ± 0.014
2.414SerAsp: 2.414 ± 0.033
2.055SerGlu: 2.055 ± 0.031
1.422SerPhe: 1.422 ± 0.028
5.989SerGly: 5.989 ± 0.064
0.861SerHis: 0.861 ± 0.021
1.6SerIle: 1.6 ± 0.026
0.71SerLys: 0.71 ± 0.022
4.235SerLeu: 4.235 ± 0.05
0.989SerMet: 0.989 ± 0.018
0.96SerAsn: 0.96 ± 0.022
3.134SerPro: 3.134 ± 0.042
1.215SerGln: 1.215 ± 0.027
3.9SerArg: 3.9 ± 0.042
2.641SerSer: 2.641 ± 0.044
3.495SerThr: 3.495 ± 0.041
4.16SerVal: 4.16 ± 0.047
0.963SerTrp: 0.963 ± 0.021
1.268SerTyr: 1.268 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.394ThrAla: 8.394 ± 0.068
0.426ThrCys: 0.426 ± 0.016
3.608ThrAsp: 3.608 ± 0.041
3.228ThrGlu: 3.228 ± 0.044
1.63ThrPhe: 1.63 ± 0.027
7.054ThrGly: 7.054 ± 0.073
0.97ThrHis: 0.97 ± 0.018
2.051ThrIle: 2.051 ± 0.032
0.808ThrLys: 0.808 ± 0.022
5.735ThrLeu: 5.735 ± 0.054
0.965ThrMet: 0.965 ± 0.018
1.119ThrAsn: 1.119 ± 0.028
4.222ThrPro: 4.222 ± 0.049
1.201ThrGln: 1.201 ± 0.026
4.199ThrArg: 4.199 ± 0.042
3.015ThrSer: 3.015 ± 0.042
3.568ThrThr: 3.568 ± 0.052
6.295ThrVal: 6.295 ± 0.065
0.863ThrTrp: 0.863 ± 0.022
1.229ThrTyr: 1.229 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
12.247ValAla: 12.247 ± 0.078
0.684ValCys: 0.684 ± 0.018
5.762ValAsp: 5.762 ± 0.053
4.945ValGlu: 4.945 ± 0.045
2.258ValPhe: 2.258 ± 0.037
7.668ValGly: 7.668 ± 0.071
1.69ValHis: 1.69 ± 0.027
2.74ValIle: 2.74 ± 0.038
1.261ValLys: 1.261 ± 0.03
10.1ValLeu: 10.1 ± 0.09
1.117ValMet: 1.117 ± 0.025
1.77ValAsn: 1.77 ± 0.032
5.707ValPro: 5.707 ± 0.058
2.043ValGln: 2.043 ± 0.031
7.617ValArg: 7.617 ± 0.058
4.306ValSer: 4.306 ± 0.05
5.865ValThr: 5.865 ± 0.056
8.604ValVal: 8.604 ± 0.074
1.131ValTrp: 1.131 ± 0.025
1.591ValTyr: 1.591 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.704TrpAla: 1.704 ± 0.026
0.159TrpCys: 0.159 ± 0.009
0.743TrpAsp: 0.743 ± 0.021
0.609TrpGlu: 0.609 ± 0.017
0.506TrpPhe: 0.506 ± 0.015
1.01TrpGly: 1.01 ± 0.02
0.416TrpHis: 0.416 ± 0.014
0.559TrpIle: 0.559 ± 0.014
0.248TrpLys: 0.248 ± 0.009
2.039TrpLeu: 2.039 ± 0.032
0.275TrpMet: 0.275 ± 0.012
0.395TrpAsn: 0.395 ± 0.014
0.954TrpPro: 0.954 ± 0.022
0.738TrpGln: 0.738 ± 0.019
1.719TrpArg: 1.719 ± 0.028
1.024TrpSer: 1.024 ± 0.023
1.061TrpThr: 1.061 ± 0.024
1.073TrpVal: 1.073 ± 0.022
0.401TrpTrp: 0.401 ± 0.011
0.391TrpTyr: 0.391 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.824TyrAla: 2.824 ± 0.038
0.189TyrCys: 0.189 ± 0.01
1.402TyrAsp: 1.402 ± 0.03
1.016TyrGlu: 1.016 ± 0.023
0.61TyrPhe: 0.61 ± 0.017
2.202TyrGly: 2.202 ± 0.033
0.444TyrHis: 0.444 ± 0.014
0.393TyrIle: 0.393 ± 0.015
0.256TyrLys: 0.256 ± 0.01
2.448TyrLeu: 2.448 ± 0.036
0.185TyrMet: 0.185 ± 0.008
0.444TyrAsn: 0.444 ± 0.017
1.305TyrPro: 1.305 ± 0.029
0.774TyrGln: 0.774 ± 0.018
2.139TyrArg: 2.139 ± 0.038
0.943TyrSer: 0.943 ± 0.022
1.142TyrThr: 1.142 ± 0.024
1.763TyrVal: 1.763 ± 0.029
0.375TyrTrp: 0.375 ± 0.014
0.468TyrTyr: 0.468 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7098 proteins (2359260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski