Amino acid dipepetide frequency for Streptococcus satellite phage Javan754

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.581AlaAla: 0.581 ± 0.375
0.291AlaCys: 0.291 ± 0.258
2.907AlaAsp: 2.907 ± 1.102
3.779AlaGlu: 3.779 ± 0.808
3.488AlaPhe: 3.488 ± 0.64
2.035AlaGly: 2.035 ± 0.518
1.163AlaHis: 1.163 ± 0.601
3.779AlaIle: 3.779 ± 1.191
7.558AlaLys: 7.558 ± 1.645
4.36AlaLeu: 4.36 ± 0.861
1.744AlaMet: 1.744 ± 0.717
2.616AlaAsn: 2.616 ± 0.765
0.872AlaPro: 0.872 ± 0.444
2.907AlaGln: 2.907 ± 0.753
2.326AlaArg: 2.326 ± 0.742
1.163AlaSer: 1.163 ± 0.413
4.942AlaThr: 4.942 ± 1.083
2.035AlaVal: 2.035 ± 0.766
0.0AlaTrp: 0.0 ± 0.0
4.07AlaTyr: 4.07 ± 1.226
0.0AlaXaa: 0.0 ± 0.0
Cys
0.581CysAla: 0.581 ± 0.317
0.0CysCys: 0.0 ± 0.0
0.291CysAsp: 0.291 ± 0.338
0.291CysGlu: 0.291 ± 0.259
0.291CysPhe: 0.291 ± 0.266
0.872CysGly: 0.872 ± 0.449
0.291CysHis: 0.291 ± 0.259
0.291CysIle: 0.291 ± 0.251
0.872CysLys: 0.872 ± 0.435
0.872CysLeu: 0.872 ± 0.448
0.291CysMet: 0.291 ± 0.275
0.291CysAsn: 0.291 ± 0.269
0.872CysPro: 0.872 ± 0.376
0.0CysGln: 0.0 ± 0.0
0.581CysArg: 0.581 ± 0.331
0.291CysSer: 0.291 ± 0.258
0.581CysThr: 0.581 ± 0.41
0.291CysVal: 0.291 ± 0.269
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.453AspAla: 1.453 ± 0.478
1.453AspCys: 1.453 ± 0.465
4.651AspAsp: 4.651 ± 1.001
3.779AspGlu: 3.779 ± 1.081
4.942AspPhe: 4.942 ± 0.933
3.779AspGly: 3.779 ± 1.01
0.0AspHis: 0.0 ± 0.0
5.523AspIle: 5.523 ± 0.908
6.105AspLys: 6.105 ± 1.355
8.14AspLeu: 8.14 ± 1.124
0.581AspMet: 0.581 ± 0.439
5.233AspAsn: 5.233 ± 0.947
0.872AspPro: 0.872 ± 0.455
0.581AspGln: 0.581 ± 0.355
1.744AspArg: 1.744 ± 0.752
4.36AspSer: 4.36 ± 1.381
3.488AspThr: 3.488 ± 0.995
3.198AspVal: 3.198 ± 0.792
0.291AspTrp: 0.291 ± 0.269
2.035AspTyr: 2.035 ± 0.802
0.0AspXaa: 0.0 ± 0.0
Glu
3.198GluAla: 3.198 ± 0.964
0.872GluCys: 0.872 ± 0.423
4.36GluAsp: 4.36 ± 1.36
4.07GluGlu: 4.07 ± 1.089
4.07GluPhe: 4.07 ± 0.95
3.198GluGly: 3.198 ± 0.833
1.453GluHis: 1.453 ± 0.856
9.884GluIle: 9.884 ± 1.112
9.302GluLys: 9.302 ± 1.526
8.43GluLeu: 8.43 ± 1.552
1.163GluMet: 1.163 ± 0.604
5.233GluAsn: 5.233 ± 0.969
0.872GluPro: 0.872 ± 0.577
3.779GluGln: 3.779 ± 0.73
3.198GluArg: 3.198 ± 0.939
6.105GluSer: 6.105 ± 1.119
5.523GluThr: 5.523 ± 1.02
1.163GluVal: 1.163 ± 0.544
0.581GluTrp: 0.581 ± 0.389
4.07GluTyr: 4.07 ± 1.077
0.0GluXaa: 0.0 ± 0.0
Phe
0.581PheAla: 0.581 ± 0.349
0.872PheCys: 0.872 ± 0.56
3.198PheAsp: 3.198 ± 0.898
2.907PheGlu: 2.907 ± 0.741
2.907PhePhe: 2.907 ± 0.782
1.744PheGly: 1.744 ± 0.713
0.872PheHis: 0.872 ± 0.391
2.035PheIle: 2.035 ± 0.6
5.814PheLys: 5.814 ± 1.1
4.651PheLeu: 4.651 ± 1.096
1.163PheMet: 1.163 ± 0.529
1.744PheAsn: 1.744 ± 0.746
0.872PhePro: 0.872 ± 0.525
1.163PheGln: 1.163 ± 0.636
1.453PheArg: 1.453 ± 0.425
4.651PheSer: 4.651 ± 1.3
1.163PheThr: 1.163 ± 0.49
2.907PheVal: 2.907 ± 1.032
0.872PheTrp: 0.872 ± 0.405
1.744PheTyr: 1.744 ± 0.736
0.0PheXaa: 0.0 ± 0.0
Gly
2.616GlyAla: 2.616 ± 0.805
0.0GlyCys: 0.0 ± 0.0
1.453GlyAsp: 1.453 ± 0.925
2.616GlyGlu: 2.616 ± 0.669
1.453GlyPhe: 1.453 ± 0.585
1.744GlyGly: 1.744 ± 0.619
0.872GlyHis: 0.872 ± 0.425
4.36GlyIle: 4.36 ± 0.873
4.942GlyLys: 4.942 ± 0.945
3.488GlyLeu: 3.488 ± 0.745
1.744GlyMet: 1.744 ± 0.693
2.035GlyAsn: 2.035 ± 0.667
0.0GlyPro: 0.0 ± 0.0
2.907GlyGln: 2.907 ± 0.816
2.326GlyArg: 2.326 ± 0.696
2.907GlySer: 2.907 ± 0.824
1.744GlyThr: 1.744 ± 0.569
3.198GlyVal: 3.198 ± 0.801
0.291GlyTrp: 0.291 ± 0.269
3.488GlyTyr: 3.488 ± 1.106
0.0GlyXaa: 0.0 ± 0.0
His
2.616HisAla: 2.616 ± 0.897
0.0HisCys: 0.0 ± 0.0
0.872HisAsp: 0.872 ± 0.495
0.291HisGlu: 0.291 ± 0.338
0.581HisPhe: 0.581 ± 0.532
0.581HisGly: 0.581 ± 0.389
0.291HisHis: 0.291 ± 0.266
0.581HisIle: 0.581 ± 0.416
1.453HisLys: 1.453 ± 0.567
1.744HisLeu: 1.744 ± 0.542
0.291HisMet: 0.291 ± 0.279
1.453HisAsn: 1.453 ± 0.639
0.291HisPro: 0.291 ± 0.292
0.581HisGln: 0.581 ± 0.367
0.872HisArg: 0.872 ± 0.567
1.163HisSer: 1.163 ± 0.53
0.581HisThr: 0.581 ± 0.518
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.872HisTyr: 0.872 ± 0.574
0.0HisXaa: 0.0 ± 0.0
Ile
2.907IleAla: 2.907 ± 0.741
0.0IleCys: 0.0 ± 0.0
4.36IleAsp: 4.36 ± 1.093
6.105IleGlu: 6.105 ± 1.342
3.198IlePhe: 3.198 ± 0.807
3.488IleGly: 3.488 ± 1.254
1.163IleHis: 1.163 ± 0.516
7.558IleIle: 7.558 ± 1.36
9.012IleLys: 9.012 ± 1.596
9.302IleLeu: 9.302 ± 1.329
0.291IleMet: 0.291 ± 0.258
3.488IleAsn: 3.488 ± 0.957
2.907IlePro: 2.907 ± 0.839
2.907IleGln: 2.907 ± 0.52
2.035IleArg: 2.035 ± 0.639
5.233IleSer: 5.233 ± 1.022
3.779IleThr: 3.779 ± 1.167
3.488IleVal: 3.488 ± 0.636
0.291IleTrp: 0.291 ± 0.338
3.488IleTyr: 3.488 ± 0.962
0.0IleXaa: 0.0 ± 0.0
Lys
6.686LysAla: 6.686 ± 1.611
0.872LysCys: 0.872 ± 0.43
6.977LysAsp: 6.977 ± 1.073
11.047LysGlu: 11.047 ± 1.268
4.07LysPhe: 4.07 ± 1.07
5.233LysGly: 5.233 ± 1.162
2.616LysHis: 2.616 ± 0.906
6.977LysIle: 6.977 ± 1.541
9.593LysLys: 9.593 ± 1.728
7.558LysLeu: 7.558 ± 1.321
1.744LysMet: 1.744 ± 0.677
6.686LysAsn: 6.686 ± 0.954
1.744LysPro: 1.744 ± 0.593
4.07LysGln: 4.07 ± 0.99
6.395LysArg: 6.395 ± 1.195
6.105LysSer: 6.105 ± 0.875
7.558LysThr: 7.558 ± 1.693
3.488LysVal: 3.488 ± 0.605
0.872LysTrp: 0.872 ± 0.432
3.488LysTyr: 3.488 ± 0.762
0.0LysXaa: 0.0 ± 0.0
Leu
8.14LeuAla: 8.14 ± 1.641
0.581LeuCys: 0.581 ± 0.379
9.012LeuAsp: 9.012 ± 1.256
9.884LeuGlu: 9.884 ± 1.439
2.907LeuPhe: 2.907 ± 0.8
4.651LeuGly: 4.651 ± 0.721
0.291LeuHis: 0.291 ± 0.266
5.233LeuIle: 5.233 ± 1.12
8.14LeuLys: 8.14 ± 1.501
8.721LeuLeu: 8.721 ± 1.605
3.198LeuMet: 3.198 ± 0.751
7.558LeuAsn: 7.558 ± 1.738
4.07LeuPro: 4.07 ± 0.947
2.907LeuGln: 2.907 ± 0.999
5.233LeuArg: 5.233 ± 0.996
6.977LeuSer: 6.977 ± 1.094
6.686LeuThr: 6.686 ± 1.316
5.523LeuVal: 5.523 ± 1.173
0.291LeuTrp: 0.291 ± 0.251
3.198LeuTyr: 3.198 ± 0.989
0.0LeuXaa: 0.0 ± 0.0
Met
1.744MetAla: 1.744 ± 0.606
0.291MetCys: 0.291 ± 0.283
2.035MetAsp: 2.035 ± 0.594
1.744MetGlu: 1.744 ± 0.638
0.291MetPhe: 0.291 ± 0.338
0.291MetGly: 0.291 ± 0.283
0.0MetHis: 0.0 ± 0.0
1.163MetIle: 1.163 ± 0.678
2.035MetLys: 2.035 ± 0.561
1.163MetLeu: 1.163 ± 0.376
0.0MetMet: 0.0 ± 0.0
1.453MetAsn: 1.453 ± 0.618
0.291MetPro: 0.291 ± 0.251
0.581MetGln: 0.581 ± 0.365
1.163MetArg: 1.163 ± 0.54
1.453MetSer: 1.453 ± 0.553
2.616MetThr: 2.616 ± 0.961
0.291MetVal: 0.291 ± 0.251
0.0MetTrp: 0.0 ± 0.0
0.872MetTyr: 0.872 ± 0.462
0.0MetXaa: 0.0 ± 0.0
Asn
3.488AsnAla: 3.488 ± 0.844
0.581AsnCys: 0.581 ± 0.367
1.744AsnAsp: 1.744 ± 0.542
2.326AsnGlu: 2.326 ± 0.817
2.326AsnPhe: 2.326 ± 0.637
2.326AsnGly: 2.326 ± 0.716
1.453AsnHis: 1.453 ± 0.921
3.779AsnIle: 3.779 ± 1.265
6.395AsnLys: 6.395 ± 1.343
4.942AsnLeu: 4.942 ± 1.023
2.326AsnMet: 2.326 ± 0.769
4.07AsnAsn: 4.07 ± 1.915
2.326AsnPro: 2.326 ± 0.786
3.198AsnGln: 3.198 ± 0.813
3.198AsnArg: 3.198 ± 0.713
4.651AsnSer: 4.651 ± 0.926
5.233AsnThr: 5.233 ± 1.391
2.035AsnVal: 2.035 ± 0.735
0.872AsnTrp: 0.872 ± 0.409
3.488AsnTyr: 3.488 ± 0.891
0.0AsnXaa: 0.0 ± 0.0
Pro
1.453ProAla: 1.453 ± 0.675
0.0ProCys: 0.0 ± 0.0
2.616ProAsp: 2.616 ± 0.859
2.907ProGlu: 2.907 ± 1.021
2.326ProPhe: 2.326 ± 0.797
0.291ProGly: 0.291 ± 0.251
0.291ProHis: 0.291 ± 0.258
1.744ProIle: 1.744 ± 0.725
3.488ProLys: 3.488 ± 1.156
0.291ProLeu: 0.291 ± 0.255
0.0ProMet: 0.0 ± 0.0
1.163ProAsn: 1.163 ± 0.487
0.872ProPro: 0.872 ± 0.713
0.581ProGln: 0.581 ± 0.352
1.453ProArg: 1.453 ± 0.647
1.163ProSer: 1.163 ± 0.487
1.744ProThr: 1.744 ± 0.621
0.872ProVal: 0.872 ± 0.395
0.0ProTrp: 0.0 ± 0.0
1.163ProTyr: 1.163 ± 0.452
0.0ProXaa: 0.0 ± 0.0
Gln
3.779GlnAla: 3.779 ± 0.636
0.581GlnCys: 0.581 ± 0.368
2.326GlnAsp: 2.326 ± 0.984
2.907GlnGlu: 2.907 ± 0.471
1.744GlnPhe: 1.744 ± 0.811
0.872GlnGly: 0.872 ± 0.506
0.581GlnHis: 0.581 ± 0.369
2.907GlnIle: 2.907 ± 0.739
2.907GlnLys: 2.907 ± 0.741
3.488GlnLeu: 3.488 ± 1.227
0.291GlnMet: 0.291 ± 0.269
2.907GlnAsn: 2.907 ± 0.831
1.163GlnPro: 1.163 ± 0.57
2.035GlnGln: 2.035 ± 0.822
1.453GlnArg: 1.453 ± 0.693
1.163GlnSer: 1.163 ± 0.582
1.744GlnThr: 1.744 ± 0.626
3.198GlnVal: 3.198 ± 0.9
0.581GlnTrp: 0.581 ± 0.341
0.581GlnTyr: 0.581 ± 0.361
0.0GlnXaa: 0.0 ± 0.0
Arg
1.744ArgAla: 1.744 ± 0.576
0.291ArgCys: 0.291 ± 0.273
3.198ArgAsp: 3.198 ± 0.827
5.523ArgGlu: 5.523 ± 1.175
1.453ArgPhe: 1.453 ± 0.593
1.163ArgGly: 1.163 ± 0.473
0.872ArgHis: 0.872 ± 0.359
2.907ArgIle: 2.907 ± 0.565
4.942ArgLys: 4.942 ± 0.98
6.105ArgLeu: 6.105 ± 1.74
0.872ArgMet: 0.872 ± 0.447
2.616ArgAsn: 2.616 ± 0.792
0.581ArgPro: 0.581 ± 0.332
2.035ArgGln: 2.035 ± 0.526
1.453ArgArg: 1.453 ± 0.74
1.453ArgSer: 1.453 ± 0.717
3.198ArgThr: 3.198 ± 0.645
1.453ArgVal: 1.453 ± 0.681
0.291ArgTrp: 0.291 ± 0.255
3.488ArgTyr: 3.488 ± 1.202
0.0ArgXaa: 0.0 ± 0.0
Ser
2.616SerAla: 2.616 ± 1.104
0.291SerCys: 0.291 ± 0.251
4.651SerAsp: 4.651 ± 1.081
6.977SerGlu: 6.977 ± 1.551
2.326SerPhe: 2.326 ± 0.717
3.488SerGly: 3.488 ± 0.492
0.872SerHis: 0.872 ± 0.396
4.651SerIle: 4.651 ± 1.228
6.105SerLys: 6.105 ± 1.125
7.267SerLeu: 7.267 ± 1.278
0.872SerMet: 0.872 ± 0.555
3.198SerAsn: 3.198 ± 0.803
1.744SerPro: 1.744 ± 0.509
1.453SerGln: 1.453 ± 0.63
3.488SerArg: 3.488 ± 0.785
4.07SerSer: 4.07 ± 1.066
4.07SerThr: 4.07 ± 0.695
2.035SerVal: 2.035 ± 0.568
0.872SerTrp: 0.872 ± 0.419
1.744SerTyr: 1.744 ± 0.619
0.0SerXaa: 0.0 ± 0.0
Thr
2.616ThrAla: 2.616 ± 1.084
0.0ThrCys: 0.0 ± 0.0
1.744ThrAsp: 1.744 ± 0.591
3.488ThrGlu: 3.488 ± 0.828
1.744ThrPhe: 1.744 ± 0.607
4.651ThrGly: 4.651 ± 0.973
1.744ThrHis: 1.744 ± 0.623
4.36ThrIle: 4.36 ± 0.986
6.395ThrLys: 6.395 ± 1.237
9.593ThrLeu: 9.593 ± 1.312
1.163ThrMet: 1.163 ± 0.506
3.488ThrAsn: 3.488 ± 0.909
1.744ThrPro: 1.744 ± 0.463
2.035ThrGln: 2.035 ± 0.709
2.326ThrArg: 2.326 ± 0.859
3.198ThrSer: 3.198 ± 0.853
2.616ThrThr: 2.616 ± 1.107
6.105ThrVal: 6.105 ± 1.386
0.581ThrTrp: 0.581 ± 0.356
2.907ThrTyr: 2.907 ± 0.957
0.0ThrXaa: 0.0 ± 0.0
Val
2.616ValAla: 2.616 ± 0.876
0.291ValCys: 0.291 ± 0.338
3.198ValAsp: 3.198 ± 1.094
3.488ValGlu: 3.488 ± 0.998
0.872ValPhe: 0.872 ± 0.374
2.907ValGly: 2.907 ± 0.999
0.0ValHis: 0.0 ± 0.0
4.07ValIle: 4.07 ± 0.914
4.07ValLys: 4.07 ± 1.117
3.779ValLeu: 3.779 ± 1.123
0.581ValMet: 0.581 ± 0.367
2.616ValAsn: 2.616 ± 0.49
1.453ValPro: 1.453 ± 0.429
2.035ValGln: 2.035 ± 0.829
2.326ValArg: 2.326 ± 0.765
4.07ValSer: 4.07 ± 1.038
2.907ValThr: 2.907 ± 0.767
2.907ValVal: 2.907 ± 0.826
0.0ValTrp: 0.0 ± 0.0
2.616ValTyr: 2.616 ± 0.807
0.0ValXaa: 0.0 ± 0.0
Trp
1.163TrpAla: 1.163 ± 0.395
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.326TrpGlu: 2.326 ± 0.844
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.291TrpIle: 0.291 ± 0.275
0.581TrpLys: 0.581 ± 0.392
0.872TrpLeu: 0.872 ± 0.573
0.0TrpMet: 0.0 ± 0.0
0.291TrpAsn: 0.291 ± 0.255
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.291TrpSer: 0.291 ± 0.259
0.0TrpThr: 0.0 ± 0.0
1.163TrpVal: 1.163 ± 0.476
0.0TrpTrp: 0.0 ± 0.0
0.291TrpTyr: 0.291 ± 0.266
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.035TyrAla: 2.035 ± 0.701
0.581TyrCys: 0.581 ± 0.352
2.616TyrAsp: 2.616 ± 0.632
4.36TyrGlu: 4.36 ± 0.949
2.326TyrPhe: 2.326 ± 0.753
0.872TyrGly: 0.872 ± 0.429
0.291TyrHis: 0.291 ± 0.292
2.907TyrIle: 2.907 ± 0.725
4.07TyrLys: 4.07 ± 1.361
8.43TyrLeu: 8.43 ± 1.624
0.872TyrMet: 0.872 ± 0.466
2.616TyrAsn: 2.616 ± 1.11
0.872TyrPro: 0.872 ± 0.426
1.453TyrGln: 1.453 ± 0.59
2.616TyrArg: 2.616 ± 0.857
2.326TyrSer: 2.326 ± 0.657
2.326TyrThr: 2.326 ± 0.673
1.453TyrVal: 1.453 ± 0.627
0.581TyrTrp: 0.581 ± 0.368
1.744TyrTyr: 1.744 ± 0.818
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (3441 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski