Amino acid dipepetide frequency for Pseudomonas nosocomialis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.433AlaAla: 13.433 ± 0.151	1.269AlaCys: 1.269 ± 0.033	6.082AlaAsp: 6.082 ± 0.074	7.591AlaGlu: 7.591 ± 0.094	3.941AlaPhe: 3.941 ± 0.052	9.567AlaGly: 9.567 ± 0.114	2.229AlaHis: 2.229 ± 0.04	5.242AlaIle: 5.242 ± 0.064	2.995AlaLys: 2.995 ± 0.053	14.585AlaLeu: 14.585 ± 0.122	2.977AlaMet: 2.977 ± 0.047	2.672AlaAsn: 2.672 ± 0.046	4.867AlaPro: 4.867 ± 0.072	5.035AlaGln: 5.035 ± 0.068	8.458AlaArg: 8.458 ± 0.093	6.218AlaSer: 6.218 ± 0.092	4.971AlaThr: 4.971 ± 0.062	7.657AlaVal: 7.657 ± 0.087	1.623AlaTrp: 1.623 ± 0.04	2.462AlaTyr: 2.462 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.113CysAla: 1.113 ± 0.028	0.156CysCys: 0.156 ± 0.01	0.537CysAsp: 0.537 ± 0.02	0.582CysGlu: 0.582 ± 0.021	0.318CysPhe: 0.318 ± 0.016	0.974CysGly: 0.974 ± 0.027	0.291CysHis: 0.291 ± 0.015	0.413CysIle: 0.413 ± 0.017	0.246CysLys: 0.246 ± 0.014	1.111CysLeu: 1.111 ± 0.029	0.181CysMet: 0.181 ± 0.012	0.236CysAsn: 0.236 ± 0.015	0.507CysPro: 0.507 ± 0.022	0.369CysGln: 0.369 ± 0.016	0.698CysArg: 0.698 ± 0.022	0.577CysSer: 0.577 ± 0.021	0.414CysThr: 0.414 ± 0.018	0.641CysVal: 0.641 ± 0.024	0.147CysTrp: 0.147 ± 0.009	0.234CysTyr: 0.234 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.092AspAla: 6.092 ± 0.079	0.497AspCys: 0.497 ± 0.02	3.065AspAsp: 3.065 ± 0.059	3.876AspGlu: 3.876 ± 0.069	1.981AspPhe: 1.981 ± 0.047	4.663AspGly: 4.663 ± 0.061	1.176AspHis: 1.176 ± 0.027	2.608AspIle: 2.608 ± 0.04	1.681AspLys: 1.681 ± 0.041	5.969AspLeu: 5.969 ± 0.066	1.231AspMet: 1.231 ± 0.031	1.414AspAsn: 1.414 ± 0.035	3.04AspPro: 3.04 ± 0.051	2.037AspGln: 2.037 ± 0.037	3.661AspArg: 3.661 ± 0.056	2.749AspSer: 2.749 ± 0.051	2.355AspThr: 2.355 ± 0.043	3.583AspVal: 3.583 ± 0.057	1.011AspTrp: 1.011 ± 0.027	1.671AspTyr: 1.671 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.515GluAla: 7.515 ± 0.088	0.421GluCys: 0.421 ± 0.018	2.666GluAsp: 2.666 ± 0.047	3.303GluGlu: 3.303 ± 0.061	1.747GluPhe: 1.747 ± 0.035	4.439GluGly: 4.439 ± 0.064	1.617GluHis: 1.617 ± 0.031	2.757GluIle: 2.757 ± 0.047	2.004GluLys: 2.004 ± 0.043	7.32GluLeu: 7.32 ± 0.088	1.339GluMet: 1.339 ± 0.035	1.445GluAsn: 1.445 ± 0.032	3.059GluPro: 3.059 ± 0.047	3.788GluGln: 3.788 ± 0.062	5.866GluArg: 5.866 ± 0.081	2.65GluSer: 2.65 ± 0.043	2.764GluThr: 2.764 ± 0.053	4.376GluVal: 4.376 ± 0.06	0.731GluTrp: 0.731 ± 0.022	1.218GluTyr: 1.218 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.125PheAla: 4.125 ± 0.059	0.444PheCys: 0.444 ± 0.017	2.509PheAsp: 2.509 ± 0.043	2.221PheGlu: 2.221 ± 0.038	1.435PhePhe: 1.435 ± 0.039	3.288PheGly: 3.288 ± 0.05	0.751PheHis: 0.751 ± 0.026	1.67PheIle: 1.67 ± 0.04	1.04PheLys: 1.04 ± 0.025	3.14PheLeu: 3.14 ± 0.058	0.784PheMet: 0.784 ± 0.025	1.202PheAsn: 1.202 ± 0.032	1.453PhePro: 1.453 ± 0.034	1.159PheGln: 1.159 ± 0.031	1.925PheArg: 1.925 ± 0.035	2.316PheSer: 2.316 ± 0.043	1.81PheThr: 1.81 ± 0.037	2.649PheVal: 2.649 ± 0.048	0.544PheTrp: 0.544 ± 0.02	0.974PheTyr: 0.974 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.002GlyAla: 8.002 ± 0.122	0.981GlyCys: 0.981 ± 0.026	4.195GlyAsp: 4.195 ± 0.075	5.343GlyGlu: 5.343 ± 0.067	3.37GlyPhe: 3.37 ± 0.058	6.413GlyGly: 6.413 ± 0.108	1.868GlyHis: 1.868 ± 0.039	4.206GlyIle: 4.206 ± 0.064	2.937GlyLys: 2.937 ± 0.053	9.637GlyLeu: 9.637 ± 0.106	2.268GlyMet: 2.268 ± 0.046	2.322GlyAsn: 2.322 ± 0.042	2.754GlyPro: 2.754 ± 0.043	3.659GlyGln: 3.659 ± 0.051	5.662GlyArg: 5.662 ± 0.071	4.663GlySer: 4.663 ± 0.076	3.931GlyThr: 3.931 ± 0.058	6.104GlyVal: 6.104 ± 0.076	1.37GlyTrp: 1.37 ± 0.034	2.497GlyTyr: 2.497 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.372HisAla: 2.372 ± 0.039	0.333HisCys: 0.333 ± 0.017	1.211HisAsp: 1.211 ± 0.036	1.181HisGlu: 1.181 ± 0.031	0.978HisPhe: 0.978 ± 0.028	2.033HisGly: 2.033 ± 0.038	0.614HisHis: 0.614 ± 0.023	0.895HisIle: 0.895 ± 0.026	0.558HisLys: 0.558 ± 0.02	2.591HisLeu: 2.591 ± 0.045	0.49HisMet: 0.49 ± 0.018	0.577HisAsn: 0.577 ± 0.019	1.482HisPro: 1.482 ± 0.034	0.891HisGln: 0.891 ± 0.025	1.556HisArg: 1.556 ± 0.036	1.132HisSer: 1.132 ± 0.027	0.909HisThr: 0.909 ± 0.029	1.303HisVal: 1.303 ± 0.033	0.434HisTrp: 0.434 ± 0.022	0.731HisTyr: 0.731 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.778IleAla: 5.778 ± 0.068	0.457IleCys: 0.457 ± 0.02	3.174IleAsp: 3.174 ± 0.055	3.499IleGlu: 3.499 ± 0.055	1.328IlePhe: 1.328 ± 0.035	4.683IleGly: 4.683 ± 0.069	0.964IleHis: 0.964 ± 0.031	1.876IleIle: 1.876 ± 0.042	1.39IleLys: 1.39 ± 0.037	4.054IleLeu: 4.054 ± 0.061	0.794IleMet: 0.794 ± 0.027	1.507IleAsn: 1.507 ± 0.036	2.196IlePro: 2.196 ± 0.045	1.561IleGln: 1.561 ± 0.036	3.131IleArg: 3.131 ± 0.048	2.574IleSer: 2.574 ± 0.052	2.397IleThr: 2.397 ± 0.04	3.125IleVal: 3.125 ± 0.048	0.475IleTrp: 0.475 ± 0.02	1.071IleTyr: 1.071 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.533LysAla: 3.533 ± 0.059	0.158LysCys: 0.158 ± 0.011	1.428LysAsp: 1.428 ± 0.033	1.453LysGlu: 1.453 ± 0.038	0.765LysPhe: 0.765 ± 0.028	2.356LysGly: 2.356 ± 0.045	0.676LysHis: 0.676 ± 0.025	1.313LysIle: 1.313 ± 0.037	1.103LysLys: 1.103 ± 0.035	3.234LysLeu: 3.234 ± 0.049	0.636LysMet: 0.636 ± 0.021	0.807LysAsn: 0.807 ± 0.028	1.852LysPro: 1.852 ± 0.036	1.325LysGln: 1.325 ± 0.037	2.255LysArg: 2.255 ± 0.045	1.5LysSer: 1.5 ± 0.04	1.576LysThr: 1.576 ± 0.037	2.4LysVal: 2.4 ± 0.047	0.291LysTrp: 0.291 ± 0.014	0.557LysTyr: 0.557 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.064LeuAla: 15.064 ± 0.13	1.231LeuCys: 1.231 ± 0.033	7.032LeuAsp: 7.032 ± 0.079	7.091LeuGlu: 7.091 ± 0.09	4.246LeuPhe: 4.246 ± 0.062	9.68LeuGly: 9.68 ± 0.111	2.434LeuHis: 2.434 ± 0.045	5.443LeuIle: 5.443 ± 0.073	3.72LeuLys: 3.72 ± 0.059	13.654LeuLeu: 13.654 ± 0.156	2.539LeuMet: 2.539 ± 0.042	3.151LeuAsn: 3.151 ± 0.046	6.397LeuPro: 6.397 ± 0.082	4.605LeuGln: 4.605 ± 0.07	7.934LeuArg: 7.934 ± 0.089	6.877LeuSer: 6.877 ± 0.083	5.614LeuThr: 5.614 ± 0.068	8.246LeuVal: 8.246 ± 0.083	1.455LeuTrp: 1.455 ± 0.041	2.486LeuTyr: 2.486 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.658MetAla: 2.658 ± 0.043	0.156MetCys: 0.156 ± 0.01	1.088MetAsp: 1.088 ± 0.028	0.962MetGlu: 0.962 ± 0.028	0.652MetPhe: 0.652 ± 0.025	1.649MetGly: 1.649 ± 0.039	0.52MetHis: 0.52 ± 0.019	1.108MetIle: 1.108 ± 0.024	0.861MetLys: 0.861 ± 0.023	2.785MetLeu: 2.785 ± 0.05	0.495MetMet: 0.495 ± 0.019	0.802MetAsn: 0.802 ± 0.025	1.422MetPro: 1.422 ± 0.032	1.063MetGln: 1.063 ± 0.028	1.648MetArg: 1.648 ± 0.039	1.647MetSer: 1.647 ± 0.036	1.473MetThr: 1.473 ± 0.037	1.521MetVal: 1.521 ± 0.031	0.153MetTrp: 0.153 ± 0.01	0.334MetTyr: 0.334 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.934AsnAla: 2.934 ± 0.052	0.244AsnCys: 0.244 ± 0.015	1.42AsnAsp: 1.42 ± 0.037	1.433AsnGlu: 1.433 ± 0.031	0.917AsnPhe: 0.917 ± 0.03	2.349AsnGly: 2.349 ± 0.051	0.583AsnHis: 0.583 ± 0.018	1.267AsnIle: 1.267 ± 0.029	0.733AsnLys: 0.733 ± 0.027	3.255AsnLeu: 3.255 ± 0.045	0.555AsnMet: 0.555 ± 0.02	0.803AsnAsn: 0.803 ± 0.027	1.848AsnPro: 1.848 ± 0.037	1.114AsnGln: 1.114 ± 0.032	1.923AsnArg: 1.923 ± 0.035	1.275AsnSer: 1.275 ± 0.031	1.305AsnThr: 1.305 ± 0.036	1.807AsnVal: 1.807 ± 0.043	0.389AsnTrp: 0.389 ± 0.016	0.676AsnTyr: 0.676 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.982ProAla: 5.982 ± 0.066	0.391ProCys: 0.391 ± 0.016	3.116ProAsp: 3.116 ± 0.054	3.584ProGlu: 3.584 ± 0.064	1.84ProPhe: 1.84 ± 0.039	4.18ProGly: 4.18 ± 0.06	1.039ProHis: 1.039 ± 0.031	1.989ProIle: 1.989 ± 0.039	1.318ProLys: 1.318 ± 0.04	5.809ProLeu: 5.809 ± 0.071	1.24ProMet: 1.24 ± 0.029	1.308ProAsn: 1.308 ± 0.027	2.147ProPro: 2.147 ± 0.05	2.177ProGln: 2.177 ± 0.042	3.085ProArg: 3.085 ± 0.042	2.724ProSer: 2.724 ± 0.047	2.209ProThr: 2.209 ± 0.042	3.868ProVal: 3.868 ± 0.051	0.749ProTrp: 0.749 ± 0.026	1.271ProTyr: 1.271 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.957GlnAla: 5.957 ± 0.083	0.298GlnCys: 0.298 ± 0.013	1.805GlnAsp: 1.805 ± 0.04	1.981GlnGlu: 1.981 ± 0.046	1.213GlnPhe: 1.213 ± 0.034	3.407GlnGly: 3.407 ± 0.059	1.01GlnHis: 1.01 ± 0.024	1.868GlnIle: 1.868 ± 0.041	1.093GlnLys: 1.093 ± 0.03	5.227GlnLeu: 5.227 ± 0.065	1.015GlnMet: 1.015 ± 0.025	0.967GlnAsn: 0.967 ± 0.025	2.476GlnPro: 2.476 ± 0.041	2.438GlnGln: 2.438 ± 0.048	3.762GlnArg: 3.762 ± 0.06	2.078GlnSer: 2.078 ± 0.04	1.918GlnThr: 1.918 ± 0.04	3.507GlnVal: 3.507 ± 0.052	0.651GlnTrp: 0.651 ± 0.022	0.882GlnTyr: 0.882 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.95ArgAla: 6.95 ± 0.077	0.681ArgCys: 0.681 ± 0.021	3.959ArgAsp: 3.959 ± 0.06	4.875ArgGlu: 4.875 ± 0.069	2.977ArgPhe: 2.977 ± 0.044	4.65ArgGly: 4.65 ± 0.059	1.917ArgHis: 1.917 ± 0.04	3.723ArgIle: 3.723 ± 0.055	1.961ArgLys: 1.961 ± 0.044	9.52ArgLeu: 9.52 ± 0.115	1.823ArgMet: 1.823 ± 0.034	1.973ArgAsn: 1.973 ± 0.04	3.267ArgPro: 3.267 ± 0.048	3.75ArgGln: 3.75 ± 0.062	5.316ArgArg: 5.316 ± 0.069	3.697ArgSer: 3.697 ± 0.053	2.981ArgThr: 2.981 ± 0.046	4.95ArgVal: 4.95 ± 0.058	1.194ArgTrp: 1.194 ± 0.034	2.249ArgTyr: 2.249 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.81SerAla: 5.81 ± 0.073	0.475SerCys: 0.475 ± 0.021	2.75SerAsp: 2.75 ± 0.053	3.077SerGlu: 3.077 ± 0.05	2.055SerPhe: 2.055 ± 0.042	5.176SerGly: 5.176 ± 0.091	1.201SerHis: 1.201 ± 0.03	2.481SerIle: 2.481 ± 0.047	1.453SerLys: 1.453 ± 0.035	6.865SerLeu: 6.865 ± 0.07	1.341SerMet: 1.341 ± 0.028	1.435SerAsn: 1.435 ± 0.033	2.693SerPro: 2.693 ± 0.046	2.215SerGln: 2.215 ± 0.044	3.881SerArg: 3.881 ± 0.046	3.076SerSer: 3.076 ± 0.056	2.595SerThr: 2.595 ± 0.049	3.891SerVal: 3.891 ± 0.058	0.782SerTrp: 0.782 ± 0.023	1.314SerTyr: 1.314 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.073ThrAla: 5.073 ± 0.068	0.433ThrCys: 0.433 ± 0.016	2.338ThrAsp: 2.338 ± 0.044	2.417ThrGlu: 2.417 ± 0.044	1.72ThrPhe: 1.72 ± 0.038	4.248ThrGly: 4.248 ± 0.059	1.062ThrHis: 1.062 ± 0.027	1.878ThrIle: 1.878 ± 0.04	0.988ThrLys: 0.988 ± 0.029	6.777ThrLeu: 6.777 ± 0.069	0.801ThrMet: 0.801 ± 0.024	1.063ThrAsn: 1.063 ± 0.034	3.127ThrPro: 3.127 ± 0.049	1.749ThrGln: 1.749 ± 0.04	3.359ThrArg: 3.359 ± 0.057	2.479ThrSer: 2.479 ± 0.045	2.317ThrThr: 2.317 ± 0.045	3.406ThrVal: 3.406 ± 0.06	0.612ThrTrp: 0.612 ± 0.02	1.151ThrTyr: 1.151 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.88ValAla: 7.88 ± 0.087	0.689ValCys: 0.689 ± 0.023	3.978ValAsp: 3.978 ± 0.053	4.697ValGlu: 4.697 ± 0.06	2.52ValPhe: 2.52 ± 0.042	5.423ValGly: 5.423 ± 0.08	1.4ValHis: 1.4 ± 0.031	3.774ValIle: 3.774 ± 0.055	2.062ValLys: 2.062 ± 0.042	8.165ValLeu: 8.165 ± 0.084	1.722ValMet: 1.722 ± 0.04	2.039ValAsn: 2.039 ± 0.039	3.438ValPro: 3.438 ± 0.052	2.588ValGln: 2.588 ± 0.047	4.935ValArg: 4.935 ± 0.058	4.105ValSer: 4.105 ± 0.054	3.69ValThr: 3.69 ± 0.056	5.587ValVal: 5.587 ± 0.072	0.864ValTrp: 0.864 ± 0.032	1.554ValTyr: 1.554 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.186TrpAla: 1.186 ± 0.028	0.152TrpCys: 0.152 ± 0.01	0.633TrpAsp: 0.633 ± 0.022	0.593TrpGlu: 0.593 ± 0.02	0.52TrpPhe: 0.52 ± 0.022	0.899TrpGly: 0.899 ± 0.027	0.382TrpHis: 0.382 ± 0.016	0.622TrpIle: 0.622 ± 0.022	0.396TrpLys: 0.396 ± 0.02	2.203TrpLeu: 2.203 ± 0.052	0.361TrpMet: 0.361 ± 0.017	0.457TrpAsn: 0.457 ± 0.02	0.698TrpPro: 0.698 ± 0.024	0.891TrpGln: 0.891 ± 0.03	1.162TrpArg: 1.162 ± 0.034	0.802TrpSer: 0.802 ± 0.024	0.655TrpThr: 0.655 ± 0.022	0.926TrpVal: 0.926 ± 0.029	0.233TrpTrp: 0.233 ± 0.013	0.328TrpTyr: 0.328 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.417TyrAla: 2.417 ± 0.043	0.278TyrCys: 0.278 ± 0.015	1.375TyrAsp: 1.375 ± 0.034	1.266TyrGlu: 1.266 ± 0.03	0.917TyrPhe: 0.917 ± 0.029	2.107TyrGly: 2.107 ± 0.045	0.535TyrHis: 0.535 ± 0.02	0.902TyrIle: 0.902 ± 0.027	0.678TyrLys: 0.678 ± 0.024	2.997TyrLeu: 2.997 ± 0.045	0.407TyrMet: 0.407 ± 0.017	0.65TyrAsn: 0.65 ± 0.027	1.303TyrPro: 1.303 ± 0.03	1.14TyrGln: 1.14 ± 0.026	2.197TyrArg: 2.197 ± 0.043	1.428TyrSer: 1.428 ± 0.031	1.111TyrThr: 1.111 ± 0.03	1.564TyrVal: 1.564 ± 0.035	0.389TyrTrp: 0.389 ± 0.018	0.699TyrTyr: 0.699 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4317 proteins (1397476 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---