Amino acid dipepetide frequency for Cronobacter phage JC01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.911AlaAla: 11.911 ± 1.631
0.366AlaCys: 0.366 ± 0.144
6.373AlaAsp: 6.373 ± 0.61
6.164AlaGlu: 6.164 ± 0.69
3.552AlaPhe: 3.552 ± 0.536
7.314AlaGly: 7.314 ± 0.662
1.202AlaHis: 1.202 ± 0.276
5.538AlaIle: 5.538 ± 0.773
5.381AlaLys: 5.381 ± 0.964
8.411AlaLeu: 8.411 ± 0.64
3.709AlaMet: 3.709 ± 0.394
3.918AlaAsn: 3.918 ± 0.529
4.911AlaPro: 4.911 ± 0.617
4.388AlaGln: 4.388 ± 0.606
5.642AlaArg: 5.642 ± 0.746
5.903AlaSer: 5.903 ± 0.692
5.955AlaThr: 5.955 ± 0.704
6.478AlaVal: 6.478 ± 0.623
1.933AlaTrp: 1.933 ± 0.362
2.612AlaTyr: 2.612 ± 0.359
0.0AlaXaa: 0.0 ± 0.0
Cys
0.94CysAla: 0.94 ± 0.252
0.366CysCys: 0.366 ± 0.147
0.679CysAsp: 0.679 ± 0.188
0.522CysGlu: 0.522 ± 0.19
0.627CysPhe: 0.627 ± 0.223
0.888CysGly: 0.888 ± 0.271
0.104CysHis: 0.104 ± 0.114
0.313CysIle: 0.313 ± 0.114
0.418CysLys: 0.418 ± 0.177
0.522CysLeu: 0.522 ± 0.177
0.418CysMet: 0.418 ± 0.141
0.261CysAsn: 0.261 ± 0.116
0.47CysPro: 0.47 ± 0.191
0.261CysGln: 0.261 ± 0.117
0.784CysArg: 0.784 ± 0.188
0.627CysSer: 0.627 ± 0.203
0.679CysThr: 0.679 ± 0.223
0.627CysVal: 0.627 ± 0.168
0.209CysTrp: 0.209 ± 0.108
0.209CysTyr: 0.209 ± 0.114
0.0CysXaa: 0.0 ± 0.0
Asp
6.478AspAla: 6.478 ± 0.651
0.313AspCys: 0.313 ± 0.129
4.545AspAsp: 4.545 ± 0.788
5.015AspGlu: 5.015 ± 0.548
2.926AspPhe: 2.926 ± 0.502
5.224AspGly: 5.224 ± 0.666
1.306AspHis: 1.306 ± 0.341
3.239AspIle: 3.239 ± 0.477
4.075AspLys: 4.075 ± 0.555
4.702AspLeu: 4.702 ± 0.484
1.881AspMet: 1.881 ± 0.305
2.299AspAsn: 2.299 ± 0.369
3.343AspPro: 3.343 ± 0.555
1.463AspGln: 1.463 ± 0.304
3.448AspArg: 3.448 ± 0.445
2.664AspSer: 2.664 ± 0.371
3.082AspThr: 3.082 ± 0.625
4.858AspVal: 4.858 ± 0.469
1.411AspTrp: 1.411 ± 0.315
2.09AspTyr: 2.09 ± 0.346
0.0AspXaa: 0.0 ± 0.0
Glu
6.164GluAla: 6.164 ± 0.678
0.731GluCys: 0.731 ± 0.196
3.552GluAsp: 3.552 ± 0.687
4.336GluGlu: 4.336 ± 0.584
1.985GluPhe: 1.985 ± 0.26
3.291GluGly: 3.291 ± 0.504
1.045GluHis: 1.045 ± 0.265
3.396GluIle: 3.396 ± 0.345
3.239GluLys: 3.239 ± 0.464
4.493GluLeu: 4.493 ± 0.6
1.933GluMet: 1.933 ± 0.303
2.142GluAsn: 2.142 ± 0.307
2.246GluPro: 2.246 ± 0.389
3.5GluGln: 3.5 ± 0.469
3.448GluArg: 3.448 ± 0.514
3.082GluSer: 3.082 ± 0.518
3.709GluThr: 3.709 ± 0.432
4.963GluVal: 4.963 ± 0.456
1.567GluTrp: 1.567 ± 0.279
1.881GluTyr: 1.881 ± 0.31
0.0GluXaa: 0.0 ± 0.0
Phe
3.5PheAla: 3.5 ± 0.486
0.313PheCys: 0.313 ± 0.116
2.873PheAsp: 2.873 ± 0.5
2.403PheGlu: 2.403 ± 0.373
1.306PhePhe: 1.306 ± 0.23
2.769PheGly: 2.769 ± 0.394
0.731PheHis: 0.731 ± 0.219
1.933PheIle: 1.933 ± 0.427
1.933PheLys: 1.933 ± 0.285
1.881PheLeu: 1.881 ± 0.242
1.097PheMet: 1.097 ± 0.219
1.828PheAsn: 1.828 ± 0.262
1.358PhePro: 1.358 ± 0.326
1.149PheGln: 1.149 ± 0.285
2.403PheArg: 2.403 ± 0.464
2.246PheSer: 2.246 ± 0.369
2.821PheThr: 2.821 ± 0.51
2.821PheVal: 2.821 ± 0.43
0.575PheTrp: 0.575 ± 0.206
0.679PheTyr: 0.679 ± 0.152
0.0PheXaa: 0.0 ± 0.0
Gly
6.321GlyAla: 6.321 ± 0.601
1.149GlyCys: 1.149 ± 0.26
4.649GlyAsp: 4.649 ± 0.614
4.963GlyGlu: 4.963 ± 0.578
2.873GlyPhe: 2.873 ± 0.391
5.747GlyGly: 5.747 ± 0.675
0.836GlyHis: 0.836 ± 0.247
3.343GlyIle: 3.343 ± 0.494
4.075GlyLys: 4.075 ± 0.53
4.858GlyLeu: 4.858 ± 0.677
2.09GlyMet: 2.09 ± 0.327
2.508GlyAsn: 2.508 ± 0.405
2.142GlyPro: 2.142 ± 0.423
2.508GlyGln: 2.508 ± 0.364
4.388GlyArg: 4.388 ± 0.489
4.911GlySer: 4.911 ± 0.601
4.649GlyThr: 4.649 ± 0.652
5.224GlyVal: 5.224 ± 0.418
1.411GlyTrp: 1.411 ± 0.295
2.769GlyTyr: 2.769 ± 0.436
0.0GlyXaa: 0.0 ± 0.0
His
1.254HisAla: 1.254 ± 0.317
0.313HisCys: 0.313 ± 0.157
0.627HisAsp: 0.627 ± 0.196
0.731HisGlu: 0.731 ± 0.251
0.731HisPhe: 0.731 ± 0.207
0.993HisGly: 0.993 ± 0.233
0.313HisHis: 0.313 ± 0.137
0.784HisIle: 0.784 ± 0.217
0.731HisLys: 0.731 ± 0.233
1.254HisLeu: 1.254 ± 0.252
0.679HisMet: 0.679 ± 0.148
0.94HisAsn: 0.94 ± 0.24
0.836HisPro: 0.836 ± 0.222
0.313HisGln: 0.313 ± 0.14
1.358HisArg: 1.358 ± 0.28
0.94HisSer: 0.94 ± 0.215
1.202HisThr: 1.202 ± 0.246
1.358HisVal: 1.358 ± 0.28
0.261HisTrp: 0.261 ± 0.099
0.888HisTyr: 0.888 ± 0.253
0.0HisXaa: 0.0 ± 0.0
Ile
4.597IleAla: 4.597 ± 0.536
0.784IleCys: 0.784 ± 0.254
3.709IleAsp: 3.709 ± 0.453
3.187IleGlu: 3.187 ± 0.427
1.045IlePhe: 1.045 ± 0.28
3.187IleGly: 3.187 ± 0.421
1.463IleHis: 1.463 ± 0.304
2.664IleIle: 2.664 ± 0.33
2.351IleLys: 2.351 ± 0.36
3.082IleLeu: 3.082 ± 0.346
1.149IleMet: 1.149 ± 0.283
2.717IleAsn: 2.717 ± 0.316
2.299IlePro: 2.299 ± 0.291
1.358IleGln: 1.358 ± 0.307
3.5IleArg: 3.5 ± 0.301
3.448IleSer: 3.448 ± 0.495
3.396IleThr: 3.396 ± 0.438
2.717IleVal: 2.717 ± 0.312
0.522IleTrp: 0.522 ± 0.174
1.411IleTyr: 1.411 ± 0.316
0.0IleXaa: 0.0 ± 0.0
Lys
5.015LysAla: 5.015 ± 0.665
0.418LysCys: 0.418 ± 0.167
3.082LysAsp: 3.082 ± 0.498
3.082LysGlu: 3.082 ± 0.437
2.142LysPhe: 2.142 ± 0.372
3.03LysGly: 3.03 ± 0.499
0.993LysHis: 0.993 ± 0.226
2.455LysIle: 2.455 ± 0.327
2.873LysLys: 2.873 ± 0.438
4.545LysLeu: 4.545 ± 0.612
1.881LysMet: 1.881 ± 0.328
2.194LysAsn: 2.194 ± 0.352
3.03LysPro: 3.03 ± 0.478
2.194LysGln: 2.194 ± 0.337
3.03LysArg: 3.03 ± 0.496
2.299LysSer: 2.299 ± 0.405
2.978LysThr: 2.978 ± 0.425
2.926LysVal: 2.926 ± 0.404
0.94LysTrp: 0.94 ± 0.225
2.194LysTyr: 2.194 ± 0.377
0.0LysXaa: 0.0 ± 0.0
Leu
8.672LeuAla: 8.672 ± 0.859
0.575LeuCys: 0.575 ± 0.163
4.44LeuAsp: 4.44 ± 0.622
4.284LeuGlu: 4.284 ± 0.628
2.299LeuPhe: 2.299 ± 0.302
4.545LeuGly: 4.545 ± 0.708
0.888LeuHis: 0.888 ± 0.232
3.291LeuIle: 3.291 ± 0.421
4.911LeuLys: 4.911 ± 0.481
5.851LeuLeu: 5.851 ± 0.702
2.194LeuMet: 2.194 ± 0.401
3.5LeuAsn: 3.5 ± 0.506
3.761LeuPro: 3.761 ± 0.496
4.023LeuGln: 4.023 ± 0.499
4.858LeuArg: 4.858 ± 0.465
4.911LeuSer: 4.911 ± 0.604
4.963LeuThr: 4.963 ± 0.447
6.217LeuVal: 6.217 ± 0.755
0.993LeuTrp: 0.993 ± 0.229
3.082LeuTyr: 3.082 ± 0.439
0.0LeuXaa: 0.0 ± 0.0
Met
2.821MetAla: 2.821 ± 0.402
0.313MetCys: 0.313 ± 0.168
1.567MetAsp: 1.567 ± 0.31
1.306MetGlu: 1.306 ± 0.248
0.47MetPhe: 0.47 ± 0.18
1.724MetGly: 1.724 ± 0.27
0.575MetHis: 0.575 ± 0.166
1.567MetIle: 1.567 ± 0.284
1.202MetLys: 1.202 ± 0.303
2.299MetLeu: 2.299 ± 0.37
0.836MetMet: 0.836 ± 0.243
0.888MetAsn: 0.888 ± 0.241
1.985MetPro: 1.985 ± 0.348
1.619MetGln: 1.619 ± 0.377
2.194MetArg: 2.194 ± 0.333
3.03MetSer: 3.03 ± 0.433
2.299MetThr: 2.299 ± 0.338
1.776MetVal: 1.776 ± 0.317
0.418MetTrp: 0.418 ± 0.143
0.784MetTyr: 0.784 ± 0.203
0.0MetXaa: 0.0 ± 0.0
Asn
4.858AsnAla: 4.858 ± 0.453
0.47AsnCys: 0.47 ± 0.215
2.246AsnAsp: 2.246 ± 0.296
1.828AsnGlu: 1.828 ± 0.341
1.202AsnPhe: 1.202 ± 0.268
4.284AsnGly: 4.284 ± 0.452
0.418AsnHis: 0.418 ± 0.152
1.776AsnIle: 1.776 ± 0.371
1.567AsnLys: 1.567 ± 0.244
3.03AsnLeu: 3.03 ± 0.378
0.731AsnMet: 0.731 ± 0.203
1.881AsnAsn: 1.881 ± 0.344
2.612AsnPro: 2.612 ± 0.453
1.463AsnGln: 1.463 ± 0.239
2.56AsnArg: 2.56 ± 0.416
1.776AsnSer: 1.776 ± 0.293
2.299AsnThr: 2.299 ± 0.401
2.09AsnVal: 2.09 ± 0.268
0.731AsnTrp: 0.731 ± 0.169
1.619AsnTyr: 1.619 ± 0.361
0.0AsnXaa: 0.0 ± 0.0
Pro
4.597ProAla: 4.597 ± 0.596
0.47ProCys: 0.47 ± 0.161
3.814ProAsp: 3.814 ± 0.608
3.814ProGlu: 3.814 ± 0.601
1.828ProPhe: 1.828 ± 0.288
4.232ProGly: 4.232 ± 0.557
1.149ProHis: 1.149 ± 0.235
2.455ProIle: 2.455 ± 0.471
2.194ProLys: 2.194 ± 0.403
3.396ProLeu: 3.396 ± 0.474
1.045ProMet: 1.045 ± 0.217
1.881ProAsn: 1.881 ± 0.306
2.037ProPro: 2.037 ± 0.424
1.619ProGln: 1.619 ± 0.46
2.56ProArg: 2.56 ± 0.43
2.299ProSer: 2.299 ± 0.334
2.717ProThr: 2.717 ± 0.438
3.5ProVal: 3.5 ± 0.488
0.888ProTrp: 0.888 ± 0.248
1.515ProTyr: 1.515 ± 0.249
0.0ProXaa: 0.0 ± 0.0
Gln
4.597GlnAla: 4.597 ± 1.091
0.366GlnCys: 0.366 ± 0.151
1.672GlnAsp: 1.672 ± 0.285
1.933GlnGlu: 1.933 ± 0.335
1.672GlnPhe: 1.672 ± 0.252
2.978GlnGly: 2.978 ± 0.405
0.993GlnHis: 0.993 ± 0.261
1.567GlnIle: 1.567 ± 0.268
1.933GlnLys: 1.933 ± 0.373
4.702GlnLeu: 4.702 ± 0.518
1.619GlnMet: 1.619 ± 0.312
1.515GlnAsn: 1.515 ± 0.304
1.776GlnPro: 1.776 ± 0.31
2.508GlnGln: 2.508 ± 0.515
2.455GlnArg: 2.455 ± 0.457
1.724GlnSer: 1.724 ± 0.38
2.246GlnThr: 2.246 ± 0.582
3.396GlnVal: 3.396 ± 0.646
1.149GlnTrp: 1.149 ± 0.361
1.411GlnTyr: 1.411 ± 0.272
0.0GlnXaa: 0.0 ± 0.0
Arg
5.538ArgAla: 5.538 ± 0.626
0.522ArgCys: 0.522 ± 0.193
4.075ArgAsp: 4.075 ± 0.47
4.075ArgGlu: 4.075 ± 0.466
2.821ArgPhe: 2.821 ± 0.439
2.978ArgGly: 2.978 ± 0.381
1.097ArgHis: 1.097 ± 0.263
3.709ArgIle: 3.709 ± 0.529
3.343ArgLys: 3.343 ± 0.438
6.217ArgLeu: 6.217 ± 0.772
2.09ArgMet: 2.09 ± 0.341
1.933ArgAsn: 1.933 ± 0.297
2.717ArgPro: 2.717 ± 0.415
3.082ArgGln: 3.082 ± 0.529
3.761ArgArg: 3.761 ± 0.499
3.187ArgSer: 3.187 ± 0.44
3.082ArgThr: 3.082 ± 0.411
4.493ArgVal: 4.493 ± 0.655
1.097ArgTrp: 1.097 ± 0.238
1.619ArgTyr: 1.619 ± 0.35
0.0ArgXaa: 0.0 ± 0.0
Ser
5.903SerAla: 5.903 ± 0.761
0.575SerCys: 0.575 ± 0.186
3.187SerAsp: 3.187 ± 0.413
2.403SerGlu: 2.403 ± 0.4
2.09SerPhe: 2.09 ± 0.407
5.015SerGly: 5.015 ± 0.535
0.627SerHis: 0.627 ± 0.174
2.769SerIle: 2.769 ± 0.434
2.717SerLys: 2.717 ± 0.32
5.276SerLeu: 5.276 ± 0.551
1.515SerMet: 1.515 ± 0.251
2.142SerAsn: 2.142 ± 0.316
2.664SerPro: 2.664 ± 0.43
2.612SerGln: 2.612 ± 0.541
3.814SerArg: 3.814 ± 0.533
4.075SerSer: 4.075 ± 0.648
2.508SerThr: 2.508 ± 0.391
4.232SerVal: 4.232 ± 0.582
1.254SerTrp: 1.254 ± 0.24
2.246SerTyr: 2.246 ± 0.538
0.0SerXaa: 0.0 ± 0.0
Thr
7.053ThrAla: 7.053 ± 0.789
0.261ThrCys: 0.261 ± 0.105
3.343ThrAsp: 3.343 ± 0.479
2.664ThrGlu: 2.664 ± 0.392
2.56ThrPhe: 2.56 ± 0.462
4.963ThrGly: 4.963 ± 0.609
0.836ThrHis: 0.836 ± 0.226
2.612ThrIle: 2.612 ± 0.479
2.717ThrLys: 2.717 ± 0.426
4.336ThrLeu: 4.336 ± 0.518
1.411ThrMet: 1.411 ± 0.251
2.09ThrAsn: 2.09 ± 0.331
2.926ThrPro: 2.926 ± 0.544
3.082ThrGln: 3.082 ± 0.513
3.187ThrArg: 3.187 ± 0.401
3.552ThrSer: 3.552 ± 0.476
3.605ThrThr: 3.605 ± 0.482
4.754ThrVal: 4.754 ± 0.525
1.358ThrTrp: 1.358 ± 0.248
2.09ThrTyr: 2.09 ± 0.307
0.0ThrXaa: 0.0 ± 0.0
Val
7.209ValAla: 7.209 ± 0.688
0.836ValCys: 0.836 ± 0.23
5.642ValAsp: 5.642 ± 0.569
5.067ValGlu: 5.067 ± 0.513
2.56ValPhe: 2.56 ± 0.337
4.44ValGly: 4.44 ± 0.395
0.993ValHis: 0.993 ± 0.277
3.605ValIle: 3.605 ± 0.44
3.918ValLys: 3.918 ± 0.443
4.754ValLeu: 4.754 ± 0.545
1.672ValMet: 1.672 ± 0.393
3.03ValAsn: 3.03 ± 0.335
3.97ValPro: 3.97 ± 0.68
2.56ValGln: 2.56 ± 0.361
4.649ValArg: 4.649 ± 0.451
3.814ValSer: 3.814 ± 0.521
4.597ValThr: 4.597 ± 0.67
4.545ValVal: 4.545 ± 0.514
0.993ValTrp: 0.993 ± 0.238
2.194ValTyr: 2.194 ± 0.396
0.0ValXaa: 0.0 ± 0.0
Trp
1.567TrpAla: 1.567 ± 0.308
0.313TrpCys: 0.313 ± 0.157
1.776TrpAsp: 1.776 ± 0.318
1.149TrpGlu: 1.149 ± 0.242
0.888TrpPhe: 0.888 ± 0.184
1.202TrpGly: 1.202 ± 0.258
0.418TrpHis: 0.418 ± 0.129
0.47TrpIle: 0.47 ± 0.148
0.731TrpLys: 0.731 ± 0.211
1.776TrpLeu: 1.776 ± 0.326
0.47TrpMet: 0.47 ± 0.203
0.418TrpAsn: 0.418 ± 0.146
0.731TrpPro: 0.731 ± 0.271
1.254TrpGln: 1.254 ± 0.294
1.306TrpArg: 1.306 ± 0.288
0.731TrpSer: 0.731 ± 0.189
0.888TrpThr: 0.888 ± 0.253
1.358TrpVal: 1.358 ± 0.393
0.47TrpTrp: 0.47 ± 0.187
0.575TrpTyr: 0.575 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.664TyrAla: 2.664 ± 0.373
0.47TyrCys: 0.47 ± 0.157
2.508TyrAsp: 2.508 ± 0.37
1.776TyrGlu: 1.776 ± 0.32
1.045TyrPhe: 1.045 ± 0.294
2.612TyrGly: 2.612 ± 0.408
0.522TyrHis: 0.522 ± 0.178
1.097TyrIle: 1.097 ± 0.206
0.993TyrLys: 0.993 ± 0.218
2.873TyrLeu: 2.873 ± 0.481
1.202TyrMet: 1.202 ± 0.221
1.411TyrAsn: 1.411 ± 0.249
2.194TyrPro: 2.194 ± 0.586
1.254TyrGln: 1.254 ± 0.259
2.09TyrArg: 2.09 ± 0.331
2.403TyrSer: 2.403 ± 0.437
1.724TyrThr: 1.724 ± 0.321
2.717TyrVal: 2.717 ± 0.453
0.313TyrTrp: 0.313 ± 0.162
1.463TyrTyr: 1.463 ± 0.264
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (19143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski