Amino acid dipepetide frequency for Agrobacterium phage 7-7-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.948AlaAla: 9.948 ± 0.918
1.238AlaCys: 1.238 ± 0.263
4.814AlaAsp: 4.814 ± 0.554
6.418AlaGlu: 6.418 ± 0.469
4.447AlaPhe: 4.447 ± 0.509
6.006AlaGly: 6.006 ± 0.66
1.054AlaHis: 1.054 ± 0.239
5.547AlaIle: 5.547 ± 0.422
4.905AlaLys: 4.905 ± 0.441
6.739AlaLeu: 6.739 ± 0.672
2.842AlaMet: 2.842 ± 0.409
2.842AlaAsn: 2.842 ± 0.386
4.859AlaPro: 4.859 ± 0.723
3.209AlaGln: 3.209 ± 0.364
5.089AlaArg: 5.089 ± 0.52
4.63AlaSer: 4.63 ± 0.459
5.135AlaThr: 5.135 ± 0.478
7.381AlaVal: 7.381 ± 0.637
1.375AlaTrp: 1.375 ± 0.254
2.384AlaTyr: 2.384 ± 0.299
0.0AlaXaa: 0.0 ± 0.0
Cys
1.284CysAla: 1.284 ± 0.248
0.504CysCys: 0.504 ± 0.166
1.192CysAsp: 1.192 ± 0.202
1.329CysGlu: 1.329 ± 0.243
0.825CysPhe: 0.825 ± 0.188
1.605CysGly: 1.605 ± 0.338
0.367CysHis: 0.367 ± 0.13
0.367CysIle: 0.367 ± 0.135
0.504CysLys: 0.504 ± 0.154
0.779CysLeu: 0.779 ± 0.22
0.138CysMet: 0.138 ± 0.082
0.642CysAsn: 0.642 ± 0.176
0.596CysPro: 0.596 ± 0.209
0.367CysGln: 0.367 ± 0.119
0.871CysArg: 0.871 ± 0.242
0.963CysSer: 0.963 ± 0.213
0.779CysThr: 0.779 ± 0.215
0.917CysVal: 0.917 ± 0.23
0.275CysTrp: 0.275 ± 0.091
0.183CysTyr: 0.183 ± 0.1
0.0CysXaa: 0.0 ± 0.0
Asp
5.089AspAla: 5.089 ± 0.474
1.1AspCys: 1.1 ± 0.197
3.851AspAsp: 3.851 ± 0.409
4.814AspGlu: 4.814 ± 0.495
2.43AspPhe: 2.43 ± 0.319
5.731AspGly: 5.731 ± 0.495
1.192AspHis: 1.192 ± 0.24
3.805AspIle: 3.805 ± 0.406
2.384AspLys: 2.384 ± 0.312
3.622AspLeu: 3.622 ± 0.437
1.421AspMet: 1.421 ± 0.31
2.155AspAsn: 2.155 ± 0.343
2.888AspPro: 2.888 ± 0.405
0.963AspGln: 0.963 ± 0.195
3.759AspArg: 3.759 ± 0.421
2.659AspSer: 2.659 ± 0.323
3.163AspThr: 3.163 ± 0.426
4.401AspVal: 4.401 ± 0.445
1.192AspTrp: 1.192 ± 0.328
1.467AspTyr: 1.467 ± 0.266
0.0AspXaa: 0.0 ± 0.0
Glu
5.96GluAla: 5.96 ± 0.547
1.467GluCys: 1.467 ± 0.333
3.163GluAsp: 3.163 ± 0.326
3.943GluGlu: 3.943 ± 0.5
3.759GluPhe: 3.759 ± 0.47
4.768GluGly: 4.768 ± 0.438
1.192GluHis: 1.192 ± 0.235
4.722GluIle: 4.722 ± 0.569
3.53GluLys: 3.53 ± 0.463
5.41GluLeu: 5.41 ± 0.549
1.513GluMet: 1.513 ± 0.217
2.98GluAsn: 2.98 ± 0.318
2.613GluPro: 2.613 ± 0.323
1.788GluGln: 1.788 ± 0.267
4.264GluArg: 4.264 ± 0.477
3.255GluSer: 3.255 ± 0.377
3.163GluThr: 3.163 ± 0.444
3.622GluVal: 3.622 ± 0.359
0.963GluTrp: 0.963 ± 0.173
2.476GluTyr: 2.476 ± 0.372
0.0GluXaa: 0.0 ± 0.0
Phe
3.622PheAla: 3.622 ± 0.44
0.825PheCys: 0.825 ± 0.198
2.98PheAsp: 2.98 ± 0.348
3.53PheGlu: 3.53 ± 0.397
1.559PhePhe: 1.559 ± 0.28
3.392PheGly: 3.392 ± 0.335
0.871PheHis: 0.871 ± 0.205
3.117PheIle: 3.117 ± 0.417
2.567PheLys: 2.567 ± 0.35
3.117PheLeu: 3.117 ± 0.366
0.688PheMet: 0.688 ± 0.164
2.292PheAsn: 2.292 ± 0.352
1.971PhePro: 1.971 ± 0.319
1.238PheGln: 1.238 ± 0.204
2.613PheArg: 2.613 ± 0.336
2.613PheSer: 2.613 ± 0.377
2.796PheThr: 2.796 ± 0.325
3.163PheVal: 3.163 ± 0.35
0.275PheTrp: 0.275 ± 0.124
1.421PheTyr: 1.421 ± 0.258
0.0PheXaa: 0.0 ± 0.0
Gly
5.96GlyAla: 5.96 ± 0.52
1.375GlyCys: 1.375 ± 0.221
5.639GlyAsp: 5.639 ± 0.604
3.805GlyGlu: 3.805 ± 0.345
3.713GlyPhe: 3.713 ± 0.397
4.905GlyGly: 4.905 ± 0.822
0.825GlyHis: 0.825 ± 0.166
3.988GlyIle: 3.988 ± 0.486
4.722GlyLys: 4.722 ± 0.509
4.905GlyLeu: 4.905 ± 0.47
1.88GlyMet: 1.88 ± 0.293
3.622GlyAsn: 3.622 ± 0.443
3.072GlyPro: 3.072 ± 0.394
2.613GlyGln: 2.613 ± 0.395
4.814GlyArg: 4.814 ± 0.47
5.226GlySer: 5.226 ± 0.571
4.126GlyThr: 4.126 ± 0.477
6.143GlyVal: 6.143 ± 0.579
1.467GlyTrp: 1.467 ± 0.238
2.751GlyTyr: 2.751 ± 0.387
0.0GlyXaa: 0.0 ± 0.0
His
1.146HisAla: 1.146 ± 0.265
0.321HisCys: 0.321 ± 0.12
0.917HisAsp: 0.917 ± 0.209
1.375HisGlu: 1.375 ± 0.283
0.504HisPhe: 0.504 ± 0.132
1.467HisGly: 1.467 ± 0.29
0.413HisHis: 0.413 ± 0.114
0.963HisIle: 0.963 ± 0.221
1.146HisLys: 1.146 ± 0.251
1.054HisLeu: 1.054 ± 0.234
0.367HisMet: 0.367 ± 0.13
0.642HisAsn: 0.642 ± 0.166
1.238HisPro: 1.238 ± 0.251
0.229HisGln: 0.229 ± 0.108
1.1HisArg: 1.1 ± 0.212
1.054HisSer: 1.054 ± 0.207
0.642HisThr: 0.642 ± 0.186
1.467HisVal: 1.467 ± 0.249
0.321HisTrp: 0.321 ± 0.12
0.55HisTyr: 0.55 ± 0.185
0.0HisXaa: 0.0 ± 0.0
Ile
5.318IleAla: 5.318 ± 0.512
0.504IleCys: 0.504 ± 0.156
3.759IleAsp: 3.759 ± 0.452
4.355IleGlu: 4.355 ± 0.519
2.292IlePhe: 2.292 ± 0.379
5.043IleGly: 5.043 ± 0.639
0.963IleHis: 0.963 ± 0.193
2.98IleIle: 2.98 ± 0.312
2.934IleLys: 2.934 ± 0.398
2.567IleLeu: 2.567 ± 0.374
1.421IleMet: 1.421 ± 0.225
3.072IleAsn: 3.072 ± 0.357
3.255IlePro: 3.255 ± 0.392
1.421IleGln: 1.421 ± 0.273
3.943IleArg: 3.943 ± 0.383
3.943IleSer: 3.943 ± 0.489
3.668IleThr: 3.668 ± 0.406
4.172IleVal: 4.172 ± 0.403
0.734IleTrp: 0.734 ± 0.176
1.788IleTyr: 1.788 ± 0.316
0.0IleXaa: 0.0 ± 0.0
Lys
4.814LysAla: 4.814 ± 0.459
0.871LysCys: 0.871 ± 0.183
2.521LysAsp: 2.521 ± 0.393
3.301LysGlu: 3.301 ± 0.463
1.88LysPhe: 1.88 ± 0.301
3.53LysGly: 3.53 ± 0.407
1.238LysHis: 1.238 ± 0.258
3.484LysIle: 3.484 ± 0.41
2.659LysLys: 2.659 ± 0.414
4.08LysLeu: 4.08 ± 0.481
1.925LysMet: 1.925 ± 0.315
2.063LysAsn: 2.063 ± 0.325
3.072LysPro: 3.072 ± 0.455
1.513LysGln: 1.513 ± 0.27
3.576LysArg: 3.576 ± 0.443
3.209LysSer: 3.209 ± 0.411
3.301LysThr: 3.301 ± 0.375
3.255LysVal: 3.255 ± 0.403
1.009LysTrp: 1.009 ± 0.201
1.559LysTyr: 1.559 ± 0.27
0.0LysXaa: 0.0 ± 0.0
Leu
6.647LeuAla: 6.647 ± 0.518
0.963LeuCys: 0.963 ± 0.218
3.53LeuAsp: 3.53 ± 0.335
4.309LeuGlu: 4.309 ± 0.425
2.613LeuPhe: 2.613 ± 0.273
4.126LeuGly: 4.126 ± 0.403
1.1LeuHis: 1.1 ± 0.244
3.576LeuIle: 3.576 ± 0.387
5.318LeuLys: 5.318 ± 0.484
3.576LeuLeu: 3.576 ± 0.369
1.88LeuMet: 1.88 ± 0.245
3.301LeuAsn: 3.301 ± 0.327
3.53LeuPro: 3.53 ± 0.374
2.751LeuGln: 2.751 ± 0.382
4.859LeuArg: 4.859 ± 0.46
4.814LeuSer: 4.814 ± 0.491
5.501LeuThr: 5.501 ± 0.562
5.18LeuVal: 5.18 ± 0.509
1.054LeuTrp: 1.054 ± 0.25
1.834LeuTyr: 1.834 ± 0.311
0.0LeuXaa: 0.0 ± 0.0
Met
3.117MetAla: 3.117 ± 0.405
0.229MetCys: 0.229 ± 0.105
1.054MetAsp: 1.054 ± 0.205
1.467MetGlu: 1.467 ± 0.272
1.054MetPhe: 1.054 ± 0.227
1.329MetGly: 1.329 ± 0.285
0.596MetHis: 0.596 ± 0.175
1.742MetIle: 1.742 ± 0.264
1.88MetLys: 1.88 ± 0.343
1.467MetLeu: 1.467 ± 0.297
0.321MetMet: 0.321 ± 0.132
1.559MetAsn: 1.559 ± 0.293
0.779MetPro: 0.779 ± 0.17
0.688MetGln: 0.688 ± 0.177
1.467MetArg: 1.467 ± 0.232
1.65MetSer: 1.65 ± 0.304
2.384MetThr: 2.384 ± 0.347
1.375MetVal: 1.375 ± 0.277
0.229MetTrp: 0.229 ± 0.086
0.229MetTyr: 0.229 ± 0.108
0.0MetXaa: 0.0 ± 0.0
Asn
4.218AsnAla: 4.218 ± 0.486
0.642AsnCys: 0.642 ± 0.176
2.476AsnAsp: 2.476 ± 0.336
2.888AsnGlu: 2.888 ± 0.321
2.155AsnPhe: 2.155 ± 0.347
4.401AsnGly: 4.401 ± 0.403
0.688AsnHis: 0.688 ± 0.222
3.117AsnIle: 3.117 ± 0.315
1.696AsnLys: 1.696 ± 0.245
2.888AsnLeu: 2.888 ± 0.361
1.146AsnMet: 1.146 ± 0.226
1.788AsnAsn: 1.788 ± 0.331
2.521AsnPro: 2.521 ± 0.373
1.421AsnGln: 1.421 ± 0.255
3.301AsnArg: 3.301 ± 0.329
2.201AsnSer: 2.201 ± 0.3
2.43AsnThr: 2.43 ± 0.413
3.255AsnVal: 3.255 ± 0.425
0.688AsnTrp: 0.688 ± 0.153
1.559AsnTyr: 1.559 ± 0.262
0.0AsnXaa: 0.0 ± 0.0
Pro
4.401ProAla: 4.401 ± 0.648
0.734ProCys: 0.734 ± 0.169
2.842ProAsp: 2.842 ± 0.33
3.668ProGlu: 3.668 ± 0.411
1.925ProPhe: 1.925 ± 0.29
4.722ProGly: 4.722 ± 0.548
0.642ProHis: 0.642 ± 0.176
1.605ProIle: 1.605 ± 0.284
2.476ProLys: 2.476 ± 0.357
3.301ProLeu: 3.301 ± 0.344
1.329ProMet: 1.329 ± 0.278
2.659ProAsn: 2.659 ± 0.378
3.668ProPro: 3.668 ± 0.503
1.788ProGln: 1.788 ± 0.474
2.017ProArg: 2.017 ± 0.298
2.98ProSer: 2.98 ± 0.39
2.659ProThr: 2.659 ± 0.38
5.639ProVal: 5.639 ± 0.732
0.504ProTrp: 0.504 ± 0.163
1.192ProTyr: 1.192 ± 0.25
0.0ProXaa: 0.0 ± 0.0
Gln
2.934GlnAla: 2.934 ± 0.353
0.275GlnCys: 0.275 ± 0.111
0.917GlnAsp: 0.917 ± 0.179
1.559GlnGlu: 1.559 ± 0.248
1.375GlnPhe: 1.375 ± 0.276
1.971GlnGly: 1.971 ± 0.306
0.458GlnHis: 0.458 ± 0.145
1.559GlnIle: 1.559 ± 0.304
1.605GlnLys: 1.605 ± 0.254
2.384GlnLeu: 2.384 ± 0.312
0.779GlnMet: 0.779 ± 0.164
1.788GlnAsn: 1.788 ± 0.192
1.1GlnPro: 1.1 ± 0.21
1.284GlnGln: 1.284 ± 0.243
2.063GlnArg: 2.063 ± 0.283
1.834GlnSer: 1.834 ± 0.259
2.338GlnThr: 2.338 ± 0.313
1.88GlnVal: 1.88 ± 0.39
0.734GlnTrp: 0.734 ± 0.204
1.238GlnTyr: 1.238 ± 0.251
0.0GlnXaa: 0.0 ± 0.0
Arg
4.676ArgAla: 4.676 ± 0.495
0.55ArgCys: 0.55 ± 0.144
3.668ArgAsp: 3.668 ± 0.478
3.668ArgGlu: 3.668 ± 0.445
3.163ArgPhe: 3.163 ± 0.469
3.53ArgGly: 3.53 ± 0.379
1.559ArgHis: 1.559 ± 0.294
4.126ArgIle: 4.126 ± 0.392
3.53ArgLys: 3.53 ± 0.42
5.455ArgLeu: 5.455 ± 0.617
1.696ArgMet: 1.696 ± 0.253
2.888ArgAsn: 2.888 ± 0.438
2.613ArgPro: 2.613 ± 0.372
1.559ArgGln: 1.559 ± 0.277
4.309ArgArg: 4.309 ± 0.527
4.584ArgSer: 4.584 ± 0.485
3.484ArgThr: 3.484 ± 0.479
3.897ArgVal: 3.897 ± 0.352
0.688ArgTrp: 0.688 ± 0.178
2.155ArgTyr: 2.155 ± 0.321
0.0ArgXaa: 0.0 ± 0.0
Ser
5.731SerAla: 5.731 ± 0.506
0.779SerCys: 0.779 ± 0.233
3.301SerAsp: 3.301 ± 0.435
3.026SerGlu: 3.026 ± 0.383
3.301SerPhe: 3.301 ± 0.502
5.089SerGly: 5.089 ± 0.493
1.054SerHis: 1.054 ± 0.219
3.53SerIle: 3.53 ± 0.405
2.43SerLys: 2.43 ± 0.331
4.447SerLeu: 4.447 ± 0.531
1.1SerMet: 1.1 ± 0.24
2.751SerAsn: 2.751 ± 0.357
2.705SerPro: 2.705 ± 0.363
1.696SerGln: 1.696 ± 0.267
3.53SerArg: 3.53 ± 0.432
3.484SerSer: 3.484 ± 0.46
3.484SerThr: 3.484 ± 0.378
5.776SerVal: 5.776 ± 0.486
0.779SerTrp: 0.779 ± 0.183
1.971SerTyr: 1.971 ± 0.327
0.0SerXaa: 0.0 ± 0.0
Thr
5.731ThrAla: 5.731 ± 0.629
0.825ThrCys: 0.825 ± 0.182
3.301ThrAsp: 3.301 ± 0.374
3.484ThrGlu: 3.484 ± 0.334
2.796ThrPhe: 2.796 ± 0.325
5.41ThrGly: 5.41 ± 0.574
0.963ThrHis: 0.963 ± 0.181
4.08ThrIle: 4.08 ± 0.394
2.476ThrLys: 2.476 ± 0.306
5.318ThrLeu: 5.318 ± 0.535
1.284ThrMet: 1.284 ± 0.246
2.567ThrAsn: 2.567 ± 0.385
4.126ThrPro: 4.126 ± 0.422
1.1ThrGln: 1.1 ± 0.195
2.98ThrArg: 2.98 ± 0.394
2.751ThrSer: 2.751 ± 0.422
3.576ThrThr: 3.576 ± 0.518
5.089ThrVal: 5.089 ± 0.551
0.871ThrTrp: 0.871 ± 0.222
2.109ThrTyr: 2.109 ± 0.274
0.0ThrXaa: 0.0 ± 0.0
Val
6.739ValAla: 6.739 ± 0.612
0.688ValCys: 0.688 ± 0.16
5.18ValAsp: 5.18 ± 0.446
5.089ValGlu: 5.089 ± 0.436
3.026ValPhe: 3.026 ± 0.398
5.135ValGly: 5.135 ± 0.482
1.054ValHis: 1.054 ± 0.204
3.805ValIle: 3.805 ± 0.361
4.126ValLys: 4.126 ± 0.433
5.547ValLeu: 5.547 ± 0.518
1.65ValMet: 1.65 ± 0.282
3.897ValAsn: 3.897 ± 0.526
3.668ValPro: 3.668 ± 0.592
2.43ValGln: 2.43 ± 0.325
3.988ValArg: 3.988 ± 0.426
4.951ValSer: 4.951 ± 0.563
5.639ValThr: 5.639 ± 0.578
4.997ValVal: 4.997 ± 0.55
0.779ValTrp: 0.779 ± 0.191
2.476ValTyr: 2.476 ± 0.317
0.0ValXaa: 0.0 ± 0.0
Trp
0.963TrpAla: 0.963 ± 0.214
0.229TrpCys: 0.229 ± 0.093
0.917TrpAsp: 0.917 ± 0.19
1.1TrpGlu: 1.1 ± 0.242
0.734TrpPhe: 0.734 ± 0.157
0.917TrpGly: 0.917 ± 0.19
0.183TrpHis: 0.183 ± 0.099
0.596TrpIle: 0.596 ± 0.159
0.871TrpLys: 0.871 ± 0.216
1.421TrpLeu: 1.421 ± 0.249
0.504TrpMet: 0.504 ± 0.138
0.734TrpAsn: 0.734 ± 0.201
0.642TrpPro: 0.642 ± 0.189
0.734TrpGln: 0.734 ± 0.173
1.009TrpArg: 1.009 ± 0.185
0.734TrpSer: 0.734 ± 0.173
0.825TrpThr: 0.825 ± 0.191
0.734TrpVal: 0.734 ± 0.195
0.229TrpTrp: 0.229 ± 0.141
0.413TrpTyr: 0.413 ± 0.13
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.567TyrAla: 2.567 ± 0.277
0.367TyrCys: 0.367 ± 0.163
2.063TyrAsp: 2.063 ± 0.28
1.421TyrGlu: 1.421 ± 0.236
1.1TyrPhe: 1.1 ± 0.299
2.476TyrGly: 2.476 ± 0.307
0.504TyrHis: 0.504 ± 0.158
1.421TyrIle: 1.421 ± 0.274
1.1TyrLys: 1.1 ± 0.204
2.384TyrLeu: 2.384 ± 0.34
0.688TyrMet: 0.688 ± 0.15
1.238TyrAsn: 1.238 ± 0.238
1.834TyrPro: 1.834 ± 0.493
1.284TyrGln: 1.284 ± 0.247
2.292TyrArg: 2.292 ± 0.32
2.43TyrSer: 2.43 ± 0.383
1.742TyrThr: 1.742 ± 0.29
2.521TyrVal: 2.521 ± 0.315
0.321TyrTrp: 0.321 ± 0.125
0.825TyrTyr: 0.825 ± 0.189
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 127 proteins (21814 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski