Amino acid dipepetide frequency for Brachybacterium muris UCD-AY4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.662AlaAla: 17.662 ± 0.205	0.79AlaCys: 0.79 ± 0.03	8.066AlaAsp: 8.066 ± 0.103	8.314AlaGlu: 8.314 ± 0.107	3.235AlaPhe: 3.235 ± 0.068	11.927AlaGly: 11.927 ± 0.147	2.68AlaHis: 2.68 ± 0.059	4.845AlaIle: 4.845 ± 0.074	2.282AlaLys: 2.282 ± 0.057	13.956AlaLeu: 13.956 ± 0.183	2.845AlaMet: 2.845 ± 0.061	1.739AlaAsn: 1.739 ± 0.046	6.887AlaPro: 6.887 ± 0.113	4.356AlaGln: 4.356 ± 0.078	9.335AlaArg: 9.335 ± 0.119	6.638AlaSer: 6.638 ± 0.084	7.178AlaThr: 7.178 ± 0.094	10.768AlaVal: 10.768 ± 0.136	1.703AlaTrp: 1.703 ± 0.041	2.052AlaTyr: 2.052 ± 0.042	0.002AlaXaa: 0.002 ± 0.001
Cys	0.722CysAla: 0.722 ± 0.033	0.059CysCys: 0.059 ± 0.009	0.326CysAsp: 0.326 ± 0.02	0.372CysGlu: 0.372 ± 0.02	0.157CysPhe: 0.157 ± 0.013	0.666CysGly: 0.666 ± 0.027	0.125CysHis: 0.125 ± 0.012	0.192CysIle: 0.192 ± 0.014	0.068CysLys: 0.068 ± 0.009	0.505CysLeu: 0.505 ± 0.022	0.085CysMet: 0.085 ± 0.009	0.096CysAsn: 0.096 ± 0.01	0.337CysPro: 0.337 ± 0.02	0.117CysGln: 0.117 ± 0.011	0.408CysArg: 0.408 ± 0.023	0.312CysSer: 0.312 ± 0.017	0.42CysThr: 0.42 ± 0.025	0.414CysVal: 0.414 ± 0.019	0.077CysTrp: 0.077 ± 0.008	0.122CysTyr: 0.122 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.299AspAla: 8.299 ± 0.11	0.318AspCys: 0.318 ± 0.019	4.046AspAsp: 4.046 ± 0.103	4.506AspGlu: 4.506 ± 0.075	1.469AspPhe: 1.469 ± 0.042	6.423AspGly: 6.423 ± 0.092	1.662AspHis: 1.662 ± 0.049	2.094AspIle: 2.094 ± 0.048	0.993AspLys: 0.993 ± 0.037	7.155AspLeu: 7.155 ± 0.097	1.07AspMet: 1.07 ± 0.032	0.804AspAsn: 0.804 ± 0.03	5.056AspPro: 5.056 ± 0.08	2.105AspGln: 2.105 ± 0.042	4.742AspArg: 4.742 ± 0.074	2.988AspSer: 2.988 ± 0.062	3.015AspThr: 3.015 ± 0.064	5.243AspVal: 5.243 ± 0.077	0.875AspTrp: 0.875 ± 0.032	1.062AspTyr: 1.062 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.576GluAla: 7.576 ± 0.091	0.26GluCys: 0.26 ± 0.018	4.303GluAsp: 4.303 ± 0.079	3.97GluGlu: 3.97 ± 0.076	1.582GluPhe: 1.582 ± 0.043	5.005GluGly: 5.005 ± 0.072	1.961GluHis: 1.961 ± 0.046	2.798GluIle: 2.798 ± 0.059	1.608GluLys: 1.608 ± 0.048	6.589GluLeu: 6.589 ± 0.103	1.156GluMet: 1.156 ± 0.032	1.283GluAsn: 1.283 ± 0.042	3.446GluPro: 3.446 ± 0.062	3.444GluGln: 3.444 ± 0.066	5.139GluArg: 5.139 ± 0.08	2.782GluSer: 2.782 ± 0.051	2.902GluThr: 2.902 ± 0.057	5.263GluVal: 5.263 ± 0.079	0.662GluTrp: 0.662 ± 0.029	1.101GluTyr: 1.101 ± 0.039	0.003GluXaa: 0.003 ± 0.002
Phe	3.258PheAla: 3.258 ± 0.064	0.176PheCys: 0.176 ± 0.013	1.984PheAsp: 1.984 ± 0.046	1.699PheGlu: 1.699 ± 0.053	0.879PhePhe: 0.879 ± 0.031	2.801PheGly: 2.801 ± 0.057	0.588PheHis: 0.588 ± 0.021	0.894PheIle: 0.894 ± 0.031	0.36PheLys: 0.36 ± 0.021	2.605PheLeu: 2.605 ± 0.068	0.457PheMet: 0.457 ± 0.025	0.468PheAsn: 0.468 ± 0.025	1.288PhePro: 1.288 ± 0.038	0.723PheGln: 0.723 ± 0.031	1.661PheArg: 1.661 ± 0.045	1.648PheSer: 1.648 ± 0.046	1.994PheThr: 1.994 ± 0.05	2.367PheVal: 2.367 ± 0.052	0.447PheTrp: 0.447 ± 0.022	0.56PheTyr: 0.56 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.871GlyAla: 10.871 ± 0.148	0.549GlyCys: 0.549 ± 0.026	5.075GlyAsp: 5.075 ± 0.094	5.622GlyGlu: 5.622 ± 0.088	2.646GlyPhe: 2.646 ± 0.051	8.155GlyGly: 8.155 ± 0.138	2.054GlyHis: 2.054 ± 0.046	4.422GlyIle: 4.422 ± 0.066	2.161GlyLys: 2.161 ± 0.056	8.58GlyLeu: 8.58 ± 0.097	2.265GlyMet: 2.265 ± 0.049	1.586GlyAsn: 1.586 ± 0.047	4.678GlyPro: 4.678 ± 0.075	2.877GlyGln: 2.877 ± 0.056	6.683GlyArg: 6.683 ± 0.094	5.888GlySer: 5.888 ± 0.097	6.731GlyThr: 6.731 ± 0.101	6.96GlyVal: 6.96 ± 0.084	1.42GlyTrp: 1.42 ± 0.04	1.985GlyTyr: 1.985 ± 0.051	0.001GlyXaa: 0.001 ± 0.001
His	2.547HisAla: 2.547 ± 0.052	0.144HisCys: 0.144 ± 0.013	1.491HisAsp: 1.491 ± 0.042	1.353HisGlu: 1.353 ± 0.038	0.504HisPhe: 0.504 ± 0.023	2.298HisGly: 2.298 ± 0.051	0.718HisHis: 0.718 ± 0.029	0.66HisIle: 0.66 ± 0.026	0.286HisLys: 0.286 ± 0.015	2.763HisLeu: 2.763 ± 0.062	0.334HisMet: 0.334 ± 0.018	0.319HisAsn: 0.319 ± 0.019	1.693HisPro: 1.693 ± 0.048	0.698HisGln: 0.698 ± 0.031	2.178HisArg: 2.178 ± 0.049	1.049HisSer: 1.049 ± 0.038	1.169HisThr: 1.169 ± 0.034	1.809HisVal: 1.809 ± 0.042	0.3HisTrp: 0.3 ± 0.017	0.39HisTyr: 0.39 ± 0.022	0.001HisXaa: 0.001 ± 0.001
Ile	6.249IleAla: 6.249 ± 0.093	0.251IleCys: 0.251 ± 0.014	3.376IleAsp: 3.376 ± 0.055	2.712IleGlu: 2.712 ± 0.061	0.913IlePhe: 0.913 ± 0.035	4.27IleGly: 4.27 ± 0.08	0.791IleHis: 0.791 ± 0.029	1.564IleIle: 1.564 ± 0.048	0.667IleLys: 0.667 ± 0.027	3.365IleLeu: 3.365 ± 0.069	0.616IleMet: 0.616 ± 0.027	0.737IleAsn: 0.737 ± 0.029	2.462IlePro: 2.462 ± 0.051	0.97IleGln: 0.97 ± 0.034	2.527IleArg: 2.527 ± 0.05	2.337IleSer: 2.337 ± 0.052	2.964IleThr: 2.964 ± 0.058	3.489IleVal: 3.489 ± 0.066	0.431IleTrp: 0.431 ± 0.021	0.596IleTyr: 0.596 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.326LysAla: 2.326 ± 0.061	0.057LysCys: 0.057 ± 0.009	1.356LysAsp: 1.356 ± 0.044	1.081LysGlu: 1.081 ± 0.041	0.385LysPhe: 0.385 ± 0.021	1.632LysGly: 1.632 ± 0.051	0.454LysHis: 0.454 ± 0.026	0.804LysIle: 0.804 ± 0.03	0.842LysLys: 0.842 ± 0.047	1.607LysLeu: 1.607 ± 0.048	0.332LysMet: 0.332 ± 0.02	0.526LysAsn: 0.526 ± 0.026	1.046LysPro: 1.046 ± 0.044	0.702LysGln: 0.702 ± 0.029	1.418LysArg: 1.418 ± 0.045	1.013LysSer: 1.013 ± 0.039	0.959LysThr: 0.959 ± 0.041	1.556LysVal: 1.556 ± 0.045	0.203LysTrp: 0.203 ± 0.016	0.392LysTyr: 0.392 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.061LeuAla: 14.061 ± 0.162	0.564LeuCys: 0.564 ± 0.021	7.038LeuAsp: 7.038 ± 0.106	6.105LeuGlu: 6.105 ± 0.085	2.588LeuPhe: 2.588 ± 0.053	9.135LeuGly: 9.135 ± 0.105	2.212LeuHis: 2.212 ± 0.047	4.029LeuIle: 4.029 ± 0.077	1.572LeuLys: 1.572 ± 0.045	11.177LeuLeu: 11.177 ± 0.171	1.993LeuMet: 1.993 ± 0.051	1.609LeuAsn: 1.609 ± 0.047	5.933LeuPro: 5.933 ± 0.078	2.788LeuGln: 2.788 ± 0.051	8.089LeuArg: 8.089 ± 0.11	5.386LeuSer: 5.386 ± 0.087	6.511LeuThr: 6.511 ± 0.089	9.142LeuVal: 9.142 ± 0.116	1.216LeuTrp: 1.216 ± 0.043	1.566LeuTyr: 1.566 ± 0.041	0.001LeuXaa: 0.001 ± 0.001
Met	2.301MetAla: 2.301 ± 0.051	0.116MetCys: 0.116 ± 0.011	1.12MetAsp: 1.12 ± 0.036	0.869MetGlu: 0.869 ± 0.03	0.617MetPhe: 0.617 ± 0.027	1.568MetGly: 1.568 ± 0.043	0.425MetHis: 0.425 ± 0.021	1.014MetIle: 1.014 ± 0.034	0.416MetLys: 0.416 ± 0.022	2.189MetLeu: 2.189 ± 0.048	0.411MetMet: 0.411 ± 0.019	0.597MetAsn: 0.597 ± 0.025	1.222MetPro: 1.222 ± 0.035	0.55MetGln: 0.55 ± 0.028	1.547MetArg: 1.547 ± 0.04	1.435MetSer: 1.435 ± 0.041	1.666MetThr: 1.666 ± 0.041	1.706MetVal: 1.706 ± 0.042	0.198MetTrp: 0.198 ± 0.015	0.307MetTyr: 0.307 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.059AsnAla: 2.059 ± 0.053	0.108AsnCys: 0.108 ± 0.011	1.044AsnAsp: 1.044 ± 0.036	0.857AsnGlu: 0.857 ± 0.029	0.455AsnPhe: 0.455 ± 0.025	1.626AsnGly: 1.626 ± 0.047	0.397AsnHis: 0.397 ± 0.021	0.722AsnIle: 0.722 ± 0.027	0.273AsnLys: 0.273 ± 0.019	1.679AsnLeu: 1.679 ± 0.041	0.311AsnMet: 0.311 ± 0.017	0.38AsnAsn: 0.38 ± 0.022	1.39AsnPro: 1.39 ± 0.04	0.561AsnGln: 0.561 ± 0.025	1.241AsnArg: 1.241 ± 0.032	0.891AsnSer: 0.891 ± 0.035	0.978AsnThr: 0.978 ± 0.034	1.359AsnVal: 1.359 ± 0.04	0.271AsnTrp: 0.271 ± 0.018	0.402AsnTyr: 0.402 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.999ProAla: 7.999 ± 0.121	0.231ProCys: 0.231 ± 0.017	3.95ProAsp: 3.95 ± 0.067	4.596ProGlu: 4.596 ± 0.071	1.618ProPhe: 1.618 ± 0.041	6.087ProGly: 6.087 ± 0.098	1.253ProHis: 1.253 ± 0.038	1.933ProIle: 1.933 ± 0.047	0.942ProLys: 0.942 ± 0.034	5.185ProLeu: 5.185 ± 0.084	1.032ProMet: 1.032 ± 0.033	0.811ProAsn: 0.811 ± 0.032	2.625ProPro: 2.625 ± 0.075	1.859ProGln: 1.859 ± 0.051	3.782ProArg: 3.782 ± 0.058	3.475ProSer: 3.475 ± 0.068	3.643ProThr: 3.643 ± 0.063	5.057ProVal: 5.057 ± 0.081	0.854ProTrp: 0.854 ± 0.029	1.052ProTyr: 1.052 ± 0.035	0.001ProXaa: 0.001 ± 0.001
Gln	3.978GlnAla: 3.978 ± 0.071	0.146GlnCys: 0.146 ± 0.01	1.914GlnAsp: 1.914 ± 0.046	2.023GlnGlu: 2.023 ± 0.055	0.812GlnPhe: 0.812 ± 0.032	2.483GlnGly: 2.483 ± 0.064	0.793GlnHis: 0.793 ± 0.028	1.476GlnIle: 1.476 ± 0.044	0.759GlnLys: 0.759 ± 0.029	3.454GlnLeu: 3.454 ± 0.066	0.676GlnMet: 0.676 ± 0.029	0.617GlnAsn: 0.617 ± 0.029	1.649GlnPro: 1.649 ± 0.04	1.609GlnGln: 1.609 ± 0.048	2.75GlnArg: 2.75 ± 0.052	1.425GlnSer: 1.425 ± 0.046	1.337GlnThr: 1.337 ± 0.036	3.12GlnVal: 3.12 ± 0.062	0.516GlnTrp: 0.516 ± 0.024	0.64GlnTyr: 0.64 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.978ArgAla: 8.978 ± 0.115	0.382ArgCys: 0.382 ± 0.025	4.379ArgAsp: 4.379 ± 0.077	5.23ArgGlu: 5.23 ± 0.082	2.219ArgPhe: 2.219 ± 0.054	5.749ArgGly: 5.749 ± 0.103	1.72ArgHis: 1.72 ± 0.043	3.899ArgIle: 3.899 ± 0.064	1.362ArgLys: 1.362 ± 0.046	7.31ArgLeu: 7.31 ± 0.105	1.813ArgMet: 1.813 ± 0.041	1.23ArgAsn: 1.23 ± 0.039	4.303ArgPro: 4.303 ± 0.074	2.095ArgGln: 2.095 ± 0.046	7.264ArgArg: 7.264 ± 0.107	4.75ArgSer: 4.75 ± 0.08	5.284ArgThr: 5.284 ± 0.066	5.183ArgVal: 5.183 ± 0.081	1.155ArgTrp: 1.155 ± 0.04	1.472ArgTyr: 1.472 ± 0.036	0.004ArgXaa: 0.004 ± 0.002
Ser	6.885SerAla: 6.885 ± 0.088	0.305SerCys: 0.305 ± 0.019	3.041SerAsp: 3.041 ± 0.061	2.896SerGlu: 2.896 ± 0.059	1.671SerPhe: 1.671 ± 0.046	5.699SerGly: 5.699 ± 0.097	1.129SerHis: 1.129 ± 0.035	2.214SerIle: 2.214 ± 0.054	0.965SerLys: 0.965 ± 0.038	5.294SerLeu: 5.294 ± 0.08	1.273SerMet: 1.273 ± 0.039	0.994SerAsn: 0.994 ± 0.031	3.387SerPro: 3.387 ± 0.066	1.579SerGln: 1.579 ± 0.042	4.174SerArg: 4.174 ± 0.074	3.624SerSer: 3.624 ± 0.076	3.921SerThr: 3.921 ± 0.063	4.332SerVal: 4.332 ± 0.065	0.892SerTrp: 0.892 ± 0.031	1.017SerTyr: 1.017 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	8.097ThrAla: 8.097 ± 0.101	0.356ThrCys: 0.356 ± 0.019	3.902ThrAsp: 3.902 ± 0.071	3.647ThrGlu: 3.647 ± 0.073	1.75ThrPhe: 1.75 ± 0.045	6.361ThrGly: 6.361 ± 0.084	1.199ThrHis: 1.199 ± 0.035	2.491ThrIle: 2.491 ± 0.046	1.083ThrLys: 1.083 ± 0.041	5.795ThrLeu: 5.795 ± 0.076	1.15ThrMet: 1.15 ± 0.035	0.981ThrAsn: 0.981 ± 0.033	3.978ThrPro: 3.978 ± 0.063	1.507ThrGln: 1.507 ± 0.043	4.014ThrArg: 4.014 ± 0.058	3.608ThrSer: 3.608 ± 0.06	4.104ThrThr: 4.104 ± 0.085	5.991ThrVal: 5.991 ± 0.09	0.997ThrTrp: 0.997 ± 0.033	1.185ThrTyr: 1.185 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.836ValAla: 9.836 ± 0.133	0.55ValCys: 0.55 ± 0.023	5.501ValAsp: 5.501 ± 0.088	5.069ValGlu: 5.069 ± 0.079	2.322ValPhe: 2.322 ± 0.048	6.547ValGly: 6.547 ± 0.084	1.902ValHis: 1.902 ± 0.047	4.068ValIle: 4.068 ± 0.076	1.462ValLys: 1.462 ± 0.048	10.171ValLeu: 10.171 ± 0.129	1.786ValMet: 1.786 ± 0.042	1.498ValAsn: 1.498 ± 0.043	4.972ValPro: 4.972 ± 0.074	2.527ValGln: 2.527 ± 0.054	6.207ValArg: 6.207 ± 0.086	4.19ValSer: 4.19 ± 0.066	5.424ValThr: 5.424 ± 0.079	8.138ValVal: 8.138 ± 0.112	1.017ValTrp: 1.017 ± 0.034	1.281ValTyr: 1.281 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.452TrpAla: 1.452 ± 0.045	0.092TrpCys: 0.092 ± 0.01	0.805TrpAsp: 0.805 ± 0.031	0.81TrpGlu: 0.81 ± 0.028	0.46TrpPhe: 0.46 ± 0.022	1.032TrpGly: 1.032 ± 0.032	0.311TrpHis: 0.311 ± 0.02	0.653TrpIle: 0.653 ± 0.026	0.281TrpLys: 0.281 ± 0.019	1.424TrpLeu: 1.424 ± 0.045	0.385TrpMet: 0.385 ± 0.02	0.369TrpAsn: 0.369 ± 0.022	0.679TrpPro: 0.679 ± 0.026	0.557TrpGln: 0.557 ± 0.026	1.1TrpArg: 1.1 ± 0.035	0.826TrpSer: 0.826 ± 0.035	0.915TrpThr: 0.915 ± 0.037	1.069TrpVal: 1.069 ± 0.035	0.361TrpTrp: 0.361 ± 0.023	0.285TrpTyr: 0.285 ± 0.018	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.104TyrAla: 2.104 ± 0.049	0.126TyrCys: 0.126 ± 0.012	1.208TyrAsp: 1.208 ± 0.04	1.102TyrGlu: 1.102 ± 0.036	0.574TyrPhe: 0.574 ± 0.027	1.744TyrGly: 1.744 ± 0.047	0.333TyrHis: 0.333 ± 0.015	0.511TyrIle: 0.511 ± 0.024	0.308TyrLys: 0.308 ± 0.018	1.91TyrLeu: 1.91 ± 0.041	0.284TyrMet: 0.284 ± 0.019	0.358TyrAsn: 0.358 ± 0.02	0.951TyrPro: 0.951 ± 0.033	0.554TyrGln: 0.554 ± 0.022	1.522TyrArg: 1.522 ± 0.045	1.029TyrSer: 1.029 ± 0.036	1.079TyrThr: 1.079 ± 0.039	1.502TyrVal: 1.502 ± 0.036	0.268TyrTrp: 0.268 ± 0.015	0.418TyrTyr: 0.418 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.003XaaVal: 0.003 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2806 proteins (943634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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