Amino acid dipepetide frequency for Trichococcus palustris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.614AlaAla: 7.614 ± 0.169	0.626AlaCys: 0.626 ± 0.033	4.684AlaAsp: 4.684 ± 0.083	5.86AlaGlu: 5.86 ± 0.102	3.736AlaPhe: 3.736 ± 0.077	5.88AlaGly: 5.88 ± 0.104	1.272AlaHis: 1.272 ± 0.035	6.567AlaIle: 6.567 ± 0.097	5.139AlaLys: 5.139 ± 0.092	8.044AlaLeu: 8.044 ± 0.124	2.395AlaMet: 2.395 ± 0.057	3.358AlaAsn: 3.358 ± 0.079	2.129AlaPro: 2.129 ± 0.06	2.444AlaGln: 2.444 ± 0.058	2.732AlaArg: 2.732 ± 0.07	4.466AlaSer: 4.466 ± 0.078	4.501AlaThr: 4.501 ± 0.094	6.244AlaVal: 6.244 ± 0.097	0.562AlaTrp: 0.562 ± 0.026	3.022AlaTyr: 3.022 ± 0.073	0.0AlaXaa: 0.0 ± 0.0
Cys	0.486CysAla: 0.486 ± 0.029	0.107CysCys: 0.107 ± 0.011	0.384CysAsp: 0.384 ± 0.022	0.403CysGlu: 0.403 ± 0.022	0.361CysPhe: 0.361 ± 0.024	0.79CysGly: 0.79 ± 0.036	0.213CysHis: 0.213 ± 0.015	0.483CysIle: 0.483 ± 0.024	0.318CysLys: 0.318 ± 0.021	0.682CysLeu: 0.682 ± 0.033	0.168CysMet: 0.168 ± 0.018	0.289CysAsn: 0.289 ± 0.019	0.35CysPro: 0.35 ± 0.023	0.193CysGln: 0.193 ± 0.015	0.314CysArg: 0.314 ± 0.02	0.475CysSer: 0.475 ± 0.025	0.4CysThr: 0.4 ± 0.023	0.419CysVal: 0.419 ± 0.024	0.063CysTrp: 0.063 ± 0.009	0.283CysTyr: 0.283 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.36AspAla: 4.36 ± 0.086	0.407AspCys: 0.407 ± 0.024	2.639AspAsp: 2.639 ± 0.069	4.497AspGlu: 4.497 ± 0.094	2.85AspPhe: 2.85 ± 0.064	3.89AspGly: 3.89 ± 0.077	0.922AspHis: 0.922 ± 0.041	4.315AspIle: 4.315 ± 0.067	3.534AspLys: 3.534 ± 0.063	5.112AspLeu: 5.112 ± 0.081	1.495AspMet: 1.495 ± 0.04	2.02AspAsn: 2.02 ± 0.048	1.981AspPro: 1.981 ± 0.057	1.556AspGln: 1.556 ± 0.043	2.229AspArg: 2.229 ± 0.06	3.076AspSer: 3.076 ± 0.07	2.947AspThr: 2.947 ± 0.067	3.996AspVal: 3.996 ± 0.076	0.647AspTrp: 0.647 ± 0.031	2.569AspTyr: 2.569 ± 0.063	0.002AspXaa: 0.002 ± 0.002
Glu	5.978GluAla: 5.978 ± 0.093	0.39GluCys: 0.39 ± 0.023	3.782GluAsp: 3.782 ± 0.08	6.355GluGlu: 6.355 ± 0.104	2.258GluPhe: 2.258 ± 0.054	4.377GluGly: 4.377 ± 0.08	1.258GluHis: 1.258 ± 0.042	5.457GluIle: 5.457 ± 0.102	6.255GluLys: 6.255 ± 0.097	6.434GluLeu: 6.434 ± 0.09	2.462GluMet: 2.462 ± 0.051	3.672GluAsn: 3.672 ± 0.067	1.941GluPro: 1.941 ± 0.058	2.858GluGln: 2.858 ± 0.07	3.194GluArg: 3.194 ± 0.076	3.508GluSer: 3.508 ± 0.065	4.066GluThr: 4.066 ± 0.075	4.616GluVal: 4.616 ± 0.074	0.721GluTrp: 0.721 ± 0.032	2.264GluTyr: 2.264 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.355PheAla: 3.355 ± 0.07	0.351PheCys: 0.351 ± 0.024	2.654PheAsp: 2.654 ± 0.067	2.862PheGlu: 2.862 ± 0.064	2.226PhePhe: 2.226 ± 0.059	3.581PheGly: 3.581 ± 0.062	0.851PheHis: 0.851 ± 0.03	3.317PheIle: 3.317 ± 0.063	2.224PheLys: 2.224 ± 0.06	4.364PheLeu: 4.364 ± 0.091	1.164PheMet: 1.164 ± 0.039	1.828PheAsn: 1.828 ± 0.042	1.648PhePro: 1.648 ± 0.043	1.517PheGln: 1.517 ± 0.044	1.7PheArg: 1.7 ± 0.049	3.162PheSer: 3.162 ± 0.067	2.438PheThr: 2.438 ± 0.054	3.23PheVal: 3.23 ± 0.069	0.394PheTrp: 0.394 ± 0.022	1.635PheTyr: 1.635 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	5.03GlyAla: 5.03 ± 0.095	0.613GlyCys: 0.613 ± 0.032	3.523GlyAsp: 3.523 ± 0.067	4.203GlyGlu: 4.203 ± 0.076	3.469GlyPhe: 3.469 ± 0.076	4.832GlyGly: 4.832 ± 0.1	1.277GlyHis: 1.277 ± 0.045	6.412GlyIle: 6.412 ± 0.103	5.161GlyLys: 5.161 ± 0.074	6.505GlyLeu: 6.505 ± 0.103	2.303GlyMet: 2.303 ± 0.064	3.051GlyAsn: 3.051 ± 0.059	1.651GlyPro: 1.651 ± 0.051	2.267GlyGln: 2.267 ± 0.06	2.582GlyArg: 2.582 ± 0.057	4.053GlySer: 4.053 ± 0.07	4.438GlyThr: 4.438 ± 0.079	4.991GlyVal: 4.991 ± 0.091	0.719GlyTrp: 0.719 ± 0.03	3.029GlyTyr: 3.029 ± 0.066	0.001GlyXaa: 0.001 ± 0.001
His	1.314HisAla: 1.314 ± 0.041	0.186HisCys: 0.186 ± 0.015	1.018HisAsp: 1.018 ± 0.044	1.177HisGlu: 1.177 ± 0.037	1.078HisPhe: 1.078 ± 0.043	1.234HisGly: 1.234 ± 0.041	0.569HisHis: 0.569 ± 0.027	1.333HisIle: 1.333 ± 0.04	0.915HisLys: 0.915 ± 0.037	1.855HisLeu: 1.855 ± 0.049	0.469HisMet: 0.469 ± 0.026	0.732HisAsn: 0.732 ± 0.034	1.054HisPro: 1.054 ± 0.038	0.691HisGln: 0.691 ± 0.029	0.785HisArg: 0.785 ± 0.031	1.06HisSer: 1.06 ± 0.036	1.031HisThr: 1.031 ± 0.036	1.152HisVal: 1.152 ± 0.039	0.185HisTrp: 0.185 ± 0.016	0.876HisTyr: 0.876 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.026IleAla: 7.026 ± 0.101	0.658IleCys: 0.658 ± 0.032	4.271IleAsp: 4.271 ± 0.081	5.116IleGlu: 5.116 ± 0.095	3.261IlePhe: 3.261 ± 0.07	5.774IleGly: 5.774 ± 0.109	1.504IleHis: 1.504 ± 0.048	5.54IleIle: 5.54 ± 0.108	4.18IleLys: 4.18 ± 0.073	7.229IleLeu: 7.229 ± 0.106	1.923IleMet: 1.923 ± 0.049	2.893IleAsn: 2.893 ± 0.069	3.232IlePro: 3.232 ± 0.054	2.677IleGln: 2.677 ± 0.055	3.157IleArg: 3.157 ± 0.065	4.733IleSer: 4.733 ± 0.085	4.26IleThr: 4.26 ± 0.072	5.536IleVal: 5.536 ± 0.09	0.551IleTrp: 0.551 ± 0.027	2.483IleTyr: 2.483 ± 0.056	0.001IleXaa: 0.001 ± 0.001
Lys	5.174LysAla: 5.174 ± 0.087	0.28LysCys: 0.28 ± 0.022	3.988LysAsp: 3.988 ± 0.074	6.194LysGlu: 6.194 ± 0.092	1.879LysPhe: 1.879 ± 0.048	4.187LysGly: 4.187 ± 0.068	1.066LysHis: 1.066 ± 0.034	4.737LysIle: 4.737 ± 0.072	5.58LysLys: 5.58 ± 0.107	5.294LysLeu: 5.294 ± 0.09	2.434LysMet: 2.434 ± 0.051	3.637LysAsn: 3.637 ± 0.074	1.951LysPro: 1.951 ± 0.049	2.658LysGln: 2.658 ± 0.058	2.955LysArg: 2.955 ± 0.066	3.05LysSer: 3.05 ± 0.063	3.715LysThr: 3.715 ± 0.069	4.263LysVal: 4.263 ± 0.074	0.609LysTrp: 0.609 ± 0.026	2.269LysTyr: 2.269 ± 0.054	0.001LysXaa: 0.001 ± 0.001
Leu	8.28LeuAla: 8.28 ± 0.116	0.732LeuCys: 0.732 ± 0.033	5.169LeuAsp: 5.169 ± 0.08	6.058LeuGlu: 6.058 ± 0.108	4.588LeuPhe: 4.588 ± 0.09	6.433LeuGly: 6.433 ± 0.093	1.752LeuHis: 1.752 ± 0.048	6.339LeuIle: 6.339 ± 0.111	6.175LeuLys: 6.175 ± 0.103	9.763LeuLeu: 9.763 ± 0.134	2.641LeuMet: 2.641 ± 0.053	4.146LeuAsn: 4.146 ± 0.088	3.745LeuPro: 3.745 ± 0.067	3.575LeuGln: 3.575 ± 0.067	3.635LeuArg: 3.635 ± 0.069	6.835LeuSer: 6.835 ± 0.115	5.507LeuThr: 5.507 ± 0.084	6.231LeuVal: 6.231 ± 0.097	0.695LeuTrp: 0.695 ± 0.035	3.127LeuTyr: 3.127 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.403MetAla: 2.403 ± 0.051	0.138MetCys: 0.138 ± 0.014	1.76MetAsp: 1.76 ± 0.04	2.057MetGlu: 2.057 ± 0.052	0.851MetPhe: 0.851 ± 0.036	2.042MetGly: 2.042 ± 0.049	0.472MetHis: 0.472 ± 0.028	2.059MetIle: 2.059 ± 0.046	2.126MetLys: 2.126 ± 0.046	2.533MetLeu: 2.533 ± 0.055	0.921MetMet: 0.921 ± 0.039	1.596MetAsn: 1.596 ± 0.046	1.163MetPro: 1.163 ± 0.039	1.081MetGln: 1.081 ± 0.036	1.258MetArg: 1.258 ± 0.04	1.611MetSer: 1.611 ± 0.04	1.769MetThr: 1.769 ± 0.044	1.908MetVal: 1.908 ± 0.053	0.179MetTrp: 0.179 ± 0.014	0.734MetTyr: 0.734 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.304AsnAla: 3.304 ± 0.069	0.322AsnCys: 0.322 ± 0.022	2.252AsnAsp: 2.252 ± 0.055	3.148AsnGlu: 3.148 ± 0.065	1.777AsnPhe: 1.777 ± 0.046	3.461AsnGly: 3.461 ± 0.066	0.982AsnHis: 0.982 ± 0.032	3.304AsnIle: 3.304 ± 0.065	2.744AsnLys: 2.744 ± 0.056	3.984AsnLeu: 3.984 ± 0.076	1.134AsnMet: 1.134 ± 0.036	1.9AsnAsn: 1.9 ± 0.053	2.282AsnPro: 2.282 ± 0.055	1.9AsnGln: 1.9 ± 0.05	2.147AsnArg: 2.147 ± 0.055	2.226AsnSer: 2.226 ± 0.056	2.179AsnThr: 2.179 ± 0.057	3.022AsnVal: 3.022 ± 0.06	0.401AsnTrp: 0.401 ± 0.024	1.682AsnTyr: 1.682 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.875ProAla: 2.875 ± 0.069	0.232ProCys: 0.232 ± 0.017	2.08ProAsp: 2.08 ± 0.053	3.165ProGlu: 3.165 ± 0.06	1.945ProPhe: 1.945 ± 0.049	2.287ProGly: 2.287 ± 0.063	0.688ProHis: 0.688 ± 0.031	2.676ProIle: 2.676 ± 0.061	2.113ProLys: 2.113 ± 0.052	3.287ProLeu: 3.287 ± 0.064	0.901ProMet: 0.901 ± 0.035	1.567ProAsn: 1.567 ± 0.046	0.764ProPro: 0.764 ± 0.034	1.153ProGln: 1.153 ± 0.039	0.97ProArg: 0.97 ± 0.032	1.981ProSer: 1.981 ± 0.049	2.011ProThr: 2.011 ± 0.062	2.691ProVal: 2.691 ± 0.061	0.334ProTrp: 0.334 ± 0.024	1.367ProTyr: 1.367 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.17GlnAla: 3.17 ± 0.084	0.202GlnCys: 0.202 ± 0.015	1.658GlnAsp: 1.658 ± 0.045	2.538GlnGlu: 2.538 ± 0.066	1.462GlnPhe: 1.462 ± 0.046	1.995GlnGly: 1.995 ± 0.05	0.662GlnHis: 0.662 ± 0.029	2.509GlnIle: 2.509 ± 0.054	2.65GlnLys: 2.65 ± 0.057	3.673GlnLeu: 3.673 ± 0.068	1.137GlnMet: 1.137 ± 0.039	1.777GlnAsn: 1.777 ± 0.042	1.078GlnPro: 1.078 ± 0.037	1.565GlnGln: 1.565 ± 0.048	1.467GlnArg: 1.467 ± 0.048	2.023GlnSer: 2.023 ± 0.054	2.268GlnThr: 2.268 ± 0.064	2.343GlnVal: 2.343 ± 0.058	0.322GlnTrp: 0.322 ± 0.022	1.177GlnTyr: 1.177 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.529ArgAla: 2.529 ± 0.054	0.241ArgCys: 0.241 ± 0.019	2.092ArgAsp: 2.092 ± 0.061	3.034ArgGlu: 3.034 ± 0.064	1.908ArgPhe: 1.908 ± 0.049	2.306ArgGly: 2.306 ± 0.054	0.764ArgHis: 0.764 ± 0.025	3.326ArgIle: 3.326 ± 0.068	3.154ArgLys: 3.154 ± 0.059	3.779ArgLeu: 3.779 ± 0.076	1.319ArgMet: 1.319 ± 0.04	2.024ArgAsn: 2.024 ± 0.051	1.303ArgPro: 1.303 ± 0.041	1.462ArgGln: 1.462 ± 0.043	1.789ArgArg: 1.789 ± 0.054	2.158ArgSer: 2.158 ± 0.053	2.221ArgThr: 2.221 ± 0.049	2.529ArgVal: 2.529 ± 0.058	0.328ArgTrp: 0.328 ± 0.02	1.632ArgTyr: 1.632 ± 0.054	0.001ArgXaa: 0.001 ± 0.001
Ser	4.375SerAla: 4.375 ± 0.092	0.372SerCys: 0.372 ± 0.022	3.198SerAsp: 3.198 ± 0.067	3.968SerGlu: 3.968 ± 0.069	2.984SerPhe: 2.984 ± 0.061	4.644SerGly: 4.644 ± 0.078	1.127SerHis: 1.127 ± 0.037	4.46SerIle: 4.46 ± 0.077	3.542SerLys: 3.542 ± 0.063	5.743SerLeu: 5.743 ± 0.092	1.466SerMet: 1.466 ± 0.043	2.385SerAsn: 2.385 ± 0.055	1.966SerPro: 1.966 ± 0.053	2.053SerGln: 2.053 ± 0.056	2.429SerArg: 2.429 ± 0.06	3.672SerSer: 3.672 ± 0.072	3.042SerThr: 3.042 ± 0.063	4.125SerVal: 4.125 ± 0.088	0.567SerTrp: 0.567 ± 0.028	2.256SerTyr: 2.256 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.822ThrAla: 4.822 ± 0.087	0.379ThrCys: 0.379 ± 0.024	3.209ThrAsp: 3.209 ± 0.063	3.776ThrGlu: 3.776 ± 0.069	2.709ThrPhe: 2.709 ± 0.059	4.47ThrGly: 4.47 ± 0.081	1.007ThrHis: 1.007 ± 0.038	4.766ThrIle: 4.766 ± 0.082	3.339ThrLys: 3.339 ± 0.062	5.453ThrLeu: 5.453 ± 0.098	1.34ThrMet: 1.34 ± 0.04	2.379ThrAsn: 2.379 ± 0.057	2.331ThrPro: 2.331 ± 0.07	1.699ThrGln: 1.699 ± 0.05	1.881ThrArg: 1.881 ± 0.047	3.061ThrSer: 3.061 ± 0.062	3.299ThrThr: 3.299 ± 0.081	4.564ThrVal: 4.564 ± 0.089	0.406ThrTrp: 0.406 ± 0.023	2.014ThrTyr: 2.014 ± 0.057	0.001ThrXaa: 0.001 ± 0.001
Val	5.855ValAla: 5.855 ± 0.093	0.586ValCys: 0.586 ± 0.028	4.062ValAsp: 4.062 ± 0.076	4.493ValGlu: 4.493 ± 0.077	2.923ValPhe: 2.923 ± 0.06	4.668ValGly: 4.668 ± 0.093	1.275ValHis: 1.275 ± 0.037	5.369ValIle: 5.369 ± 0.103	4.288ValLys: 4.288 ± 0.07	6.898ValLeu: 6.898 ± 0.095	1.923ValMet: 1.923 ± 0.045	2.901ValAsn: 2.901 ± 0.066	2.697ValPro: 2.697 ± 0.063	2.309ValGln: 2.309 ± 0.049	2.621ValArg: 2.621 ± 0.059	4.603ValSer: 4.603 ± 0.087	4.313ValThr: 4.313 ± 0.062	5.12ValVal: 5.12 ± 0.095	0.57ValTrp: 0.57 ± 0.026	2.324ValTyr: 2.324 ± 0.055	0.001ValXaa: 0.001 ± 0.001
Trp	0.559TrpAla: 0.559 ± 0.026	0.074TrpCys: 0.074 ± 0.009	0.506TrpAsp: 0.506 ± 0.027	0.593TrpGlu: 0.593 ± 0.027	0.373TrpPhe: 0.373 ± 0.024	0.631TrpGly: 0.631 ± 0.03	0.189TrpHis: 0.189 ± 0.013	0.674TrpIle: 0.674 ± 0.032	0.557TrpLys: 0.557 ± 0.029	0.946TrpLeu: 0.946 ± 0.039	0.273TrpMet: 0.273 ± 0.018	0.447TrpAsn: 0.447 ± 0.026	0.213TrpPro: 0.213 ± 0.017	0.389TrpGln: 0.389 ± 0.021	0.349TrpArg: 0.349 ± 0.022	0.509TrpSer: 0.509 ± 0.029	0.491TrpThr: 0.491 ± 0.025	0.528TrpVal: 0.528 ± 0.024	0.096TrpTrp: 0.096 ± 0.011	0.301TrpTyr: 0.301 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.766TyrAla: 2.766 ± 0.064	0.284TyrCys: 0.284 ± 0.019	2.115TyrAsp: 2.115 ± 0.057	2.348TyrGlu: 2.348 ± 0.057	1.863TyrPhe: 1.863 ± 0.052	2.63TyrGly: 2.63 ± 0.058	0.865TyrHis: 0.865 ± 0.034	2.363TyrIle: 2.363 ± 0.051	1.927TyrLys: 1.927 ± 0.06	3.848TyrLeu: 3.848 ± 0.073	0.793TyrMet: 0.793 ± 0.031	1.546TyrAsn: 1.546 ± 0.047	1.607TyrPro: 1.607 ± 0.044	1.628TyrGln: 1.628 ± 0.049	1.704TyrArg: 1.704 ± 0.051	2.107TyrSer: 2.107 ± 0.061	2.007TyrThr: 2.007 ± 0.053	2.292TyrVal: 2.292 ± 0.056	0.35TyrTrp: 0.35 ± 0.023	1.638TyrTyr: 1.638 ± 0.05	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.002XaaGln: 0.002 ± 0.002	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.037XaaXaa: 0.037 ± 0.012

Statistics based on 2699 proteins (820627 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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