Amino acid dipepetide frequency for Cupriavidus plantarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.525AlaAla: 18.525 ± 0.153	1.272AlaCys: 1.272 ± 0.029	7.024AlaAsp: 7.024 ± 0.068	6.709AlaGlu: 6.709 ± 0.069	4.322AlaPhe: 4.322 ± 0.056	11.282AlaGly: 11.282 ± 0.099	2.685AlaHis: 2.685 ± 0.042	5.95AlaIle: 5.95 ± 0.06	3.223AlaLys: 3.223 ± 0.056	14.094AlaLeu: 14.094 ± 0.113	3.849AlaMet: 3.849 ± 0.042	3.169AlaAsn: 3.169 ± 0.05	6.462AlaPro: 6.462 ± 0.077	4.988AlaGln: 4.988 ± 0.059	10.232AlaArg: 10.232 ± 0.105	7.363AlaSer: 7.363 ± 0.063	6.905AlaThr: 6.905 ± 0.076	9.191AlaVal: 9.191 ± 0.087	1.758AlaTrp: 1.758 ± 0.031	2.71AlaTyr: 2.71 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.132CysAla: 1.132 ± 0.03	0.11CysCys: 0.11 ± 0.007	0.494CysAsp: 0.494 ± 0.018	0.485CysGlu: 0.485 ± 0.018	0.291CysPhe: 0.291 ± 0.014	0.95CysGly: 0.95 ± 0.024	0.25CysHis: 0.25 ± 0.013	0.366CysIle: 0.366 ± 0.016	0.189CysLys: 0.189 ± 0.01	0.787CysLeu: 0.787 ± 0.02	0.197CysMet: 0.197 ± 0.011	0.216CysAsn: 0.216 ± 0.011	0.411CysPro: 0.411 ± 0.015	0.218CysGln: 0.218 ± 0.011	0.57CysArg: 0.57 ± 0.019	0.411CysSer: 0.411 ± 0.015	0.456CysThr: 0.456 ± 0.015	0.666CysVal: 0.666 ± 0.018	0.105CysTrp: 0.105 ± 0.007	0.21CysTyr: 0.21 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.045AspAla: 8.045 ± 0.077	0.417AspCys: 0.417 ± 0.016	3.146AspAsp: 3.146 ± 0.064	2.905AspGlu: 2.905 ± 0.043	1.934AspPhe: 1.934 ± 0.033	4.942AspGly: 4.942 ± 0.064	1.132AspHis: 1.132 ± 0.026	2.775AspIle: 2.775 ± 0.039	1.635AspLys: 1.635 ± 0.038	5.22AspLeu: 5.22 ± 0.063	1.334AspMet: 1.334 ± 0.027	1.388AspAsn: 1.388 ± 0.03	2.996AspPro: 2.996 ± 0.039	1.481AspGln: 1.481 ± 0.03	3.807AspArg: 3.807 ± 0.045	2.161AspSer: 2.161 ± 0.039	2.894AspThr: 2.894 ± 0.046	4.517AspVal: 4.517 ± 0.055	0.882AspTrp: 0.882 ± 0.022	1.421AspTyr: 1.421 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.164GluAla: 7.164 ± 0.074	0.369GluCys: 0.369 ± 0.015	2.401GluAsp: 2.401 ± 0.041	2.395GluGlu: 2.395 ± 0.042	1.566GluPhe: 1.566 ± 0.032	3.739GluGly: 3.739 ± 0.049	1.269GluHis: 1.269 ± 0.028	2.666GluIle: 2.666 ± 0.042	1.575GluLys: 1.575 ± 0.038	5.033GluLeu: 5.033 ± 0.065	1.254GluMet: 1.254 ± 0.024	1.22GluAsn: 1.22 ± 0.027	2.363GluPro: 2.363 ± 0.04	2.299GluGln: 2.299 ± 0.036	4.566GluArg: 4.566 ± 0.059	2.577GluSer: 2.577 ± 0.036	2.716GluThr: 2.716 ± 0.038	3.696GluVal: 3.696 ± 0.047	0.69GluTrp: 0.69 ± 0.02	1.069GluTyr: 1.069 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.381PheAla: 4.381 ± 0.051	0.373PheCys: 0.373 ± 0.014	2.471PheAsp: 2.471 ± 0.035	1.845PheGlu: 1.845 ± 0.035	1.268PhePhe: 1.268 ± 0.032	3.459PheGly: 3.459 ± 0.05	0.772PheHis: 0.772 ± 0.02	1.435PheIle: 1.435 ± 0.029	0.883PheLys: 0.883 ± 0.025	2.997PheLeu: 2.997 ± 0.039	0.717PheMet: 0.717 ± 0.021	1.038PheAsn: 1.038 ± 0.027	1.577PhePro: 1.577 ± 0.028	0.998PheGln: 0.998 ± 0.022	2.128PheArg: 2.128 ± 0.034	2.029PheSer: 2.029 ± 0.033	1.835PheThr: 1.835 ± 0.032	2.757PheVal: 2.757 ± 0.042	0.454PheTrp: 0.454 ± 0.017	0.87PheTyr: 0.87 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	9.903GlyAla: 9.903 ± 0.1	0.802GlyCys: 0.802 ± 0.024	4.247GlyAsp: 4.247 ± 0.075	4.269GlyGlu: 4.269 ± 0.052	3.141GlyPhe: 3.141 ± 0.042	7.554GlyGly: 7.554 ± 0.113	1.936GlyHis: 1.936 ± 0.032	4.3GlyIle: 4.3 ± 0.05	3.348GlyLys: 3.348 ± 0.053	8.122GlyLeu: 8.122 ± 0.074	2.524GlyMet: 2.524 ± 0.039	2.621GlyAsn: 2.621 ± 0.056	3.131GlyPro: 3.131 ± 0.046	3.086GlyGln: 3.086 ± 0.05	5.46GlyArg: 5.46 ± 0.055	4.41GlySer: 4.41 ± 0.056	5.206GlyThr: 5.206 ± 0.089	6.686GlyVal: 6.686 ± 0.068	1.312GlyTrp: 1.312 ± 0.026	2.474GlyTyr: 2.474 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	3.262HisAla: 3.262 ± 0.05	0.235HisCys: 0.235 ± 0.013	1.341HisAsp: 1.341 ± 0.029	1.036HisGlu: 1.036 ± 0.026	0.798HisPhe: 0.798 ± 0.019	2.245HisGly: 2.245 ± 0.038	0.632HisHis: 0.632 ± 0.018	0.946HisIle: 0.946 ± 0.021	0.483HisLys: 0.483 ± 0.014	2.109HisLeu: 2.109 ± 0.034	0.5HisMet: 0.5 ± 0.016	0.464HisAsn: 0.464 ± 0.016	1.524HisPro: 1.524 ± 0.031	0.624HisGln: 0.624 ± 0.018	1.595HisArg: 1.595 ± 0.032	0.909HisSer: 0.909 ± 0.022	1.071HisThr: 1.071 ± 0.025	1.711HisVal: 1.711 ± 0.032	0.369HisTrp: 0.369 ± 0.016	0.602HisTyr: 0.602 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.967IleAla: 6.967 ± 0.065	0.412IleCys: 0.412 ± 0.016	3.431IleAsp: 3.431 ± 0.041	2.925IleGlu: 2.925 ± 0.042	1.302IlePhe: 1.302 ± 0.025	4.722IleGly: 4.722 ± 0.058	0.954IleHis: 0.954 ± 0.025	1.494IleIle: 1.494 ± 0.033	1.227IleLys: 1.227 ± 0.029	3.495IleLeu: 3.495 ± 0.049	0.775IleMet: 0.775 ± 0.02	1.329IleAsn: 1.329 ± 0.033	2.124IlePro: 2.124 ± 0.035	1.236IleGln: 1.236 ± 0.027	2.96IleArg: 2.96 ± 0.04	2.401IleSer: 2.401 ± 0.033	2.376IleThr: 2.376 ± 0.032	4.26IleVal: 4.26 ± 0.053	0.487IleTrp: 0.487 ± 0.017	0.95IleTyr: 0.95 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.413LysAla: 3.413 ± 0.049	0.14LysCys: 0.14 ± 0.01	1.442LysAsp: 1.442 ± 0.028	1.328LysGlu: 1.328 ± 0.029	0.813LysPhe: 0.813 ± 0.02	2.131LysGly: 2.131 ± 0.044	0.543LysHis: 0.543 ± 0.018	1.381LysIle: 1.381 ± 0.031	1.01LysLys: 1.01 ± 0.034	3.158LysLeu: 3.158 ± 0.053	0.667LysMet: 0.667 ± 0.023	0.725LysAsn: 0.725 ± 0.024	1.906LysPro: 1.906 ± 0.037	1.11LysGln: 1.11 ± 0.027	1.992LysArg: 1.992 ± 0.033	1.53LysSer: 1.53 ± 0.034	1.764LysThr: 1.764 ± 0.033	2.252LysVal: 2.252 ± 0.044	0.352LysTrp: 0.352 ± 0.014	0.622LysTyr: 0.622 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.065LeuAla: 14.065 ± 0.111	0.961LeuCys: 0.961 ± 0.02	5.768LeuAsp: 5.768 ± 0.064	4.829LeuGlu: 4.829 ± 0.068	3.369LeuPhe: 3.369 ± 0.044	8.228LeuGly: 8.228 ± 0.072	2.225LeuHis: 2.225 ± 0.035	4.329LeuIle: 4.329 ± 0.051	2.807LeuLys: 2.807 ± 0.043	10.252LeuLeu: 10.252 ± 0.106	2.337LeuMet: 2.337 ± 0.04	2.513LeuAsn: 2.513 ± 0.036	6.164LeuPro: 6.164 ± 0.058	3.433LeuGln: 3.433 ± 0.041	7.823LeuArg: 7.823 ± 0.087	6.022LeuSer: 6.022 ± 0.068	5.702LeuThr: 5.702 ± 0.059	7.475LeuVal: 7.475 ± 0.072	1.129LeuTrp: 1.129 ± 0.029	2.141LeuTyr: 2.141 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.046MetAla: 3.046 ± 0.039	0.162MetCys: 0.162 ± 0.009	1.085MetAsp: 1.085 ± 0.027	1.111MetGlu: 1.111 ± 0.023	0.768MetPhe: 0.768 ± 0.024	1.765MetGly: 1.765 ± 0.032	0.572MetHis: 0.572 ± 0.017	1.094MetIle: 1.094 ± 0.027	0.819MetLys: 0.819 ± 0.021	2.9MetLeu: 2.9 ± 0.039	0.641MetMet: 0.641 ± 0.019	0.756MetAsn: 0.756 ± 0.02	1.692MetPro: 1.692 ± 0.037	1.056MetGln: 1.056 ± 0.023	1.936MetArg: 1.936 ± 0.03	1.705MetSer: 1.705 ± 0.028	1.89MetThr: 1.89 ± 0.03	1.704MetVal: 1.704 ± 0.031	0.208MetTrp: 0.208 ± 0.011	0.402MetTyr: 0.402 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.576AsnAla: 3.576 ± 0.05	0.226AsnCys: 0.226 ± 0.01	1.425AsnAsp: 1.425 ± 0.037	1.14AsnGlu: 1.14 ± 0.025	0.886AsnPhe: 0.886 ± 0.021	2.469AsnGly: 2.469 ± 0.057	0.508AsnHis: 0.508 ± 0.017	1.221AsnIle: 1.221 ± 0.028	0.766AsnLys: 0.766 ± 0.025	2.606AsnLeu: 2.606 ± 0.04	0.566AsnMet: 0.566 ± 0.018	0.781AsnAsn: 0.781 ± 0.024	1.8AsnPro: 1.8 ± 0.033	0.82AsnGln: 0.82 ± 0.025	1.757AsnArg: 1.757 ± 0.032	1.136AsnSer: 1.136 ± 0.024	1.502AsnThr: 1.502 ± 0.038	2.252AsnVal: 2.252 ± 0.039	0.418AsnTrp: 0.418 ± 0.019	0.673AsnTyr: 0.673 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.489ProAla: 7.489 ± 0.071	0.324ProCys: 0.324 ± 0.015	3.551ProAsp: 3.551 ± 0.047	3.185ProGlu: 3.185 ± 0.043	1.852ProPhe: 1.852 ± 0.029	4.547ProGly: 4.547 ± 0.057	1.207ProHis: 1.207 ± 0.028	2.168ProIle: 2.168 ± 0.041	1.353ProLys: 1.353 ± 0.029	5.089ProLeu: 5.089 ± 0.059	1.307ProMet: 1.307 ± 0.03	1.435ProAsn: 1.435 ± 0.029	2.857ProPro: 2.857 ± 0.044	1.847ProGln: 1.847 ± 0.034	3.277ProArg: 3.277 ± 0.051	3.056ProSer: 3.056 ± 0.046	2.803ProThr: 2.803 ± 0.046	4.412ProVal: 4.412 ± 0.054	0.686ProTrp: 0.686 ± 0.022	1.339ProTyr: 1.339 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.677GlnAla: 4.677 ± 0.054	0.27GlnCys: 0.27 ± 0.012	1.531GlnAsp: 1.531 ± 0.028	1.407GlnGlu: 1.407 ± 0.03	1.223GlnPhe: 1.223 ± 0.022	2.618GlnGly: 2.618 ± 0.034	0.849GlnHis: 0.849 ± 0.019	1.742GlnIle: 1.742 ± 0.031	0.985GlnLys: 0.985 ± 0.026	3.711GlnLeu: 3.711 ± 0.047	0.973GlnMet: 0.973 ± 0.024	0.854GlnAsn: 0.854 ± 0.025	2.129GlnPro: 2.129 ± 0.035	1.835GlnGln: 1.835 ± 0.044	3.037GlnArg: 3.037 ± 0.046	1.93GlnSer: 1.93 ± 0.032	1.96GlnThr: 1.96 ± 0.032	2.511GlnVal: 2.511 ± 0.036	0.551GlnTrp: 0.551 ± 0.018	0.877GlnTyr: 0.877 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.04ArgAla: 9.04 ± 0.089	0.552ArgCys: 0.552 ± 0.019	4.196ArgAsp: 4.196 ± 0.053	4.47ArgGlu: 4.47 ± 0.058	2.751ArgPhe: 2.751 ± 0.044	5.069ArgGly: 5.069 ± 0.056	2.007ArgHis: 2.007 ± 0.035	3.672ArgIle: 3.672 ± 0.046	2.166ArgLys: 2.166 ± 0.035	7.656ArgLeu: 7.656 ± 0.075	2.135ArgMet: 2.135 ± 0.033	1.984ArgAsn: 1.984 ± 0.036	3.344ArgPro: 3.344 ± 0.047	2.961ArgGln: 2.961 ± 0.04	5.492ArgArg: 5.492 ± 0.06	3.2ArgSer: 3.2 ± 0.037	3.64ArgThr: 3.64 ± 0.048	5.576ArgVal: 5.576 ± 0.062	1.101ArgTrp: 1.101 ± 0.026	1.998ArgTyr: 1.998 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.558SerAla: 6.558 ± 0.066	0.403SerCys: 0.403 ± 0.017	2.624SerAsp: 2.624 ± 0.038	2.346SerGlu: 2.346 ± 0.038	1.937SerPhe: 1.937 ± 0.033	5.156SerGly: 5.156 ± 0.06	1.254SerHis: 1.254 ± 0.029	2.473SerIle: 2.473 ± 0.038	1.371SerLys: 1.371 ± 0.032	5.565SerLeu: 5.565 ± 0.056	1.411SerMet: 1.411 ± 0.027	1.44SerAsn: 1.44 ± 0.032	3.081SerPro: 3.081 ± 0.049	1.8SerGln: 1.8 ± 0.036	3.803SerArg: 3.803 ± 0.047	2.943SerSer: 2.943 ± 0.04	2.92SerThr: 2.92 ± 0.049	4.045SerVal: 4.045 ± 0.047	0.68SerTrp: 0.68 ± 0.018	1.232SerTyr: 1.232 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	6.538ThrAla: 6.538 ± 0.082	0.399ThrCys: 0.399 ± 0.014	2.8ThrAsp: 2.8 ± 0.038	2.44ThrGlu: 2.44 ± 0.032	1.962ThrPhe: 1.962 ± 0.03	4.948ThrGly: 4.948 ± 0.07	1.286ThrHis: 1.286 ± 0.027	2.615ThrIle: 2.615 ± 0.043	1.182ThrLys: 1.182 ± 0.03	6.556ThrLeu: 6.556 ± 0.071	1.299ThrMet: 1.299 ± 0.023	1.346ThrAsn: 1.346 ± 0.032	3.783ThrPro: 3.783 ± 0.055	1.881ThrGln: 1.881 ± 0.03	3.806ThrArg: 3.806 ± 0.051	2.861ThrSer: 2.861 ± 0.041	3.133ThrThr: 3.133 ± 0.056	4.73ThrVal: 4.73 ± 0.063	0.68ThrTrp: 0.68 ± 0.02	1.232ThrTyr: 1.232 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.959ValAla: 9.959 ± 0.072	0.712ValCys: 0.712 ± 0.022	4.091ValAsp: 4.091 ± 0.049	4.128ValGlu: 4.128 ± 0.052	2.649ValPhe: 2.649 ± 0.04	5.648ValGly: 5.648 ± 0.058	1.497ValHis: 1.497 ± 0.031	3.664ValIle: 3.664 ± 0.053	2.19ValLys: 2.19 ± 0.039	7.973ValLeu: 7.973 ± 0.071	1.985ValMet: 1.985 ± 0.036	2.236ValAsn: 2.236 ± 0.036	4.522ValPro: 4.522 ± 0.053	2.502ValGln: 2.502 ± 0.041	5.608ValArg: 5.608 ± 0.059	4.57ValSer: 4.57 ± 0.054	4.684ValThr: 4.684 ± 0.063	6.488ValVal: 6.488 ± 0.066	0.906ValTrp: 0.906 ± 0.025	1.578ValTyr: 1.578 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.135TrpAla: 1.135 ± 0.024	0.14TrpCys: 0.14 ± 0.009	0.596TrpAsp: 0.596 ± 0.019	0.547TrpGlu: 0.547 ± 0.017	0.554TrpPhe: 0.554 ± 0.021	0.886TrpGly: 0.886 ± 0.021	0.421TrpHis: 0.421 ± 0.018	0.703TrpIle: 0.703 ± 0.019	0.412TrpLys: 0.412 ± 0.016	1.815TrpLeu: 1.815 ± 0.039	0.397TrpMet: 0.397 ± 0.014	0.399TrpAsn: 0.399 ± 0.015	0.636TrpPro: 0.636 ± 0.018	0.68TrpGln: 0.68 ± 0.021	1.185TrpArg: 1.185 ± 0.027	0.721TrpSer: 0.721 ± 0.022	0.712TrpThr: 0.712 ± 0.023	0.852TrpVal: 0.852 ± 0.027	0.229TrpTrp: 0.229 ± 0.012	0.33TrpTyr: 0.33 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.84TyrAla: 2.84 ± 0.04	0.237TyrCys: 0.237 ± 0.01	1.368TyrAsp: 1.368 ± 0.027	1.126TyrGlu: 1.126 ± 0.024	0.901TyrPhe: 0.901 ± 0.025	2.174TyrGly: 2.174 ± 0.041	0.459TyrHis: 0.459 ± 0.014	0.83TyrIle: 0.83 ± 0.022	0.652TyrLys: 0.652 ± 0.02	2.433TyrLeu: 2.433 ± 0.034	0.443TyrMet: 0.443 ± 0.016	0.616TyrAsn: 0.616 ± 0.019	1.283TyrPro: 1.283 ± 0.024	0.815TyrGln: 0.815 ± 0.02	1.974TyrArg: 1.974 ± 0.035	1.107TyrSer: 1.107 ± 0.025	1.31TyrThr: 1.31 ± 0.026	1.808TyrVal: 1.808 ± 0.035	0.351TyrTrp: 0.351 ± 0.014	0.672TyrTyr: 0.672 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5711 proteins (1919394 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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