Amino acid dipepetide frequency for Paracoccus sp. S-4012

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.372AlaAla: 23.372 ± 0.239	1.11AlaCys: 1.11 ± 0.032	7.319AlaAsp: 7.319 ± 0.088	10.16AlaGlu: 10.16 ± 0.132	4.324AlaPhe: 4.324 ± 0.058	13.057AlaGly: 13.057 ± 0.137	2.321AlaHis: 2.321 ± 0.045	5.898AlaIle: 5.898 ± 0.086	2.611AlaLys: 2.611 ± 0.057	15.299AlaLeu: 15.299 ± 0.15	4.008AlaMet: 4.008 ± 0.059	2.324AlaAsn: 2.324 ± 0.05	7.518AlaPro: 7.518 ± 0.131	4.278AlaGln: 4.278 ± 0.069	11.967AlaArg: 11.967 ± 0.153	5.836AlaSer: 5.836 ± 0.092	6.369AlaThr: 6.369 ± 0.082	10.104AlaVal: 10.104 ± 0.097	1.86AlaTrp: 1.86 ± 0.041	2.276AlaTyr: 2.276 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.02CysAla: 1.02 ± 0.034	0.09CysCys: 0.09 ± 0.011	0.532CysAsp: 0.532 ± 0.021	0.416CysGlu: 0.416 ± 0.021	0.266CysPhe: 0.266 ± 0.016	0.938CysGly: 0.938 ± 0.034	0.269CysHis: 0.269 ± 0.017	0.351CysIle: 0.351 ± 0.018	0.116CysLys: 0.116 ± 0.011	0.709CysLeu: 0.709 ± 0.026	0.156CysMet: 0.156 ± 0.012	0.175CysAsn: 0.175 ± 0.013	0.477CysPro: 0.477 ± 0.024	0.185CysGln: 0.185 ± 0.014	0.646CysArg: 0.646 ± 0.025	0.367CysSer: 0.367 ± 0.021	0.393CysThr: 0.393 ± 0.02	0.494CysVal: 0.494 ± 0.019	0.094CysTrp: 0.094 ± 0.009	0.165CysTyr: 0.165 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.742AspAla: 7.742 ± 0.097	0.466AspCys: 0.466 ± 0.021	3.059AspAsp: 3.059 ± 0.068	3.642AspGlu: 3.642 ± 0.064	2.089AspPhe: 2.089 ± 0.043	5.271AspGly: 5.271 ± 0.081	1.221AspHis: 1.221 ± 0.035	2.431AspIle: 2.431 ± 0.041	0.95AspLys: 0.95 ± 0.03	6.224AspLeu: 6.224 ± 0.081	1.277AspMet: 1.277 ± 0.036	0.917AspAsn: 0.917 ± 0.028	4.244AspPro: 4.244 ± 0.068	1.409AspGln: 1.409 ± 0.035	4.91AspArg: 4.91 ± 0.074	1.925AspSer: 1.925 ± 0.048	2.35AspThr: 2.35 ± 0.058	3.459AspVal: 3.459 ± 0.059	1.188AspTrp: 1.188 ± 0.037	1.384AspTyr: 1.384 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	10.52GluAla: 10.52 ± 0.153	0.328GluCys: 0.328 ± 0.018	3.033GluAsp: 3.033 ± 0.056	3.199GluGlu: 3.199 ± 0.063	1.567GluPhe: 1.567 ± 0.04	5.886GluGly: 5.886 ± 0.078	1.117GluHis: 1.117 ± 0.031	3.263GluIle: 3.263 ± 0.06	1.398GluLys: 1.398 ± 0.039	5.338GluLeu: 5.338 ± 0.073	1.59GluMet: 1.59 ± 0.031	1.289GluAsn: 1.289 ± 0.035	3.036GluPro: 3.036 ± 0.056	1.734GluGln: 1.734 ± 0.047	5.169GluArg: 5.169 ± 0.077	2.094GluSer: 2.094 ± 0.049	3.367GluThr: 3.367 ± 0.048	4.824GluVal: 4.824 ± 0.073	0.788GluTrp: 0.788 ± 0.03	0.851GluTyr: 0.851 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.461PheAla: 4.461 ± 0.069	0.38PheCys: 0.38 ± 0.019	2.433PheAsp: 2.433 ± 0.048	1.916PheGlu: 1.916 ± 0.046	1.147PhePhe: 1.147 ± 0.033	3.396PheGly: 3.396 ± 0.062	0.744PheHis: 0.744 ± 0.025	1.399PheIle: 1.399 ± 0.044	0.562PheLys: 0.562 ± 0.024	3.259PheLeu: 3.259 ± 0.058	0.732PheMet: 0.732 ± 0.028	0.792PheAsn: 0.792 ± 0.028	1.567PhePro: 1.567 ± 0.043	0.894PheGln: 0.894 ± 0.031	2.368PheArg: 2.368 ± 0.044	1.76PheSer: 1.76 ± 0.046	1.803PheThr: 1.803 ± 0.045	2.439PheVal: 2.439 ± 0.054	0.522PheTrp: 0.522 ± 0.022	0.777PheTyr: 0.777 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	11.383GlyAla: 11.383 ± 0.1	0.841GlyCys: 0.841 ± 0.032	4.62GlyAsp: 4.62 ± 0.088	5.401GlyGlu: 5.401 ± 0.072	3.704GlyPhe: 3.704 ± 0.069	8.673GlyGly: 8.673 ± 0.147	1.978GlyHis: 1.978 ± 0.041	4.47GlyIle: 4.47 ± 0.072	2.254GlyLys: 2.254 ± 0.049	10.017GlyLeu: 10.017 ± 0.118	2.786GlyMet: 2.786 ± 0.064	2.02GlyAsn: 2.02 ± 0.071	4.436GlyPro: 4.436 ± 0.062	2.953GlyGln: 2.953 ± 0.058	7.792GlyArg: 7.792 ± 0.091	4.252GlySer: 4.252 ± 0.076	4.842GlyThr: 4.842 ± 0.077	6.468GlyVal: 6.468 ± 0.088	1.77GlyTrp: 1.77 ± 0.044	2.01GlyTyr: 2.01 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.504HisAla: 2.504 ± 0.053	0.194HisCys: 0.194 ± 0.014	1.299HisAsp: 1.299 ± 0.035	1.125HisGlu: 1.125 ± 0.033	0.699HisPhe: 0.699 ± 0.028	2.125HisGly: 2.125 ± 0.044	0.539HisHis: 0.539 ± 0.027	0.75HisIle: 0.75 ± 0.03	0.323HisLys: 0.323 ± 0.018	2.119HisLeu: 2.119 ± 0.047	0.452HisMet: 0.452 ± 0.02	0.375HisAsn: 0.375 ± 0.018	1.54HisPro: 1.54 ± 0.039	0.517HisGln: 0.517 ± 0.02	1.716HisArg: 1.716 ± 0.045	0.836HisSer: 0.836 ± 0.027	0.676HisThr: 0.676 ± 0.026	1.536HisVal: 1.536 ± 0.042	0.32HisTrp: 0.32 ± 0.019	0.503HisTyr: 0.503 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.112IleAla: 7.112 ± 0.078	0.457IleCys: 0.457 ± 0.02	3.152IleAsp: 3.152 ± 0.056	3.368IleGlu: 3.368 ± 0.057	1.412IlePhe: 1.412 ± 0.042	4.569IleGly: 4.569 ± 0.068	0.96IleHis: 0.96 ± 0.03	1.709IleIle: 1.709 ± 0.043	0.796IleLys: 0.796 ± 0.03	4.284IleLeu: 4.284 ± 0.073	0.914IleMet: 0.914 ± 0.031	0.998IleAsn: 0.998 ± 0.031	2.22IlePro: 2.22 ± 0.045	0.913IleGln: 0.913 ± 0.029	3.515IleArg: 3.515 ± 0.054	2.284IleSer: 2.284 ± 0.048	2.473IleThr: 2.473 ± 0.054	3.582IleVal: 3.582 ± 0.066	0.604IleTrp: 0.604 ± 0.026	0.915IleTyr: 0.915 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.89LysAla: 2.89 ± 0.06	0.109LysCys: 0.109 ± 0.01	1.113LysAsp: 1.113 ± 0.038	0.981LysGlu: 0.981 ± 0.033	0.522LysPhe: 0.522 ± 0.021	1.936LysGly: 1.936 ± 0.04	0.424LysHis: 0.424 ± 0.017	1.036LysIle: 1.036 ± 0.034	0.627LysLys: 0.627 ± 0.033	2.115LysLeu: 2.115 ± 0.047	0.508LysMet: 0.508 ± 0.025	0.479LysAsn: 0.479 ± 0.023	1.323LysPro: 1.323 ± 0.036	0.593LysGln: 0.593 ± 0.025	1.583LysArg: 1.583 ± 0.041	1.114LysSer: 1.114 ± 0.03	1.184LysThr: 1.184 ± 0.034	1.582LysVal: 1.582 ± 0.047	0.244LysTrp: 0.244 ± 0.015	0.374LysTyr: 0.374 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.894LeuAla: 15.894 ± 0.171	0.813LeuCys: 0.813 ± 0.028	6.314LeuAsp: 6.314 ± 0.085	5.097LeuGlu: 5.097 ± 0.074	3.051LeuPhe: 3.051 ± 0.067	9.313LeuGly: 9.313 ± 0.115	1.956LeuHis: 1.956 ± 0.045	4.931LeuIle: 4.931 ± 0.078	2.405LeuLys: 2.405 ± 0.051	9.514LeuLeu: 9.514 ± 0.145	2.662LeuMet: 2.662 ± 0.06	2.185LeuAsn: 2.185 ± 0.047	6.482LeuPro: 6.482 ± 0.073	2.513LeuGln: 2.513 ± 0.051	8.363LeuArg: 8.363 ± 0.108	5.822LeuSer: 5.822 ± 0.076	6.145LeuThr: 6.145 ± 0.086	7.146LeuVal: 7.146 ± 0.103	1.48LeuTrp: 1.48 ± 0.04	1.765LeuTyr: 1.765 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.547MetAla: 3.547 ± 0.055	0.132MetCys: 0.132 ± 0.011	1.262MetAsp: 1.262 ± 0.037	1.273MetGlu: 1.273 ± 0.035	0.706MetPhe: 0.706 ± 0.025	2.121MetGly: 2.121 ± 0.049	0.418MetHis: 0.418 ± 0.019	1.335MetIle: 1.335 ± 0.039	0.692MetLys: 0.692 ± 0.023	2.657MetLeu: 2.657 ± 0.06	0.645MetMet: 0.645 ± 0.028	0.704MetAsn: 0.704 ± 0.025	1.615MetPro: 1.615 ± 0.035	0.866MetGln: 0.866 ± 0.026	2.09MetArg: 2.09 ± 0.037	1.442MetSer: 1.442 ± 0.032	1.956MetThr: 1.956 ± 0.041	1.755MetVal: 1.755 ± 0.04	0.219MetTrp: 0.219 ± 0.015	0.255MetTyr: 0.255 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.691AsnAla: 2.691 ± 0.052	0.208AsnCys: 0.208 ± 0.013	1.111AsnAsp: 1.111 ± 0.036	0.961AsnGlu: 0.961 ± 0.031	0.712AsnPhe: 0.712 ± 0.026	1.928AsnGly: 1.928 ± 0.051	0.405AsnHis: 0.405 ± 0.021	1.009AsnIle: 1.009 ± 0.033	0.396AsnLys: 0.396 ± 0.019	2.23AsnLeu: 2.23 ± 0.044	0.516AsnMet: 0.516 ± 0.022	0.431AsnAsn: 0.431 ± 0.023	1.683AsnPro: 1.683 ± 0.042	0.553AsnGln: 0.553 ± 0.021	1.628AsnArg: 1.628 ± 0.04	0.884AsnSer: 0.884 ± 0.03	0.957AsnThr: 0.957 ± 0.03	1.485AsnVal: 1.485 ± 0.036	0.394AsnTrp: 0.394 ± 0.021	0.475AsnTyr: 0.475 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	8.086ProAla: 8.086 ± 0.11	0.353ProCys: 0.353 ± 0.02	3.904ProAsp: 3.904 ± 0.062	4.847ProGlu: 4.847 ± 0.072	1.892ProPhe: 1.892 ± 0.041	5.786ProGly: 5.786 ± 0.078	1.147ProHis: 1.147 ± 0.033	2.005ProIle: 2.005 ± 0.045	1.14ProLys: 1.14 ± 0.034	5.305ProLeu: 5.305 ± 0.07	1.374ProMet: 1.374 ± 0.036	1.097ProAsn: 1.097 ± 0.029	3.368ProPro: 3.368 ± 0.073	1.839ProGln: 1.839 ± 0.039	4.005ProArg: 4.005 ± 0.073	2.553ProSer: 2.553 ± 0.049	2.314ProThr: 2.314 ± 0.046	4.855ProVal: 4.855 ± 0.076	0.813ProTrp: 0.813 ± 0.027	1.022ProTyr: 1.022 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.981GlnAla: 3.981 ± 0.078	0.148GlnCys: 0.148 ± 0.012	1.341GlnAsp: 1.341 ± 0.034	1.302GlnGlu: 1.302 ± 0.038	0.922GlnPhe: 0.922 ± 0.027	2.588GlnGly: 2.588 ± 0.046	0.552GlnHis: 0.552 ± 0.023	1.561GlnIle: 1.561 ± 0.038	0.723GlnLys: 0.723 ± 0.03	2.777GlnLeu: 2.777 ± 0.058	0.849GlnMet: 0.849 ± 0.028	0.677GlnAsn: 0.677 ± 0.023	1.828GlnPro: 1.828 ± 0.043	0.996GlnGln: 0.996 ± 0.034	2.277GlnArg: 2.277 ± 0.049	1.384GlnSer: 1.384 ± 0.038	1.519GlnThr: 1.519 ± 0.038	2.214GlnVal: 2.214 ± 0.044	0.366GlnTrp: 0.366 ± 0.016	0.434GlnTyr: 0.434 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.522ArgAla: 10.522 ± 0.126	0.528ArgCys: 0.528 ± 0.02	4.638ArgAsp: 4.638 ± 0.071	4.968ArgGlu: 4.968 ± 0.071	3.002ArgPhe: 3.002 ± 0.056	6.224ArgGly: 6.224 ± 0.095	1.95ArgHis: 1.95 ± 0.046	4.249ArgIle: 4.249 ± 0.065	1.647ArgLys: 1.647 ± 0.042	9.628ArgLeu: 9.628 ± 0.123	2.264ArgMet: 2.264 ± 0.046	1.66ArgAsn: 1.66 ± 0.043	4.504ArgPro: 4.504 ± 0.081	2.568ArgGln: 2.568 ± 0.05	7.428ArgArg: 7.428 ± 0.114	3.488ArgSer: 3.488 ± 0.063	3.272ArgThr: 3.272 ± 0.061	5.683ArgVal: 5.683 ± 0.086	1.183ArgTrp: 1.183 ± 0.034	1.499ArgTyr: 1.499 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.653SerAla: 5.653 ± 0.078	0.353SerCys: 0.353 ± 0.02	2.537SerAsp: 2.537 ± 0.051	2.355SerGlu: 2.355 ± 0.045	1.954SerPhe: 1.954 ± 0.042	5.189SerGly: 5.189 ± 0.077	0.961SerHis: 0.961 ± 0.03	2.038SerIle: 2.038 ± 0.052	0.942SerLys: 0.942 ± 0.034	4.816SerLeu: 4.816 ± 0.066	1.135SerMet: 1.135 ± 0.033	0.95SerAsn: 0.95 ± 0.029	2.608SerPro: 2.608 ± 0.047	1.271SerGln: 1.271 ± 0.034	3.562SerArg: 3.562 ± 0.064	2.109SerSer: 2.109 ± 0.053	2.223SerThr: 2.223 ± 0.042	3.303SerVal: 3.303 ± 0.06	0.652SerTrp: 0.652 ± 0.025	1.018SerTyr: 1.018 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.697ThrAla: 6.697 ± 0.078	0.444ThrCys: 0.444 ± 0.023	2.851ThrAsp: 2.851 ± 0.056	2.749ThrGlu: 2.749 ± 0.05	1.595ThrPhe: 1.595 ± 0.041	5.359ThrGly: 5.359 ± 0.082	1.035ThrHis: 1.035 ± 0.03	2.413ThrIle: 2.413 ± 0.047	0.857ThrLys: 0.857 ± 0.03	5.757ThrLeu: 5.757 ± 0.076	1.037ThrMet: 1.037 ± 0.032	0.997ThrAsn: 0.997 ± 0.034	3.43ThrPro: 3.43 ± 0.065	1.25ThrGln: 1.25 ± 0.037	4.035ThrArg: 4.035 ± 0.066	2.227ThrSer: 2.227 ± 0.047	2.629ThrThr: 2.629 ± 0.062	4.106ThrVal: 4.106 ± 0.063	0.636ThrTrp: 0.636 ± 0.026	0.901ThrTyr: 0.901 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.124ValAla: 10.124 ± 0.116	0.549ValCys: 0.549 ± 0.023	3.583ValAsp: 3.583 ± 0.064	4.86ValGlu: 4.86 ± 0.073	2.546ValPhe: 2.546 ± 0.047	5.332ValGly: 5.332 ± 0.078	1.359ValHis: 1.359 ± 0.038	3.966ValIle: 3.966 ± 0.059	1.597ValLys: 1.597 ± 0.04	7.898ValLeu: 7.898 ± 0.103	2.048ValMet: 2.048 ± 0.045	1.743ValAsn: 1.743 ± 0.04	4.052ValPro: 4.052 ± 0.057	1.948ValGln: 1.948 ± 0.044	5.001ValArg: 5.001 ± 0.073	3.568ValSer: 3.568 ± 0.058	4.811ValThr: 4.811 ± 0.075	5.887ValVal: 5.887 ± 0.083	1.054ValTrp: 1.054 ± 0.03	1.24ValTyr: 1.24 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.485TrpAla: 1.485 ± 0.037	0.156TrpCys: 0.156 ± 0.013	0.763TrpAsp: 0.763 ± 0.028	0.722TrpGlu: 0.722 ± 0.026	0.572TrpPhe: 0.572 ± 0.023	1.114TrpGly: 1.114 ± 0.037	0.362TrpHis: 0.362 ± 0.021	0.668TrpIle: 0.668 ± 0.027	0.36TrpLys: 0.36 ± 0.019	1.932TrpLeu: 1.932 ± 0.052	0.354TrpMet: 0.354 ± 0.019	0.402TrpAsn: 0.402 ± 0.022	0.797TrpPro: 0.797 ± 0.029	0.638TrpGln: 0.638 ± 0.026	1.331TrpArg: 1.331 ± 0.03	0.813TrpSer: 0.813 ± 0.032	0.846TrpThr: 0.846 ± 0.028	0.945TrpVal: 0.945 ± 0.026	0.276TrpTrp: 0.276 ± 0.018	0.254TrpTyr: 0.254 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.329TyrAla: 2.329 ± 0.049	0.199TyrCys: 0.199 ± 0.015	1.293TyrAsp: 1.293 ± 0.035	1.047TyrGlu: 1.047 ± 0.037	0.669TyrPhe: 0.669 ± 0.027	1.87TyrGly: 1.87 ± 0.047	0.427TyrHis: 0.427 ± 0.022	0.755TyrIle: 0.755 ± 0.03	0.341TyrLys: 0.341 ± 0.017	1.975TyrLeu: 1.975 ± 0.045	0.383TyrMet: 0.383 ± 0.021	0.444TyrAsn: 0.444 ± 0.02	0.975TyrPro: 0.975 ± 0.03	0.52TyrGln: 0.52 ± 0.022	1.521TyrArg: 1.521 ± 0.04	0.871TyrSer: 0.871 ± 0.028	0.878TyrThr: 0.878 ± 0.028	1.299TyrVal: 1.299 ± 0.035	0.326TyrTrp: 0.326 ± 0.019	0.469TyrTyr: 0.469 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3506 proteins (1100487 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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